Clinical trials: Adipokines
Grade III Obesity, Type 2 Diabetes Mellitus
Metabolic Changes After Bariatric Surgery
Literature data clearly demonstrate that treatment of obese patients is very expensive, long and achieve weight loss may not be permanent, and regardless of whether the treatment dominated diet therapy, physical activity, or…
- Trial name
- NCT02893891
- Testing
- Laparoscopic sleeve gastrectomy, Laparoscopic gastric plication, Intragastric balloon
- Where
- 2 sites in Czechia
- Volunteers
- 150 people
- Sponsor
- University Hospital Ostrava
Obesity Hypoventilation Syndrome
The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment
Main objective: To describe clinical and functional characteristics of the obese hypoventilating patient; to study the relation between the obesity-hypoventilation syndrome (OHS) and the obstructive sleep apnea hypopnea syndrome…
- Trial name
- NCT00938977
- Testing
- CPAP, Bilevel Support Ventilation (Non-Invasive Ventilation)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Systemic Lupus Erythematosus
Omega 3 Fatty Acids and Systemic Lupus Erythematosus
Omega-3 fatty acids have been considered anti-inflammatory lipids based on data from epidemiological studies of Greenland Eskimos whose diet is rich in fish, sources of polyunsaturated fatty acids.
- Trial name
- OM3LES (NCT02524795)
- Testing
- Hiomega-3 supplement of Naturalis® company -
- Volunteers
- 49 people
- Sponsor
- Federal University of Minas Gerais
Obesity, Inflammation
Gene Expression and Inflammation in Overweight Subjects
This study will look at gene expression (whether particular sets of genes are activated ["turned on"] or deactivated ["turned off"]) in overweight people as compared to non-overweight individuals.
- Conditions
- Obesity, Inflammation, Nutrition Therapy
- Trial name
- NCT00344266
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Psoriasis, Arthritic Psoriasis
Evaluation of Adipokines and Fat Tissue in Psoriasis and Psoriatic Arthritis
Body composition analysis and especially body fat distribution in regions of interest (android and in particular intra-abdominal region) provides some information on the risk of cardiovascular disease.
- Trial name
- ADIPSO (NCT02849795)
- Testing
- bone densitometry, questionnaires, biological analyses
- Where
- France
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Hyperlipidemia, Impaired Fasting Glycemia
Effects of Hypolipemic Treatment on Adipokines
The study is planned to show whether monotherapies or combined hypolipemic therapy influence the fasting plasma glucose, serum adipokines (leptin, adiponectin, resistin) and proinflammatory cytokines (interleukin-6, TNF alpha)…
- Trial name
- NCT01099176
- Testing
- To compare monotherapies and combined therapy with each other
- Where
- Poland
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Endometrial Cancer
Adipocytokines in Endometrial Cancer
Endometrial cancer incidence rates were increasing in the past two decades with a continuous rising trend in Taiwan. Uterine cancer was attributable to obesity based on their association with excess body weight in most…
- Trial name
- ACEmCa (NCT05018195)
- Testing
- Excise adipose tissue
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
NAFLD, NASH - Nonalcoholic Steatohepatitis
Adipokine Genetic Variations in predictingNAFLD Progression to NASH in Egyptian Patients
Due to the limited data concerning Egyptian population. authors aimed to investigate the differentadipokine gene polymorphism related to non alcoholic fatty liver disease incidence, prognosis and progression to steotosis and also…
- Trial name
- NCT04561895
- Testing
- DNA extraction
- Where
- Egypt
- Volunteers
- 224 people
- Sponsor
- Cairo University
Type 2 Diabetes Mellitus
Comparison of Metformin and Pioglitazone Effects on Adipokines Concentrations in Newly Diagnosed Type 2 Diabetes Patients
Oral hypoglycemic agents encompass the mainstay of treatment in the majority of patients with type 2 diabetes. Thiazolidinediones (such a pioglitazone) and Biguanides (such as metformin), are two major groups of hypoglycemic…
- Trial name
- NCT01593371
- Testing
- Metformin, Pioglitazone
- Where
- Iran
- Volunteers
- 98 people
- Sponsor
- Tehran University of Medical Sciences
Type 1 Diabetes, Coronary Artery Calcifications
Relation of Visceral Fat and Associated Cytokines With Early Cardiovascular Complications in Type 1 Diabetes.
