Clinical trials: Acute Heart Failure (AHF)
Acute Heart Failure (AHF), Sarcopenia
Sarcopenia in Older Patients Hospitalized for Acute Heart Failure.
Acute heart failure (AHF) is the leading cause of hospitalization in people over 65, with the group with preserved ejection fraction (HFpEF) being the most closely related to aging.
- Conditions
- Acute Heart Failure (AHF), Sarcopenia, Heart Failure
- Trial name
- MUSICA (NCT07530029)
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Acute Heart Failure
Efficacy and Safety of corticoSTEROids Added to Standard Therapy in Patients With Acute Heart Failure (STERO-AHF)
STERO-AHF is a pilot, prospective, multicenter, randomized, open-label, controlled study aimed to evaluate the diuretic efficacy and early clinical benefit of corticosteroid therapy administered for 7 days, in addition to…
- Trial name
- STERO-AHF (NCT05809011)
- Testing
- Dexamethasone, Prednisone
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
Acute Heart Failure (AHF), Heart Failure (for Example, Fluid Overload)
ReDS-guided Decongestion Strategy in Patients Hospitalized for Heart Failure
This clinical trial aims to determine whether a ReDS-guided treatment strategy is superior to the current standard of care for adults hospitalized with heart failure.
- Conditions
- Acute Heart Failure (AHF), Heart Failure (for Example, Fluid Overload), Heart Failure Hospitalization
- Trial name
- ReDS-SAFE HF 2 (NCT07484009)
- Testing
- Remote Dielectric Sensing System, Blinded ReDS data
- Where
- 25 sites in Spain
- Volunteers
- 1,014 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Acute Heart Failure (AHF)
Comprehensive Clinical Prediction Rule for Acute Heart Failure
The goal of this prospective observational cohort study is to establish a comprehensive clinical prediction rule integrating clinical characteristics, point-of-care testing (POCT) of NT-proBNP, an 8-point LUS, and a rapid cardiac…
- Trial name
- NCT07754084
- Testing
- Acute Heart Failure Diagnostic Method
- Where
- 3 sites in Hong Kong
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Acute Heart Failure (AHF), Heart Failure
Bedside Ultrasound in the Emergency Department for Predicting Acute Heart Failure Outcomes
Acute heart failure is a common and serious condition that frequently brings patients to the emergency department. Emergency physicians need quick and reliable methods to evaluate the severity of the condition and monitor the…
- Trial name
- NCT07905443
- Testing
- Point-of-Care Ultrasound (POCUS) Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Sakarya University
Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive
The FOCUS-ADHF Registry
Acute heart failure (AHF) represents a significant clinical and economic burden due to its impact on patients' quality of life, poor prognosis, and high healthcare costs.
- Conditions
- Acute Heart Failure With Reduced Ejection Fraction, Decompensation; Heart, Congestive, Regurgitation, Mitral
- Trial name
- FOCUS-ADHF (NCT06726109)
- Where
- 4 sites in Belgium, Italy
- Volunteers
- 600 people
- Sponsor
- ASL Città di Torino
Acute Decompensated Heart Failure
Study to Assess Hemodynamic Effects, Safety and Tolerability of Chimeric Natriuretic Peptide (CD-NP) in Patients With Stabilized Acute Heart Failure (AHF)
To access the efficacy of intravenous (IV) administration of CD-NP on changes in cardiac output and wedge pressure in patients with stabilized acute heart failure
- Trial name
- PreCONDITION (NCT00699712)
- Testing
- CD-NP (Chimeric natriuretic peptide)
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Nile Therapeutics
Heart Failure
Study to Evaluate the Safety and Efficacy of IV Infusion Treatment With Omecamtiv Mecarbil in Subjects With Left Ventricular Systolic Dysfunction Hospitalized for Acute Heart Failure (ATOMIC-AHF)
The primary objective of the study is to evaluate the effect of 48 hours of intravenous (IV) omecamtiv mecarbil compared with placebo on dyspnea in subjects with left ventricular systolic dysfunction hospitalized for acute heart…
- Trial name
- NCT01300013
- Testing
- Omecamtiv mecarbil
- Where
- 150 sites in United States, Australia and 17 more
- Volunteers
- 614 people
- Sponsor
- Cytokinetics
Heart Failure Acute
Investigating a Tailored Diuretic Algorithm in Acute Heart Failure Patients
Acutely decompensated heart failure (ADHF) is highly prevalent and has a high (financial) burden on the health care system. Treatment often consists of the administration of IV decongestive agents.
- Trial name
- TAILOR-AHF (NCT06092437)
- Testing
- Urine sodium guided diuretic algorithm, Usual care
- Where
- 2 sites in Netherlands
- Volunteers
- 556 people
- Sponsor
- Zuyderland Medisch Centrum
Acute Heart Failure
Effect of Dapagliflozin in Patients With Acute Heart Failure (DAPA-RESPONSE-AHF)
Dapagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2i), increases natriuresis alone and synergistically when combined with loop diuretics in patients with AHF without increasing renin angiotensin- aldosterone…
- Trial name
- NCT05406505
- Testing
- Dapagliflozin 10mg Tab
- Where
- Egypt
- Volunteers
- 87 people
- Sponsor
- Mansoura University
Heart Failure
Comparative Evaluation of the Evolution of Emerging Biological Markers in Patients Hospitalized for Acute Heart Failure According to Conventional Management or Therapeutic Adjustment Via Daily Ultrasound.
