Clinical trials: After Lumbar Spine Surgery
Cervical Spondylosis, Lumbar Spondylosis
Safety and Efficacy of Pre-incisional Intravenous Ibuprofen to Reduce Postoperative Pain and Opioid Dependence After Posterior Cervical or Lumbar Instrumented Spine Surgery
A prospective, randomized, placebo controlled, double-blinded study at a single institution.
- Trial name
- NCT02276911
- Testing
- Ibuprofen, normal saline
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Spine Degeneration, Spine Disorder
Rate of Bone Union After Surgery With Stand-alone Fibergraft
Some people have back problems caused by degenerative conditions or instability of the spine (eg. Spondylolisthesis). These problems can lead to pain, nerve issues, or difficulties in walking.
- Conditions
- Spine Degeneration, Spine Disorder, Spine Pain, Spine Fusion
- Trial name
- Fibergraft (NCT07199075)
- Testing
- Questionnaires, Computer Tomography
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- AO Innovation Translation Center
Erector Spina Plan Block
The Effect of bılateral Erector spına Plan Block on postoperatıve paın ın spınal Surgery
Patients undergoing lumbar spinal stabilization surgery may experience severe postoperative pain lasting at least three days. Analgesia after lumbar stabilization surgery is beneficial for early recovery and is therefore…
- Trial name
- ESPB (NCT07537647)
- Testing
- UNDER ULTRASOUND GUİDANCE ESPB BLOCK, PROCEDURE/SURGERY: ERECTOR SPİNAE (ESP) BLOCK WİTH BUPİVACAİNE
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Physical Capability Outcomes
Physical Capability Outcomes After Single-Level PD-L vs Single-Level ALIF: a Multi-Center Clinical Trial
The purpose of this study is to compare the physical capability outcomes of patients who undergo single-level ProDisc-L disc replacement with those of patients who undergo stand-alone, single-level anterior lumbar interbody…
- Trial name
- NCT01055574
- Where
- 6 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gundersen Lutheran Medical Foundation
Pain, Opioid Use
Comparison of Quadratus Lumborum Block Types
This study will compare the quality of analgesia and reduction of opioid use, between standard of care and two groups of local anesthetic blocks in different location in the quadratus lumborum plane, for postoperative pain…
- Conditions
- Pain, Opioid Use, Lumbar Disc Herniation
- Trial name
- NCT04588389
- Testing
- Ropivacaine injection Location 1, Ropivacaine injection Location 2, Multimodal Pharmacological Management
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Massachusetts, Worcester
Lumbar Spinal Stenosis, Thoracic Spinal Stenosis
Effectiveness Study of the Drug Tranexamic Acid to Reduce Post-surgery Blood Loss in Spinal Surgery
Hypothesis: Topical application of Tranexamic acid into the surgical wound during spine surgery will decrease the overall blood loss post-operatively. This reduction in blood loss will reduce the need for transfusion.
- Trial name
- NCT02063035
- Testing
- Tranexamic Acid
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Massachusetts General Hospital
Assess Motion in Flexion/Extension and Lateral Bending of the Lumbar Vertebrae in Vivo Following Motion Sparing Surgery Using Radiostereometric Analysis (RSA.)
A Biomechanical Assessment of the AST Stabilimax BAR Using Radiostereometric Analysis (RSA)
Assessment of segmental spine motion has been and continues to be, a difficult clinical problem. Errors of up to 10 degrees for simple measurements of flexion, extension and side bending have been recorded using conventional…
- Trial name
- NCT00634465
- Testing
- RSA Beads
- Where
- United States
- Sponsor
- State University of New York - Upstate Medical University
Lumbar Spine Stenosis, Lumbar Spine Degeneration
OpalGenix- Personalized Postoperative Pain Management Following Lumbar Spinal Fusion and Decompression Surgery in Adults
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
- Trial name
- NCT05452694
- Where
- 3 sites in United States
- Volunteers
- 235 people
- Sponsor
- OpalGenix, Inc
Lumbar Spine Surgery Postoperative Ileus
Ileus After Lumbar Spine Surgery
Postoperative ileus (POI) after lumbar spine surgery is not uncommon. However, the incidence, severity and risk factors of ileus after spine surgery remain uncertain because there is not yet a prospective investigation using a…
- Trial name
- NCT04057599
- Where
- Taiwan
- Volunteers
- 156 people
- Sponsor
- National Taiwan University Hospital
Postoperative Recovery, Lumbar Disc Herniation
Lower Back Muscle Size and Recovery After Lumbar Disc Herniation Surgery
Recovery after surgery for a herniated disc in the lower back differs from person to person. The size of the muscles around the lower spine may be related to recovery, but this relationship is not well understood.
