Clinical trials: Acute Sinusitis
Acute Bacterial Sinusitis (ABS)
Comparative Study of the Safety and Efficacy of Clarithromycin Extended-Release Tablets Versus Amoxicillin-Clavulanate for the Treatment of Acute Bacterial Sinusitis
To compare the safety/tolerability and efficacy of a 14-day course of clarithromycin extended-release tablets (2 x 500 mg QD) with that of a 14-day course of amoxicillin-clavulanate tablets (875/125 mg BID) for the treatment of…
- Trial name
- NCT00644553
- Testing
- Clarithromycin, Amoxicillin
- Where
- 53 sites in United States, Canada and 7 more
- Volunteers
- 437 people
- Sponsor
- Abbott
Acute Bacterial Sinusitis
Single Use Device Endoscopy for the Diagnosis of Acute Bacterial Rhinosinusitis in Primary Care
This is a pilot study to assess the first time use of the JGG endoscope® in humans and in primary care. The JGG endoscope® is attached to a Heine® otoscope and allows to inspect and to collect samples from the middle meatus of…
- Trial name
- Sinus-Endo (NCT03766568)
- Testing
- JGG endoscope(R)
- Where
- 6 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Dominik Glinz
Rhino Sinusitis
Herbal Tea Extract for Management of Rhinosinusitis
The objective of this phase I controlled clinical trial is to determine the safety and efficacy of Berry leaves \& Mango leaves mixture in symptomatic treatments on disease-related quality of life in adults with clinically…
- Trial name
- NCT07534280
- Testing
- mango leaves extract, local steroids, nasal saline
- Where
- 2 sites in Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Deraya University
Covid19
COVID-19 and Acute Invasive Fungal Rhinosinusitis
Data for acute invasive rhinosinusitis was obtained from the Otorhinolaryngology departments at our tertiary hospital at the period from January 2017 to December 2020.
- Trial name
- NCT04809480
- Testing
- Fungal rhinosinusitis
- Volunteers
- 56 people
- Sponsor
- Al-Azhar University
Mucormycosis; Rhinocerebral (Etiology), Post COVID-19 Condition, Unspecified
Post-COVID-19 Mucormycosis in Critical Care
Background: Mucormycosis is a life-threatening opportunistic fungal infection. Despite mucormycosis having existed for decades, it has gained notice of its widespread in many parts of the world during the second wave of the…
- Trial name
- NCT05911035
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Zagazig University
Rhinosinusitis
Study of Cefditoren Pivoxil in Treatment of Childhood With Acute Rhinosinusitis
Cefditoren pivoxil has been used in rhinosinusitis treatment. However, little is known about the efficacy of this drug at low and high doses.
- Trial name
- RS (NCT01553006)
- Testing
- cefditoren pivoxil
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Thammasat University
ACUTE SINUSITIS
Pilot Study to Determine Efficacy of Cyclamen Europaeum Extract Nasal Spray in Patients With Acute Sinusitis
To evaluate the efficacy and safety of Cyclamen europaeum extract 10 % (v/v) compared to placebo in subjects with acute sinusitis
- Trial name
- NCT00552773
- Testing
- Cyclamen Europaeum
- Where
- 25 sites in United States
- Volunteers
- 48 people
- Sponsor
- Dey
Rhinosinusitis
Levofloxacin in Bacterial Rhinosinussitis
Inflammatory paranasal diseases are among the most common diseases in ENT In Russia, puncture method has been conventional approach to treatment of maxillary sinusitis.
- Trial name
- Levolet (NCT02712502)
- Testing
- Levofloxacin, Amoxicillin-Potassium Clavulanate Combination
- Volunteers
- 100 people
- Sponsor
- Dr. Reddy's Laboratories Limited
Common Cold
Testing the Efficacy in Adults With Cold of HEalsea Rescue*
Healsea® Rescue* is a CE-marked class I medical device. This is a saline-based nasal spray supplemented with a natural Symbiofilm™ extract (0.04%) isolated from the marine bacteria.
- Trial name
- TEACHER (NCT05819190)
- Testing
- Healsea Rescue*
- Where
- Bulgaria
- Volunteers
- 200 people
- Sponsor
- Lallemand Pharma AG
Sinusitis, Acute
Treatment of Acute Sinusitis With High-Dose vs. Standard-Dose Amoxicillin/Clavulanate
Comparative-effectiveness study of the treatment of acute bacterial sinusitis with amoxicillin/clavulanate 875mg/125mg bid for 7 days with or without the addition of immediate-release amoxicillin 875 mg bid x 7 days. .
- Trial name
- NCT03431337
- Testing
- Amoxicillin 875 mg
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Paul Sorum, MD
Anti-Infective Agents
Special Drug Use Investigation - Assessment of Efficacy and Safety in Treating Secondary Infection of Chronic Respiratory Disease
The objective of this study is to assess the efficacy and safety of Avelox Tablet 400 mg (hereinafter as "Avelox") in treating secondary infection of chronic respiratory disease.It is a local prospective and observational study…
- Trial name
- NCT01690533
- Testing
- Avelox (Moxifloxacin, BAY12-8039)
- Where
- Japan
- Volunteers
- 497 people
- Sponsor
- Bayer
Acute Sinusitis, Streptococcal Pharyngitis
Antimicrobial Stewardship for Primary Care Pediatricians
The purpose of the study is to determine if physician education coupled with audit and feedback of antibiotic prescribing can improve antibiotic prescribing by primary care clinicians.
