Clinical trials: Adult-onset Diabetes
Diabetes, Diabetes Mellitus, Type 2
Investigation on Safety, Tolerability, and Pharmacokinetics of Single Doses of NNC0113-0987 in Healthy Male Subjects
This trial is conducted in Europe. The aim of the trial is to investigate safety, tolerability and pharmacokinetics (the exposure of the trial drug in the body) of single doses of NNC0113-0987 in healthy male subjects.
- Conditions
- Diabetes, Diabetes Mellitus, Type 2, Healthy
- Trial name
- NCT01690169
- Testing
- NNC0113-0987
- Where
- United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Type II Diabetes
A Study to Assess the Bioequivalence of Fixed Dose Combination of HR20033 Relative to Co-administration of the Individual Components in Healthy Chinese Subjects
The trial is to assess the bioequivalence between HR20033 FDC tablet and co-administration of SHR3824 tablets and metformin XR tablets.
- Trial name
- NCT05108350
- Testing
- T1: FDC 5/500 mg; R1+R: SHR3824 5 mg + Metformin 500 mg XR, T2: FDC 5/1000 mg; R2+R: SHR3824 5 mg + two Metformin 500 mg XR
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Diabetes
Vitamins C and Vitamin E and Cardiovascular Risk
The proposed study will examine the hypothesis that vitamin C and vitamin E given to type 2 diabetic individuals will provide effective anti-inflammatory, anti-thrombotic, and anti-oxidative atherosclerotic protection when…
- Trial name
- NCT00362518
- Testing
- Study Arm A, Study Arm B, Study Arm C
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Type 2 Diabetes Mellitus
The Effects of Pilates on Functional Capacity and Blood Glucose Levels in Adults With Diabetes Type 2
The aim of this study is to investigate the effects of the Pilates training on Functional Capacity among adults with type 2 diabetes The aim of this study is to investigate the effects of the Pilates training on blood glucose…
- Trial name
- NCT05261776
- Testing
- pilates exercise, brisk walk
- Where
- Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Overweight and Obesity, Risk Reduction
Healthy Lifestyle Intervention on Diabetes Risk Reduction Among Bruneian Young Adults
The general research question posed was 'How effective is a healthy lifestyle intervention using behavioural change strategies in the prevention of Type 2 Diabetes Mellitus (T2DM)?'.
- Conditions
- Overweight and Obesity, Risk Reduction, Diabetes Mellitus, Type 2
- Trial name
- NCT04217759
- Testing
- Healthy lifestyle intervention
- Where
- Brunei
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Universiti Brunei Darussalam
Type 2 Diabetes Mellitus
Bioequivalence Study of Saxagliptin and Glucophage Combination Formulations in Healthy Subjects (A)
To demonstrate bioequivalence of a 2.5 mg saxagliptin/500 mg metformin (glucophage) immediate release (IR) fixed dose combination (FDC) tablet to the 2.5 mg saxagliptin tablet and 500 mg metformin IR tablet co-administered to…
- Trial name
- NCT00899470
- Testing
- Co-administration of Saxagliptin and Metformin IR, Fasted, Saxagliptin/Metformin, Fasting, Co-administration of Saxagliptin and Metformin IR, Fed
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Bariatric Surgery, Bone Health
Bone Health After Bariatric Surgery in Patients With Type 2 Diabetes
Background: Bone fragility is a complication of type 2 diabetes. Diabetes treatments may ameliorate or deteriorate bone fragility in this population.
- Conditions
- Bariatric Surgery, Bone Health, Obesity, Morbid, Diabetes Mellitus, Type 2
- Trial name
- BODI (NCT03455868)
- Testing
- Bariatric surgery
- Where
- 3 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Obesity, Type 2 Diabetes Mellitus
Gut Microbiota in Obesity and Diabetes
An altered gut microbiota composition has recently been linked to obesity and diabetes. The principal aim of this study was to investigate and compare the gut microbiota composition of obese, diabetic and control individuals.
- Trial name
- NCT02180191
- Testing
- Comparison of the gut microbiota composition
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Diabetes Mellitus, Type 2, Neuropathy;Peripheral
A Collaborative Approach in Diabetes Foot Education - A Pragmatic Randomised Control Trial
Traditional directive style of requesting or demanding compliance to set behavior is found to have little effect on patient's self-care behavior.
