Clinical trials: Acute Post Operative Pain
Pain, Acute, Pain, Chronic
Butyrate and Taurine for Chronic Postsurgical Pain in Adult Cardiac Surgical Patients
This study is a single-center, phase II, randomized, placebo-controlled, Bayesian-designed, double-blinded trial Goal and Questions: The primary goal is to evaluate if a combination of taurine and butyrate can reduce chronic…
- Conditions
- Pain, Acute, Pain, Chronic, Chronic Post Operative Pain
- Trial name
- NCT07144033
- Testing
- Butyrate and Taurine
- Where
- Hong Kong
- Volunteers
- 216 people
- Sponsor
- Chinese University of Hong Kong
Pain, Acute Post-Operative, Anxiety
Effects of Reflexology and Cold Application Before Chest Tube Removal in CABG Patients
This randomized controlled trial evaluated the effects of foot reflexology and cold application, administered separately before chest tube removal, on pain, state anxiety, and physiological parameters in patients following…
- Conditions
- Pain, Acute Post-Operative, Anxiety, Chest Tube Removal, Coronary Artery Bypass
- Trial name
- NCT07528482
- Testing
- Reflexology, Cryotherapy alone
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Ankara University
Apical Periodontitis, Post Operative Pain, Acute
Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation
When a tooth's nerve dies, inflammation can develop at the tip of the tooth's root. Root canal treatment is carried out to allow this inflammation to heal.
- Trial name
- NCT07883486
- Testing
- sonically activated irrigation, laser activated irrigation, conventional needle irrigation
- Where
- 2 sites in Belgium
- Volunteers
- 183 people
- Sponsor
- University Ghent
Acute Post Operative Pain, Laparotomy
PIB for Post-operative Analgesia After Laparotomy : Determining the Optimum Dose
Pain control after surgery is a crucial component of postoperative recovery. Thus, in open abdominal surgery, the use of TEA (Thoracic epidural analgesia) has become a gold standard.
- Conditions
- Acute Post Operative Pain, Laparotomy, Epidural Analgesia
- Trial name
- PIBDOSE (NCT05534945)
- Testing
- Programmed intermittent epidural bolus 5 ml, Programmed intermittent epidural bolus 6 ml, Programmed intermittent epidural bolus 7 ml
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Post Operative Pain, Anesthesia
Dexmedetomidine and Dexamethasone Added as Adjuvant Infraclavicular Brachial Plexus Block in Upper Limb Surgery
The aim of this study was to investigate the effect of dexmedetomidine and dexamethasone added during USG-guided infraclavicular block on block onset time, total block time and time to first analgesic need in patients undergoing…
- Conditions
- Post Operative Pain, Anesthesia, Acute Pain
- Trial name
- NCT06779604
- Testing
- Infraclavicular Block with Dexmedetomidine and Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Umraniye Education and Research Hospital
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Post Operative Pain, Acute, Periodontitis
The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration
Possible participants will be scheduled to have 2 gum flap surgeries done on 2 similar surgical sites in the mouth. The study looks at two different ways of giving dexamethasone, a medication used to reduce inflammation.
- Trial name
- NCT07832110
- Testing
- Dexamethasone IV injection, Dexamethasone Capsule
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Laparoscopic Surgery, Post Operative Pain, Acute
Maneuvers to Reduce Laparoscopic Pain
Laparoscopic surgery has revolutionized surgical care by reducing morbidity and improving post operative recovery. Laparoscopic surgery involves the use of carbon dioxide for insufflation to achieve optimal visualization.
- Conditions
- Laparoscopic Surgery, Post Operative Pain, Acute, Pneumoperitoneum
- Trial name
- NCT07583433
- Testing
- Smoke Evacuation Group, Recruitment Breath Group, Control Group
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Knee Arthroplasty, Total, Post Operative Pain, Acute
Suzetrigine vs. Standard Care Pain Relief Following Outpatient Knee Replacement Surgery
The purpose of this research is to see if a person having an outpatient total knee replacement will have a difference in their pain and the amount of pain medication (opioids) used after discharge if they are given suzetrigine (a…
- Conditions
- Knee Arthroplasty, Total, Post Operative Pain, Acute, Opioid Consumption, Postoperative
- Trial name
- NCT07796152
- Testing
- Suzetrigine, Opioid standard care pain medicine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Endeavor Health
Modified Radical Mastectomy, Post Operative Pain, Acute
Comparıson of Analgesıc Effıcacy of Dıfferent Volumes of Serratus Posterior Superıor Intercostal Plane Block After Modıfıed Radıcal Mastectomy Surgery
The aim of researchers is to compare the effects of three different local anesthetic concentrations and volumes on opioid consumption, postoperative analgesic efficacy, and pain scores during ultrasound-guided SPSIP blocks in…
- Conditions
- Modified Radical Mastectomy, Post Operative Pain, Acute, Facial Plane Blocks
- Trial name
- NCT07670078
- Testing
- Serratus Posterior Superior Intercostal Plane (SPSIP) block 40 ml of 0.1875% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 50 ml of 0.15% bupivacaine, Serratus Posterior Superior Intercostal Plane (SPSIP) 30 ml of 0.25% bupivacaine
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Cumhuriyet University
Abdominal Laparoscopic and/or Robotic Surgery, Local Anasthesia
Intraperitoneal Lidocaine and Bupivacaine for Postoperative Pain After Laparoscopic Surgery
The goal of this clinical trial is to determine the safety and efficacy of combined intraperitoneal local anesthetic instillation and port-site infiltration using lidocaine and bupivacaine in adults aged 18 to 60 undergoing…
- Conditions
- Abdominal Laparoscopic and/or Robotic Surgery, Local Anasthesia, Post Operative Pain, Acute, Lidocaine
- Trial name
- IPLA (NCT07775599)
- Testing
- Lidocaine, Bupivacaine
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Misr University for Science and Technology
Post Operative Pain, Acute
Postoperative Pain After Dexamethasone Injection by Two Techniques in Irreversible Pulpitis
The aim of this randomized clinical trial to evaluate the effect of dexamethasone in two different techniques on postoperative pain by dividing patients randomly into three groups: Group I: buccinator injection of dexamethasone.
- Trial name
- Dex/postop (NCT07755306)
- Testing
- dexamethasone 8mg
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Laparoscopic Inguinal Hernia Repair, Acute Post Operative Pain
Transversalis Fascia Plane Block for Laparoscopic Inguinal Hernia Repair
Transversalis Fascia Plane Block (TFPB) is a trunk block that blocks the T12- L2 spinal nerves by injection of local anesthetic between the transversus abdominis muscle and transversalis fascia on the lateral abdominal wall.
- Trial name
- TFPB (NCT06778629)
- Testing
- Transversalis Fascia Plane Block, Post Operative Pain Management, Port Site Infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Medipol University Hospital
Analgesia, Pain Management
Ultrasound-Guided Recto-Intercostal Fascial Plane Block in Laparoscopic Cholecystectomy
The aim of the study is to reduce postoperative pain by performing rectointercostal block in L/S cholecystectomy surgeries. Main goal is to provide well managed post-operative analgesia.
- Conditions
- Analgesia, Pain Management, Pain, Acute Post-Operative
- Trial name
- NCT07745972
- Testing
- Rectointercostal facial plane block using bupivacaine 0.25%
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istinye University
Acute Pain, Post Operative Analgesia
Analgesic Efficacy of Combined PECS II and PIP Block Versus Thoracic Paravertebral Block Post-Mastectomy
Postoperative pain management is crucial for patients undergoing mastectomy for breast cancer. Regional analgesia techniques, such as the Thoracic Paravertebral Block (TPVB), are commonly used to reduce pain and opioid…
- Conditions
- Acute Pain, Post Operative Analgesia, Post Operative Pain, Acute, Breast Cancer
- Trial name
- PECS-TPVB (NCT07738770)
- Testing
- Combined PECS II and Superficial PIP Block, Thoracic paravertebral block (TPVB)
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Dharmais National Cancer Center Hospital
Acute Post Operative Pain
Acute Postoperative Pain in Outpatient UKA
This study determined or observe the acute postoperative between outpatient UKA and inpatient UKA. We observe the acute post op. at at 0,1, and 2. The acute post op pain compeared between two groups.
- Trial name
- Outpatient UKA (NCT07686523)
- Where
- 2 sites in Thailand
- Volunteers
- 244 people
- Sponsor
- Thammasat University
Cardiac Surgery, Post Operative Pain, Acute
Serratus Posterior Superior Plane Block for Postoperative Pain in Cardiac Surgery
The aim of this study is to investigate the efficacy of bilateral serratus posterior superior intercostal plane (SPSIP) block on postoperative acute pain and opioid consumption in patients undergoing on-pump open-heart surgery.
- Trial name
- NCT07164677
- Testing
- Bilateral ultrasound guided Serratus Posterior Superior Plane Block, IV morphine patient-controlled analgesia
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Ondokuz Mayıs University
Post Operative Pain, Acute
A Study of Combogesic® 325 in Adolescent Patients With Moderate to Severe Postoperative Pain Associated With Orthopedic Surgery
Combogesic® 325 contains a combination of ibuprofen and acetaminophen. The purpose of this study is to compare the pain relief effects of Combogesic® 325mg and acetaminophen and to evaluate the safety of Combogesic® 325mg in…
- Trial name
- NCT07225140
- Testing
- Combogesic® tablets, Acetaminophen 500mg
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- AFT Pharmaceuticals, Ltd.
Post Operative Pain, Acute, Laparoscopic Appendectomy
Intraoperative Intravenous Lidocaine for Pain After Laparoscopic Appendectomy
This randomized, double-blind, placebo-controlled clinical trial evaluated whether intraoperative intravenous lidocaine infusion improves postoperative analgesia and recovery in patients undergoing laparoscopic appendectomy.
- Trial name
- LIDO-APP (NCT07678385)
- Testing
- Lidocaine (drug)
- Where
- Venezuela
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario de Caracas
Post Operative Analgesia, Rebound Pain
Prevention of Rebound Pain After Orthopaedic Surgery With Peripheral Nerve Block (REBOUND)_part B
Rebound pain after peripheral nerve blocks reduces the benefits of regional anesthesia and increases opioid consumption. This rebound pain most likely results from suboptimal pain management, as patients receiving a peripheral…
- Conditions
- Post Operative Analgesia, Rebound Pain, Post Operative Pain, Acute
- Trial name
- REBOUND (NCT07666009)
- Testing
- Morphine provided via oral PCA, Morphine provided via oral PCA + morphine administered at a scheduled regimen
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois