Clinical trials: Acute Hypoxic Respiratory Failure, active
Acute Respiratory Failure With Hypoxia
PEEP in Patients With Acute Respiratory Failure
Positive end-expiratory pressure (PEEP) has become an essential component of the care of critically ill patients who require ventilatory support.
- Trial name
- NCT04912960
- Testing
- Mechanical ventilation
- Where
- 3 sites in Spain
- Volunteers
- 15 people
- Sponsor
- Jesus Villar
Mechanical Ventilation Complication, Hypoxemia
Trial of Venovenous ECMO to De-Sedate, Extubate and Mobilise in Hypoxic Respiratory Failure
To determine whether a strategy of adding venovenous ECMO to mechanical ventilation, as compared to mechanical ventilation alone, increases the number of intensive care free days at day 60, in patients with moderate to severe…
- Conditions
- Mechanical Ventilation Complication, Hypoxemia, Acute Respiratory Distress Syndrome Due to COVID-19, COVID-19 Respiratory Infection
- Trial name
- REDEEM (NCT05562505)
- Testing
- Venovenous ECMO
- Where
- 7 sites in Australia, Germany
- Volunteers
- 140 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Acute Respiratory Failure
Correlation Between Trans Esophageal Pressure and Non-invasive Respiratory Support Failure in Patients With Acute Hypoxic Respiratory Failure
This study aims at assessing the correlation between trans esophageal pressure and related respiratory mechanics (including, among others, nasal pressure-Pnose) and non-invasive respiratory support failure in patients with acute…
- Trial name
- TEMPO (NCT03826797)
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Modena and Reggio Emilia
Acute Hypoxemic Respiratory Failure, Hypoxemia
Evaluation of the FreeO2 System for Oxygen Weaning After Acute Hypoxemic Respiratory Failure
Acute hypoxemic respiratory failure (AHRF) is a common condition associated with substantial morbidity, mortality, and healthcare resource utilization.
- Trial name
- EVOLUERA (NCT07794124)
- Testing
- FreeO2 automated oxygen titration system, Standard oxygen weaning
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Acute Respiratory Failure
Improving Non-invasive Ventilation
A single center, observational, prospective study to improve knowledge about non-invasive ventilation, obtaining data about compliance, efficacy, imaging in patients who already receive non-invasive ventilation as standard of…
- Trial name
- Improving NIV (NCT01571986)
- Testing
- Non-invasive ventilation
- Where
- Italy
- Volunteers
- 750 people
- Sponsor
- Università Vita-Salute San Raffaele
Critical Care, Acute Hypoxic Respiratory Failure
A Pilot Trial of Pressure Muscle Index-Targeted PSV Trial
Pressure support ventilation (PSV) is one of the most frequently used ventilator modes in the intensive care unit (ICU). The successful implementation of PSV depends on matching the patient's inspiratory effort with the…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator Lung
- Trial name
- NCT06769360
- Testing
- PMI-targeted PSV setting, VT/RR-targeted PSV setting
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Capital Medical University
Acute Hypoxemic Respiratory Failure
Awake Prone Positioning in Spontaneous Breathing Patients With Acute Hypoxic Respiratory Failure Due to Pneumonia
Prone positioning has shown beneficial effects in intubated patients with severe respiratory failure and positive effects in awake patients with COVID-19 pneumonia.
- Trial name
- PROSA (NCT06931938)
- Testing
- Awake Prone Positioning
- Where
- Germany
- Volunteers
- 342 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Critical Care, Acute Hypoxic Respiratory Failure
Inspiratory Effort-Targeted Pressure Support Ventilation (IT-PSV) Trial
The Inspiratory effort-Targeted Pressure Support Ventilation (IT-PSV) is a cluster randomized controlled trial. Its main aim is to determine whether an inspiratory effort-targeted pressure support setting strategy, compared to…
- Conditions
- Critical Care, Acute Hypoxic Respiratory Failure, Ventilator-Induced Lung Injury
- Trial name
- IT-PSV (NCT06526598)
- Testing
- PMI-targeted pressure support setting and adjustment, VT/RR-targeted pressure support setting and adjustment
- Where
- China
- Volunteers
- 619 people
- Sponsor
- Capital Medical University
Respiratory Failure with Hypoxia
Comparison Between Four Weaning Methods from High-velocity Nasal Insufflation Device in Acute Hypoxemic Respiratory Failure
High-flow nasal oxygen therapy (HFNO) is an innovative high-flow system that allows for delivering up to 60 liters/ min of heated and fully humidified gas with a fraction of inspired oxygen (FIO2) ranging between 21% and 100% .
