Clinical trials: Acute Exacerbation of Asthma, open to volunteers
Asthma Acute, Exacerbation of Allergic Asthma
Nebulized Ketamine for Severe Asthma Attacks in Children
This is a double-blinded, randomised, placebo-controlled trial enrolling 60 children aged 1 to 13 years with severe asthma exacerbation. All participants will receive standard therapy.
- Trial name
- NCT07728851
- Testing
- Ketamine (1 mg/kg)
- Where
- Oman
- Volunteers
- 60 people
- Sponsor
- Sultan Qaboos University
Allergic Asthma, Thunderstorm Asthma
Creating A Risk Assessment Tool for Thunderstorm Asthma: the CARISTA Study
Thunderstorm asthma is a recurring public health emergency in South-Eastern Australia which occurs in springtime. The major identified risk factors for thunderstorm asthma is hay fever and allergy to ryegrass pollen.
- Conditions
- Allergic Asthma, Thunderstorm Asthma, Seasonal Allergic Rhinitis, Grass Pollen Allergy
- Trial name
- CARISTA (NCT07055542)
- Testing
- Observational
- Where
- 6 sites in Australia
- Volunteers
- 530 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Pulmonary Edema, Pneumonia
Clinical Utility of Portable Dynamic Chest X Ray (DDR) in the ICU
Dynamic digital radiography (DDR) is a new advanced version of chest radiography that captures dynamic images at a rate of 15 frames per second.
- Conditions
- Pulmonary Edema, Pneumonia, Atelectasis, Pleural Effusion
- Trial name
- NCT06538376
- Testing
- Portable Dynamic Digital Radiography (DDR)
- Where
- United States
- Volunteers
- 230 people
- Sponsor
- Brigham and Women's Hospital
Asthma Acute, Asthma Childhood
ASMact: Study on Management of Bronchial Asthma
Standardization According to GINA 2025 Recommendations for the Treatment, Management, and Follow-up of Acute Asthma Attacks: Observational, Multicenter Cohort Study.
- Conditions
- Asthma Acute, Asthma Childhood, Asthma in Children, Asthma Crisis
- Trial name
- NCT07412769
- Where
- 2 sites in Italy
- Volunteers
- 500 people
- Sponsor
- Meyer Children's Hospital IRCCS
Asthma
Magnesium Trial in Acute Asthma in Emergency Department
Despite optimal initial emergency department (ED) therapy, 50% of children with severe acute asthma have ongoing moderate-severe respiratory distress.
- Trial name
- MAGICIAN (NCT06785272)
- Testing
- magnesium sulfate, Normal Saline
- Where
- 6 sites in Canada
- Volunteers
- 192 people
- Sponsor
- Suzanne Schuh
Bronchial Asthma
Evaluation of Clinical Effect of Acupuncture on Acute Exacerbation of Bronchial Asthma
Based on the bioholographic theory, this study preliminarily explores the clinical efficacy of hand acupuncture in treating acute exacerbation of bronchial asthma and evaluates its immediate anti-asthmatic effect, so as to…
- Trial name
- NCT07632352
- Testing
- Acupuncture, Standard Western medicine treatment
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Thyroid Eye Disease, Vasculitis
Evaluation of High Dose Prednisolone Pharmacokinetics in the Acute and Chronic Setting
This is a pilot study to investigate serum prednisolone profiles in: Patients on high doses of prednisolone for any inflammatory disorder, both in the acute and chronic setting.
- Conditions
- Thyroid Eye Disease, Vasculitis, COPD Exacerbation Acute, Asthma
- Trial name
- EHD-Pred PK (NCT05012033)
- Testing
- No intervention - prednisolone is taken as part if routine clinical care.
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Imperial College London
Acute Asthma, Dexamethasone
Dosing of Steroids for Acute Asthma Given in the Emergency Department - a Pilot Randomised Feasibility Trial of Dexamethasone in Children
Steroids given by mouth are an important first line treatment for children presenting with asthma attacks. Dexamethasone is the steroid used in some emergency departments (EDs) because of the need for a single dose and as it is…
- Trial name
- DOSAGE (NCT07402707)
- Testing
- dexamethasone oral
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- Sheffield Children's NHS Foundation Trust
Asthma, Asthma Attack
Remote Patient Monitoring Solution for Chronic Respiratory Disease Management
Aim: To evaluate the use of AeviceMD Monitoring System (AeviceMD) asthma in reducing acute exacerbation. Methodology: Using a randomized controlled trial design, this project aims evaluate the effectiveness of AeviceMD in…
- Conditions
- Asthma, Asthma Attack, Asthma in Children, Asthma Acute
- Trial name
- NCT06377345
- Testing
- AeviceMD device, Standard care
- Where
- Singapore
- Volunteers
- 180 people
- Sponsor
- SingHealth Polyclinics
Asthma in Children
High-dose Vitamin D Supplement for the Prevention of Acute Asthma-like Symptoms in Preschool Children
To investigate whether high-dose vitamin D supplementation may have a beneficial effect on secondary prevention in preschool children (1-5 years of age), with respiratory infections being the primary cause of acute exacerbations…
- Trial name
- COPSACvitd (NCT05043116)
- Testing
- Cholecalciferol D3
- Where
- Denmark
- Volunteers
- 320 people
- Sponsor
- Copenhagen Studies on Asthma in Childhood
Anxiety/Depression and Asthma
The Impact of Anxiety/Depression on the Efficacy of Asthma Control Drugs and the Construction of a Predictive Model for the Risk of Acute Asthma Attacks
The goal of this clinical trial is to explore the impact of anxiety/depression on the efficacy of asthma controller medications and to develop a risk prediction model for asthma acute exacerbations in patients with asthma.
