Clinical trials: Acute Respiratory Infections (ARIs)
Acute Respiratory Infections (ARIs)
Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Main Study)
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior.
- Trial name
- BEARI (NCT01454947)
- Testing
- Clinical Decision Support (CDS): Accountable Justifications, Audit and Feedback: Peer Comparison, CDS Order Sets: Suggested Alternatives
- Where
- 55 sites in United States
- Volunteers
- 248 people
- Sponsor
- University of Southern California
Influenza A, Influenza B
Adaptive Platform Trial of Treatments for Respiratory Infections in Community Settings (TreatResp)
TreatResp is a double-blind, individually randomized, multi-centre adaptive platform trial. TreatResp aims to establish an adaptive platform trial aimed at evaluating the clinical- and cost-effectiveness, practical challenges…
- Conditions
- Influenza A, Influenza B, SAR-CoV-2, Acute Respiratory Infections (ARIs)
- Trial name
- TreatResp (NCT07314905)
- Testing
- Baloxavir
- Where
- Canada
- Volunteers
- 264 people
- Sponsor
- Unity Health Toronto
Acute Disease Respiratory
Use Of The ABSS In Infants With ARIS Treated With Outpatient Respiratory Physiotherapy
Background. Acute respiratory infections in childhood have high incidence and morbimortality rates, generating significant sanitary and social costs.
- Trial name
- NCT04036591
- Testing
- Acute Bronchiolitis Severity Scale (ABSS)
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- FisioRespiración
Acute Respiratory Infections (ARIs)
Use of Behavioral Economics to Improve Treatment of Acute Respiratory Infections (Pilot Study)
Bacteria resistant to antibiotic therapy are a major public health problem. The evolution of multi-drug resistant pathogens may be encouraged by provider prescribing behavior.
- Trial name
- BEARI (NCT01454960)
- Testing
- Clinical Decision Support: Accountable Justification, Audit and Feedback: Peer Comparison, CDS Order Sets: Suggested Alternatives
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Southern California
Healthy
Acute Respiratory Illness Surveillance (AcRIS) With Mobile Application in a Low-Interventional Decentralized Study.
The purpose of the AcRIS study is to obtain data to characterize the relationship between symptoms and voice features for (reverse transcription polymerase chain reaction (RT-PCR) confirmed severe acute respiratory syndrome…
- Trial name
- NCT04748445
- Testing
- SARS-CoV-2/Influenza/RSV RT-PCR
- Where
- United States
- Volunteers
- 9,151 people, healthy volunteers welcome
- Sponsor
- Pfizer
Acute Respiratory Infections (ARIs), Influenza
Effect of Surgical Masks in Preventing Acute Respiratory Infections
The goal of this clinical trial is to evaluate the efficacy of surgical masks in preventing acute respiratory tract infections. The main question it aims to answer is: Does wearing a mask prevent you from getting acute…
- Conditions
- Acute Respiratory Infections (ARIs), Influenza, COVID - 19
- Trial name
- NCT07739446
- Testing
- Surgical masks
- Where
- Japan
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Chiba University
Acute Respiratory Infections
C Reactive Protein (CRP) Intervention to Reduce Inappropriate Antibiotic Prescriptions in the Primary Healthcare Setting
Many studies have showed that rapid point-of-care (POC) c-reactive protein (CRP) test can reduce inappropriate use of antibiotic at primary health care level.
- Trial name
- CRP (NCT01918579)
- Testing
- Patients will be tested by rapid POC CRP test
- Where
- Vietnam
- Volunteers
- 2,037 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Acute Respiratory Infections (ARIs)
RSV in Acute Respiratory Infection Surveillance Among Community-Dwelling Elderly Aged ≥50 Years in China
This is a multicenter, prospective, observational, community-based study designed to evaluate the incidence of respiratory syncytial virus (RSV) infection among community-dwelling elderly individuals in China, as well as their…
- Trial name
- RAISE (NCT07075029)
- Testing
- NP swabs
- Where
- 13 sites in China
- Volunteers
- 28,800 people, healthy volunteers welcome
- Sponsor
- Huashan Hospital
Acute Respiratory Infections (ARIs)
Impact of a Multiplex Respiratory PCR Test on Outcomes for Patients Presenting With Respiratory Illness in the Urgent Care Setting: A Hybrid-Effectiveness Quasi-Experimental Trial
This research study will use a hybrid effectiveness-implementation type 1 design to assess effectiveness of the Spotfire R/ST assay in the urgent care setting.
- Trial name
- NCT07513519
- Testing
- SPOTFIRE R/ST Diagnostic Test
- Where
- 2 sites in United States
- Volunteers
- 800 people
- Sponsor
- BioMérieux
Smoking Cessation, Emergency Department Visit
Acute Respiratory Disease as a Fulcrum Point to Quit Smoking: Evaluation of an ED-based Intervention
This study aims to evaluate smoking cessation success rates using the Fagerström Test for Nicotine Dependence (FTND) in smoking cessation treatment.
- Conditions
- Smoking Cessation, Emergency Department Visit, Acute Respiratory Infections (ARIs)
- Trial name
- Intervention (NCT06923852)
- Testing
- Smoking cessation support that World Health Organization (WHO) 5A model (Ask, Advise, Assess, Assist, Arrange).
- Volunteers
- 288 people
- Sponsor
- Seda Oğuz
Acute Respiratory Infections (ARIs)
FebriDx® Pediatric Validation Study
The primary objective of this study is to determine performance characteristics of the FebriDx® test in differentiating bacterial from non-bacterial etiology among febrile pediatric patients (2-11 years) presenting to the…
- Trial name
- NCT07211997
- Testing
- FebriDx
- Where
- 10 sites in United States
- Volunteers
- 800 people
- Sponsor
- Lumos Diagnostics
Influenza, COVID-19
Routine Application of Point-of-care PCR Test to Identify and Direct Therapy for Acute Respiratory Infection in the Emergency Department Trial
The RAPID-ARIED Trial is a pragmatic, single-centre, parallel group, open-label, randomised controlled trial to be conducted in the Accident and Emergency Department of Queen Mary Hospital in Hong Kong.
- Conditions
- Influenza, COVID-19, Acute Respiratory Infections (ARIs)
- Trial name
- RAPID-ARIED (NCT06780566)
- Testing
- Point-of-care PCR testing for respiratory viruses, Laboratory PCR testing for respiratory viruses
- Where
- Hong Kong
- Volunteers
- 1,050 people
- Sponsor
- The University of Hong Kong
Acute Respiratory Infections (ARIs)
Epidemiological Characteristics and Clinical Burden of RSV Infection in Children Under 24 Months in Ho Chi Minh City (2026-2028)
This is a prospective, observational, multicenter study employing continuous, convenience sampling, stratified by study site and by fortnightly interval, enrolling until the target sample sizes are achieved over the first…
- Trial name
- RSV pediatric (NCT07640581)
- Where
- 3 sites in Vietnam
- Volunteers
- 2,000 people
- Sponsor
- Tam Anh Research Institute
Acute Respiratory Infections (ARIs)
Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments
Inappropriate antibiotic prescribing for acute respiratory infections (ARIs) persists despite decades of intervention efforts. Negative outcomes of inappropriate antibiotics include increased costs of care, adverse drug…
- Trial name
- NCT01767064
- Testing
- Posted commitment letter
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Acute Respiratory Infections (ARIs)
FebriDx® Method Comparison Study Protocol
The goal of this observational study is to learn about the performance and ease of use of FebriDx when operated by persons without laboratory experience or training in patients with acute respiratory symptoms.
- Trial name
- NCT06746259
- Testing
- Rapid point of care test to detect host immune response in ARI
- Where
- 8 sites in United States
- Volunteers
- 800 people
- Sponsor
- Lumos Diagnostics
Respiratory Tract Infections (RTI), Respiratory Syndrome, Acute, Severe
Clinical Multimodal Surveillance of Respiratory Syndrome Pathogens
This nationwide, multicenter observational study will establish and improve a hospital-based clinical surveillance and early warning system for respiratory syndrome pathogens.
- Conditions
- Respiratory Tract Infections (RTI), Respiratory Syndrome, Acute, Severe, Acute Respiratory Infections (ARIs)
- Trial name
- NCT07694648
- Testing
- Tiered pathogen testing and multi-omics analysis
- Where
- 31 sites in China
- Volunteers
- 2,398 people
- Sponsor
- Huashan Hospital
Antibacterial Agents, Ambulatory Care
Improving Antibiotic Use for ARIs in Urgent Care Clinics
Many clinicians prescribe antibiotics for patients with acute respiratory infections even when antibiotics will not benefit the patient because the infection is due to a virus.
- Trial name
- NCT06144242
- Testing
- Feedback on RTD metric
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Daniel Livorsi