Clinical trials: Acute Respiratory Failure (ARF)
Acute Respiratory Failure, Ventilator Weaning Assessment
Electrical Impedance Tomography-derived Flow Index During Spontaneous Breathing Trial Stratifies the Risk of Reintubation Within 48 h After Extubation
Accurate prediction of readiness to liberate patients from mechanical ventilation remains challenging. Conventional indices such as the rapid shallow breathing index (RSBI) and maximal inspiratory pressure (MIP) often miss early…
- Trial name
- EIT-FI Weaning (NCT06876792)
- Testing
- electrical impedance tomography
- Where
- 3 sites in China
- Volunteers
- 150 people
- Sponsor
- Ruijin Hospital
Acute Respiratory Failure With Hypoxia
pRotective vEntilation With Veno-venouS Lung assisT in Respiratory Failure
This is a trial of a new way of treating patients with respiratory failure. The investigators propose to deliver a multi-centre clinical trial to determine whether veno-venous extracorporeal carbon dioxide removal (VV-ECCO2R) and…
- Trial name
- REST (NCT02654327)
- Testing
- VV-ECCO2R to enable lower tidal volume mechanical ventilation
- Where
- United Kingdom
- Volunteers
- 1,120 people
- Sponsor
- Belfast Health and Social Care Trust
Hypoxemic Acute Respiratory Failure
Effects of Nasal Ventilation on Cerebral and Pulmonary Function in Orally Intubated Patients
The passage of air through the nasal cavity generates rhythmic oscillations transmitted by the olfactory bulb to the brain, which induces cerebral activation in functional areas and is associated with better cognitive performance…
- Trial name
- VENTINA (NCT06438302)
- Testing
- EEG activity measurement
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Failure, Immunocompromised Patients
Empirical Steroids and/or Antifungals in Immunocompromised Patients With Acute Respiratory Failure From Undetermined Etiology: a Multicenter Double-blind Randomized Controlled Trial
Acute respiratory failure (ARF) is the leading reason of ICU admission in immunocompromised patients. Failure to identify the ARF etiology is associated with increased mechanical ventilation and mortality rates.
- Trial name
- EFRAIM II (NCT04680884)
- Testing
- Experimental for steroid, Experimental for antifungals, Experimental for steroids and antifungals
- Volunteers
- 420 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Post-Traumatic Stress Disorder, Acute Respiratory Failure
Effect of Ketamine and Etomidate During RSI on Long Term Outcomes
The RSI-LTO study collects long-term outcomes from the RSI trial (NCT05277896). One-third of adults who are intubated in the ED or ICU experience symptoms of posttraumatic stress disorder (PTSD).
- Trial name
- RSI-LTO (NCT06179485)
- Testing
- Ketamine, Etomidate
- Where
- 6 sites in United States
- Volunteers
- 1,756 people
- Sponsor
- Vanderbilt University Medical Center
Respiratory Insufficiency, Diaphragm Injury
Diaphragm Injury and Dysfunction During Mechanical Ventilation
This study is designed to evaluate the relationship between diaphragm activity during mechanical ventilation and the development of ventilator-induced diaphragm dysfunction (VIDD).
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Mechanical Ventilation Complication
- Trial name
- MYOTRAUMA (NCT03108118)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto