Clinical trials: Acute Ulcerative Colitis
Ulcerative Colitis (UC), Acute Severe Ulcerative Colitis
Effectiveness and Safety of Upadacitinib for Acute Severe Ulcerative Colitis
The aim of this retrospective observational study is to investigate and compare the real-world effectiveness and safety of upadacitinib when used as first-line exposure versus rescue exposure in patients with acute severe…
- Conditions
- Ulcerative Colitis (UC), Acute Severe Ulcerative Colitis, Upadacitinib
- Trial name
- NCT07472309
- Testing
- Upadacitinib
- Where
- China
- Volunteers
- 81 people
- Sponsor
- Xijing Hospital of Digestive Diseases
Colitis, Ulcerative
TITRATE (inducTIon for acuTe ulceRATivE Colitis)
The aim of this study is to investigate whether intensive, personalized IFX dosing by using a pharmacokinetics driven dashboard system during the induction phase in patients with acute severe UC leads to increased treatment…
- Trial name
- TITRATE (NCT03937609)
- Testing
- Infliximab
- Where
- 7 sites in Ireland, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ulcerative Colitis, Ulcerative Colitis Flare
Transfer of Feces in Ulcerative Colitis 2
The goal of this placebo-controlled randomised multicenter trial is to evaluate the efficacy and safety of anaerobic prepared donor fecal microbiota transplantation (FMT) compared to autologous FMT in patient with ulcerative…
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Flare, Ulcerative Colitis Acute
- Trial name
- TURN2 (NCT05998213)
- Testing
- Fecal microbiota transplant
- Where
- Netherlands
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ulcerative Colitis
Efficacy of Subcutaneous Infliximab in Acute Severe Ulcerative Colitis: a Multicenter Retrospective Study
Around 25% of patients with ulcerative colitis will develop acute severe colitis during the course of their disease. The first-line treatment for acute severe colitis is intravenous corticosteroid therapy.
- Trial name
- ISAC (NCT06998797)
- Testing
- Data collection
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Ulcerative Colitis
Serum Lactate and Ulcerative Colitis
Patients presenting with severe symptoms of ulcerative colitis (UC) require hospital admission for urgent assessment and therapy.
- Trial name
- NCT05876494
- Testing
- serum lactate
- Where
- Egypt
- Volunteers
- 137 people
- Sponsor
- Assiut University
Ulcerative Colitis
Tofacitinib Versus Cyclosporine for Steroid Refractory Acute Severe Ulcerative Colitis
This randomised trial plans to compare oral tofacitinib with intravenous cyclosporine in patients with acute severe ulcerative colitis who have failed to respond to intravenous steroids
- Trial name
- TOCASU (NCT05112263)
- Testing
- Tofacitinib, Cyclosporine
- Volunteers
- 96 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Ulcerative Colitis
Multi-center Acute Severe Ulcerative Colitis Cohort Study (MASCC)
Ulcerative colitis (UC) is a chronic, progressive immunologically mediated disease affecting nearly 1 million Americans. Up to one third of patients with UC will require hospitalization for severe disease (termed 'acute severe…
- Trial name
- MASCC (NCT03669822)
- Testing
- Standard of care
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- Johns Hopkins University
Ulcerative Colitis Acute
Tofacitinib for Hospitalized Acute Severe Ulcerative Colitis Management
The TRIUMPH study was designed to build on the existing literature by studying the efficacy of tofacitinib in hospitalized patients with acute severe ulcerative colitis.
- Trial name
- TRIUMPH (NCT04925973)
- Testing
- Tofacitinib 10 MG [Xeljanz]
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
Ulcerative Colitis, Ulcerative Colitis Chronic Moderate
Study of Novel Therapeutics for Acute Remedy of Colitis
This study is a clinical trial being done to investigate the efficacy of drug BRS201 as a treatment in patients with acute ulcerative colitis.
- Conditions
- Ulcerative Colitis, Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic Severe
- Trial name
- SHARC (NCT06420492)
- Testing
- BRS201
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Ulcerative Colitis (UC), Crohn's Diseases
Cardiovascular Risk in Patients With IBD
In this study the Research Hospital San Donato Policlinic ask the participation with the aim to evaluate the risk of cardiovascular complication (i.e. stroke, myocardial infarction) in patients with inflammatory bowel disease.
