Clinical trials: Acute Ischemic Stroke
Stroke, Stroke Acute
Research on the Effectiveness of Neurorehabilitation After Stroke
This clinical trial aims to investigate the effectiveness of a novel neurorehabilitation technology for treating stroke in adults.
- Conditions
- Stroke, Stroke Acute, Stroke with Hemiparesis, Stroke, Acute
- Trial name
- NCT06753006
- Testing
- Neurorehabilitation simulator, Standard course
- Where
- Russia
- Volunteers
- 44 people
- Sponsor
- Neurotechnika
Stroke
Augmenting Cerebral Blood Flow in Acute Ischemic Stroke
The most common type of stroke is ischemic (lack of blood flow to the brain due to a clot blocking a blood vessel). Time is brain and an average of 1.9 million brain nerve cells per minute are destroyed in patients experiencing a…
- Trial name
- NCT06911385
- Testing
- Arm Remote Ischemic Conditioning plus Pneumatic Compression lower limb
- Volunteers
- 150 people
- Sponsor
- University of Alberta
Transcranial Magnetic Stimulation
Effects of Repetitive Transcranial Magnetic Stimulation on Cerebral Autoregulation in Patients With Acute Ischemic Stroke
The purpose of this study was to investigate the effect of repetitive transcranial magnetic stimulation on cerebral autoregulation in patients with acute ischemic stroke.
- Trial name
- NCT05843240
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Yi Yang
Stroke
Extremely Low Frequency Magnetic Fields in Acute Ischemic Stroke
There is great interest in the development of novel therapies for acute ischemic stroke because, to date, the thrombolysis is the only approved treatment.
- Trial name
- NCT01941147
- Testing
- pulsed ELF-MF
- Where
- Italy
- Volunteers
- 9 people
- Sponsor
- Campus Bio-Medico University
Acute Stroke, Hyperglycemia
SELESTIAL: Trial of Insulin to Control Blood Sugar After Acute Stroke Using Magnetic Resonance Imaging (MRI) End-Points
High blood sugar (hyperglycaemia) affects 40% of acute stroke patients and has a major adverse effect on survival and recovery. Increased production of lactic acid in brain tissue that has a poor blood supply is postulated to be…
- Trial name
- NCT00124826
- Testing
- Insulin
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Glasgow
Acute Ischemic Stroke
Intravenous Recombinant Human Prourokinase for Acute Medium Vessel Occlusion 4.5-24 Hours After Ischemic Stroke
The HOPE-MeVO study aims to evaluate the efficacy and safety of intravenous recombinant human prourokinase (rhPro-UK) in patients with acute ischemic stroke due to medium vessel occlusion presenting 4.5 to 24 hours after stroke…
- Trial name
- HOPE-MeVO (NCT07776873)
- Testing
- Recombinant Human Prourokinase for Injection (rhPro-UK), Standard medical treatment (SMT)
- Where
- China
- Volunteers
- 616 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Acute Ischemic Stroke AIS
Palmitoylethanolamide and Luteolin in Patients with Acute Ischemic Stroke
Acute ischemic stroke is caused by reduced blood supply to the brain associated with neuroinflammation. This mechanism contributes to acute neuronal death and persists even after reopening of the closed vessel, with consequent…
- Trial name
- NCT06777680
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (770 mg), Thrombectomy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Ospedali Riuniti Trieste
Stroke
Alteplase in Elderly Acute Ischemic Stroke (AIS) Patients During Hospitalization
The objective of the study is to find out the in-hospital clinical outcomes among Chinese Acute Ischaemic Stroke (AIS) patients, who were treated with intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) within 4.5…
- Trial name
- NCT05395351
- Testing
- rt-PA
- Where
- China
- Volunteers
- 113,035 people
- Sponsor
- Boehringer Ingelheim
Large Vessel Occlusion, Acute Ischemic Stroke
Intracranial Thrombosis Aspiration Catheter for Recanalization in Acute Ischemic Stroke Therapy (RECOVER)
This study is a prospective, multi-center, open-label, end-point blinded, randomized, parallel positive control, non-inferiority clinical trial, with a purpose to evaluate the safety and efficacy of Hemo Jirui intracranial…
- Conditions
- Large Vessel Occlusion, Acute Ischemic Stroke, Cerebrovascular Disorders
- Trial name
- NCT03753061
- Testing
- Aspiration Catheter, Solitaire FR
- Where
- 23 sites in China
- Volunteers
- 204 people
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Ischemic Stroke
European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Stroke
Prospective, single-arm, multicenter, observational registry of the ACE Reperfusion Catheters and the Penumbra System in Europe.
- Trial name
- PROMISE (NCT02678169)
- Testing
- Penumbra Aspiration System
- Where
- Germany
- Volunteers
- 204 people
- Sponsor
- Penumbra Inc.
