Clinical trials: Acute Respiratory Failure (ARF)
Respiratory Failure
Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilator Assist (NAVA) During Acute Respiratory Failure (ARF)
Acute respiratory failure (ARF) is a life-threatening emergency which occurs due to impaired gas exchange. In the US, the number of hospitalisations owing to acute respiratory failure was 1,917,910 in the year 2009.(1) The…
- Trial name
- NCT03271671
- Testing
- NAVA during Non invasive ventilation, PSV during Non invasive ventilation
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Acute Respiratory Distress Syndrome, Noninvasive Ventilation
Helmet vs Face Mask in Patients With Acute Respiratory Distress Syndrome
The objective of this study is to evaluate the efficacy of noninvasive ventilation with helmet in reducing endotracheal intubation rates in comparison with Noninvasive Ventilation (NIV) facemask among patients with Acute…
- Conditions
- Acute Respiratory Distress Syndrome, Noninvasive Ventilation, Corona Virus Disease, Acute Respiratory Failure
- Trial name
- NCT04507802
- Testing
- Non invasive ventilation via helmet
- Where
- Qatar
- Volunteers
- 60 people
- Sponsor
- Hamad Medical Corporation
Acute Respiratory Distress Syndrome, ARDS
Implementation of Lung Protective Ventilation in Patients With Acute Respiratory Failure
This is a quality improvement study with the purpose of observing and measuring the effects of implementation of a proven standardized lung protective ventilation protocol in the new electronic medical record system iCentra…
- Conditions
- Acute Respiratory Distress Syndrome, ARDS, Respiratory Distress Syndrome, Acute, Respiratory Insufficiency
- Trial name
- IMPROVENT (NCT03225807)
- Where
- United States
- Volunteers
- 8,692 people
- Sponsor
- Intermountain Health Care, Inc.
ARDS (Acute Respiratory Distress Syndrome)
Pressure Release Ventilation Compared to Lung Protective Ventilation in Moderate and Severe ARDS
This study compares two different ways of providing mechanical ventilation to patients with moderate to severe acute respiratory distress syndrome (ARDS), a serious condition in which the lungs become inflamed and make it…
- Trial name
- NCT07803614
- Testing
- Arm 1 Intervention Name: Low-Tidal-Volume Ventilation (LTV)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Koot Ahmad
Chronic Respiratory Failure, Acute Respiratory Failure
Validation Study of the EMILY AI Device in Acute and Chronic Respiratory Failure
Currently, there is no holistic solution for patients with respiratory diseases that includes oxygenation and management of a patient with respiratory disease, combining dynamic and automatic O2 administration and the detection…
- Trial name
- NCT06952816
- Testing
- Emily.AI
- Where
- 2 sites in Spain
- Volunteers
- 20 people
- Sponsor
- Aether Tech S.L.
Acute Respiratory Failure, Diaphragmatic Function
Efficacy of High Velocity Nasal Insufflation
The purpose of this study is to assess the effect of HFNC on esophageal pressure and diaphragmatic function in patients with acute respiratory failure
- Conditions
- Acute Respiratory Failure, Diaphragmatic Function, Esophageal Pressure
- Trial name
- NCT03929055
- Testing
- Physiological assesment
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- University of Milan
Covid19
Epidemiologic, Clinical and Molecular Characteristics of Patients With Acute Respiratory Failure Affected by 2019-NCOV.
The main purpose of this study is to identify possible predictor factor of mortality in patients affected by COVID-19 with respiratory failure needing oxygen therapy or ventilatory support.
- Trial name
- NCT04552340
- Testing
- Patient with SAR-CoV-2 infection
- Where
- Italy
- Volunteers
- 1,500 people
- Sponsor
- Istituto Clinico Humanitas
Hydrostatic Pulmonary Edema, Acute Respiratory Failure
Acute DYSPnea in the Emergency Department: Diagnostic Value of Point-of-care UltraSound
Acute dyspnea is a common reason for emergency department (ED) admission and is frequently caused by acute heart failure with pulmonary edema.
- Conditions
- Hydrostatic Pulmonary Edema, Acute Respiratory Failure, Dyspnea
- Trial name
- DYSP-ED-US (NCT07324980)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Acute Respiratory Distress Syndrome, Acute Respiratory Failure
Explore Potential Plasma and BALF Immunometabolic and Lipidomic Biomarkers for Identifying ARDS Endotypes
Acute respiratory distress syndrome (ARDS) is a life-threatening condition that causes high mortality (41% to 58%). Previous studies have reported that biomarkers can facilitate phenotypic diagnosis of ARDS, enabling precision…
- Trial name
- NCT05451342
- Testing
- Integrated Transcriptomics, Metabolomics, and Lipidomics Profiling
- Where
- 2 sites in China
- Volunteers
- 200 people
- Sponsor
- Peking Union Medical College Hospital
COVID-19
ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19
A phase 2/3, randomized, double blind, placebo-controlled study to evaluate the efficacy and the safety of ABX464 in treating inflammation and preventing acute respiratory failure in patients aged ≥65 and patients aged ≥18 with…
- Trial name
- Mir-Age (NCT04393038)
- Testing
- ABX464
- Where
- 30 sites in Belgium, Brazil and 6 more
- Volunteers
- 509 people
- Sponsor
- Abivax S.A.
