Clinical trials: Adipose Tissue
Caffeine-Induced Thermogenesis, Brown Adipose Tissue Activation
Caffeine-Induced Thermogenesis Assessed by Infrared Thermography
This study evaluated thermogenic and physiological responses to 200 mg of caffeine administered following a carbohydrate gel in healthy adults.
- Trial name
- NCT07868302
- Testing
- Carbohydrate Gel, Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Brown Adipose Tissue (BAT) Physiology, Phenotyping
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
Background: The body uses energy from calories for basic functions like breathing and digesting food. Over time, when a person eats more calories than they burn, they may become overweight or obese.
- Conditions
- Brown Adipose Tissue (BAT) Physiology, Phenotyping, Brown Adipocytes
- Trial name
- NCT02692885
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Diabetes, Brown Adipose Tissue
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
To examine MA (Maslinic Acid) safety and efficacy in ameliorating insulin resistance and the cardinal features of metabolic syndrome.
- Trial name
- NCT06484543
- Testing
- Maslinic Acid
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Brown Adipose Tissue, Metabolic Disease
Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active BAT.
- Trial name
- BANDIT (NCT06078345)
- Testing
- Carbohydrate, Fat, Protein
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Adipose Tissue, Brown, Adipose Tissue
The Physiology of Human Brown Adipose Tissue
Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories.
- Conditions
- Adipose Tissue, Brown, Adipose Tissue, Obesity
- Trial name
- NCT04352244
- Testing
- Fat biopsy, Blood sampling, Blood sample for DNA analysis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Brown Adipose Tissue
Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using [18F]-2-fluoro-2-deoxy-D-glucose (fluorodeoxyglucose) -PET…
- Trial name
- BAT_PET/MRI (NCT02237872)
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adipose Tissue
Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women - GLUTAB
The purpose of this study is to compare, in healthy women, the adipose tissue composition between abdomen and thigh and then determine whether differences exist independently of the state of obesity.
- Trial name
- NCT01605578
- Testing
- Biopsies
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Brown Adipose Tissue
Effect of Glyceroltrinitrate on Human Energy Expenditure and Brown Adipose Tissue Thermogenesis
The aim of this study is to evaluate the efficacy of glyceroltrinitrate (Nitroderm® TTS) to activate and expand human BAT as compared to mild cold exposure.
- Trial name
- NEXT (NCT05711199)
- Testing
- Glyceroltrinitrat
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Resting Energy Expenditure, Thermogenesis
MIrabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT05990387
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Indiana University
Obesity and Obesity-related Medical Conditions, Sarcopenic Obesity
Changes in Fat and Muscle Tissue Function and Their Impact on Metabolic Health After Bariatric Surgery
This prospective, single-center observational cohort study aims to explore the relationship between skeletal muscle quality, fat distribution, and metabolic health in Chinese patients with obesity, and to evaluate how bariatric…
- Conditions
- Obesity and Obesity-related Medical Conditions, Sarcopenic Obesity, Adipose Tissue, Abdominal
- Trial name
- NCT07035483
- Testing
- bariatric surgery
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Shaihong Zhu
Energy Expenditure, Obesity
Brown Fat Activation and Browning Efficiency Augmented by Chronic Cold and Nutraceuticals for Brown Adipose Tissue-mediated Effect Against Metabolic Syndrome (BEACON BEAMS Study)
Our body fat (adipose tissue) is largely made up of white adipose tissue (WAT) that stores surplus energy as white fat depots. In addition, adult humans have another type of fat similar to the brown fat in babies that burns up…
- Conditions
- Energy Expenditure, Obesity, Brown Adipose Tissue
- Trial name
- NCT04595006
- Testing
- Cold Stimulation (CS), Browning Nutraceutical (BN), Cold Stimulation and Browning Nutraceutical (CSBN)
- Where
- Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Neonatal Hypothermia, Brown Adipose Tissue
Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates
Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue.
- Conditions
- Neonatal Hypothermia, Brown Adipose Tissue, Preterm and Term Infants, Neonate
- Trial name
- NCT06803069
- Where
- 2 sites in Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Obesity and Type 2 Diabetes, Bariatric Patients Undergoing Bariatric Surgery
Regional Adipose Tissue Characteristics in Type II Diabetes
Fat tissue in different parts of the body has different characteristics. Several studies have associated abdominal fat to an increased risk for multiple metabolic diseases, such as type 2 diabetes and cardiovascular disease…
- Conditions
- Obesity and Type 2 Diabetes, Bariatric Patients Undergoing Bariatric Surgery, Adipose Tissue Dysfunction Type 2 Diabetes Mellitus Bariatric Surgery, Adipose Tissue Inflammation
- Trial name
- NCT06599047
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Concordia University, Montreal
Adipose Tissue Atrophy, Deformity of Reconstructed Breast
Effect of N-Acetylcysteine on Autologous Fat Graft Survival
A single-centre triple-blind study looking at the addition of NAC to tumescent solution for liposuction and fat grafting in healthy patient volunteers already undergoing bilateral breast reduction.
- Conditions
- Adipose Tissue Atrophy, Deformity of Reconstructed Breast, Graft Loss
- Trial name
- NCT02788292
- Testing
- Acetylcysteine
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Adipose Tissue Atrophy
Analysis of the Performance of 1060 nm Diode and Radio Frequency Prior to Abdominoplasty
To evaluate the safety and efficacy of treatment with 1060nm diode laser and radio frequency to be analyzed through histological and molecular analysis.
- Trial name
- NCT04616898
- Testing
- Venus Bliss
- Where
- 2 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Venus Concept
Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities, Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile
Skeletal Muscle and Adipose Tissue Responses After Acute Exercise: Comparing Effects of Three Different Intensities
The study will assess the exercise-induced changes in chromatin accessibility and gene expression in a cell type-specific manner in skeletal muscle from healthy adults in response to exercise at three different intensities - 1)…
- Conditions
- Cellular Responses Within Skeletal Muscle in Response to Exercise of Different Intensities, Relationship Between the Cellular Responses in Skeletal Muscle and the Changes in the Metabolomic Profile, Changes Within Adipose Tissue in Response to Exercise at the Three Different Intensities
- Trial name
- 3X (NCT05365334)
- Testing
- Low intensity exercise session, Moderate intensity exercise session, High intensity exercise session
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Adolescents, Physical Activity
School-based HIIT and Dose-Response Effects
There are experimental evidences of the importance of high intensity exercises in health outcomes improvement. However, there are limited knowledge about possibility to affect health outcomes in adolescents through exercises…
- Conditions
- Adolescents, Physical Activity, Adipose Tissue, Blood Pressure
- Trial name
- PEER-HEART (NCT06431230)
- Testing
- standard high-intensity interval training, plyometric high-intensity interval training
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Wroclaw University of Health and Sport Sciences
Resting Energy Expenditure, Thermogenesis
Mirabegron and Physiological Function in Cold Environments
Many Navy diving operations are performed in cold water. Despite technical advances to improve thermal protection for cold water diving, these applications are cumbersome and do not provide complete thermal protection as thermal…
- Conditions
- Resting Energy Expenditure, Thermogenesis, Brown Adipose Tissue
- Trial name
- NCT04766021
- Testing
- Mirabegron
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Indiana University