- Conditions
- Acute Sinusitis, Streptococcal Pharyngitis, Pneumonia, Viral Infection
- Trial name
- PARTI (NCT01806103)
- Testing
- Antimicrobial Stewardship Bundle
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Children's Hospital of Philadelphia
Rhinosinusitis, Rhinitis
Safety and Efficacy of DSM 32444 Postbiotic in the Treatment of Acute Rhinosinusitis
Rhinitis is a type of upper respiratory infection with a common nasal pathology especially in Southeast Asia, which is characterized by the presence of one or more of the following symptoms: itchy nose, sneezing, runny nose, and…
- Trial name
- NCT05999955
- Testing
- Neomycin/ Dexameythasone/Xylometazoline, Bacillus subtilis DSM32444
- Where
- Vietnam
- Volunteers
- 60 people
- Sponsor
- Huro Biotech Joint Stock Company
Acute Bronchitis, ACUTE SINUSITIS
Improving Patient-centered Communication and Antibiotic Use With Information Sheets for Acute Respiratory Tract Infections: A Study Protocol
The goal of this trial is to investigate if the use of information sheets regarding acute respiratory tract infections will lead to more rational antibiotic prescribing and increase patient-centered communication i Danish general…
- Conditions
- Acute Bronchitis, ACUTE SINUSITIS, Sore Throat
- Trial name
- NCT07383350
- Testing
- ARTI Info-sheets
- Where
- Denmark
- Volunteers
- 1,144 people
- Sponsor
- Research Unit for General Practice in Aalborg
Peri-Implantitis, Sinusitis
"Association of Peri-implantitis and Maxillary Sinusitis: a Case-control Study".
Scientific evidence regarding the influence of peri-implantitis on Schneider's membrane thickening is scarce and limited. Similarly, to date, there is no literature documenting the resolution of implant-associated maxillary…
- Conditions
- Peri-Implantitis, Sinusitis, Sinusitis, Acute, Sinusitis, Chronic
- Trial name
- NCT05924711
- Testing
- Retrospective analysis of demographic and radiographic data previously obtained from the patient.
- Where
- 2 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Universitat Internacional de Catalunya
Sinusitis, Acute
Dose Finding Study of Fluticasone Furoate Nasal Spray for Uncomplicated Acute Rhinosinusitis
The purpose of this study is to assess the safety and efficacy of fluticasone furoate nasal spray (FFNS), without the use of an antibiotic, in the treatment of adult and adolescent subjects who are 12 years of age and older with…
- Trial name
- NCT01018030
- Testing
- FFNS 110 mcg QD, FFNS 110 mcg BID
- Where
- 87 sites in Bulgaria, Canada and 10 more
- Volunteers
- 741 people
- Sponsor
- GlaxoSmithKline
Conscripts, Military Induction Board
Prevalence of ENT Diseseas
The aim of the present study will be to evaluate in conscripts at the military induction board the prevalence of rhinosinusitis, the prevalence of HPV vaccinations, the prevalence of hearing impairments and the prevalence of…
- Conditions
- Conscripts, Military Induction Board, ENT Disease, Rhinosinusitis Chronic
- Trial name
- PrENT (NCT06105346)
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Acute Respiratory Tract Infection, Otitis Media
Broad Implementation of Outpatient Stewardship
Reducing inappropriate antibiotic use is a key strategy to mitigate antibiotic resistance and adverse health effects associated with antibiotic exposure.
- Conditions
- Acute Respiratory Tract Infection, Otitis Media, Pharyngitis, Acute Sinusitis
- Trial name
- BIOS (NCT05127161)
- Testing
- Broad Implementation of Outpatient Stewardship (BIOS) intervention
- Where
- 5 sites in United States
- Volunteers
- 1,032 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Acute Respiratory Infections, Acute Rhinosinusitis
Treatment of Acute Sinusitis
This study will compare the symptom relief provided by 5 cold medicines versus the symptom relief provided by the same 5 cold medicines plus the antibiotic, amoxicillin, in people who have sinus infections.
- Trial name
- NCT00377403
- Testing
- Acetaminophen, Amoxicillin, Dextromethorphan hydrobromide with guaifenesin
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Washington University School of Medicine
Sinus Infection, Acute Sinusitis
Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis
Sinus infections (also called acute rhinosinusitis or ARS) affect about 15% of adults each year, and are one of the top reasons people receive antibiotics in outpatient settings.
- Trial name
- NOSES (NCT06076304)
- Testing
- amoxicillin/clavulanate potassium, Budesonide nasal spray
- Where
- 7 sites in United States
- Volunteers
- 3,720 people
- Sponsor
- Daniel Merenstein