Clinical trials: Acute Compartment Syndrome
Intra-abdominal Hypertension, Acute Respiratory Distress Syndrome (ARDS)
End-expiratory Transpulmonary Pressure-guided vs Electrical Impedance Tomography-guided PEEP Titration Methods in Patients With Intra-abdominal Hypertension Combined With Acute Respiratory Distress Syndrome: a Randomized Crossover Controlled Study
This study aims to adopt a randomized crossover design to compare the effects of end-expiratory transpulmonary pressure-guided PEEP titration and EIT-guided PEEP titration on local lung ventilation, shunt, dead space, and…
- Trial name
- NCT06697717
- Testing
- Transpulmonary Pressure-Guided PEEP Titration in IAH and ARDS Patients, EIT-Guided PEEP Titration in IAH and ARDS Patients
- Where
- China
- Volunteers
- 15 people
- Sponsor
- XiaoJing Zou,MD
Mortality, Acute Pancreatitis
Laparotomy Versus Percutaneous Puncture in Patients With Abdominal Compartment Syndrome During Acute Pancreatitis
Decompressive laparotomy with temporary abdominal closure, will decrease of overall mortality and major morbidity in patients with abdominal compartment syndrome during acute pancreatitis in comparison with percutaneous puncture…
- Trial name
- DECOMPRESS (NCT00793715)
- Testing
- Decompressive laparotomy with temporary abdominal closure, Percutaneous puncture with placement of abdominal catheter
- Where
- 5 sites in Serbia
- Volunteers
- 100 people
- Sponsor
- University of Belgrade
Acute Compartment Syndrome
MY01 - An Aid for Diagnosing Acute Compartment Syndrome in Real Time
Compartment syndrome can result from extremity trauma. It can also be caused by procedural cases that involve lower or upper extremity surgery.
- Trial name
- NCT04016103
- Testing
- MY01 - Continuous Compartmental Pressure Monitor
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- MY01 Inc.
Acute Compartment Syndrome, Tibia Fracture
Biomarkers in the Diagnosis of Acute Compartment Syndrome
This prospective multinational, multicentre cohort study aims to investigate the hypothesis that biomarkers of muscle cell damage can predict acute compartment syndrome in patients with tibial fractures.
- Trial name
- BioFACTS (NCT04674592)
- Testing
- Blood samples and biopsies
- Where
- Sweden
- Volunteers
- 250 people
- Sponsor
- University Hospital, Linkoeping
Intraabdominal Hypertension, Abdominal Compartment Syndrome
Physiologic Signals and Signatures With the Accuryn Monitoring System - The Accuryn Registry
The Accuryn Registry Study is an open-ended, global, multi-center, retrospective and prospective, single-arm data collection study with an FDA cleared device. The target population are cardiovascular surgery patients.
- Conditions
- Intraabdominal Hypertension, Abdominal Compartment Syndrome, Acute Kidney Injury, Cardiovascular Surgery
- Trial name
- NCT04669548
- Testing
- Accuryn Monitoring System
- Where
- 9 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Potrero Medical
Acute Pancreatitis, Intra-abdominal Hypertension
Neostigmine Treatment of Acute Pancreatitis Combined With Intra-abdominal Hypertension
Acute pancreatitis(A) often complicated with Intra-abdominal Hypertension. After the onset of acute pancreatitis, capillary leakage causing ascites,upper gastrointestinal tract obstruction and paralytic ileus leading to an…
- Trial name
- NCT02543658
- Testing
- Neostigmine Methylsulfate 1 MG/ML, Conservative treatment
- Where
- China
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Acute Compartment Syndrome
Use of Near Infrared Spectroscopy to Detect Muscle Perfusion in the Lower Extremity of Uninjured Subjects
Acute compartment syndrome (ACS) is a complication of lower leg trauma that occurs when the pressure inside the leg due to swelling exceeds the body's ability to provide blood to the muscle of the leg.
- Trial name
- NCT01284023
- Testing
- Shaving
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- J&M Shuler
Acute Compartment Syndrome
Real-time Soft Tissue Assessment Using a Technologically Advanced pH Monitoring System
Acute Compartment Syndrome (ACS) can occur when there is a gradual reduction in the blood supply to injured limbs, most commonly after fractures or crush injuries.
- Trial name
- SoftpH (NCT04725604)
- Testing
- pH probe
- Where
- 7 sites in United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Aberdeen
Compartment Syndromes, Compartment Syndrome of Lower Leg
NIRST and ICG-based Perfusion Imaging in Acute Compartment Syndrome
This is a prospective observational study of patients with suspected Acute Compartment Syndrome. The primary objective of this work is to determine whether intensity changes associated with the NIRST signal, reflecting oxy- and…
- Conditions
- Compartment Syndromes, Compartment Syndrome of Lower Leg, Compartment Syndrome of Forearm
- Trial name
- NCT05672381
- Testing
- Lower extremity and/or upper extremity surgery
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tibial Shaft Fracture, Tibial Plateau Fracture
Gene Expression in Lower Extremity Acute Traumatic Compartment Syndrome
The purpose of this study is to evaluate both genotypic differences and differences in local gene expression in individuals who develop acute traumatic compartment syndrome relative to control patients with at-risk lower…
- Trial name
- NCT05521958
- Testing
- Acute injury without compartment syndrome, Acute injury with compartment syndrome, Exertional compartment syndrome
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Utah
Ischemia Limb, Blood Circulation Disorder
Ischemia Detection During Development of Acute Compartment Syndrome
This is an open, observational, prospective, descriptive, single-centre study including 60 patients. The study is designed to investigate if IscAlert sensor system can be used for reliable and continuous tissue carbon dioxide…
- Conditions
- Ischemia Limb, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- IDEA (NCT06079255)
- Testing
- IscAlert sensor(s) in patient with risk of acute compartment syndrome
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Acute Compartment Syndrome
The Use of Near Infrared Spectroscopy in the Diagnosis of Acute Compartment Syndrome in Injured Soldiers
The purpose of this study is to define the reliability and accuracy of Near Infrared Spectroscopy (NIRS) in the detection of intra-compartmental tissue perfusion in injured and noninjured extremities over time.
