Clinical trials: Acute Pulmonary Embolism, open to volunteers
Acute Pulmonary Embolism (PE)
Assessment of Right Ventricular Function After Acute Pulmonary Embolism: a Comparison of Speckle Tracking Strain and Conventional Echocardiographic Parameters
Echocardiographic Assessment: Performed within 24h of PE diagnosis Conventional parameters: TAPSE, RV FAC, RV/LV ratio, tricuspid S', PASP STE parameters: RV free wall longitudinal strain (RVFWS), global longitudinal strain (GLS)…
- Trial name
- NCT07107347
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Myocardial Infarction, Decompensated Chronic Heart Failure
Pre-discharge Influenza Vaccination in Patients Hospitalized for Acute Cardiac Conditions
Patients hospitalized for acute cardiac conditions-including acute myocardial infarction, acute heart failure, pulmonary embolism, arrhythmias, and hypertensive emergencies-represent a heterogeneous population at very high risk…
- Conditions
- Myocardial Infarction, Decompensated Chronic Heart Failure, Acute Heart Failure (AHF), Pulmonary Embolism Acute
- Trial name
- NCT07617376
- Testing
- Influenza vaccination
- Where
- Poland
- Volunteers
- 400 people
- Sponsor
- Wroclaw Medical University
Pulmonary Embolism Acute Massive
Early Catheter-directed Treatment of High Risk Pulmonary Embolism
Prospective, multicenter, open label, randomized controlled clinical trial to compare the effects of an early catheter-directed treatment plus conventional care with conventional care in patients with high-risk pulmonary embolism
- Trial name
- CATCH-PE II (NCT06672081)
- Testing
- Early Catheter-Interventional Treatment, Conventional care
- Where
- 18 sites in Germany
- Volunteers
- 210 people
- Sponsor
- Leipzig Heart Science gGmbH
Acute Pulmonary Embolism
Clinical Scores, Biomarkers, and CT Findings in Acute Pulmonary Embolism
This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments.
- Trial name
- PEST (NCT07566858)
- Testing
- No Intervention (Observational Study Data Collection)
- Volunteers
- 50 people
- Sponsor
- Sohag University
Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis)
Intraoperative Paravertebral Block and Postoperative Complications
This study aims to evaluate the clinical association between intraoperative paravertebral block and the reduction of postoperative complications following thoracic surgery.
- Conditions
- Video-assisted Thoracoscopic Surgery (VATS), Lung Cancer (Diagnosis), Pulmonary Infections, Respiratory Failure Without Hypercapnia
- Trial name
- IPVB and POCs (NCT07211529)
- Testing
- Paravertebral Block (PVB)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Pulmonary Embolism
Ultrasound-assisted, Catheter-directed Thrombolysis for Acute Intermediate-high-risk Pulmonary Embolism
The purpose of this retrospective and prospective multicenter study is to evaluate the incidence of pulmonary hypertension (PH) within 6 months from ultrasound-assisted, Catheter-directed Thrombolysis for acute intermediate…
- Trial name
- USAT IH-PE (NCT06143969)
- Testing
- ultrasound-assisted, catheter-directed thrombolysis
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Niguarda Hospital
Pulmonary Embolism Acute
Hemodynamic and Respiratory Instability During Percutaneous Pulmonary Thrombectomy
Pulmonary embolism (PE) is a potentially life-threatening condition caused by the obstruction of pulmonary arteries by thrombi. Patients with high-risk or intermediate-high-risk PE may require immediate reperfusion therapies…
- Trial name
- INSTAB-PE (NCT07509541)
- Testing
- Percutaneous Pulmonary Thrombectomy (FlowTriever), Percutaneous Pulmonary Thrombectomy (Indigo)
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Pulmonary Embolism
Point-of-Care Ultrasound in Predicting Adverse Outcomes in Emergency Department Patients With Acute Pulmonary Embolism
This study is an observational, prospective study examining the role point-of-care echocardiography of predicting short term adverse outcomes in emergency department patients with acute pulmonary embolism.
