Acute Pulmonary EmbolismPESTNCT07566858
Clinical Scores, Biomarkers, and CT Findings in Acute Pulmonary Embolism
An observational study of Acute Pulmonary Embolism, run by Sohag University.
Trial summary
This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments. The study will include patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Pulmonary Embolism
- How many people
- 50 participants
- Where
- No sites listed yet
- Study dates
- 1 May 2026to 1 Jul 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients with confirmed acute pulmonary embolism admitted to Sohag University Hospital from different departments including Emergency, ICU, Medical, and Surgical wards.
Who may be able to join
- • Adults aged ≥ 18 years
- Confirmed acute pulmonary embolism by CTPA
Who cannot join
- • Chronic pulmonary embolism
- Non-diagnostic CTPA
- Refusal to participate
- Severe renal impairment precluding contrast-enhanced CT
- Known hypersensitivity to contrast media
About this study
Official title: Comparing Clinical Scores, Biomarkers, and CT Findings in Patients With Acute Pulmonary Embolism Across Different Hospital Departments
This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments.
The study will include patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Clinical data, laboratory results, and imaging findings will be collected and analyzed to evaluate their diagnostic and prognostic value.
Read more
The goal of this research is to identify the most reliable and practical tools for early diagnosis and risk stratification of acute pulmonary embolism, which may help improve patient management and outcomes.
This is an observational study and does not involve any intervention or change in standard patient care.
Read the detailed description
This study is an observational analytical study designed to evaluate and compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients presenting with acute pulmonary embolism (PE) across different hospital departments at Sohag University Hospital.
Acute pulmonary embolism is a potentially life-threatening condition that requires prompt diagnosis and risk stratification. Various clinical scores (such as Wells score and Geneva score), along with laboratory biomarkers (such as D-dimer and others), and imaging modalities (especially CT pulmonary angiography), are commonly used in the diagnostic and assessment process.
The study aims to assess the diagnostic accuracy and clinical usefulness of these parameters, individually and in combination, in patients with confirmed acute pulmonary embolism.
Data will be collected retrospectively and/or prospectively from patient records and clinical assessments. Variables will include demographic data, clinical presentation, risk factors, laboratory investigations, clinical scoring systems, and radiological findings.
The study will compare these parameters across different hospital departments to determine variations in presentation and diagnostic approaches, as well as to evaluate the best predictive indicators for disease severity and outcomes.
The findings of this study may contribute to improving clinical decision-making, optimizing diagnostic strategies, and enhancing early identification of high-risk patients with acute pulmonary embolism.
This is a non-interventional observational study, and no experimental treatment or intervention will be applied. All data will be handled with confidentiality and in accordance with ethical standards and institutional review board (IRB) approval.
- Conditions
- Acute Pulmonary Embolism
- Being tested
- No Intervention (Observational Study Data Collection)
- Keywords
- Acute Pulmonary Embolism, Pulmonary Embolism, CT Pulmonary Angiography, Clinical Scores, D-dimer
- Medical subject headings
- Pulmonary Embolism
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No Intervention (Observational Study Data Collection)Other
This is an observational study with no active intervention. All data are collected from routine clinical care, including clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings in patients with acute pulmonary embolism.
| Study group | Role | What they receive |
|---|---|---|
| Acute Pulmonary Embolism Group | This cohort includes patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Participants will be evaluated using clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings. No interventions will be applied, and all data will be collected as part of routine clinical care for observational analysis. Receives: Other: No Intervention (Observational Study Data Collection) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of Participants with In-Hospital All-Cause Mortality
All-cause mortality among adult patients with confirmed acute pulmonary embolism, defined as death from any cause occurring during hospitalization. The outcome will be assessed as the number of participants who die before hospital discharge.
Measured: Up to 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 May 2026
- Study start1 May 2026 (estimated)
- Primary completion1 May 2027 (estimated)
- Study completion1 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Pulmonary EmbolismStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Esraa Elbadry Elrabie, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07566858
- Sponsor's protocol ID
- PE-Score-CT-2025
- Acronym
- PEST
- Status last verified
- Apr 2026
- First submitted
- 4 Apr 2026
- Last updated
- 5 May 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 May 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparing Clinical Scores, Biomarkers, and CT Findings in Patients With Acute Pulmonary Embolism Across Different Hospital Departments
- ClinicalTrials.gov ID
- NCT07566858
- Acronym / sponsor ID
- PEST / PE-Score-CT-2025
- Conditions
- Acute Pulmonary Embolism
- Keywords
- Acute Pulmonary Embolism, Pulmonary Embolism, CT Pulmonary Angiography, Clinical Scores, D-dimer
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 1 May 2026 (estimated)
- Primary completion
- 1 May 2027 (estimated)
- Study completion
- 1 Jul 2027 (estimated)
- First posted
- 5 May 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients diagnosed with acute pulmonary embolism in different hospital departments.
The study will include patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Clinical data, laboratory results, and imaging findings will be collected and analyzed to evaluate their diagnostic and prognostic value.
The goal of this research is to identify the most reliable and practical tools for early diagnosis and risk stratification of acute pulmonary embolism, which may help improve patient management and outcomes.
This is an observational study and does not involve any intervention or change in standard patient care.
Detailed description
This study is an observational analytical study designed to evaluate and compare clinical scoring systems, laboratory biomarkers, and computed tomography (CT) findings in patients presenting with acute pulmonary embolism (PE) across different hospital departments at Sohag University Hospital.
Acute pulmonary embolism is a potentially life-threatening condition that requires prompt diagnosis and risk stratification. Various clinical scores (such as Wells score and Geneva score), along with laboratory biomarkers (such as D-dimer and others), and imaging modalities (especially CT pulmonary angiography), are commonly used in the diagnostic and assessment process.
The study aims to assess the diagnostic accuracy and clinical usefulness of these parameters, individually and in combination, in patients with confirmed acute pulmonary embolism.
Data will be collected retrospectively and/or prospectively from patient records and clinical assessments. Variables will include demographic data, clinical presentation, risk factors, laboratory investigations, clinical scoring systems, and radiological findings.
The study will compare these parameters across different hospital departments to determine variations in presentation and diagnostic approaches, as well as to evaluate the best predictive indicators for disease severity and outcomes.
The findings of this study may contribute to improving clinical decision-making, optimizing diagnostic strategies, and enhancing early identification of high-risk patients with acute pulmonary embolism.
This is a non-interventional observational study, and no experimental treatment or intervention will be applied. All data will be handled with confidentiality and in accordance with ethical standards and institutional review board (IRB) approval.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Acute Pulmonary Embolism Group | – | Other: No Intervention (Observational Study Data Collection)This cohort includes patients diagnosed with acute pulmonary embolism at Sohag University Hospital. Participants will be evaluated using clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings. No interventions will be applied, and all data will be collected as part of routine clinical care for observational analysis. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients with confirmed acute pulmonary embolism admitted to Sohag University Hospital from different departments including Emergency, ICU, Medical, and Surgical wards.
Key inclusion criteria (2 listed)
- • Adults aged ≥ 18 years
Key exclusion criteria (5 listed)
- • Chronic pulmonary embolism
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No Intervention (Observational Study Data Collection)This is an observational study with no active intervention. All data are collected from routine clinical care, including clinical scoring systems, laboratory biomarkers, and computed tomography pulmonary angiography (CTPA) findings in patients with acute pulmonary embolism. | Other | Acute Pulmonary Embolism Group |
Primary outcome
Number of Participants with In-Hospital All-Cause Mortality
Time frame: Up to 30 days
All-cause mortality among adult patients with confirmed acute pulmonary embolism, defined as death from any cause occurring during hospitalization. The outcome will be assessed as the number of participants who die before hospital discharge.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 May 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Pulmonary Embolism, run by Sohag University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 5 May 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of Participants with In-Hospital All-Cause Mortality (time frame: Up to 30 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 May 2026.