- Trial name
- NCT07768241
- Testing
- Preoperative Psoas and Multifidus Muscle Measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hyperalgesia
Local Anesthetic Infiltration to Prevent Postoperative Pain After Lumbar Surgery
Posterior lumbar arthrodesis causes severe postoperative pain, hampering patients's postoperative reconvalescence especially functional rehabilitation.
- Trial name
- ICALP (NCT00825422)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Lumbar Spine Degeneration, Cervical Spine Degeneration
Randomized Controlled Trial Comparing Irrisept Versus Normal Saline for Wound Irrigation After Posterior Spine Surgery
To compare post-operative wound complications in patients randomized to normal saline versus Irrisept solution and any other adverse reactions from the solution.
- Trial name
- Irrisept (NCT05408923)
- Testing
- saline 0.9%, (0.05% chlorhexidine gluconate (CHG) in sterile water)
- Where
- United States
- Sponsor
- University of Missouri-Columbia
Spine Surgery
3rd-year Post-surgical Evaluation of Adjacent Segment Disc Degeneration Onset in Lumbar Spine (Spinal Fusion vs. Lumbar Arthroplasty With Disc Replacement)
The main objective of the study is to compare the onset of adjacent segment disk degeneration in two groups of patients (one "spinal fusion group" and one "lumbar arthroplasty with disc replacement" group) with each patient…
- Trial name
- ARTHRO-DEGE (NCT05561322)
- Testing
- Consultation involving pain evaluation, questionnaires and the Lasègue Manoeuver, Magnetic Resonance Imaging of the lumbar spine
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Spine Surgery, Reversal of Neuromuscular Blockade
Sugammadex vs Neostigmine/Glycopyrrolate on Urinary Retention After Spine Surgery
This is an active-comparator controlled study to evaluate the effect of sugammadex compared to neostigmine/glycopyrrolate for reversal of rocuronium on the incidence of urinary retention after subjects undergo elective ambulatory…
- Conditions
- Spine Surgery, Reversal of Neuromuscular Blockade, Urinary Retention Postoperative
- Trial name
- NCT05887375
- Testing
- Sugammadex, Neostigmine, Glycopyrrolate
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- University of Missouri-Columbia
Low Back Pain
Modified Thoracolumbar Interfascial Plane Block Versus Erector Spinae Plane Block For Enhancement Of Quality of Recovery After Lumbar Spine Surgery: A Prospective Randomized Controlled Study.
Aim of study The objective of the current study is to compare the efficacy of ultrasound-guided bilateral modified thoracolumbar interfascial plane (TLIP) block versus erector spinae (ES) block in optimizing early quality of…
- Trial name
- NCT07166900
- Testing
- Modified Thoracolumbar Interfascial Plane Block
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Fayoum University
Spinal Degenerative Disorder, Spinal Stenosis
Physical Activity Intervention for Patients Following Lumbar Spine Surgery
There is a critical need to target physical activity during postoperative management to optimize long-term recovery after lumbar spine surgery.
- Conditions
- Spinal Degenerative Disorder, Spinal Stenosis, Spondylosis
- Trial name
- PASS (NCT04591249)
- Testing
- Physical activity intervention, Usual care
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Vanderbilt University Medical Center
Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons
Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover
Chronic back pain is the world's leading cause of disability, with spine surgery being a common yet costly intervention. However, many patients experience suboptimal recovery, with persistent pain and functional limitations…
- Conditions
- Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons, Chronic Low Back Pain, Scoliosis Patients
- Trial name
- NCT07766824
- Testing
- Ready Set Recover
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National University of Natural Medicine
Pain, Postoperative
TAP Block Efficacy After Lumbar Spine Surgery Through Anterior Approach: a Randomized, Placebo-controlled Study
Anterior Lumbar Interbody Fusion (ALIF) as well as Direct Lateral Interbody Fusion (DLIF) are established techniques for lumbar interbody fusion.
- Trial name
- TAP-LIF (NCT02778178)
- Testing
- ropivacaine plus clonidine, ultrasound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Lille
Lumbar Spine Surgery, Quality of Life
Assessment of the Effects of Maela Connected Follow-up on Well-being and Pain After Lumbar Spine Surgery
Digital technologies could reduce the length of hospital stay and improve post-operative recuperation after discharge by offering a remote follow-up.
- Conditions
- Lumbar Spine Surgery, Quality of Life, Pain
- Trial name
- HOSPITEL (NCT05680259)
- Testing
- Maela connected follow-up, traditional follow-up
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postoperative Pain, Neuropathic Pain
Impact of Pregabalin in Chronic Users vs. a Perioperative Limited Prescription on Oxycodone Requirement
Spinal surgery is associated with intense pain and associated to a history of preoperative chronic pain. Pregabalin is licensed to treat chronic neuropathic pain, particularly when high dose of opioid are required.
- Trial name
- PREGAB (NCT02866396)
- Testing
- Pregabalin, Naive patient
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Christophe Aveline, MD