- Trial name
- NCT05050617
- Testing
- Point-of-care echocardiography
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- WellSpan Health
Pulmonary Embolism
Evaluation of the Magneto eTrieve™ PE Kit for Endovascular Thrombectomy in Subjects With Acute Pulmonary Embolism
Prospective, multi-center, open-label, single-arm clinical study of the safety and effectiveness of the eTrieve™ in subjects presenting with signs and symptoms of acute intermediate-risk pulmonary embolism
- Trial name
- eTrieve II (NCT05821426)
- Testing
- eTrieve PE Kit
- Volunteers
- 130 people
- Sponsor
- Magneto Thrombectomy Solutions
Venous Thromboembolism (VTE), Exercise Therapy
Early Exercise-Based Rehabilitation in Patients Hospitalized for Acute Pulmonary Embolism
Up to half of patients with pulmonary embolism (PE) suffer from impaired quality of life, reduced physical capacity, and symptoms like shortness of breath even three months after diagnosis, despite standard treatment with…
- Conditions
- Venous Thromboembolism (VTE), Exercise Therapy, Quality of Life (QOL), Anxiety Depression
- Trial name
- RehabPE (NCT07143539)
- Testing
- Exercise-based rehabilitation program
- Where
- 6 sites in Switzerland
- Volunteers
- 160 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke, Acute, Venous Thromboembolism
GEKO Venous Thromboembolism Prevention Study
This multicentre, randomised geko™ venous thromboembolism (VTE) prevention study will prospectively collect clinical data on VTE occurrences in immobile patients after stroke, who will be randomised, on a 1:1 allocation, to…
- Conditions
- Stroke, Acute, Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism
- Trial name
- NCT05476913
- Testing
- geko™ device
- Where
- 18 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- Firstkind Ltd
Pulmonary Embolism, Venous Thromboembolism
Prognostic Value of 2026 AHA/ACC Clinical Categorization in Acute Pulmonary Embolism Patients Presenting to the Emergency Department
Background: The 2026 American Heart Association/American College of Cardiology (AHA/ACC) Pulmonary Embolism Guideline (Creager et al., Circulation 2026) introduced a novel five-category (A-E) clinical classification system with…
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Acute Pulmonary Embolism
- Trial name
- APEX-2026 (NCT07805616)
- Testing
- 2026 AHA/ACC Clinical Risk Categorization
- Where
- Turkey (Türkiye)
- Volunteers
- 600 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Pulmonary Embolism
Reduced-Dose Thrombolysis in Intermediate-Risk Pulmonary Embolism With High-Risk Features
Alteplase, a recombinant tissue plasminogen activator (rt-PA), is commonly used for thrombolytic treatment in patients with high-risk acute pulmonary thromboembolism (PTE), whereas the role of thrombolysis in intermediate-risk…
- Trial name
- REDUCTION (NCT07917078)
- Testing
- Alteplase, Standard Anticoagulation
- Where
- 26 sites in China
- Volunteers
- 270 people
- Sponsor
- China National Center for Cardiovascular Diseases
Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis)
Pulmonary Embolism in Patients With Acute Heart Failure (PEHF Study)
This study focuses on two serious and common medical conditions: heart failure and pulmonary embolism (a blood clot in the lungs).
- Conditions
- Acute Heart Failure (AHF), Pulmonary Embolism (Diagnosis), Venous Thromboembolism
- Trial name
- PEHF (NCT07499661)
- Testing
- Systematic screening for pulmonary embolism in all patients using a guideline-recommended diagnostic algorithm
- Where
- 10 sites in France
- Volunteers
- 740 people
- Sponsor
- University Hospital, Angers
Acute Pulmonary Embolism
A Real-World Study of EkoSonic Endovascular System in Chinese Populations With Acute Pulmonary Embolism
This study to collect the real-world clinical outcome data of EkoSonicTM Endovascular System in Chinese patients with acute pulmonary embolism during practical clinical care.
- Trial name
- ANTEATER (NCT06819865)
- Testing
- EkoSonicTM Endovascular System
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Boston Scientific Corporation
Pulmonary Embolism With Acute Cor Pulmonale
Polish Multicenter PERTs PE Outcomes Registry
Pulmonary embolism (PE) is the third leading cause of cardiovascular mortality. The Pulmonary Embolism Response Team (PERT) concept offers a rapid and multidisciplinary approach focused on improving outcomes for patients with PE.
- Trial name
- PolPERTs (NCT04879069)
- Where
- Poland
- Volunteers
- 10,000 people
- Sponsor
- Poznan University of Medical Sciences
Acute Deep Vein Thrombosis, Acute Pulmonary Embolism
Registry of Patients Prescribed Anticoagulation
The Gonda Vascular Center- Thrombophilia Clinic at Mayo Clinic in Rochester, Minnesota utilizes a standardized, guideline-directed, yet patient-oriented approach for treating patients diagnosed with venous thromboembolism…
- Trial name
- STAGPOR (NCT03504007)
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- Mayo Clinic
Pulmonary Embolism, Interstitial Lung Disease
Predictors of Pulmonary Embolism in Interstitial Lung Disease With Worsening Symptoms
People with interstitial lung disease (ILD) can sometimes experience a sudden and severe worsening of their breathing. While this can be caused by a flare-up of the lung disease itself, it can also be caused by a blood clot in…
- Conditions
- Pulmonary Embolism, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Connective Tissue Disease-associated Interstitial Lung Disease
- Trial name
- NCT07728448
- Volunteers
- 70 people
- Sponsor
- Assiut University
Acute Coronary Syndromes, Heart Failure
Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting
Suspected acute or subacute cardiovascular diseases-including chest pain, dyspnea, and palpitations-are among the most common reasons for unscheduled emergency department visits and pre-hospital referrals.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Embolism, Deep Vein Thrombosis, HTN-Hypertension
- Trial name
- CESAR (NCT07675434)
- Volunteers
- 25,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Disease Acute, Emergency Department Patient
Cardiac point-of Care Ultrasound Training Pathway for Emergency Department Advanced Practice Providers
The aim of this study is to assess emergency medicine physician and advanced practice provider (APP) knowledge and technical skill in performance of a point-of-care ultrasound simulation and just-in-time training pathway to…
- Conditions
- Cardiovascular Disease Acute, Emergency Department Patient, Heart Failure Acute, Pulmonary Embolism (Diagnosis)
- Trial name
- NCT07159269
- Testing
- Cardiac point-of-care ultrasound (POCUS) training and clinical pathway
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Duke University