Clinical trials: Addiction Gambling
Pathological Gambling
D1 and D2 Dopamine Receptors in Gambling and Amphetamine Reinforcement
To determine if: 1. pathological gambling is similar to psychostimulant addiction as reflected by parallel roles for D1 and D2 receptors in gambling and stimulant reinforcement. 2.
- Trial name
- HFDEX (NCT02203786)
- Testing
- Haloperidol, Fluphenazine, Dexedrine
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Substance Use Disorder
OPAL: "Opiates and PhArmacoLogy"
The aim of this study is to determine the current prevalence of co-addictions, including problem/pathological gambling, in patients receiving Opiate Substitution Treatment (OST), and to then compare patients receiving OST with or…
- Trial name
- OPAL (NCT01847729)
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- Nantes University Hospital
Pathological Gambling
Investigation of Naltrexone for Pathological Gambling
The investigators plan to investigate the safety, tolerability, and efficacy of the opioid antagonist naltrexone in Pathological Gambling.
- Trial name
- NCT01057862
- Testing
- Naltrexone
- Where
- 3 sites in United States
- Volunteers
- 9 people
- Sponsor
- Yale University
Internet Addiction
Internet Addiction and Sleep Disorders
This is an open label randomized controlled trial, comparing two modes of treatment for internet addiction (gaming or gambling online) with sleep disorders associated.
- Trial name
- ADDICSOM (NCT02390583)
- Testing
- CBT treatment of internet dependence, CBT treatment of sleep disorders
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Gambling Disorder
Contingency Management as an Adjunct Treatment for Rural and Remote Disordered Gamblers
The purpose of this project is to pilot contingency management as an adjunct treatment to counselling as usual using internet delivered video-conferencing applications for remote disordered gamblers.
- Trial name
- NCT02953899
- Testing
- Contingency Management, Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Lethbridge
Pathological Gambling, Obsessive Compulsive Disorder
Functional Magnetic Resonance Imaging (fMRI) Studies in Pathological Gambling (PG) and Obsessive-Compulsive Disorder (OCD)
This study will explore the brain processes associated with inhibition and reward processing in pathological gamblers and people with obsessive compulsive disorder compared to healthy controls.
- Trial name
- NCT00211822
- Testing
- fMRI
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Gambling Disorder
Internet-CBT for Gambling Disorder - a Randomized Controlled Trial
The study is a randomized controlled trial (Total N=150; each condition n=75) of internet-based cognitive behavioral therapy (iCBT), with measures at pre, weekly during treatment, post, three and at six month follow-up.
- Trial name
- NCT06099522
- Testing
- Internet-based cognitive behavioral therapy (iCBT)
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Karolinska Institutet
Pathological Gambling
Dopamine Responsivity in Gamblers
This study deals with how people decide between rewards of different value. The investigators want to understand how the brain's dopamine system impacts this kind of decision making.
- Trial name
- NCT02772978
- Testing
- Tolcapone
- Volunteers
- 19 people
- Sponsor
- University of California, San Francisco
Pathological Gambling
Community Reinforcement Approach and Family Training (CRAFT) for Problem Gambling
Nova Scotia is experiencing a proliferation of gambling opportunities and their related gambling problems. The 2003 Nova Scotia Prevalence Study (2004) found that approximately 50,000 adult Nova Scotians are at some risk for…
- Trial name
- NCT01340274
- Testing
- CRAFT treatment, Treatment as Usual
- Where
- 3 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Colchester East Hants Health Authority
Pathological Gambling
Impulsivity in Pathological Gambling
The purpose of the this study is to compare pathological gamblers versus non-pathological gamblers using tests that measure different components of impulsivity.
- Trial name
- NCT00580567
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Gambling Disorder
Modeling Clinical Outcomes in Gambling Addiction
Gambling disorder (GD) is recognized as an addictive disorder. Financial consequences of GD are often dramatic, inducing professional, familial, legal and medical repercussions and particularly mental health consequences.
- Trial name
- MOGADOR (NCT06981546)
- Where
- 9 sites in France
- Volunteers
- 268 people
- Sponsor
- Hospices Civils de Lyon
Gambling Disorder
The Effect of Transcranial Direct Current Stimulation on Decision Making and Cognitive Flexibility in Gambling Disorder
The investigators conducted a double-blind randomised sham-controlled study. Upon enrollment into the study, participants were randomly assigned to one of two conditions: (i) active group: anodal stimulation over the right dlPFC…
- Trial name
- NCT03477799
- Testing
- Transcranial direct current stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul University
Pathological Gambling
Repeated Low-frequency Transcranial Magnetic Stimulation Reduces Cue-induced Craving: a Randomized, Prospective, Double-blind, Sham-controlled, Cross-over Study
The aim of this study is to evaluate the effect of repeated low-frequency Transcranial Magnetic Stimulation (rTMS) of the right dorsolateral prefrontal cortex, combined with gambling cues, on gambling craving.
- Trial name
- STIMJEU (NCT01560351)
- Testing
- rTMS
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Nantes University Hospital
Impulse Control Disorder, Parkinson Disease
Naltrexone for Impulse Control Disorders in Parkinson's Disease
This study will evaluate the effectiveness of naltrexone in reducing ICD symptoms in Parkinson's disease patients taking a dopamine agonist.
- Trial name
- NCT01052831
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Pennsylvania
Behavioural Addiction
NAlmefene Versus Placebo in Addition to Treatment as Usual on Craving in Behavioural Addictions
Behavioural addictions (BAs) [gambling disorder (GD), food addiction (FA), sexual addiction (SA)] may lead to disastrous consequences.
- Trial name
- NABAb (NCT05540288)
- Testing
- Nalmefene
- Where
- 13 sites in France
- Volunteers
- 266 people
- Sponsor
- Nantes University Hospital
Alcoholism, Gambling
Effectiveness of Sertraline in Treating Pathological Gamblers With a Diagnosis of Alcohol Dependence - 1
Pathological gamblers often are also dependent on alcohol and clinically depressed. Sertraline (Zoloft) is currently used to treat depression, panic disorder, and obsessive-compulsive disorder.
- Trial name
- NCT00249431
- Testing
- Sertraline, Relapse Prevention Therapy
- Volunteers
- 9 people
- Sponsor
- New York State Psychiatric Institute
Gambling Disorder
Virtual Reality Exposure Therapy for Gambling Disorder
Gambling disorder (GD) is recognized as an addictive disorder in the DSM-5. Craving is a core phenomenon in addiction that can lead to relapse in problem gambling for pathological gamblers.
- Trial name
- VIRET-GAD (NCT04467502)
- Testing
- cognitive-behavioral therapy for gambling disorder, imaginal exposure therapy focus on gambling cues, virtual reality exposure therapy focus on gambling cues
- Where
- 10 sites in France
- Volunteers
- 124 people
- Sponsor
- University Hospital, Lille
Impulsive Behavior, Impulse Disorders
Clinical Response of Impulsivity After Brain Stimulation in Parkinson's Disease
The objective of this prospective observational cohort study is to answer the following clinically important questions: 1. In patients with a pre-operative history of ICBs, what is the likelihood of improvement or deterioration…
- Conditions
- Impulsive Behavior, Impulse Disorders, Gambling, Pathological, Eating, Binge
- Trial name
- CRIPS (NCT04811807)
- Testing
- Subthalamic Nucleaus Deep brain stimulation
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King's College London
Gambling Addiction
Testing the Interplay of Gambling, Emotion and Reward
Background The nature and direction of dysfunctional reward processing in gambling disorder remains unclear. We aim to test a novel neurobiological model of gambling addiction, that takes into account inter-individual…
- Trial name
- TIGER (NCT06122298)
- Testing
- fMRI, Ecological Momentary Assessment
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Deep Brain Stimulation
Efficacy and Safety of Combo-stim Deep Brain Stimulation for Treatment-refractory Mental Disorders
This is a multi-center, single arm, prospective, open-label, extendable study for the efficacy and safety of combo-stim deep brain stimulation for treatment-refractory mental disorders (obsessive-compulsive disorder…
- Trial name
- NCT06112067
- Testing
- deep brain stimulation
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Mental Health Center