- Trial name
- NCT04278742
- Testing
- Patient education
- Where
- Singapore
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Impaired Glucose Tolerance, Type 2 Diabetes
Impact of 3-year Lifestyle Intervention on Postprandial Glucose Metabolism: the SLIM Study
To evaluate the effect of a 3-year diet- and exercise lifestyle intervention, based on general public health recommendations, on glucose tolerance, insulin resistance and metabolic cardiovascular risk factors in Dutch subjects…
- Trial name
- NCT00381186
- Testing
- diet- and exercise intervention
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Diabetes
Hypothalamic Function Before and After Bariatric Surgery
The purpose of this study is to determine the effect of gastric banding or gastric bypass on hypothalamic morphology and function, gut hormones and systems biology in obese subjects with and without type 2 diabetes.
- Trial name
- NCT01167959
- Testing
- Roux en Y gastric bypass and lap. gastric banding, Prodimed dietary intervention
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Sedentary Behavior, Affect
Effects of Multi-day Interruptions in Sitting on Type 2 Diabetes-relevant Outcomes in Children
The overall objective of this in-lab randomized controlled trial is to test the efficacy of multi-day interruptions in sedentary behavior vs.
- Conditions
- Sedentary Behavior, Affect, Metabolic Disturbance, Anxiety
- Trial name
- NCT04469790
- Testing
- SIT+WALK, EX
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Type 1 Diabetes, Type 2 Diabetes
Exercise and Diabetes - an Observational Study of Exercise and Blood Glucose Control
This proposal seeks to gather continuous blood glucose and physical activity data from individuals with and without diabetes.
- Trial name
- NCT02190669
- Testing
- exercise
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Sansum Diabetes Research Institute
Prediabetes, Type 2 Diabetes
RISE Adult Medication Study
The RISE Adult Medication Study is a 4-arm, 3-center, clinical trial of adults with prediabetes and early type 2 diabetes to address the hypothesis that aggressive glucose lowering will lead to recovery of beta-cell function that…
- Trial name
- RISE Adult (NCT01779362)
- Testing
- Metformin, Liraglutide, Glargine
- Where
- 4 sites in United States
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- RISE Study Group
Type 2 Diabetes (T2DM)
Investigation of the Effect of Intrinsic Foot Muscle Training on Plantar Pressure Distribution in Individuals With Type 2 Diabetes Mellitus
The goal of this experimental randomized controlled study is to evaluate the effectiveness of the exercise program to be applied to prevent foot wounds, which is one of the leading foot problems that develop as a result of…
- Trial name
- NCT05974020
- Testing
- Control, Intrinsic Muscle Training, Aerobic Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Diabetes Mellitus, Type 2, Osteoporosis
MR-based Characterization of Bone Marrow in Its Relevance to Skeletal Disease in Patients With Diabetes
For a long time, no direct connection was seen between the two common diseases diabetes mellitus and osteoporosis. However, as more and more younger people are affected by obesity, develop type 2 diabetes mellitus and suffer…
- Conditions
- Diabetes Mellitus, Type 2, Osteoporosis, Insulin Resistance
- Trial name
- NCT04950283
- Testing
- magnetic resonance examination, anthropometric and metabolic characterization
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Pre Diabetes, Insulin Resistance
Precision Diets for Diabetes Prevention
With this study the investigators want to understand the physiological differences for people developing pre-diabetes and diabetes.
- Conditions
- Pre Diabetes, Insulin Resistance, Diabetes Mellitus, Type 2
- Trial name
- NCT03919877
- Testing
- Dietary, Oral Food Challege
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Stanford University
Essential Hypertension, Type 2 Diabetes
A Study to Evaluate the Pharmacokinetics and the Safety After Administration of "BR1019" and Co-administration of "BR1019-3" and "BR1019-2" in Healthy Volunteers
The purpose of this clinical trial is to evaluate the pharmacokinetics and the safety after administration of "BR1019" and co-administration of "BR1019-3" and "BR1019-2" in healthy volunteers
- Trial name
- NCT06636877
- Testing
- BR1019, BR1019-2, BR1019-3
- Where
- South Korea
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Obesity, Childhood, Diabetes Mellitus, Type 2
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort
The QUebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort study is a unique and comprehensive longitudinal study of 630 Caucasian children and their parents that was designed to investigate the natural history and…
- Conditions
- Obesity, Childhood, Diabetes Mellitus, Type 2, Cardiovascular Risk Factor, Pediatric ALL
- Trial name
- QUALITY (NCT03356262)
- Volunteers
- 630 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Diabetes Mellitus, Type 2
The Role of Gut Hormones and Hepcidin in Type 2 Diabetes Mellitus
This study aims to investigate the potential of the gut hormones GLP-1, PP, PYY and the iron regulatory hormone hepcidin as biomarkers for progression to complications in diabetes mellitus.
- Trial name
- NCT02413762
- Testing
- No intervention
- Where
- United Arab Emirates
- Volunteers
- 1,512 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
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