Clinical trials: Acute Allergic Reaction
Acute Bronchial Obstruction, Asthma
Efficacy of Formoterol vs Ipatropioum Bromide Plus Fenoterol in Children (5-<12 Years) With Acute Bronchial Obstruction
To determine efficacy and tolerability of inhaled Formoterol vs nebulized Ipatropioum Bromide plus Fenoterol in cumulative sequential doses in asthmatic children (5-<12 years) with acute bronchial obstruction attending emergency…
- Trial name
- NCT00460577
- Testing
- Formoterol fumerate, fenoterol/ipratropium bromide
- Where
- 2 sites in Venezuela
- Volunteers
- 60 people
- Sponsor
- Novartis
Bacterial Infections
Study of Debio 1450 for Bacterial Skin Infections
The primary objective of this study is to evaluate the efficacy of 2 different doses of intravenous and oral Debio 1450 compared with intravenous vancomycin and oral linezolid in the treatment of patients with staphylococcal…
- Trial name
- NCT02426918
- Testing
- Debio 1450 IV, Debio 1450 Oral, Linezolid
- Where
- 22 sites in United States
- Volunteers
- 330 people
- Sponsor
- Debiopharm International SA
Pulmonary Disease, Chronic Obstructive
Etiology of Acute Exacerbations of Chronic Obstructive Pulmonary Disease (AECOPD) in Japan
The purpose of this prospective, epidemiological, cohort study is to evaluate the lung microbiome in stable-state chronic obstructive pulmonary disease (COPD) in Japanese participants
- Trial name
- NCT03957577
- Testing
- Prospective observational cohort study
- Where
- 13 sites in Japan
- Volunteers
- 70 people
- Sponsor
- GlaxoSmithKline
Angioedema
A Study of Lanadelumab in Teenagers and Adults to Prevent Acute Attacks of Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH)
The main aim of this study is to check if repeated subcutaneous (SC) injections of lanadelumab can prevent angioedema attacks in teenagers and adults with non-histaminergic angioedema with normal C1-INH.
- Trial name
- NCT04206605
- Testing
- Lanadelumab
- Where
- 45 sites in United States, Canada and 8 more
- Volunteers
- 77 people
- Sponsor
- Takeda
Acute Severe Asthma
Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children
The purpose of this study is to determine whether nebulized magnesium sulphate is effective in the treatment of acute severe asthma when comparison with intravenous magnesium sulphate
- Trial name
- NCT02112305
- Testing
- isotonic magnesium sulphate, 50% magnesium sulphate
- Where
- Thailand
- Volunteers
- 40 people
- Sponsor
- Queen Sirikit National Institute of Child Health
Asthma
Reversal of Acute β-Blocker Induced Bronchoconstriction
Current therapies for the management of asthma include inhalers. Types of these medications (beta agonists), improve asthma symptoms by stimulating areas (receptors) within the human airway resulting in dilation of the human…
- Trial name
- NCT01070225
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- University of Dundee
Cough
A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough.
To assess the effect of a single doses of 20 mg ambroxol hydrochloride on cough reflex sensitivity to citric acid, capsaicin, adenosine triphosphate (ATP) and distilled water in patients with acute cough related to upper…
- Trial name
- NCT03415269
- Testing
- Ambroxol Hydrochloride
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Asthma, Reactive Airway Disease
Single Oral Dose of Dexamethasone Versus Five Days of Prednisone in Adult Asthma
This study seeks to compare the effectiveness of a single dose of oral dexamethasone versus 5 days of oral prednisone in the treatment of mild to moderate asthma exacerbations to prevent relapse with an unscheduled return visit…
- Trial name
- NCT01241006
- Testing
- Dexamethasone, Prednisone
- Where
- United States
- Volunteers
- 376 people
- Sponsor
- Alameda County Medical Center
Allergic Conjunctivitis
Study Evaluating the Efficacy and Safety of PRT-2761 for the Treatment of Acute and Chronic Allergic Conjunctivitis
To evaluate the efficacy and safety of two concentrations of PRT-2761 as a topical ophthalmic solution for the treatment of the signs and symptoms of acute and chronic allergic conjunctivitis.
- Trial name
- NCT03320434
- Testing
- PRT-2761 0.5%, PRT-2761 1%, Patanol
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- ORA, Inc.
Transfusion Reaction
Transfusion Associated Dyspnea Profiling
Transfusion reactions are defined as harms occurring during or after blood transfusion, with new heart/lung stress (eg. troubled breathing) regarded as cardiorespiratory transfusion reactions (CRTRs).
