Clinical trials: Acute Kidney Injury (AKI)
Acute Kidney Injury
Neutrophil Gelatinase Associated Liocalin in Predicting AKI in Coronary Artery Disease
The aim of this work is to assess the clinical significance of serum levels of neutrophil gelatinase-associated lipocalin (NGAL) to predict AKI in patients exposed to PCI.
- Trial name
- NCT03266367
- Testing
- Neutrophil gelatinase-associated lipocalin (NAGL)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury
Renal Replacement Therapy Plus Extracorporeal Carbon Dioxide Removal
This study aims to assess whether in patients with acute kidney injury (AKI) requiring mechanical ventilation, a strategy that combines renal replacement therapy (RRT) and extracorporeal carbon dioxide removal (ECCO2R) allows…
- Trial name
- NCT02595619
- Testing
- RRT plus ECCO2R
- Where
- Italy
- Volunteers
- 14 people
- Sponsor
- University of Turin, Italy
Acute Kidney Injury, VExUS
VExUS Score and AKI in Critically Ill Adult patients-a Prospective Observational Study.
Introduction Renal perfusion is dependent on the renal perfusion pressure across the renal capillaries. Venous congestion due to excess fluid therapy can drastically reduce the renal perfusion pressure in spite of a normal mean…
- Trial name
- NCT06889116
- Where
- Nepal
- Volunteers
- 52 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Ischemia Reperfusion Injury, Cardiac Surgery Associated - Acute Kidney Injury
A Study to Evaluate the Efficacy and Safety of BX-001N in Preventing Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI) and Major Adverse Kidney Events (MAKE)
This is a Randomized, Single-blind, Multi-center, Placebo-controlled, Phase 2a clinical trial of BX-001N to prevent patients from Cardiac Surgery Associated Acute Kidney Injury (CSA-AKI) and subsequent Major Adverse Kidney Events…
- Trial name
- NCT07164833
- Testing
- BX-001N Experimental group 1, BX-001N Experimental group 2
- Where
- 8 sites in South Korea
- Volunteers
- 50 people
- Sponsor
- Bilix Co.,Ltd.
Cardiac Surgery Associated - Acute Kidney Injury, Critical Illness
Prognostic Value of Metabolic Characteristics in High-Risk Populations for Acute Kidney Injury After Cardiac Surgery
This project aims to explore the metabolic characteristics of adverse renal outcomes in high-risk populations after cardiac surgery by using multi-omics techniques, in order to understand the metabolic changes in patients during…
- Trial name
- NCT07521787
- Testing
- Standard care "bundle"
- Where
- China
- Volunteers
- 540 people
- Sponsor
- Shanghai Zhongshan Hospital
Acute Kidney Injury
Electronic Warning Systems in Diagnosis and Treatment of AKI
To set up electronic early warning system of AKI patients; To develop AKI's intervention, the follow-up process, and the renal physician is responsible for the implementation.
- Trial name
- NCT03119480
- Testing
- electronic alerts
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Acute Kidney Injury, Delirium
AKI and Delirium Risk Prediction and Cost Burden Study
The goal of this study is to learn how to better predict two common health problems that can happen during a hospital stay: acute kidney injury (AKI) and delirium. AKI is a sudden decline in kidney function.
- Trial name
- HAAKID (NCT07866560)
- Testing
- It is observational trial with no intervention being evaluated
- Where
- United States
- Volunteers
- 25,000 people
- Sponsor
- University of Nebraska
Acute Kidney Injury, Coronary Artery Disease
A Zero Acute Kidney Injury Strategy for Percutaneous Coronary Intervention in Patients With ChronicKidney Disease
The purpose of this study is to compare the outcomes of Percutaneous Coronary Intervention (PCI) in patients with chronic kidney disease (CKD) using smaller doses of contrast dye that are validated as being at low risk of causing…
- Conditions
- Acute Kidney Injury, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- Zero-AKI (NCT04928092)
- Testing
- Standard of care Ultra Low Contrast PCI
- Where
- United States
- Sponsor
- Virginia Commonwealth University
Acute Kidney Injury, Hypotension
A Pilot Analysis of the Association Between Anesthesia Induction Dosing and AKI in the Elderly Population
This study proposes to perform a pilot observational study looking at the doses of propofol used for the induction of general anesthesia and its association with the development of hypotension and AKI among elderly patients at…
- Conditions
- Acute Kidney Injury, Hypotension, Anesthesia; Adverse Effect
- Trial name
- NCT03699696
- Testing
- Propofol
- Where
- United States
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Yale University
Acute Kidney Injury, Covid19
Renal Involvement in Hospitalized Children With COVID-19
Covid-19 is an important human and animal pathogen, it mostly causes respiratory and gastrointestinal symptoms. Clinical features range from a common cold to severe diseases such as severe acute respiratory distress syndrome…
- Conditions
- Acute Kidney Injury, Covid19, Renal Dysfunction, Coronavirus Infection
- Trial name
- RIHCC (NCT04788394)
- Testing
- data review, data comparing
- Where
- Qatar
- Volunteers
- 400 people
- Sponsor
- Hamad Medical Corporation
Acute Kidney Injury
Effect of CVVH on NGAL in Septic AKI
The plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in critically ill patients with AKI is not affected by continuous venovenous hemofiltration (CVVH).