- Conditions
- Ulcerative Colitis (UC), Crohn's Diseases, Cardiovascular Risk
- Trial name
- DICOM-IBD (NCT07663201)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Alopecia Areata, Depressive Episode
The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia Areata
This study series consists of four related studies and aims to explore and describe many important elements of alopecia areata over three key areas: (1) the current epidemiology of alopecia areata, (2) the prevalence and…
- Conditions
- Alopecia Areata, Depressive Episode, Recurrent Depressive Disorder, Anxiety Disorders
- Trial name
- NCT04239521
- Testing
- Exposure of interest (studies 2 & 3).
- Where
- United Kingdom
- Volunteers
- 51,955 people
- Sponsor
- Momentum Data
Acute Severe Ulcerative Colitis
Combination Therapy With Infliximab and Tofacitinib for Acute Severe Ulcerative Colitis - CINTO Trial
In adults hospitalized with acute severe ulcerative colitis who fail to respond to intravenous steroids, does treatment with a combination of infliximab and tofacitinib, compared with infliximab alone or tofacitinib alone, result…
- Trial name
- NCT07297069
- Testing
- Infliximab, Tofacitinib
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Asian Institute of Gastroenterology, India
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Ulcerative Colitis Acute
Efficacy of Cyclosporine Rescue Therapy in Acute Ulcerative Colitis.
The efficacy and safety of Cyclosporine A as rescue therapy for acute severe ulcerative colitis in long-term follow-up.
- Trial name
- Cyclo (NCT05219656)
- Testing
- Cyclosporine A
- Volunteers
- 182 people
- Sponsor
- Tampere University Hospital
Ulcerative Colitis
A Randomized, Multicenter Open Label Study Comparing Early Administration of Azathioprine Plus IFX to Steroids Plus Azathioprine for Acute Severe Colitis
PHASE : IV TYPE OF STUDY : With direct benefit. DESCRIPTIVE : Multicentre, randomized, open label study. INCLUSION CRITERIA : Acute severe ulcerative colitis.
- Trial name
- ACTIVE (NCT02425852)
- Testing
- Azathioprine, Infliximab, Prednisolone
- Where
- 16 sites in France
- Volunteers
- 65 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Ulcerative Colitis
Oncostatin M in Ulcerative Colitis Patients
Ulcerative colitis (UC) is a refractory disease characterized by symptoms such as diarrhea, bloody stools, and abdominal pain with repeated relapses and remissions.
- Trial name
- NCT05974332
- Testing
- Oncostatin M
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Ulcerative Colitis, Inflammatory Bowel Diseases
Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis
The study is planned as a randomised control trial to study the adjuvant use of antibiotics (ceftriaxone and metronidazole) to achieve a clinical response in hospitalised patients with acute severe ulcerative colitis
- Conditions
- Ulcerative Colitis, Inflammatory Bowel Diseases, Acute Severe Colitis
- Trial name
- AAASUC (NCT03794765)
- Testing
- Ceftriaxone, Metronidazole
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Ulcerative Colitis, Inflammatory Bowel Diseases
Russian Extremely Severe Ulcerative Colitis Study
The purpose of this study is prove the need to selection of a extremely severe ulcerative colitis, to identify predictors of colectomy, which will reduce the optimal time for surgery.
- Trial name
- REXs_UC (NCT03947931)
- Where
- Russia
- Volunteers
- 71 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Acute Ulcerative Colitis
TP05 for the Treatment of Mild to Moderate Active Ulcerative Colitis (UC)
The purpose of this research study was to compare the medication TP05 to the medication Asacol™ for the treatment of ulcerative colitis (UC) and to assess the safety and tolerability of TP05.
- Trial name
- Precision-UC (NCT01903252)
- Testing
- TP05, Asacol 400 mg
- Where
- Switzerland
- Volunteers
- 817 people
- Sponsor
- Tillotts Pharma AG
UC - Ulcerative Colitis
Upadacitinib in Patients Hospitalized With Acute Severe Ulcerative Colitis
The goal of this clinical trial is to learn if the oral medication upadacitinib can safely and effectively treat acute severe ulcerative colitis (ASUC) in adults who are hospitalized.
- Trial name
- NCT07502339
- Testing
- Upadacitinib
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, San Francisco