Clinical trials: Addiction Nicotine, open to volunteers
Smoking, Smoking Behaviors
Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction
The study will recruit an anticipated 256 adults who currently smoke cigarettes and report a willingness to try switching to alternative, non-combustible products.
- Conditions
- Smoking, Smoking Behaviors, Nicotine Dependence
- Trial name
- NCT06077240
- Testing
- E-cigarette with 2.4% Nicotine with Menthol and Tobacco Flavors, E-cigarette with 2.4% Nicotine with Tobacco Flavor Only, E-cigarette with 5% Nicotine with Menthol and Tobacco Flavors
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Yale University
Tobacco Use Disorder, Nicotine Dependence
Beta-Adrenergic Modulation of Drug Cue Reactivity
This study is designed to investigate the effects of a beta-adrenergic antagonist (Propranolol; 40 mg IR) and nicotine patch (14 mg) administered alone and in combination on neurobiological and behavioral responses to smoking…
- Conditions
- Tobacco Use Disorder, Nicotine Dependence, Cigarette Smoking
- Trial name
- NCT05587361
- Testing
- Propranolol, Nicotine Patch
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Smoking Cessation, Cigarette Smoking
Quit With Sense: Using Mindful Smoking and Wearable Device for Smoking Cessation
This pilot randomized controlled trial will test the feasibility of a smoking cessation intervention using mindful smoking practice and a smartphone-based sensor-band among adults who regularly smoke cigarettes.
- Conditions
- Smoking Cessation, Cigarette Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- NCT07789496
- Testing
- Mindful Smoking and Sensor-Band Intervention, Smoking Cessation Information
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Tobacco-Related Carcinoma, Addiction
Comparative Evaluation of Nicotine Analogs
This phase I trial compares electronic cigarette (EC) user preferences and smoking behaviors of nicotine analogs to nicotine to improve the understanding of nicotine analog addictiveness.
- Trial name
- CENA (NCT07585006)
- Testing
- Biospecimen Collection, Nicotine, 6-Methyl Nicotine
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Adverse Childhood Experiences, Nicotine Dependence, Cigarettes
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
The purpose of this study is to evaluate how certain childhood experiences influences brain function and responses to nicotine exposure in a group of nonsmoking young adults.
- Trial name
- NCT05665465
- Testing
- Nicotine nasal spray 0.5 mg
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Duke University
Thromboangiitis Obliterans (Buerger's Disease)
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the…
- Trial name
- NCT07215923
- Testing
- ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Antidote Therapeutics, Inc
Coronary Artery Disease, Coronary Atherosclerosis
Effects of Switching From Cigarettes to Tobacco Heating System on Coronary Atherosclerosis Progression
Objective: To evaluate the impact of heated versus combustion tobacco products on progression of atherosclerosis in patients with CAD unable(unwilling) to quit smoking.
- Conditions
- Coronary Artery Disease, Coronary Atherosclerosis, Nicotine Dependence
- Trial name
- SWITCH (NCT05660798)
- Testing
- heated tobacco - lifestyle intervention
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Nicotine Use Disorder
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
This study is an examination of the influence of cooling components of WS-3, WS-23, and menthol on the appeal and addiction potential of nicotine-containing e-liquids among adults.
- Trial name
- NCT05932745
- Testing
- E-liquid coolant (No WS-3) for non-menthol (1), E-liquid coolant (No WS-3) for low (0.1%) menthol (1), E-liquid coolant (No WS-3) for high (2.0%) menthol (1)
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Yale University
CBD, Stress
Effects of Cannabidiol on Stress and Nicotine Withdrawal
The purpose of this study is to examine the effect of doses of cannabidiol (CBD) during exposure to stress and nicotine withdrawal in nicotine users.
- Conditions
- CBD, Stress, Nicotine Dependence, Tobacco Smoking
- Trial name
- CREWS (NCT07001930)
- Testing
- Epidiolex
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence, Tobacco Use
Puff Topography and Sensory Effects Across IQOS Device Generations
The goal of this clinical trial is to learn how people use two generations of IQOS heated tobacco devices and how each device affects their smoking behavior and sensory experience.
- Trial name
- NCT07712887
- Testing
- IQOS Iluma i with TEREA Tobacco Sticks, IQOS 2.4 with HEETS Tobacco Sticks
- Where
- 2 sites in Lebanon
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Diabetes Mellitus, Type 2, Nicotine Addiction
Semaglutide for Smoking Cessation in Patients With Diabetes
To assess the feasibility of conducting a randomized controlled trial (RCT) to determine the effectiveness of semaglutide as an adjunct to combination NRT in supporting smoking cessation for patients with diabetes.
- Conditions
- Diabetes Mellitus, Type 2, Nicotine Addiction, Tobacco Dependence
- Trial name
- GLP1-SC (NCT07059377)
- Testing
- Semaglutide, Nicotine replacement
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Nicotine Dependence
Abuse Liability and Appeal of Oral Nicotine Products
There has been a recent proliferation of novel oral nicotine products (ONPs) brought to market, including new nicotine gums and pouches.
- Trial name
- NCT06506162
- Testing
- Flavor, Nicotine concentration
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Smoking Addiction
Addictive Threshold of Nicotine
To determine the nicotine threshold dose(s) for discrimination, subjective-rewarding effects, -and reinforcement in smokers with different levels of dependence.
- Trial name
- NCT06096714
- Testing
- Nicotine, Saline
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 2, Nicotine Dependence, Cigarettes
Effect of Glucagon-like Peptide-1 (GLP-1) Receptor Agonist Stimulation on Smoking Consumption in Type 2 Diabetes Patients
Diabetes has become an increasingly serious global health issue. In 2024, approximately 537 million adults were living with diabetes, and this number is projected to rise to 783 million by 2045, representing a 46% increase.
- Trial name
- NCT06924697
- Testing
- Application of GLP-1RAs drugs, DPP-4i group
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai East Hospital
Nicotine Dependence
Smart Olfaction App to Reduce Relapse
The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based…
- Trial name
- SOARR (NCT07007195)
- Testing
- Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Houston
Smoking, Nicotine
Impact of Daridorexant on Sleep, Daytime Alertness, and Smoking
Tobacco use is the leading cause of preventable death in the U.S., with 480,000 deaths per year and 7.7 million deaths globally.
- Conditions
- Smoking, Nicotine, Tobacco, Addiction
- Trial name
- NCT07328594
- Testing
- Daridorexant 50 mg
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Legacy Health System
Nicotine Dependence, Nicotine Withdrawal
Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients
The goal of this clinical trial is to evaluate the feasibility and preliminary effectiveness of auricular acupressure (ear seeds) combined with nicotine replacement therapy (NRT) in psychiatric inpatients (both male and female…
- Conditions
- Nicotine Dependence, Nicotine Withdrawal, Tobacco Use Disorder, Anxiety
- Trial name
- NCT07466875
- Testing
- Auricular acupressure, Nicotine Replacement Therapy (Nicotine patch plus NRT gum or lozenge)
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chiao-Chiao Liao
Tobacco Use Behavior, Nicotine Dependence Tobacco Product
§SMOKE Nicotine and Tobacco Youth Cohort
The §SMOKE Cohort Study aims to improve understanding of tobacco and nicotine use among adolescents and young adults in Denmark.
- Conditions
- Tobacco Use Behavior, Nicotine Dependence Tobacco Product, E-Cigarette Use, Smoking ( Cigarette)
- Trial name
- NCT07910331
- Where
- Denmark
- Volunteers
- 10,000 people
- Sponsor
- University of Southern Denmark
Nicotine Addiction, Craving
Advancing VR-based Attentional Bias as a Biomarker for Tobacco Use Disorder
The proposed project will include enrollment of 200 daily tobacco cigarette users, ages 22+, from the San Diego community. Participants will be assessed on the VR Nicotine Cue Exposure paradigm then randomized (stratified on age…
- Trial name
- VR (NCT06582888)
- Testing
- Varenicline Tartrate
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Diego