Acute Ischemic Stroke, Reperfusion
Cilostazol Dexborneol Versus Placebo for Microcirculation Dysfunction After Reperfusion Therapy in Patients With Acute Ischemic Stroke With Large Vessel Occlusion
This study aims to evaluate the efficacy of Y-6 sublingual tablets in improving microcirculation dysfunction and reducing thrombo-inflammation in patients who had AIS caused by LVO and received reperfusion therapy.
- Conditions
- Acute Ischemic Stroke, Reperfusion, Large Vessel Occlusion
- Trial name
- CRYSTAL (NCT05836766)
- Testing
- Y-6 sublingual tablets
- Where
- 3 sites in China
- Volunteers
- 120 people
- Sponsor
- Beijing Tiantan Hospital
Ischaemic Stroke
The RETRAIN Trial Phase 2
Ischaemic strokes, caused by a disruption in the brain's blood supply, are the second leading cause of death and disability in the United Kingdom.
- Trial name
- RETRAIN 2 (NCT07197996)
- Testing
- Intermittent Pneumatic Compression, geko® T3
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Firstkind Ltd
Acute Ischemic Stroke
Efficacy and Safety of PCSK9 Inhibitors in Patients With Large-Artery Atherosclerosis (LAA) Ischemic Stroke
This prospective multicenter cohort study aims to evaluate the effectiveness and safety of early PCSK9 inhibitor therapy in patients with large-artery atherosclerotic ischemic stroke.
- Trial name
- NCT07540741
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Acute Ischemic Stroke
Treatment of Acute Ischemic Stroke With Rt-PA Combined With Edaravone Dexborneol
In this study, a multicenter, randomized, controlled, prospective cohort study was conducted to observe the effect of Edaravone Dexborneol on the incidence and outcome of bleeding transformation after thrombolysis in acute…
- Trial name
- TASPE (NCT06248242)
- Testing
- Edaravone dexborneol
- Where
- China
- Volunteers
- 400 people
- Sponsor
- The Second Hospital of Hebei Medical University
Myocardial Infarction, Stroke
The Brain Heart Interaction in Acute Stroke
Many studies have shown that acute cerebral dysfunction can impair cardiac function and autonomic control of blood pressure, heart rate and vascular tone, however, the size of the stroke is rarely reported.
- Trial name
- NCT02734082
- Where
- Switzerland
- Volunteers
- 204 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Acute Ischemic Stroke, Endovascular Thrombectomy
Effects of Post-Operative Sedation for Endovascular Thrombectomy
Studies from our lab indicated that long-term sedation is protective in mice with midbrain infarct. To assess whether post-operative sedation has protective effects on clinical outcomes in patients with ischemic stroke undergoing…
- Trial name
- POSET (NCT04517383)
- Testing
- post-operative sedation, routine recovery
- Where
- China
- Volunteers
- 1,286 people
- Sponsor
- RenJi Hospital
Cerebrovascular Stroke
Sonothrombolysis Potentiated by Microbubbles for Acute Ischemic Stroke
It has proposed the use of ST without microbubble treatment in randomized association with both intravenous and intra-arterial thrombolysis, but combined treatment (rtPA + U.S.) associated with MB diagnostic not yet been…
- Trial name
- NCT01678495
- Testing
- Sulfur hexafluoride + ultrasounds, Recombinant tissue plasminogen activator
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Ischemic Stroke
Effect of Aspirin at the Acute Phase of Cerebral Ischemic Event.
Aspirin is the only anti-platelet medication used at the acute phase of ischemic stroke. The investigators would like to study laboratory effect of the first oral 300 mg dose of aspirin, given at hospital, after an ischemic…
- Trial name
- Aspirin (NCT01375400)
- Testing
- Aspirin, blood sample
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Central Hospital, Nancy, France
Stroke Acute, Thrombectomy
Thrombectomy Versus Best Medical Management in Large Vessel Occlusion Stroke Patients Presenting Beyond 24 Hours and With Presence of Collateral Flow on CT Angiography
The goal of this clinical trial is to investigate if endovascular treatment (EVT) can effectively treat patients with large vessel occlusion (LVO) who present beyond the typical 24-hour window after symptom onset.
- Conditions
- Stroke Acute, Thrombectomy, Medical Treatment, Large Vessel Occlusion
- Trial name
- NCT06654375
- Testing
- Endovascular Thrombectomy
- Where
- China
- Volunteers
- 350 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke, Endovascular Thrombectomy
Evaluation of Endovascular Treatment in Acute Intracranial Distal Medium Vessel Occlusion Stroke
Rationale: Distal Medium Vessel Occlusion (MeVO) are thought to cause as many as 25% to 40% of all acute ischemic strokes (AIS).
- Trial name
- NCT06146790
- Testing
- endovascular treatment, Standard medical management
- Where
- China
- Volunteers
- 564 people
- Sponsor
- The First Affiliated Hospital of University of Science and Technology of China