Clinical trials: Age-Related Frailty
Aging, Cellular Senescence
BIOANCIENT: Cohort of Centenarians in Navarra (1926-1927)
Demographic aging is a growing global challenge, driven by increasing life expectancy and declining birth rates, with projections indicating that more than 30% of the European population will be over 65 years old by 2100.
- Conditions
- Aging, Cellular Senescence, Biomarkers / Blood, Age-Related Diseases
- Trial name
- BIOANCIENT (NCT07707297)
- Where
- Spain
- Volunteers
- 333 people
- Sponsor
- Fundacion Miguel Servet
Geriatric Assessment, Frail Elderly Syndrome
Frailty Prevention in Elders From Reunion Island
In Reunion Island, people encounter environmental and social conditions leading to premature ageing and subsequent frailty. The study evaluates tools, supported by the latest scientific advances in "machine learning" to detect…
- Conditions
- Geriatric Assessment, Frail Elderly Syndrome, Prevention, Fall Patients
- Trial name
- 5P-ECHELLE (NCT05090241)
- Testing
- Instrumental measurement of balance and gait
- Where
- 2 sites in Reunion
- Volunteers
- 147 people
- Sponsor
- Universite de La Reunion
Nursing Caries, Old Age; Debility
Multifactorial Study of the Relationship Between the Conditions of Life and the Incidence of Risk of Falling
HYPOTHESIS: The incidence of risk of falls is related to the living conditions of elderly people in the community. OBJECTIVES: To study the relationship between living conditions and the incidence of risk of falls in older adults…
- Conditions
- Nursing Caries, Old Age; Debility, Aging Disorder
- Trial name
- NCT04301713
- Testing
- Evaluation of rik of falls
- Where
- Spain
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Frailty in Older Adults, Intrinsic Capacity
Optimizing INtrinsic Capacity for Functional INdependence and to Impede FrailTY in Older Adults: Adaptation of the WHO-ICOPE for Healthy Ageing in Singapore
The goal of this intervention study is to screen and identify frailty and decline in intrinsic capacity (physical and mental capacities) in community-dwelling older adults in Singapore, and to evaluate whether early…
- Conditions
- Frailty in Older Adults, Intrinsic Capacity, Age-related Functional Decline, Healthy Ageing
- Trial name
- INFINITY-ICOPE (NCT07477561)
- Testing
- INFINITY-ICOPE programme
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Sengkang General Hospital
Neuropathic Pain, Old Age; Debility
Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older
This study aimed to determine the frequency of neuropathic pain in individuals aged 80 years and older and to evaluate the relationship between neuropathic pain and comprehensive geriatric assessment parameters.
- Conditions
- Neuropathic Pain, Old Age; Debility, Pain
- Trial name
- NCT07487610
- Testing
- Detailed geriatric assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 450 people
- Sponsor
- Sultan 1. Murat State Hospital
Aging
Preliminary Testing of Cafe Move for Primary Prevention of Physical Frailty
This project explores a novel means of health promotion and prevention of age-related physical frailty, which is designed to overcome barriers to access and promote autonomy in managing physical health.
- Trial name
- NCT05720507
- Testing
- Cafe Move
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Montana
Fraility, Anxiety, Preoperative
The Relationship Between Preoperative Anxiety Level and Frailty Score in Elderly Patients Scheduled for Elective Hip Arthroplasty: A Prospective Observational Study
Frailty is a state of vulnerability resulting from decreased physiological reserve across multiple organ systems, impairing an individual's ability to withstand stressors.
- Conditions
- Fraility, Anxiety, Preoperative, Hip Arthroplasty
- Trial name
- NCT07633483
- Where
- Turkey (Türkiye)
- Volunteers
- 142 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Frailty, Aging
Open Label Study for the Use of Transcranial Ultrasound for Treatment of Age-Related Frailty
The purpose of this Phase I open label study is to evaluate longer term tolerability and potential effectiveness of transcranial ultrasound in people with age-related frailty.
- Trial name
- fUS-ARF (NCT04770350)
- Testing
- Focused Ultrasound
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Neurological Associates of West Los Angeles
Frailty Syndrome, Geriatric Health
Longitudinal Assessment of Lung Function and Respiratory Muscle Strength Following Training of the Inspiratory Muscles in Frail Older Adults (IMT-3)
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on lung function and respiratory muscle strength in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Geriatric Health, Respiratory Muscle Weakness, Age-Related Frailty
- Trial name
- NCT07556445
- Testing
- Inspiratory Muscle Training
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Francisco de Vitoria
Health Services Accessibility, Rural Health
Health Ahead Comparative Effectiveness Study
The Health Ahead Comparative Effectiveness Study is a pragmatic, parallel-arm interventional platform that systematically compares successive changes to preventive health screening on the path toward a fully automated screening…
- Conditions
- Health Services Accessibility, Rural Health, Medically Underserved Area, Preventive Health Services
- Trial name
- HACE (NCT07669168)
- Testing
- AI-Assisted Screening Interpretation (AI Reads), Human-Only Screening Interpretation
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- William Brandenburg, MD
Malnutrition, Sarcopenia
Nutritional Status in Hospitalized Patients Over 65 Years of Age With Mental Disorders
The objective of of this observational study is to evaluate the nutritional status and the prevalence of nutrition-related conditions, as well as dysphagia, among patients aged 65 years and older with mental disorders.
- Conditions
- Malnutrition, Sarcopenia, Obesity, Sarcopenic Obesity
- Trial name
- NutriP-SI65 (NCT07710456)
- Volunteers
- 450 people
- Sponsor
- University Psychiatric Clinic Ljubljana
Geriatric Pain
Frailty and Chronic Pain Profiles in Patients Aged ≥65 Years
The primary aim of this study is to investigate the relationship between frailty status and pain type, pain localization, and the Geriatric Nutritional Risk Index (GNRI) in individuals aged 65 years and older who present to an…
- Trial name
- F&P (NCT07373860)
- Where
- Turkey (Türkiye)
- Volunteers
- 393 people
- Sponsor
- Ankara City Hospital Bilkent
Sarcopenia, Frailty
Protein and Skeletal Muscle in Older Twins: Role of the Gut Microbiome
Research Question: Does the gut microbiome contribute to muscle anabolic resistance to protein supplementation in older adults? Background: Loss of muscle occurs with age and skeletal muscle in older adults can display anabolic…
- Conditions
- Sarcopenia, Frailty, Age-Related Sarcopenia
- Trial name
- PROMOTe (NCT04309292)
- Testing
- Prebiotic food supplement, Protein supplement
- Where
- United Kingdom
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- King's College London
Cancer, Frailty
Association of ICU Admission Time, Age Stratification, and Clinical Frailty Scale With 30-Day Mortality in Geriatric Oncology Patients
Geriatric oncology patients frequently require intensive care admission and are at increased risk of adverse outcomes due to advanced age, frailty, and critical illness.
- Conditions
- Cancer, Frailty, Mortality
- Trial name
- NCT07825090
- Testing
- Observation
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
LONGEVITY 1, Frailty
Longevity in Russia
This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.
- Conditions
- LONGEVITY 1, Frailty, Aging, Age-related Cognitive Decline
- Trial name
- NCT06268132
- Where
- Russia
- Volunteers
- 4,000 people
- Sponsor
- Center for Strategic Planning, of the Federal Medical and Biological Agency
Age-related Cognitive Decline, Age-related Physiology Decline
Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline
The primary goal is to develop a multidomain intervention program focused on preserving global or regional brain volume and functions while simultaneously improving physical mobility and cognitive functions in older individuals…
- Trial name
- NCT05828043
- Testing
- Multi-domain intervention
- Where
- Taiwan
- Volunteers
- 102 people
- Sponsor
- National Yang Ming Chiao Tung University
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass (CALM)
Up to 66 healthy elderly individuals (at least 65 years old) are recruited as subjects. They will be recruited as a subgroup to protocol ID: H-4-2013-070.
- Trial name
- CALM (NCT02115698)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Frailty Syndrome, Respiratory Muscle Weakness
Longitudinal Ultrasound Assessment of Diaphragmatic and Respiratory Muscle Function Following Respiratory Muscle Training in Frail Older Adults
This study aims to evaluate the effects of an 8-week inspiratory muscle training program on diaphragmatic and respiratory muscle function in frail older adults aged 80 years and above.
- Conditions
- Frailty Syndrome, Respiratory Muscle Weakness, Age-Related Frailty, Geriatric Health
- Trial name
- IMT-1 (NCT07258615)
- Testing
- Inspiratory Muscle Training
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Universidad Francisco de Vitoria
Sarcopenia, Muscle Loss
Counteracting Age-related Loss of Skeletal Muscle Mass
Up to approximately 205 (dependent on drop-out rate) healthy elderly individuals (at least 65 years old) are recruited as subjects.
- Trial name
- CALM (NCT02034760)
- Testing
- Heavy Resistance Training, Light Intensity Training, Protein Whey
- Where
- Denmark
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Preventing Age-Related Muscle Loss: the Role of Exercise in Improving Strength, Function, and Well-being
Muscle Aging Evaluation
This study aims to assess the effects of physical activity in counteracting muscle aging. The increasing life expectancy worldwide has led to a rise in age-related muscle decline, which negatively impacts strength, function, and…
- Trial name
- NCT06845748
- Testing
- Physical activity Group
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Milan