- Trial name
- HVNI (NCT06746636)
- Testing
- High velocity nasal insufflation
- Volunteers
- 120 people
- Sponsor
- Assiut University
Acute Brain Injury, Mechanical Ventilation
Regional Ventilation Evaluation During Neuro-injury Weaning Study
This study evaluates changes in regional lung ventilation using thoracic electrical impedance tomography (EIT) during the weaning process from mechanical ventilation in ICU patients with acute brain injury.
- Conditions
- Acute Brain Injury, Mechanical Ventilation, Prolonged Weaning, Traumatic Brain Injury
- Trial name
- ReVENtS (NCT07067671)
- Testing
- Internal Thoracic Impedance
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Respiratory Failure With Hypoxia, Respiratory Failure, ICU
Weaning From High Flow Nasal Oxygen in Acute Respiratory Failure : a Target Trial Emulation
Acute respiratory failure is a frequent reason for admission to the intensive care unit (ICU). It is associated with high healthcare consumption and mortality.
- Conditions
- Respiratory Failure With Hypoxia, Respiratory Failure, ICU, High-Flow Nasal Oxygen Therapy
- Trial name
- HFNO-Weaning (NCT07030413)
- Where
- 3 sites in France
- Volunteers
- 2,000 people
- Sponsor
- Poitiers University Hospital
Acute Hypoxic Respiratory Failure, Acute Respiratory Distress Syndrome (ARDS)
WIN Ratio Analysis to Determine a Strategy of Non- Invasive SUpport for Respiratory Failure in the EmeRgency Department
The purpose of this clinical trial is to determine the best initial non-invasive respiratory support (NIRS) strategy for adults who present to the emergency department with acute hypoxemic respiratory failure, a condition in…
- Trial name
- WINDSURFER (NCT07558265)
- Testing
- Non-Invasive Positive Pressure Ventilation, High Flow Nasal Oxygen
- Where
- 9 sites in United States
- Volunteers
- 500 people
- Sponsor
- Ohio State University
Respiratory Failure, Acute Hypoxemic Respiratory Failure
Optimizing Care in Critically Ill at UCHealth by Liberalizing the Target O2 in Mechanically-ventilated ICU Patients
A multimodal educational intervention to target an oxygen saturation target range (SpO2 90-96%) will reduce ventilator length of stay and reduce occult hypoxemia by increased awareness and adherence to a designated oxygen…
- Conditions
- Respiratory Failure, Acute Hypoxemic Respiratory Failure, Acute Hypoxic Respiratory Failure, Hypoxemia
- Trial name
- NCT06501118
- Testing
- Education, Epic notification alert
- Where
- United States
- Volunteers
- 3,600 people
- Sponsor
- University of Colorado, Denver
ARDS (Acute Respiratory Distress Syndrome), Acute Hypoxic Respiratory Failure
Precision Medicine Adaptive Network Platform Trial in Hypoxemic Acute Respiratory Failure
The goal of this trial is to accelerate the development of pharmacological therapies for critical illness by identifying biological sub phenotypes in patients with acute respiratory distress syndrome (ARDS).
- Trial name
- US-PANTHER (NCT07779642)
- Testing
- Simvastatin, Baricitinib
- Volunteers
- 300 people
- Sponsor
- University of Colorado, Denver
Acute Respiratory Failure, Critical Illness
ICU-SUCCEED for Survivors of Acute Respiratory Failure and Their Caregivers
This study will investigate whether a family-centered intervention that has been adapted for patients with critical illness and their caregivers is possible, acceptable, and helpful
- Conditions
- Acute Respiratory Failure, Critical Illness, Sepsis, Hypoxia
- Trial name
- ICU-SUCCEED (NCT07778004)
- Testing
- ICU-SUCCEED, Augmented Usual Care
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of North Carolina, Chapel Hill
Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Failure with Hypoxia
Physiologic Effects of Continuous Positive Airway Pressure and High Flow Nasal Oxygenation in Patients with Acute Respiratory Distress Syndrome.
The acute respiratory distress syndrome (ARDS) consists on a lack of breath due to fluid overload in the lungs that is not produced by a heart desease.
- Trial name
- NCT06694311
- Testing
- CPAP, HFNO 50 L/min
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Ricard Mellado Artigas
SARS-CoV-2 Infections, Respiratory Failure With Hypoxia
Automated Quantification of Radiologic Pulmonary Alteration During Acute Respiratory Failure: Application to the COVID-19 Pandemic
Automated quantification of the pulmonary volume impaired during acute respiratory failure could be helpful to assess patient severity during COVID-19 infection or perioperative medicine, for example.
- Trial name
- QUANTICO-PRO (NCT05278390)
- Testing
- Thoracic CT scan
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France