- Trial name
- NCT02536027
- Testing
- continuous venovenous hemofiltration
- Volunteers
- 30 people
- Sponsor
- First People's Hospital of Chenzhou
Acute Kidney Injury (Nontraumatic)
Comparison Between Right and Left Ventricular Systolic Dysfunction as a Risk Factors for Aki in Critical Care Patients
The cardio renal syndrome generally focuses on left ventricular function, and the importance of the right ventricle as a determinant of renal function is described less frequently.
- Trial name
- NCT03369561
- Testing
- Serum urea and creatinine and the calculated e GFR
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Kidney Injury, Congenital Heart Disease
Acute Kidney Injury After Cardiac Surgery on CPB
The purpose of this retrospective study is to determine the incidence and severity of acute kidney injuries (AKI) after heart surgery on cardiopulmonary bypass (CPB) in the pediatric intensive care unit (PICU) in Lausanne…
- Conditions
- Acute Kidney Injury, Congenital Heart Disease, Surgery, CBP
- Trial name
- NCT03513718
- Where
- Switzerland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Contrast-Induced Acute Kidney Injury in ST-Segment Elevation Myocardial Infarction, Contrast Induced AKI
The Effect of Hydration on the Prevention of CI-AKI in STEMI Patients Undergoing Primary PCI (Hydro-AKI Trial)
The goal of this clinical trial is to determine whether a structured oral hydration regimen reduces the incidence of contrast-induced acute kidney injury (CI-AKI) in patients with ST-segment elevation myocardial infarction…
- Trial name
- Hydro-AKI (NCT07761754)
- Testing
- oral hydration protocol
- Volunteers
- 384 people
- Sponsor
- Assiut University
Contrast-induced Nephropathy, Contrast-induced Acute Kidney Injury
Effect of Allopurinol or Febuxostat to Prevent Contrast Induced Acute Kidney Injury (CI-AKI)
A randomized, placebo-controlled, double-blind clinical trial of effect of allopurinol or febuxostat to prevent contrast induced acute kidney injury (CI-AKI)
- Trial name
- CI-AKI (NCT03767322)
- Testing
- Allopurinol, Febuxostat
- Where
- Mexico
- Volunteers
- 558 people
- Sponsor
- Instituto Nacional de Cardiologia Ignacio Chavez
Intraoperative, Venous Congestion
Venous Congestion and Cardiac Surgery-Associated Acute Kidney Injury
Venous pressure is often overlooked as an important hemodynamic parameter. Elevated venous pressure and blood stasis in organ tissues can lead to interstitial edema.
- Conditions
- Intraoperative, Venous Congestion, Cardiac Surgery-associated Acute Kidney Injury
- Trial name
- NCT07232277
- Testing
- collection of demographic characteristics and comorbidities, surgery-related parameters and kidney function assessments, collection of biological (laboratory) parameters
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Zhuan Zhang
Sepsis, Acute Kidney Injury
NGAL and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-associated AKI
AKI develops frequently in patients hospitalized in the intensive care unit, and the biggest risk factor is sepsis. Creatine, which is traditionally used in the diagnosis of AKI, is affected by many factors, causes the diagnosis…
- Trial name
- NGAL (NCT05374759)
- Testing
- neutrophil gelatinase-associated lipocalin, renal resistive index
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Inonu University
Acute Kidney Injury
Prospective Validation of AKI Prediction
The purpose of this prospective observational study is to implement, deploy, and quantify accuracy of an existing Pediatric Early AKI Risk Score algorithm.
- Trial name
- NCT06804200
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Adam C Dziorny
Acute Kidney Injury
European Registry of Dialysis Treatment of Pediatric Acute Kidney Injury (AKI)
Acute kidney injury (AKI) is a frequent clinical condition in hospitalized, in particular, in critically ill children. Moreover, AKI is an independent predictor of mortality.
- Trial name
- EurAKID (NCT02960867)
- Where
- Italy
- Volunteers
- 1,892 people
- Sponsor
- Mariella Enoc
Acute Kidney Injury, Hepatorenal Syndrome
Study of Accuracy of NGAL, a Renal Injury Biomarker, in Patients With Cirrhosis
The purpose of this study is to test the accuracy of urinary neutrophil-gelatinase associated lipocalin (NGAL) and other biomarkers (plasma renin, norepinephrine) to predict acute kidney injury (AKI) development in patients with…
- Trial name
- NCT02049125
- Where
- 4 sites in Brazil
- Volunteers
- 300 people
- Sponsor
- University of Sao Paulo