Clinical trials: Adipose Tissue
Caffeine-Induced Thermogenesis, Brown Adipose Tissue Activation
Caffeine-Induced Thermogenesis Assessed by Infrared Thermography
This study evaluated thermogenic and physiological responses to 200 mg of caffeine administered following a carbohydrate gel in healthy adults.
- Trial name
- NCT07868302
- Testing
- Carbohydrate Gel, Caffeine
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Istanbul Health and Technology University
Brown Adipose Tissue (BAT) Physiology, Phenotyping
Molecular, Cellular, and Genetic Characterization of Human Adipose Tissue and Its Role in Metabolism
Background: The body uses energy from calories for basic functions like breathing and digesting food. Over time, when a person eats more calories than they burn, they may become overweight or obese.
- Conditions
- Brown Adipose Tissue (BAT) Physiology, Phenotyping, Brown Adipocytes
- Trial name
- NCT02692885
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Heart Failure Preserved Ejection Fraction, Epicardial Adipose Tissue
Epicardial Adipose Tissue Composition and Heart Failure With Preserved Ejection Fraction
This study seeks to develop improved cardiac MRI (CMR) methods to quantify epicardial adipose tissue (EAT) composition and to demonstrate the advantages of EAT composition imaging (a) in advancing the understanding of the…
- Trial name
- NCT07178145
- Testing
- GLP-1RA
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- University of Virginia
Adipocytic Neoplasm, Liposarcoma
NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)
The study participant has been diagnosed with non-rhabdomyosarcoma (NRSTS). Primary Objectives Intermediate-Risk To estimate the 3-year event-free survival for intermediate-risk patients treated with ifosfamide, doxorubicin…
- Conditions
- Adipocytic Neoplasm, Liposarcoma, Atypical Fibroxanthoma, Angiomatoid Fibrous Histiocytoma
- Trial name
- NCT06239272
- Testing
- Surgical resection, Proton beam radiation therapy, Pazopanib
- Where
- 7 sites in United States
- Volunteers
- 139 people
- Sponsor
- St. Jude Children's Research Hospital
Brown Adipose Tissue (BAT) Physiology, Cold Exposure
Effect of Caffeine on Cold-stimulated Brown Adipose Tissue Activity
The purpose of the study is to asses brown adipose tissue activity after a cold mild stimulus, preceded by 200mg caffeine or placebo administration.
- Trial name
- ACROBAT (NCT06978777)
- Testing
- Caffeine (200 mg)
- Where
- Switzerland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Obesity, Metabolic Syndrome
Brown Adipose Tissue as a Mechanistic Determinant of Semaglutide Treatment Response in Obesity (BAT-Sema Study)
This study investigates whether the activity of brown adipose tissue (BAT) - a special type of fat that burns energy as heat - can predict how well individuals with obesity respond to semaglutide (Wegovy), a once-weekly…
- Conditions
- Obesity, Metabolic Syndrome, Brown Adipose Tissue
- Trial name
- BAT-Sema (NCT07621640)
- Testing
- Semaglutide (Wegovy®), ¹⁸FDG-PET/CT with cold stimulation, Liver MRI (PDFF + MRE)
- Where
- 2 sites in South Korea
- Volunteers
- 80 people
- Sponsor
- Hallym University
Brown Adipose Tissue, Cold Exposure
Intermittent Cold Exposure and Brown Adipose Tissue Hyperplasia
This clinical trial explores how repeated short-term cold exposure impacts the molecular and physiological function of brown adipose tissue (BAT), a thermogenic organ associated with improved cardiometabolic health.
- Conditions
- Brown Adipose Tissue, Cold Exposure, 18F-FDG PET/CT
- Trial name
- ICEBATH (NCT07048405)
- Testing
- Cooling, Biopsies, Injection of 18F-FDG
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Arthroscopic Rotator Cuff Repair, Augmentation
Long Term Clinical Outcome After Arthroscopic Rotator Cuff Repair Augmentation With Autologous Microfragmented Lipoaspirate Tissue
Specific Aims : The aim of this prospective randomized controlled single-blind clinical trial was to evaluate the safety and efficacy of autologous microfragmented lipoaspirate tissue in arthroscopic rotator cuff repair.
- Conditions
- Arthroscopic Rotator Cuff Repair, Augmentation, Microfragmented Adipose Tissue
- Trial name
- NCT06960343
- Testing
- magnetic resonance imaging (MRI), VAS, SST, ASES, CMS scores, and strength measurements in external rotation and abduction
- Where
- Italy
- Volunteers
- 52 people
- Sponsor
- University of Milan
Diabetes, Brown Adipose Tissue
Brown Fat as Therapeutic Strategy for Obesity and Associated Metabolic Diseases Via Functional Food/Nutraceutical Approach - Molecular Mechanisms of Pentacyclic Triterpenes (BRACE)
To examine MA (Maslinic Acid) safety and efficacy in ameliorating insulin resistance and the cardinal features of metabolic syndrome.
- Trial name
- NCT06484543
- Testing
- Maslinic Acid
- Where
- Singapore
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
CABG, Visceral Adipose Tissue
Impact of Visceral Adiposity on Postoperative Atrial Fibrillation After CABG
Obesity has become a major public health problem in both developed and developing countries, with a continuous increase particularly since the 1980s.
