Clinical trials: Acute Spinal Cord Injury
Spinal Cord Injury, Tetraplegia
Effect of Air-stacking on Peak Cough Flow in Patients With Acute Cervical or High Thoracic Spinal Cord Injury
Respiratory complications continue to be one of the leading causes of morbidity and mortality in people with spinal cord injury, especially among cervical and higher thoracic injuries.
- Trial name
- NCT01046175
- Testing
- Air-stacking with a manual resuscitator, Air-stacking with ventilator
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Ullevaal University Hospital
Spinal Cord Injury, Acute
Systemic Hypothermia in Acute Cervical Spinal Cord Injury
This study is a prospective multi-center trial designed to determine the safety profile and efficacy of modest (33ºC) intravascular hypothermia following acute cervical (C1 to C8) Spinal Cord Injury (SCI).
- Trial name
- NCT02991690
- Testing
- Alsius Icy CoolGuard® Catheter
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Miami
Spinal Cord Injuries, Pain, Chronic
Hypnotic Cognitive Therapy Reduce Acute & Chronic SCI Pain in Inpatient Rehabilitation
Chronic spinal cord injury (SCI) pain is complex and difficult to treat. For individuals with SCI, pain often begins early in the course of their SCI and continues longitudinally.
- Conditions
- Spinal Cord Injuries, Pain, Chronic, Spinal Cord Injury, Acute
- Trial name
- HYPCT (NCT05047120)
- Testing
- Hypnosis enhanced cognitive behavioral therapy, Pain Education
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Washington
Spinal Cord Injury
Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries
Autologous Incubated Macrophages (ProCord) is being developed as a therapy for acute, complete spinal cord injury (SCI). The therapy is intended to reverse the loss of motor and sensory function.
- Trial name
- NCT00073853
- Testing
- Autologous Incubated Macrophages (cell therapy)
- Where
- 7 sites in United States, Israel
- Volunteers
- 61 people
- Sponsor
- Proneuron Biotechnologies
Spinal Cord Injuries (SCI)
Spasticity in SCI Following Acute Intermittent Hypoxia
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury.
- Trial name
- NCT07583498
- Testing
- Acute Intermittent Hypoxia (AIH)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Zev Rymer
Spinal Cord Injuries
Exoskeleton Use in Acute Rehab Post Spinal Cord Injury; a Safety and Feasibility Study
This study will examine the safety and feasibility of using an exoskeleton in subjects who are less than 6 months post spinal cord injury (SCI).
- Trial name
- NCT03144830
- Testing
- Exoskeleton
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- University of Calgary
Spinal Cord Injury
Study on Feasibility of Stimulation on the Lumbar Part of the Spinal Cord to Improve Mobility Recovery in Patients With Sub-acute Spinal Cord Injury
The STIMO-2 study aims to investigate TESS-supported rehabilitation training in sub-acute spinal cord injury (< 6 months post-injury). The primary endpoint of this study is to assess the safety and feasibility of TESS.
- Trial name
- STIMO-2 (NCT04196114)
- Testing
- STIMO-2 device implantation
- Where
- Switzerland
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Spinal Cord Injuries
Timing and Dosage of Acute Intermittent Hypoxia in Persons With SCI
This study will utilize short duration and mild levels of reduced oxygen (hypoxia) to induce spinal plasticity while evaluating the appropriate timing schedule for this intervention, as well as, the effects of superimposing…
- Trial name
- NCT03774043
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
TNFα Monoclonal Antibody for Acute Spinal Cord Injury
The purpose of this study is to evaluate the safety and effectiveness of subcutaneous injection of TNFα monoclonal antibody cells for the treatment of traumatic acute spinal cord injury.
- Trial name
- NCT04988425
- Testing
- TNFα Monoclonal Antibody, Methylprednisolone, Saline
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Shanghai Changzheng Hospital
Spinal Cord Injury, Acute, Spinal Cord Injury (SCI), Initial Encounter
Duraplasty for Acute Traumatic Spinal Cord Injury
The goal of this clinical trial is to learn if a procedure called "expansile duraplasty" can improve recovery in adults who have experienced an acute traumatic spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury, Acute, Spinal Cord Injury (SCI), Initial Encounter, Spinal Cord Injury Cervical
- Trial name
- DATSCI (NCT07280351)
- Testing
- Expansile duraplasty
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, San Francisco
Acute Stroke, Cervical Spinal Cord Injury
Motor Recovery Training for Hand and Digits in Stroke and SCI
This study will use evaluate a hand therapy device training isolated finger control with engaging video gaming technology to facilitate hand and digit recovery in patients with acute stroke and cervical spinal cord injury.
- Trial name
- NCT04688229
- Testing
- Hummingbird hand training device plus standard of care rehabilitation
- Volunteers
- 24 people
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injury
Acute Effect of Ventilatory Support During Exercise in Spinal Cord Injury
The investigators have an existing exercise program (N>70) with a unique population of individuals with spinal cord injury (SCI) who have been enrolled in Functional Electrical Stimulation - Rowing Training (FES-RT) for at least…
- Trial name
- NIV-Ex-CS (NCT03267212)
- Testing
- Non-invasive ventilation(NIV), Functional Electrical Stimulation Row Training (FESRT)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Spaulding Rehabilitation Hospital
Acute Spinal Cord Injury
Transplantation of Autologous Adipose Derived Stem Cells (ADSCs) in Spinal Cord Injury Treatment
This study is designed to assess the safety and effect of autologous adipose derived stem cell (ADSCs) transplantation in acute spinal cord injury patients. 1.
- Trial name
- NCT02034669
- Testing
- Laminectomy, Intradural space, Intrathecal
- Where
- Vietnam
- Volunteers
- 48 people
- Sponsor
- Tri Phuoc Biotechnology., JSC
Acute Spinal Cord Injury of Traumatic Origin (tSCI)
Surgical Treatment for Spinal Cord Injury
Despite many years of research, an incomprehensible amount of scientific efforts worldwide and billions of dollars invested, no effective therapy resulting in major neurological or functional recovery is available to date for…
- Trial name
- SCI-POEM (NCT01674764)
- Testing
- Early surgical intervention, Late surgical intervention
- Where
- 17 sites in Austria, Bulgaria and 10 more
- Volunteers
- 297 people
- Sponsor
- AOSpine Europe
Spinal Cord Injuries
Difference Between Rehabilitation Therapy and Stem Cells Transplantation in Patients With Spinal Cord Injury in China
The morbidity of spinal cord injury (SCI) is increasing significantly in China. The methods to treat SCI patients in sequela stage update are poor.
- Trial name
- NCT01393977
- Testing
- rehabilitation of limb function, Stem Cells Transplantation
- Where
- China
- Volunteers
- 60 people
- Sponsor
- General Hospital of Chinese Armed Police Forces
Traumatic Spinal Cord Injury
Shoulder Kinematics and Acute Ultrasonographic Changes in Manual Wheelchair Users With Spinal Cord Injury
People who lose function of the lower limb due to spinal cord injury (SCI) need to use their arms for activities of daily life especially during weight-bearing tasks, such as transfers, and manual wheelchair (MWC) propulsion in…
- Trial name
- NCT04712188
- Testing
- Musculoskeletal ultrasonography, Wheelchair propelling test
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
Spinal Cord Injuries
Acute Intermittent Hypoxia on Leg Function Following Spinal Cord Injury
The purpose of this study is to determine how the nervous system controlling leg muscles is altered following spinal cord injury and how they may be affected by brief periods of low oxygen inhalation over time.
- Trial name
- NCT02274116
- Testing
- AIH - Intermittent Hypoxia - hypoxia air mixture
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Spaulding Rehabilitation Hospital
Spinal Cord Injury, Respiratory Insufficiency
A Comparison of High vs. Low Tidal Volumes in Ventilator Weaning for Individuals With Cervical Spinal Cord Injuries
The study will compare outcomes between individuals with sub-acute, ventilator-dependent tetraplegia using high (20 cc/kg) vs. low (10 cc/kg) tidal volumes during mechanical ventilator support.
- Trial name
- NCT00412308
- Testing
- Tidal volume used in mechanical ventilation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Craig Hospital
Spinal Cord Injury
Safety and Pharmacokinetics Study of MT-3921 in Spinal Cord Injury
The purpose of this study is to assess the safety, tolerability and pharmacokinetics of MT-3921 in subjects with spinal cord injury.
- Trial name
- NCT04096950
- Testing
- MT-3921 Low dose
- Where
- 13 sites in United States
- Volunteers
- 3 people
- Sponsor
- Tanabe Pharma America, Inc.
Spinal Cord Injury
Autologous Bone Marrow-derived Mononuclear Cells for Acute Spinal Cord Injury
The purpose of this study is to evaluate the safety and effectiveness of intrathecal transplantation of autologous bone marrow-derived mononuclear cells for the treatment of traumatic acute spinal cord injury.
- Trial name
- NCT04528550
- Testing
- Autologous bone marrow-derived mononuclear cells
- Where
- China
- Volunteers
- 45 people
- Sponsor
- Shanghai Changzheng Hospital