Clinical trials: Adenoma
Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present
Genetically Modified T Cells in Treating Patients With Stage III-IV Non-small Cell Lung Cancer or Mesothelioma
This phase I/II trial studies the side effects and best dose of genetically modified T cells in treating patients with stage III-IV non-small cell lung cancer (NSCLC) or mesothelioma.
- Conditions
- Advanced Pleural Malignant Mesothelioma, HLA-A*0201 Positive Cells Present, Recurrent Non-Small Cell Lung Carcinoma, Recurrent Pleural Malignant Mesothelioma
- Trial name
- NCT02408016
- Testing
- Aldesleukin, Autologous WT1-TCRc4 Gene-transduced CD8-positive Tcm/Tn Lymphocytes, Cyclophosphamide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Fred Hutchinson Cancer Center
Colorectal Cancer, Colorectal Disorders
Reducing Colonoscopies in Patients Without Significant Bowel Disease
Investigating people with bowel symptoms uses a test that detects traces of blood in the stools, the FIT test. There are many possible reasons for positive tests. A few people have cancer.
- Conditions
- Colorectal Cancer, Colorectal Disorders, Colorectal Adenoma, Colorectal Polyp
- Trial name
- RECEDE (NCT04516785)
- Testing
- FIT and VOC
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,181 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Colitis, Adenoma
Colonoscope Passive Bending Function
A prototype colonoscope with an extra passively bending distal section has been developed by Olympus Japan (ref. publications). The present study (2006-2007) is testing refinements of this function.
- Conditions
- Colitis, Adenoma, Carcinoma, Functional Colonic Disease
- Trial name
- NCT00518349
- Testing
- Passive bending function, No passive bending function
- Where
- Norway
- Volunteers
- 120 people
- Sponsor
- Norwegian Department of Health and Social Affairs
Colorectal Adenoma, Colorectal Polyp
Examining Techniques on Adenoma Miss Rate in Proximal Colon
The primary aim of this study is to explore the usefulness of re-examination and retroflexion on adenoma miss rate (AMR) in the proximal colon.
- Trial name
- SINOCOLO2017 (NCT03355443)
- Testing
- Retroflexion, Re-examination
- Where
- 3 sites in China
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Breast Carcinoma, Prostate Cancer Surgery
High-resolution PET-CT Specimen Imaging for the Perioperative Visualization of Resection Margins
These are patients in whom a benign or malignant tumor was recorded requiring surgery. During that surgery, the surgeon will cut away the tumor as part of the treatment of the disease.
- Conditions
- Breast Carcinoma, Prostate Cancer Surgery, Thyroid Cancer, Parathyroid Adenomas
- Trial name
- NCT06835426
- Testing
- Single intravenous injection of the radiotracer, Imaging resected specimen using the high-resolution PET-CT specimen imager
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Algemeen Ziekenhuis Maria Middelares
Colorectal Cancer, Colorectal Adenoma
Adenoma Detection Rate With Endocuff-Assisted Colonoscopy - an Italian Trial
In European countries, colorectal cancer (CRC) represents an important public health problem. It is widely held view that most carcinomas develop from an adenoma-carcinoma progression.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp, Colorectal Neoplasms
- Trial name
- ITAvision (NCT03612674)
- Testing
- Standard colonoscopy, ARC Endocuff Vision
- Where
- 12 sites in Italy
- Volunteers
- 2,100 people
- Sponsor
- Cancer Prevention and Research Institute, Italy
Lung Cancer, Non-small Cell, Small Cell Lung Cancer
TRAcking Thoracic Cancer Evolution Through Therapy (Rx) EVO
TRACERx EVO is a programme of work using a prospective observational cohort study of participants with early- and late-stage non-small cell lung cancer (NSCLC), small cell lung cancer (SCLC) and pleural mesothelioma.
- Conditions
- Lung Cancer, Non-small Cell, Small Cell Lung Cancer, Pleural Mesothelioma
- Trial name
- NCT05628376
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- University College, London
Lung Cancer, Mesothelioma
CryoSpray Ablation(tm)in Malignant Airway Disease to Determine Safety, and Tissue Effect in the Lung (ICE the MAD)
The purpose of this study is to evaluate the safety, and tissue effect of the CryoSpray Ablation(TM) System (CryoSpray Ablation(TM), "CSA" or "cryospray therapy") at multiple centers to treat malignant airway disease in the lung…
- Trial name
- ICEtheMAD (NCT00748085)
- Testing
- CryoSpray Ablation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- CSA Medical, Inc.
Solid Tumors
A Clinical Study of Anetumab Ravtansine in Adults With Solid Tumors Who Have Been Treated in Previous Bayer-sponsored Anetumab Ravtansine Studies
The purpose of this study is to enable patients with solid tumors, who received anetumab ravtansine in a Bayer-sponsored clinical trial, to continue treatment after their respective study has been closed.
- Trial name
- NCT03926143
- Testing
- BAY94-9343 (Anetumab ravtansine)
- Where
- 7 sites in United States, France and 2 more
- Volunteers
- 9 people
- Sponsor
- Bayer
Colorectal Cancer, Adenoma
Effect of an Advanced Notification Letter on Screening Colonoscopy Participation
Participation in a primary screening colonoscopy programs remains low. Advanced notification letter has been shown to increase participation in colorectal cancer screening with fecal occult blood testing and to be cost effective…
- Conditions
- Colorectal Cancer, Adenoma, Rectal Cancer
- Trial name
- NCT02188927
- Testing
- Implementation of ANL, No included ANL
- Where
- Poland
- Volunteers
- 6,800 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Pleural Mesothelioma, Asbestos Exposure
Mesothelioma Early Detection by VOCs
This is a two phase study, The first phase (phase 1) will identify potential biomarkers among asbestos exposed individuals with pleural mesothelioma.