Acute Respiratory Failure, Post Intensive Care Syndrome
Observational Study of Expected ARF Recovery
This is an observational cohort study of the association between patient expectations for functional recovery and quality of life among acute respiratory failure survivors 6 months after hospital discharge.
- Trial name
- OSEAR (NCT03797313)
- Where
- 4 sites in United States
- Volunteers
- 180 people
- Sponsor
- Johns Hopkins University
Respiratory Failure
Negative Pressure Ventilation Imapcts Weaning Ventilator In Medical Intensive Care Units (ICUs)
This is a Quasi-experimental research design. The subjects are limited in intensive care unit within north medical center hospital. All subjects depend on ventilator and receive weaning plans.
- Trial name
- NCT01155596
- Testing
- negative pressure ventilator use
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Patients at Risk of Acute Respiratory Failure
Early Detection of Acute Respiratory Failure Using an Intelligent Respiratory Monitoring System
Introduction: The monitoring of respiratory patterns is crucial in the management of respiratory diseases, but in many cases, it still relies on subjective and visual assessment.
- Trial name
- NCT07164586
- Testing
- Respiratory Pattern Monitoring, Diaphragmatic Excursion, Respiratory muscle electrical activity
- Where
- 3 sites in Brazil
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Pernambuco
Weaning Failure, Acute Respiratory Failure
Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
The purpose of this study is to determine whether, as compared with the Venturi mask, a nasal, high-flow oxygenation device (Optiflow) may reduce the extubation failure rate in patients needing oxygen therapy after extubation.
- Trial name
- RINO (NCT02107183)
- Testing
- Optiflow (Fisher & Paykel Healthcare), Venturi mask
- Where
- 14 sites in France, Greece and 2 more
- Volunteers
- 500 people
- Sponsor
- Catholic University of the Sacred Heart
Respiratory Failure With Hypoxia, Respiratory Failure Without Hypercapnia
PRone positioN in Patients With spontanEous ventiLation and Acute Hypoxemic respIratory FailurE
The proposed randomized controlled trial aims at comparing the application of the prone position in spontaneously breathing patients with acute hypoxemic respiratory failure from any cause versus standard treatment on the rate of…
- Trial name
- PRONELIFE (NCT04142736)
- Testing
- Prone Position
- Where
- Spain
- Volunteers
- 650 people
- Sponsor
- Corporacion Parc Tauli
Respiratory Insufficiency, Depression
Behavioral Activation-Rehabilitation to Improve Depressive Symptoms & Physical Function After Acute Respiratory Failure
More and more people are surviving after receiving life support for respiratory failure in the intensive care unit, but these patients often experience problems with depression and physical functioning that lead to reduced…
- Conditions
- Respiratory Insufficiency, Depression, Rehabilitation, Critical Care
- Trial name
- BEHAB (NCT03431493)
- Testing
- Behavioral Activation - Rehabilitation
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Johns Hopkins University
Chronic Obstructive Pulmonary Disease, Acute Respiratory Failure
Protocol Chronic Obstructive Pulmonary Disease
The main objective of the study is to evaluate the predictive factors of the endothelial function to the waning of an acute exacerbation in COPD.
- Trial name
- NCT00404430
- Where
- France
- Volunteers
- 121 people
- Sponsor
- University Hospital, Grenoble
Hematologic Disease
Early Application of CPAP in Hematologic
The purpose of this study is to evaluate the use of CPAP in the prevention of acute respiratory failure in neutropenic ( or hematologic malignancy ) patients .CPAP applied preventively in hematological patients with high risk of…
- Trial name
- HEMOCPAP (NCT00507533)
- Testing
- Continuous positive airway pressure
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Turin, Italy
Acute Respiratory Failure
Hyperangulated Versus Standard Geometry Laryngoscope Blade Trial
The Hyperangulated versus Standard Geometry Laryngoscope Blade (ANGLE) Trial is a multi-center, non-blinded, parallel-group, randomized clinical trial evaluating the effect of use of a hyperangulated video laryngoscope blade…
- Trial name
- ANGLE (NCT07223762)
- Testing
- Hyperangulated video laryngoscope blade, Standard geometry video laryngoscope blade
- Where
- 19 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Vanderbilt University Medical Center
Acute Respiratory Failure
Noninvasive Positive Airway Pressure Ventilation and Risk of Facial Pressure Ulcers
To assess risk of skin pressure lesions in patients treated with noninvasive mechanical ventilation.
- Trial name
- NCT01828151
- Testing
- Noninvasive ventilation mask
- Where
- Italy
- Volunteers
- 170 people
- Sponsor
- Ospedale S. Giovanni Bosco