Clinical trials: Adjuvants
HIV Infections
A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of MN Recombinant Soluble gp120/HIV-1 (rsgp120/HIV-1) (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults
To extend the evaluation of safety and immunogenicity of MN recombinant soluble gp120/HIV-1 (MN rsgp120/HIV-1) in combination with QS21 with or without alum and on two different vaccination schedules.
- Trial name
- NCT00001052
- Testing
- Aluminum hydroxide, QS-21, rgp120/HIV-1MN
- Where
- 5 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Carcinoma, Basal Cell
Safety and Efficacy Study of Imiquimod 5% Cream Applied 3x Per Week for 8 or 12 Weeks in Low Risk Nodular Basal Cell Carcinoma
Results from a pilot study demonstrated that topical imiquimod could clear superficial and nodular BCCs. Three phase II dose response studies in subjects with nodular BCC (nBCC) showed that the histological cure rates with…
- Trial name
- NCT00204555
- Testing
- Imiquimod
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University Hospital Tuebingen
Adjuvants, Anesthesia, Subarachnoid Block
Intrathecal Nalbuphine Versus Intrathecal Tramadol in Subarachnoid Block for Lower Limb Orthopaedic Surgeries
This study compares the use of intrathecal nalbuphine versus intrathecal tramadol as adjuvant agents to local anaesthetics in subarachnoid block for lower-limb orthopaedic surgeries.
- Trial name
- NCT07294352
- Testing
- Intrathecal tramadol with spinal anesthsia, Intrathecal nalbuphine and spinal anesthesia
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry
Influenza
Study to Evaluate Safety, Tolerability and Immunogenicity of a Bedside Mixing Combination of Two Adjuvanted Influenza Vaccines
This trial is designed to evaluate safety, tolerability and immunogenicity of a bedside mixing formulation of adjuvanted influenza vaccines.
- Trial name
- NCT00735020
- Testing
- Adjuvanted Influenza Vaccine, Influenza Vaccine
- Where
- Switzerland
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Thyroidectomy, Bupivacaine
Ketamine Versus Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound Guided Bilateral Superficial Cervical Plexus Block in Thyroidectomy
The aim of this study is to compare the analgesic efficacy of Dexmedetomidine and Ketamine as adjuvants to Bupivacaine in ultrasound-guided Bilateral SCPB in patients undergoing thyroidectomy
- Conditions
- Thyroidectomy, Bupivacaine, Dexmedetomidine
- Trial name
- NCT07838831
- Testing
- Group C (Control group), Group D (Dexmedetomidine group), Group K (Ketamine group)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Malaria,Falciparum
Coadministration of GA2 Sporozoites With Adjuvants
This study will assess the coadministration of genetically attenuated Plasmodium falciparum ∆mei2 (GA2) sporozoites with adjuvants (BCG and YF-17D vaccination and imiquimod cream).
- Trial name
- CoGA (NCT05468606)
- Testing
- GA2, BCG, YF-17D (fractional ID dose)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Urinary Bladder Neoplasms
Safety and Efficacy Study of MAGE-A3 + AS-15 in Patients With Muscle-invasive Bladder Cancer After Cystectomy
The purpose of this clinical trial was to demonstrate the benefit of the immunotherapeutic product recMAGE-A3 + AS-15 given to patients with bladder cancer after removal of the bladder.
- Trial name
- MAGNOLIA (NCT01435356)
- Testing
- recMAGE-A3 + AS15 ASCI
- Where
- 50 sites in Czechia, France and 8 more
- Volunteers
- 83 people
- Sponsor
- European Association of Urology Research Foundation
Caudal Analgesia for Lumosacral Spine Surgeries
Caudal Epidural With Non Opioid Adjuvants in Lumbosacral Spine Surgery
Lumbosacral spine surgeries are accompanied with severe postoperative pain which has a negative effect on patients' recovery. Preemptive analgesia before lumbosacral spine surgeries should be implemented to prevent CNS plasticity…
- Trial name
- NCT04411329
- Testing
- Bupivacaine, Dexamethasone, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Post Spinal Shivering
Dexmedetomidine and Fentanyl As Adjuvants to Hyperbaric Bupivacaine for the Prevention of Post-spinal Shivering in Hip Arthroplasty Surgeries
The aim of this study is to compare the efficacy of intrathecal dexmedetomidine versus intrathecal fentanyl when added to hyperbaric bupivacaine in the prevention of post-spinal shivering in patients undergoing hip arthroplasty…
- Trial name
- NCT06834841
- Testing
- Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Influenza, Human
Panblok H7 Vaccine Adjuvanted With AS03 or MF59
The main purpose of this study is to assess the safety and ability of a Panblok H7 influenza vaccine adjuvanted with AS03 or MF59 to generate an immune response after 2 doses separated by 28 days.