- Trial name
- NCT07679321
- Testing
- No intervention measures
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Xiangya Hospital of Central South University
Asthma
Mechanism(s) of Airflow Limitation During Exacerbation of Asthma
The purpose of this study is to evaluate the site and mechanisms responsible for expiratory airflow limitation in chronic, treated, non-smoking, stable asthmatics with moderate to severe persistent expiratory airflow obstruction.
- Trial name
- NCT01225913
- Testing
- fluticasone/salmeterol in all asthmatics, budesonide/formoterol or fluticasone/salmeterol in all asthmatics
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Gelb, Arthur F., M.D.
Asthma Acute, Asthma Attack
Post Exacerbation Asthma Clinic Telecare Intervention to Reduce Recurrent Exacerbations
Asthma exacerbations leading to emergency department visits or hospitalization are associated with a high risk of recurrent exacerbations, poor disease control, and increased healthcare utilization in the months following…
- Trial name
- PACT (NCT07629830)
- Testing
- Follow-up in a remote flare-up clinic
- Where
- Israel
- Volunteers
- 220 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Falls Injury, Falls
Potential of Interface Care Models to Deliver More Appropriate Care to Patients With Acute Medical Illness
Every country in the world is experiencing growth in both the size and the proportion of older persons. As a result of the changes, the profile and needs of people with medical illnesses have evolved.
- Conditions
- Falls Injury, Falls, Hospitalization in Acute Care, Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- NCT07536035
- Where
- Singapore
- Volunteers
- 220 people
- Sponsor
- National University Hospital, Singapore
Asthma Acute, Asthma Attack
Nebulized Ketamine Plus Standard Care vs. Standard Care Alone in Moderate to Severe Asthma Exacerbations
The goal of this clinical trial is to learn if nebulized ketamine helps treat moderate to severe asthma attacks in adults in the emergency department.
- Conditions
- Asthma Acute, Asthma Attack, Asthma Exacerbations
- Trial name
- KET-AIR (NCT07112456)
- Testing
- Nebulized ketamine (0.5 mg/kg in normal saline to a total volume of 5ml) plus standard asthma excaerbationcare
- Where
- Oman
- Volunteers
- 100 people
- Sponsor
- Oman Medical Speciality Board
Asthma Acute, Asthma Exacerbation
45th Multicenter Airway Research Collaboration
The study is a randomized controlled trial on the effect of emergency department initiation of Airsupra on acute asthma "recurrence" at 3 months and other related outcomes (acute asthma relapse, asthma control).
- Conditions
- Asthma Acute, Asthma Exacerbation, Asthma, Asthma Control Level
- Trial name
- MARC-45 (NCT07166939)
- Testing
- Airsupra
- Where
- United States
- Volunteers
- 1,860 people
- Sponsor
- Massachusetts General Hospital
Acute Otitis Media (AOM), Strep Pharyngitis
Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma
This study evaluates the diagnostic performance, usability, and clinical utility of the Medentum Diagnostik platform, a multisensor device with integrated software and artificial intelligence, in pediatric patients with asthma…
- Conditions
- Acute Otitis Media (AOM), Strep Pharyngitis, Asthma Exacerbation, Pediatric Asthma
- Trial name
- NCT07500532
- Testing
- Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medentum Innovations
COPD Exacerbation Acute, Asthma Acute
Study on Acupuncture Treatment of Chronic Airway Diseases(Asthma and Chronic Obstructive Pulmonary Disease)
For patients in the acute phase of chronic airway diseases, on the basis of guideline-directed treatment, the experimental group was given acupuncture treatment, while the control group was given sham acupuncture treatment.
- Trial name
- NCT06869525
- Testing
- Acupuncture
- Volunteers
- 576 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Asthma Acute, COPD Exacerbation Acute
Rademikibart IV for Acute Asthma and COPD Exacerbation
A Phase 2, open-label, single-arm trial to evaluate IV rademikibart as an add-on treatment for acute exacerbation in participants with asthma or COPD with type 2 inflammation
- Trial name
- NCT07705737
- Testing
- Rademikibart
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- Connect Biopharm LLC