- Conditions
- Pleural Mesothelioma, Asbestos Exposure, Pleural Plaque
- Trial name
- MED-VOC (NCT04106973)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Henry Ford Health System
Colonic Adenoma, Water Exchange Colonoscopy
Adenoma Miss Rate With Water Exchange vs Carbon Dioxide Colonoscopy
This was an observational study comparing consecutive group of WE and CO2 insufflation in terms of right and proximal colon AMR by tandem colonoscopy.
- Trial name
- NCT03832322
- Testing
- Water exchange colonoscopy, CO2 insufflation colonoscopy
- Where
- Taiwan
- Volunteers
- 176 people
- Sponsor
- Evergreen General Hospital, Taiwan
Lung Cancer, Esophageal Cancer
Pilot Study of Allogeneic Tumor Cell Vaccine With Metronomic Oral Cyclophosphamide and Celecoxib in Patients Undergoing Resection of Lung and Esophageal Cancers, Thymic Neoplasms, and Malignant Pleural Mesotheliomas
Background: Certain types of lung, esophageal, or thymic cancers and mesotheliomas have specific antigens (protein molecules) on their surfaces.
- Conditions
- Lung Cancer, Esophageal Cancer, Malignant Pleural Mesothelioma, Sarcoma
- Trial name
- NCT01143545
- Testing
- Allogeneic Tumor Cell Vaccine (K562), Celecoxib, cyclophosphamide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Cancer Institute (NCI)
Ampulla of Vater Adenoma, Ampulla of Vater Disease (Benign/Malignancy)
Predictors of Therapeutic Success and Adverse Events in Endoscopic Ampullectomy
Although ampullary tumors are rare (representing 0.6-0.8 % of all digestive cancers), their estimated incidence has increased in recent years (<1 per 100 000 per year).
- Trial name
- NCT06648746
- Volunteers
- 100 people
- Sponsor
- Universidade do Porto
Colon Polyp, Adenoma Colon
AmplifEYE Colonoscopy vs Standard Colonoscopy
Colonoscopy screening is proven to reduce mortality rates for colorectal cancer, which relies on early detection and removal of colonic polyps.
- Conditions
- Colon Polyp, Adenoma Colon, Serrated Polyp, Colonic Neoplasms
- Trial name
- NCT03814369
- Testing
- AmplifEYE
- Where
- Hong Kong
- Volunteers
- 355 people, healthy volunteers welcome
- Sponsor
- Queen Elizabeth Hospital, Hong Kong
Colorectal Cancer
Non-invasive Identification of Colorectal Cancer and Adenomas in Early Stages
The NICE study is a prospective, multi-site study to train and validate a blood-based, glycoproteomic test for the early detection of advanced adenoma and colorectal cancer by collecting blood samples and associated relevant…
- Trial name
- NICE (NCT05445570)
- Testing
- Non-Interventional
- Where
- 12 sites in United States
- Volunteers
- 3,002 people
- Sponsor
- Venn Biosciences Corporation
Colorectal Cancer, Colorectal Adenoma
Accuracy of Real Time Characterization in Artificial Intelligence-assisted Colonoscopy
The goal of this substudy is to investigate the accuracy of a computer-aided polyp characterization (CADx) system. The main question[s] it aims to answer are: How high is the specificity of the AI system when characterizing…
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- NCT05754229
- Testing
- AI-assisted colonoscopy
- Where
- 4 sites in Denmark
- Volunteers
- 395 people, healthy volunteers welcome
- Sponsor
- Ismail Gögenur
Colonic Adenoma, Colonic Cancer
R vs L Lateral Decubitus Positioning in Colonoscopy
Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions.
- Trial name
- NCT03355495
- Testing
- Colonoscopy - Position Change
- Where
- Canada
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Malignant Pleural Mesothelioma, Advanced
Oncolytic Adenovirus(H101) Combined With PD-1 Inhibitors in Patients With Advanced Malignant Pleural Mesothelioma
The purpose of this study is to evaluate the efficacy and safety of Oncolytic Adenovirus(H101) combined with PD-1 inhibitor in patients with advanced malignant pleural mesothelioma who have previously been resistant to advanced…
- Trial name
- NCT06031636
- Testing
- Oncolytic Adenovirus H101, Programmed death receptor-1 inhibitor
- Where
- China
- Volunteers
- 15 people
- Sponsor
- Tianjin Medical University Second Hospital
Lung Cancer, Lung Cancer Non-Small Cell Cancer (NSCLC)
Pulmonary Interstitial Lymphography in Early Stage Lung Cancer
The stereotactic body radiation therapy (SBRT) procedure is an emerging alternative to the standard treatment for early stage non-small cell lung cancer (NSCLC), typically lobectomy with lymphadenectomy.
- Conditions
- Lung Cancer, Lung Cancer Non-Small Cell Cancer (NSCLC), Lung Cancer Small Cell Lung Cancer (SCLC), Mesothelioma
- Trial name
- NCT01188486
- Testing
- Stereotactic Body Radiation Therapy (SBRT), Computed Tomography (CT), Cyberknife
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
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