- Trial name
- NCT03283319
- Testing
- 3.75 ug Panblok H7, 7.5 ug Panblok H7, 15 ug Panblok H7
- Where
- 4 sites in United States
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Biomedical Advanced Research and Development Authority
Peribulbar Anesthesia
Atracurium Versus Atracurium and Magnesium Sulphate As Adjuvants to Local Anesthetic
To evaluate the effects of adding magnesium sulfate to atracurium with local anesthetic mixture on akinesia of globe and eyelid regarding onset and duration in cataract surgery using peribulbar technique
- Trial name
- NCT06600945
- Testing
- Cataract surgery
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Dalia yousry Mohamed elsayed
Influenza
A Study of a Bivalent Influenza Peptide Conjugate Vaccine in Healthy Adults
This is a first in man study evaluating the tolerability and immunogenicity of BIPCV/IMX (V512) at increasing concentrations of influenza viral peptides A/M2+B/HA0 peptides and IMX, a saponin-based adjuvant.
- Trial name
- NCT00851266
- Testing
- V512
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Prostate Cancer
Efficacy and Safety Study of the Therapeutic Vaccine PEP223 in Prostate Cancer Patients
The purpose of this trial is to investigate whether treatment with this new drug will result in lower testosterone levels in men with prostate cancer.
- Trial name
- NCT00895466
- Testing
- PEP-223/CoVaccine HT
- Where
- 2 sites in Netherlands
- Volunteers
- 12 people
- Sponsor
- Pepscan Therapeutics
Foreign Body Granuloma, Surgery
"Outcomes of Surgical Removal of Foreign Body Granulomas"
Illicit subcutaneous injection of high-viscosity fluids for restoration and improvement of body contour is a growing trend all around the world. Many local and systemic complications have been described.
- Conditions
- Foreign Body Granuloma, Surgery, Complication
- Trial name
- NCT04661969
- Testing
- Surgery
- Where
- Mexico
- Volunteers
- 35 people
- Sponsor
- Hospital Angeles del Pedregal
Healthy Volunteers
Does Perineural Dexamethasone Prolong Duration of a Nerve Block?
The purpose of this study is to investigate whether dexamethasone as an adjuvant to ropivacaine for adductor canal block increases duration of the sensory block, when controlling for a systemic effect using a paired design and…
- Trial name
- NCT02351804
- Testing
- Ropivacaine + dexamethasone
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Postoperative Pain
Adjuvants With Intrathecal Bupivacaine for Postoperative Analgesia
The aim of this study is to compare the postoperative analgesic effect of intrathecal dexmedetomidine combined with bupivacaine and midazolam combined with bupivacaine in high tibial osteotomy.
- Trial name
- NCT06082232
- Testing
- Dexmedetomidine, Midazolam, Bupivacain
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Melanoma
Pegylated Interferon-alpha-2a in Patients With Malignant Melanoma Stage IIA-IIIB
The purpose of this study is to evaluate the efficacy and safety of adjuvant treatment with pegylated interferon-α-2a (PEG-IFN) vs. 'low dose' interferon-α-2a in patients with malignant melanoma in stage IIA (T3a) - IIIB.
- Trial name
- NCT00204529
- Testing
- pegylated interferon-alpha-2a, interferon-alpha-2a
- Where
- Germany
- Volunteers
- 901 people
- Sponsor
- University Hospital Tuebingen
Dexmedetomidine, Lidocaine
Dexmedetomidine Versus Lidocaine Infusions as Adjuvants to General Anesthesia for Chronic Pain Management After Mastectomy
This study aims to compare dexmedetomidine and lidocaine infusions as adjuvants to general anesthesia for chronic pain management after mastectomy.
- Conditions
- Dexmedetomidine, Lidocaine, Infusion, Adjuvants
- Trial name
- NCT06910644
- Testing
- Dexmedetomidine, Lidocaine, Isotonic saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Cytomegalovirus Infections
A Study of Human Cytomegalovirus (HCMV) Vaccine SPYVLP01 With and Without Adjuvants
The main purpose of the study is to evaluate the safety and immunogenicity of SPYVLP01 in two different doses with and without adjuvants in healthy adults aged 18-50 years old.
- Trial name
- SPYVAC01 (NCT06145178)
- Testing
- SPYVAC01
- Where
- 2 sites in United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- SpyBiotech Limited
Anesthesia
Comparison Between Adjuvants Added to Bupivacaine in Adductor Canal Block
Adult patients undergoing anterior cruciate ligament repair under Spinal Anaesthesia will be randomly assigned into one of the following groups (The Four study groups will receive the standard treatment in the form of spinal…
- Trial name
- NCT04892420
- Testing
- Dexamethasone, Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University