- Trial name
- TADPOL (NCT04267029)
- Testing
- TADPOL battery (deep clinicolaboratory profile)
- Where
- 4 sites in Canada
- Volunteers
- 151 people
- Sponsor
- Toronto Transfusion Medicine Collaborative
Metabolic Syndrome, Obesity
Impact of Acute Exercise on Vascular Insulin Sensitivity in Metabolic Syndrome
Obesity is an independent risk factor for type 2 diabetes and cardiovascular disease. The increased prevalence of obesity worldwide is a major concern among the scientific and medical communities.
- Trial name
- NCT03894527
- Testing
- Single Bout of Exercise, Control Condition
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Virginia
Acute Interstitial Nephritis, Drug-Induced Interstitial Nephritis
Identification of the Causative Drug in Drug-induced Acute Interstitial Nephritis
Drug-induced acute interstitial nephritis (DAIN) is a rare entity characterized by acute renal failure linked to inflammation of the renal parenchyma secondary to allergenic drug exposure.
- Trial name
- IDENIAM (NCT05233241)
- Testing
- in vitro Allergological test Allergological skin tests
- Where
- France
- Volunteers
- 44 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Allergic Rhinitis
Topical Allstate and Nasal Allergen Challenge
The purpose of this study is to see whether Allstate Nasal Spray when given in the nose is safe and can reduce the signs and symptoms of allergic rhinitis (hayfever).
- Trial name
- NCT01231724
- Testing
- Allstate Nasal Spray
- Where
- United States
- Sponsor
- University of Chicago
Hereditary Angioedema (HAE)
Efficacy and Safety Study of DX-2930 to Prevent Acute Angioedema Attacks in Patients With Type I and Type II HAE
This is a phase 3, multicenter, randomized, double-blind, placebo-controlled trial to evaluate the efficacy and safety of DX-2930 in preventing acute angioedema attacks in patients with Type I and Type II HAE.
- Trial name
- NCT02586805
- Testing
- DX-2930 - 300mg/2wk, DX-2930 - 300mg/4wk, DX-2930 - 150mg/4wk
- Where
- 41 sites in United States, Canada and 5 more
- Volunteers
- 125 people
- Sponsor
- Shire
Asthma Exacerbation
Effectiveness of the Aeroneb in Acute Severe Asthma
Background: The bronchodilator therapy is an essential component of the management of asthma exacerbation. The delivery of bronchodilators to the lungs in asthma exacerbations is usually achieved through nebulization (creating…
- Trial name
- NCT03029156
- Testing
- Aeroneb nebulizer, Small volume jet nebulizer
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Tufts Medical Center
Traumatic Brain Injury, Trauma, Head
Complement Inhibition: Attacking the Overshooting Inflammation @Fter Traumatic Brain Injury
Severe Traumatic Brain Injury (s-TBI) is a major cause of death and disability across all ages. Besides the primary impact, the pathophysiologic process of major secondary brain damage consists of a neuroinflammation response…
- Trial name
- CIAO@TBI (NCT04489160)
- Testing
- C1 Inhibitor, Human
- Where
- 3 sites in Netherlands
- Volunteers
- 106 people
- Sponsor
- Leiden University Medical Center
Severe Acute Malnutrition
Performance of Mid-Upper Arm Circumference for Detection of Severe Acute Malnutrition in Indonesian Under-Fives
WHO recommends 11.5 cm as a cut-off point of Mid-Upper Arm Circumference (MUAC) to detect and/or diagnose severe acute malnutrition (SAM) in under-five.
- Trial name
- NCT06545240
- Testing
- Mid-upper arm circumference
- Where
- 2 sites in Indonesia
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram
Calibration Study PREDICT - Prehospital Triage for Suspected Acute Coronary Syndrome Without ST-segment Elevation
The PREDICT calibration study is a prospective, non-interventional trial aiming to adapt and calibrate the ACS-Pathfinder algorithm for prehospital triage of patients with suspected non-ST-elevation acute coronary syndrome…
- Trial name
- PREDICT (NCT07419139)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Leipzig Heart Science gGmbH
Chest Pain, Acute Coronary Syndrome, Myocardial Infarction
Magnetocardiography in the Accurate Identification of Severe Coronary Lesions and Myocardial Necrosis
Magnetocardiography (MCG) is a promising noninvasive and accurate method for detecting myocardial ischemia. Although progress has been made in this area, there is a lack of studies using up-to-date examination instruments for the…
- Trial name
- NCT05392712
- Testing
- Magnetometer
- Where
- China
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Qilu Hospital of Shandong University