- Trial name
- NCT01123798
- Testing
- near-infrared spectroscopy
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- J&M Shuler
Acute Compartment Syndrome
Real-Time Muscle Pressure Measurements in Patients at Risk for Acute Compartment Syndrome
The purpose of this trial is to conduct a pilot study that will aid in the design of an evaluation of the clinical benefit of MY01, an FDA cleared device, that allows continuous monitoring of intracompartmental muscle pressure in…
- Trial name
- NCT04671173
- Testing
- Measurement of the Intra-Compartmental Pressure with the MY01 device
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Acute Limb Ischemia
Evaluation of Acute Lower Limb Ischemia
The primary objective of this study is to evaluate the effect of different treatment modalities on clinical outcome of patients suffering from acute lower limb ischemia (ALI).
- Trial name
- PROMOTE-ALI (NCT05138679)
- Testing
- Revascularization, Primary major amputation, Best medical treatment
- Where
- 37 sites in Austria, Croatia and 8 more
- Volunteers
- 700 people
- Sponsor
- Medical University Innsbruck
Severe Acute Pancreatitis, Intra-abdominal Hypertension
Efficacy and Safety of Da-Cheng-Qi Decoction in Severe Acute Pancreatitis
This single-center prospective randomized controlled trial evaluated Da-Cheng-Qi Decoction (DCQD) as the acute-stage intervention of an integrated traditional Chinese and Western medicine whole-stage treatment protocol for severe…
- Trial name
- NCT07816900
- Testing
- Da-Cheng-Qi Decoction Plus Standard Western Treatment, Standard Western Treatment
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Ascites Hepatic, Cirrhosis, Liver
Continuous Passive Paracentesis for Intra-abdominal Hypertension
Liver cirrhosis patients in Intensive Care present intra-abdominal hypertension and this is an independent risk factor for increased organ disfunction and mortality.
- Conditions
- Ascites Hepatic, Cirrhosis, Liver, Hypertension, Intraabdominal, Critical Illness
- Trial name
- COPPTRIAHL (NCT04322201)
- Testing
- continuous drainage of ascitic fluid using an intra-abdominal double lumen central venous catheter, Ultrasound-guided intermittent large-volume paracentesis
- Where
- Portugal
- Volunteers
- 60 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Traumatic Brain Injuries, Intracranial Hypertension
Effectiveness of Surgical Procedures for Acute Cranial Expansion in Traumatic Brain Injury
Traumatic brain injury (TBI) patients often exhibit an increase in their intracranial volume due to blood collection or brain tissue edema.
- Trial name
- E-SPACE-TBI (NCT06776614)
- Testing
- Decompressive Craniectomy, Expansion Craniotomy
- Volunteers
- 292 people
- Sponsor
- Meditech Foundation
Critical Illness, Acute Kidney Injury
Collective Accuryn Physiologic Signals and Signatures
The CAPSS Study is a retrospective and prospective, multi-center, single-arm post-market data collection study with an FDA cleared device.
- Conditions
- Critical Illness, Acute Kidney Injury, Sepsis, Septic Shock
- Trial name
- CAPSS (NCT03817281)
- Testing
- Accuryn Monitoring System
- Where
- United States
- Sponsor
- Potrero Medical
Compartment Syndrome of Leg
Evaluating the Diagnostic Performance of ACS Using NIRS in Traumatized Lower Extremities
This is a study intended to validate a new set of guidelines for a device that uses light to measure the amount of oxygen in the muscles of injured and non-injured legs and forearms in specific situations.
- Trial name
- NCT03604029
- Testing
- Near Infrared Spectroscopy
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Nonin Medical, Inc
Air or Gas Embolism, Carbon Monoxide Poisoning
Hyperbaric Oxygen Therapy Registry
The purpose of the Hyperbaric Oxygen Therapy Registry (HBOTR) is to provide real world patient outcome and side effect information from electronic health records submitted to a specialty specific hyperbaric registry as part of…
- Conditions
- Air or Gas Embolism, Carbon Monoxide Poisoning, Clostridial Myositis and Myonecrosis (Gas Gangrene), Crush Injury, Compartment Syndrome & Other Acute Traumatic Ischemias
- Trial name
- HBOTR (NCT02483650)
- Volunteers
- 5,000 people
- Sponsor
- U.S. Wound Registry