- Conditions
- CABG, Visceral Adipose Tissue, Atrial Fibrillation (AF)
- Trial name
- NCT07467941
- Testing
- Postoperative AF Group, Non-AF Group
- Volunteers
- 300 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Obesity, Visceral Adipose Tissue
Nutritional Oleic Acid Modulation of adIpose Cholesterol Metabolism in Patients Living With Obesity
Disruption of white adipose tissue (WAT) homeostasis during obesity is central to the development of associated cardiometabolic complications.
- Conditions
- Obesity, Visceral Adipose Tissue, White Adipose Tissue Inflammation, Subcutaneous Adipose Tissue
- Trial name
- NAMICO (NCT07027033)
- Testing
- acid-rich sunflower oil oleic acid, conventional sunflower oil
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Nantes University Hospital
Decrease of Inflammation of Adipose Tissue, Sleep Apnea Syndrome
Inflammation and Oxidative Stress of Adipose Tissue in Sleep Apnea Syndrome
The main objective of this study is to evaluate the decrease of inflammation of adipose tissue in obese and non-obese patients having a sleep apnea syndrome and treated or not by continuous positive airway pressure (cPAP).
- Trial name
- ADISAS (NCT01196845)
- Testing
- cPAP
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Grenoble
Diabetes Mellitus, Visceral Adipose Tissue
Sex-specific Differences in the Association Between Leg Fat and Diabetes Risk
This study investigates the association between LFP, VAT and T2DM using DXA in 542 adults. We apply penalized regression, generalized additive models (GAM), and causal mediation analysis to explore whether higher LFP reduces…
- Conditions
- Diabetes Mellitus, Visceral Adipose Tissue, Body Fat Distribution
- Trial name
- NCT07261800
- Testing
- Not Applicable - Retrospective study
- Where
- China
- Volunteers
- 542 people
- Sponsor
- Qianfoshan Hospital
Brown Adipose Tissue, Metabolic Disease
Brown Adipose Tissue as Nutrient Buffer Through Diet Induced Thermogenesis
To test the hypothesis that active BAT improves metabolic health by buffering postprandial metabolites plasma metabolites and energy expenditure will be compared in volunteers with and without active BAT.
- Trial name
- BANDIT (NCT06078345)
- Testing
- Carbohydrate, Fat, Protein
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Adipose Tissue, Brown, Adipose Tissue
The Physiology of Human Brown Adipose Tissue
Brown fat is a type of fat, found in both children and adults, which can produce heat and regulate the body's metabolism and energy use. White fat is the more common type of fat which is used to store extra calories.
- Conditions
- Adipose Tissue, Brown, Adipose Tissue, Obesity
- Trial name
- NCT04352244
- Testing
- Fat biopsy, Blood sampling, Blood sample for DNA analysis
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obesity, Brown Adipose Tissue
Detection of Brown Adipose Tissue by Magnetic Resonance Imaging
The primary goal of this study is to assess the accuracy of conventional fat fraction proton MRI for the detection of Brown Adipose Tissue (BAT) in healthy subjects using [18F]-2-fluoro-2-deoxy-D-glucose (fluorodeoxyglucose) -PET…
- Trial name
- BAT_PET/MRI (NCT02237872)
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Adipose Tissue
Description of Abdominal and Gluteo-femoral Subcutaneous Adipose Tissue Cell Population in Women - GLUTAB
The purpose of this study is to compare, in healthy women, the adipose tissue composition between abdomen and thigh and then determine whether differences exist independently of the state of obesity.
- Trial name
- NCT01605578
- Testing
- Biopsies
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus
Fat Around Heart Arteries as a Measure of Inflammation in Patients With Glycometabolic Disease
In this study, the objective is to investigate inflammation in the arteries of the heart. A heart CT scan (CCTA) will be used to measure inflammation by assessing the fat tissue surrounding the arteries of the heart.
- Conditions
- Obesity &Amp; Overweight, Obesity Type 2 Diabetes Mellitus, Type 2 Diabetes (T2DM), Prediabetes
- Trial name
- PCAT-GMD (NCT07144670)
- Where
- Denmark
- Volunteers
- 747 people
- Sponsor
- Odense University Hospital
Adipose Tissue, Brown, Brown Adipose Tissue
Winter-Swimming and Brown Adipose Tissue Activity in Middel-aged Obese Subjects (WinterBAT).
This study investigates repetitive cold-water exposure on brown fat activity assessed by PET/CT scanning. Furthermore we will assess glucose control upon winter-swimming.
- Conditions
- Adipose Tissue, Brown, Brown Adipose Tissue, Uncoupling Protein 1, Cold Exposure
- Trial name
- WinterBAT (NCT03541096)
- Testing
- Winter Swimming, Control group
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Kristian Karstoft
Bilateral Knee Osteoarthritis, Autologous Adipose Tissue
Bilateral Knee Osteoarthritis: Intra-articular Injection of Filtered Autologous Adipose Tissue Versus Placebo
The purpose of the study is to assess the radiological and clinical outcomes comparing two different treatments (Filtered Autologous Adipose Tissue versus Placebo) in patients affecting bilateral knee osteoarthritis.
- Trial name
- NCT04567732
- Testing
- injection of Filtered Autologous Adipose Tissue
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli