Clinical trials: Adaptive Support Condition
Acute Exacerbation of COPD
Non Invasive Ventilation With NAVA vs ASV for AECOPD
Non invasive ventilation is the standard of care in managing patients with exacerbation of chronic obstructive pulmonary disease.
- Trial name
- NCT04414891
- Testing
- Non invasive ventilation
- Where
- India
- Volunteers
- 76 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Respiratory Distress Syndrome
Adaptive Support Ventilation in Acute Respiratory Distress Syndrome
The purpose of this protocol is to compare standard of care lung protective ventilation settings with an automated ventilator setting, called Adaptive Support Ventilation (ASV), in patients with acute respiratory distress…
- Trial name
- ARDS (NCT03715751)
- Testing
- ASV, Lung Protective Ventilation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Beth Israel Deaconess Medical Center
Bipolar Disorder, Mania
Clocks in Sync - Circadian Rhythm and Bipolar Mania
The sleep-wake cycle is severely disrupted during an episode of mania. Often mania is treated with medications that can come with significant side effects.
- Trial name
- CIS (NCT06504342)
- Testing
- Blue-blocking glasses, Time-restricted eating, Lightly tinted glasses
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Ottawa Hospital Research Institute
Chronic Obstructive Pulmonary Disease (COPD)
Exacerbation Self-management in COPD: The ACCESS Study
Aim is to test the effect of ACCESS ("Adaptive Computerized COPD Exacerbation Self-management Support"), a software application designed to support patients with COPD in self-management of exacerbations.
- Trial name
- ACCESS (NCT02553096)
- Testing
- ACCESS
- Where
- Netherlands
- Volunteers
- 87 people
- Sponsor
- Radboud University Medical Center
Pulmonary Disease, Chronic Obstructive
Adaptive Support Ventilation in the Weaning of COPD
Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both as pressure support (PSV) and pressure controlled (PCV) ventilation.
- Trial name
- NCT00969605
- Testing
- Comparison of two different modes for weaning from mechanical ventilation
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people
- Sponsor
- Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital
Covid19
COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Acebilustat Sub-Protocol
The overall objective of this study is to efficiently evaluate the clinical efficacy and safety of different investigational therapeutics among adults who have COVID-19 but are not yet sick enough to require hospitalization.
- Trial name
- COPPS (NCT04662060)
- Testing
- Acebilustat
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Stanford University
Opioid-use Disorder
Examining an Adaptive Approach to Providing Psychosocial Support to Buprenorphine Patients
The purpose of this study is to address important knowledge gaps regarding the optimal way to provide psychosocial treatment to patients who are receiving buprenorphine for opioid use disorder (OUD) in office-based settings.
- Trial name
- NCT04650386
- Testing
- Psychosocial support determined by adaptive treatment algorithm
- Where
- 2 sites in United States
- Volunteers
- 125 people
- Sponsor
- Public Health Management Corporation
HIV/AIDS, Trauma
Trauma Informed Intervention to Support Engagement in HIV Care Among MSM (THRIVE+)
This purpose of this project is to specify and provide an initial test of a 10 session, individual-based cognitive therapy intervention to address symptoms of PTSD and poor engagement in HIV care among men who have sex with men…
- Trial name
- THRIVE+ (NCT05822206)
- Testing
- CBT-TSC, Life Steps and Sexual Decision-Making
- Where
- 2 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Behavior, Adaptive, Mental Illness
IPS/Peer Support Intervention in the DTES
Individual placement support (IPS) is an evidence-based supported employment model for people with severe mental illness, designed to achieve employment in mainstream competitive jobs, either part-time or full-time.
- Conditions
- Behavior, Adaptive, Mental Illness, Substance Use
- Trial name
- NCT03748004
- Testing
- IPS/SP, WorkBC
- Where
- 3 sites in Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Obesity
Support and Tracking to Achieve Results (Project STAR)
The investigators propose to conduct a randomized controlled trial assessing the impact of phone-based extended care delivered on an ADAPTIVE (when participants are at "high risk" for weight regain as assessed by a predictive…
- Trial name
- NCT04116853
- Testing
- ADAPTIVE Extended-Care Program, STATIC Extended-Care Program
- Where
- United States
- Volunteers
- 255 people
- Sponsor
- University of Florida
Hypertrophy
Mycoprotein, Resistance Training, and Hypertrophy
Protein is vital for the preservation of health and optimal adaptation to training. However, animal proteins come with economic and environmental issues.
- Trial name
- HAM (NCT03572127)
- Testing
- Diet
- Where
- United Kingdom
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Medication Adherence
Adaptive Cell Phone Support (ACPS)
The goal of this pilot clinical trial is to test a mobile health intervention for promoting medication adherence in a population of adolescents and young adults with chronic health conditions.
- Trial name
- ACPS (NCT07064824)
- Testing
- Adaptive Cell Phone Support, Computer-Delivered Cell Phone Support, Automated Text Reminders
- Where
- United States
- Volunteers
- 96 people
- Sponsor
- Children's Hospital Los Angeles
Opioid Abuse (Disorder), Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 3
This study is stage 2, round 3 of a larger study which refines and optimizes the EMBED clinical decision support (CDS) to increase number of ED physicians following standard of care for the administration of buprenorphine to…
- Trial name
- NCT07793383
- Testing
- Refined EMBED CDS, Provider alert that nurse completed COWS
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Dementia
Supporting Caregivers of PWD and Identifying an Effective Intervention to Reduce Their Depressive Symptoms
Effective clinical management of chronic conditions like depressive symptoms of caregivers actually requires a sequence of interventions, each adapts to responses to prior interventions, and hence multiple intervention decisions…
- Trial name
- NCT05634317
- Testing
- Smartphone delivered Behavioral activation, Smartphone delivered Mindfulness
- Where
- Hong Kong
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
COPD (Chronic Obstructive Pulmonary Disease)
Development And Evaluation of An Adaptive Web-Based Intervention for COPD
Narrative-based tiered asynchronous psychosocial and behavioral whole health support for people adjusting to living with COPD. The intervention is administered by experienced LCSWs under the PI's supervision.
- Trial name
- NCT06770777
- Testing
- Tiered whole health support for people living with COPD
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Opioid Use Disorder, Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 2
This study is stage 2, round 2 of a larger study which refines and optimizes the EMBED clinical decision support (CDS); see NCT03658642 to increase number of ED physicians following standard of care for the administration of…
- Trial name
- NCT07602218
- Testing
- Refined EMBED CDS, Provider alert to order consultation with addiction counselor
- Where
- 3 sites in United States
- Volunteers
- 379 people
- Sponsor
- Yale University
COPD Exacerbation Acute, COPD Exacerbation
PSV Versus ASV With Intellisync Mode for Delivery of NIV in AECOPD
Acute exacerbation of chronic obstructive pulmonary disease (COPD) is defined acute worsening of respiratory symptoms requiring additional therapy.
- Trial name
- PAINT-COPD (NCT06160687)
- Testing
- PSV mode during NIV, ASV intellisync
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Opioid Use Disorder, Clinical Decision Support
Adaptive Decision Support for Addiction Treatment (ADAPT) Serial Randomized Testing for Usability, Round 1
This study is stage 2, round 1 of a larger study which refines and optimizes the EMBED clinical decision support (CDS); see NCT03658642 to increase number of ED physicians following standard of care for the administration of…
- Trial name
- NCT07549126
- Testing
- Nurse prompt to complete COWS under required documentation, Refined EMBED CDS
- Where
- 3 sites in United States
- Volunteers
- 267 people
- Sponsor
- Yale University
Veno-occlusive Disease
Study Comparing Efficacy and Safety of Defibrotide vs Best Supportive Care in the Prevention of Hepatic Veno-Occlusive Disease in Adult and Pediatric Patients
This study is to compare the efficacy and safety of defibrotide prophylaxis in addition to best supportive care versus best supportive care alone in the prevention of hepatic veno- occlusive disease (VOD) in adult and pediatric…
- Trial name
- NCT02851407
- Testing
- Defibrotide, Best Supportive Care
- Where
- 114 sites in United States, Australia and 12 more
- Volunteers
- 372 people
- Sponsor
- Jazz Pharmaceuticals
Opioid Use Disorder
Adaptive Decision Support for Addiction Treatment Master
This study refines and optimizes the EMBED* clinical decision support (CDS; see NCT03658642) to increase number of ED physicians following standard of care for the administration of buprenorphine to appropriate patients with…
- Trial name
- ADAPT (NCT06799117)
- Testing
- EMBED CDS, Nurse prompt to complete COWS, Provider Prompt
- Where
- 3 sites in United States
- Volunteers
- 1,912 people
- Sponsor
- Yale University