Objective: To investigate whether visceral adipose tissue (VAT) and its adipokines contribute to early signs of cardiovascular disease, meaning coronary artery calcifications (CAC) and diastolic dysfunction in type 1 diabetes…
- Conditions
- Type 1 Diabetes, Coronary Artery Calcifications, Diastolic Dysfunction
- Trial name
- VISCERA (NCT02689570)
- Testing
- observational
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- University Hospital, Antwerp
Diet Habit
Arbutus Berry - Intervention Study to Evaluate the Modulation of Intestinal Microbiota and Metabolic Parameters
The tree that produces the arbutus berry, the strawberry tree, scientific name Arbutus unedo L., belongs to the family of Ericaceae.
- Trial name
- F4F (NCT05810922)
- Testing
- arbutus berry
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Menopause
Menopausal Sleep Fragmentation and Body Fat Gain
This study aims to investigate the impact of menopause-related sleep fragmentation on metabolic biomarkers of body fat gain. The investigators hypothesize that experimental sleep fragmentation will result in an adverse leptin…
- Trial name
- NCT03047330
- Testing
- Estradiol withdrawal, Fragmented sleep
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Gestational Diabetes Mellitus
Adipocytokines, Gestational Diabetes Mellitus and Lipid Metabolism
Apelin, Visfatin, Omentin and Resistin are adipocytokines derived from human adipose tissue as well as placental tissue and have been shown to be potential mediators of insulin resistance.
- Trial name
- NCT02378675
- Testing
- Blood draw
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 2 Diabetes Mellitus
Effects of ROSIglitazone on Inflammatory Markers and Adipokines in Diabetic Patients Using an Angiotensin Receptor Blocker (TELmisartan) - The ROSITEL Study
The purpose of the ROSITEL study is to assess the effects of rosiglitazone, as compared to standard oral therapies for diabetes (metformin/sulfonylurea), on inflammatory markers and adipokine levels in diabetic patients using an…
- Trial name
- NCT00486187
- Testing
- rosiglitazone, metformin or sulfonylurea
- Where
- Canada
- Volunteers
- 103 people
- Sponsor
- Dr. Milan Gupta
Overweight, Obesity
Correlation of Irisin and Adipokine Levels With Body Mass Index and Risk Factors for Metabolic Syndrome in Hispanic Children
Childhood obesity is one of the most serious global public health challenges of the 21st century (Daniels et al., 2009). Mexico has the highest prevalence of obesity, (Secretaría de Salud, 2009); 34.4% of children and 35% of…
- Conditions
- Overweight, Obesity, Thinness
- Trial name
- NCT02320110
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Instituto Tecnologico y de Estudios Superiores de Monterey
Metabolic Syndrome, Obesity
Effects of Ezetimibe Add-On to Statin Therapy on Adipokine Production in Obese and Metabolic Syndrome Patients With Atherosclerosis
The purpose of this study is to investigate the effects of adding ezetimibe to statin therapy on levels of inflammatory markers and adipokines in patients with atherosclerosis disease and features of the metabolic syndrome,whose…
- Conditions
- Metabolic Syndrome, Obesity, Coronary Artery Disease
- Trial name
- NCT00485121
- Testing
- Ezetimibe
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Canadian Collaborative Research Network
Cushing's Disease
Long-term Cardiovascular Risk in Cured Cushing's Patients
The purpose of this study is to determine whether subjects who have been affected by Cushing's disease in the past maintain some different characteristics compared with subjects who have never been diagnosed with the disease.
- Trial name
- NCT00881283
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Massachusetts General Hospital
Fatty Liver, Steatohepatitis
Effect of Spironolactone and Vitamin E in Patients With Nonalcoholic Fatty Liver Disease
The primary aim of the study is the effect of spironolactone and vitamin E versus vitamin E on serum levels of adipokines 52 weeks post-treatment.
- Trial name
- NAFLD (NCT01147523)
- Testing
- Spironolactone/Vitamin E
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- Aristotle University Of Thessaloniki
Anorexia Nervosa, Adipokines
Adipokines and Ghrelin Concentrations in Different Stages of Anorexia Nervosa
The aim of this study is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of anorectic patients and to evaluate their relationships between biochemical, hormonal and anthropometric…
- Trial name
- NCT00602264
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Atrial Fibrillation, Adiposity
The Role of Adipokines In Atrial Fibrillation
The principal aim of the present study is to analyze adiponectin, omentin-1, apelin and visfatin plasma levels in patients with and without AF in an effort to identify their potential role in the development of AF.
- Conditions
- Atrial Fibrillation, Adiposity, Adiponectin, Visceral Obesity
- Trial name
- NCT03592732
- Testing
- Blood sample
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Athens