This is a bi-centric, prospective randomized study to evaluate the contribution of rapid echocardioscopy at the patient's bedside to improving the prognosis of patients hospitalized for acute heart failure.
- Trial name
- JECICA2 (NCT05297630)
- Testing
- Evaluation of the evolution of biological markers from the biobank.
- Where
- 2 sites in France
- Volunteers
- 169 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute Heart Failure
Dynamic Variation of Impedance Cardiography(DYVIC) as a Diagnostic Tool of Acute Heart Failure (AHF)
Dynamic variations of bio-impedance measured cardiac output using non pharmacologic intervention (sitting position, passive leg rising and valsalva maneuver) could be used to detect acute heart failure in patients admitted to the…
- Trial name
- DYVIC (NCT03241069)
- Testing
- Reference position, sitting position, Valsalva maneuver
- Where
- Tunisia
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Acute Heart Failure (AHF)
Routine Magnesium Testing and Supplementation in Acute Heart Failure (MAG-HF)
This study is an investigator-initiated, pragmatic, randomized controlled feasibility trial evaluating two strategies for magnesium management in adults hospitalized with acute heart failure (AHF).
- Trial name
- MAG-HF (NCT07906353)
- Testing
- No Routine Magnesium Testing or Supplementation, Routine Magnesium Testing and Supplementation
- Volunteers
- 260 people
- Sponsor
- University of Alberta
Acute Heart Failure (AHF), Cardiac Arrhythmia
Arrhythmia Detection With MEMO Patch Plus in Patients With Acute Heart Failure
This prospective, multicenter, open-label, single-group exploratory clinical trial evaluates the clinical effectiveness of extended electrocardiographic monitoring with MEMO Patch Plus for detecting clinically significant…
- Trial name
- MMPP-HF (NCT07792772)
- Testing
- MEMO Patch Plus
- Where
- 3 sites in South Korea
- Volunteers
- 45 people
- Sponsor
- HUINNO Co., Ltd
Acute Heart Failure (AHF), Congestive Heart Failure Acute
POcus INTERvention for Tailoring Diuretic Strategy in Acute Decompensated Heart Failure
Acute decompensated heart failure (ADHF) is a frequent cause of hospitalization and is associated with high morbidity and mortality.
- Conditions
- Acute Heart Failure (AHF), Congestive Heart Failure Acute, Diuretic Effect, Lung Ultrasonography Score
- Trial name
- POINTER-HF (NCT07469722)
- Testing
- Furosemide 40 Milligrams., Hydrochlorothiazide (HCTZ) 25 milligrams., Acetazolamide 250 milligrams.
- Where
- Brazil
- Volunteers
- 128 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Heart Failure Acute, Heart Failure，Congestive
Effects of Empagliflozin on Clinical Outcomes in Patients With Acute Decompensated Heart Failure
Acute decompensated heart failure is the fastest growing disease in the world and the leading cause of hospital admissions worldwide.
- Conditions
- Heart Failure Acute, Heart Failure，Congestive, Heart Failure; With Decompensation
- Trial name
- EMPA-RESPONSE (NCT03200860)
- Testing
- Empagliflozin 10 MG
- Where
- 5 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- University Medical Center Groningen
Dyspnea; Cardiac
Contribution LUS in the Diagnosis of Acute Heart Failure (AHF) in Patients Admitted to the ED
This study assesses the potential of lung ultrasonography to diagnose heart failure.
- Trial name
- NCT03717779
- Testing
- lung ultrasound
- Where
- Tunisia
- Volunteers
- 600 people
- Sponsor
- University of Monastir
Acute Heart Failure (AHF)
Restrictive Versus Liberal Fluid Intake in Acute Decompensated Heart Failure
The aim of this clinical trial is to learn whether a thirst-driven, liberal fluid-intake strategy is comparable to a fluid-restriction strategy in patients hospitalized for acute decompensated heart failure (ADHF).
- Trial name
- RELIEF-AHF (NCT07400991)
- Testing
- Fluid restriction strategy, Thirst-driven, liberal fluid intake
- Where
- Denmark
- Volunteers
- 420 people
- Sponsor
- Gødstrup Hospital
Acute Heart Failure (AHF)
Impact of Clinical Ultrasound in Patients With Heart Failure Treated in Home Hospitalization
The purpose of this study is to assess whether clinical ultrasound (CU)-guided treatment in acute heart failure (AHF) is superior to the standard care (SC)-guided treatment.
- Trial name
- AHF-CU (NCT05042752)
- Testing
- CLINICAL ULTRASOUND
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Lara Palacios
Acute Heart Failure
Acute Heart Failure - COngestion Repeated Evaluation (AHF-CORE)
The AHF-CORE study is a prospective, non-randomized, multicenter regional study. The main objective of the AHF-CORE study is to identify congestion markers (clinical, biological and ultrasound) at the beginning and at the end of…
- Trial name
- AHF-CORE (NCT03327532)
- Testing
- Clinical examination centered on congestion, Cardio-pulmonary and peritoneal ultrasound, Blood sample retrieved for biological assessment and biobanking
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Central Hospital, Nancy, France