Clinical trials: Acquired Brain Injury
Concussion, Mild
Mindfulness-Based Intervention for Mild Traumatic Brain Injury
Mindfulness is a promising tool which may foster adaptative interpersonal qualities to reduce the risk of persistent post-concussion symptoms.
- Trial name
- MBI-4-mTBI (NCT05105802)
- Testing
- Mindfulness-Based Intervention
- Where
- Canada
- Volunteers
- 99 people
- Sponsor
- Children's Hospital of Eastern Ontario
Mild Traumatic Brain Injury
Balance and Mild Traumatic Brain Injury: The Effect of a Weighted Compression Vest
After a mild traumatic brain injury (mTBI) people often report balance problems. At Parkwood hospital we have noticed that balance is improved when patients with mTBI wear a weighted compression vest.
- Trial name
- NCT02084329
- Testing
- Weighted Compression Vest
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Traumatic Brain Injury
Treating Emotional Processing Impairments in Individuals With TBI
The current project will examine the impact of an emotional processing intervention on emotional processing abilities in a sample of 50 persons with moderate to severe TBI. Outcome will be assessed across 3 domains.
- Trial name
- NCT03373331
- Testing
- Emotional Processing Training
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Kessler Foundation
Traumatic Brain Injury
Long Pressure Autoregulation Index
The pressure reactivity index (PRx) has emerged as a surrogate method for the continuous bedside estimation of global cerebral autoregulation and a significant predictor of unfavorable outcomes.
- Trial name
- Long PAx (NCT05043545)
- Where
- Italy
- Volunteers
- 263 people
- Sponsor
- Papa Giovanni XXIII Hospital
Posttraumatic Stress Disorder, Traumatic Brain Injury
Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder
Background: Some people who have a traumatic brain injury (TBI) recover completely. Others, however, develop post-traumatic stress disorder (PTSD), with anxiety and depression.
- Trial name
- NCT01547819
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Traumatic Brain Injury, Intracranial Hemorrhages
Improving Diagnosis and Prediction of Outcome in Patients With Severe Disorders of Consciousness
Patients with acute severe brain injury are usually admitted to the Intensive Care Unit. A substantial proportion of these patients will have disorders of consciousness (DOC) after interruption of sedation.
- Conditions
- Traumatic Brain Injury, Intracranial Hemorrhages, Subarachnoid Hemorrhage, Meningitis
- Trial name
- IMPROVE-DOC (NCT06283901)
- Where
- 5 sites in Netherlands
- Volunteers
- 160 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Traumatic Brain Injury
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy for the Treatment of Traumatic Brain Injury and Hypoxic-Ischemic Encephalopathy
This study aims to determine the safety of HB-adMSC infusion and treatment effects of HB-adMSC infusion on brain structure, neurocognitive/functional outcomes, and neuroinflammation after subacute and chronic neurological injury…
- Trial name
- NCT04063215
- Testing
- HB-adMSCs
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hope Biosciences LLC
Mild to Moderate Traumatic Brain Injury
PoNS Clinical Experience Program in Traumatic Brain Injury Patients (TBI)
Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT03881176
- Testing
- PoNS Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Helius Medical Inc
Hypoxic Ischaemic Encephalopathy Due to Cardiac Arrest
MLC901 in Hypoxic-ischemic Brain Injury Patients; A Double-blind, Randomized Placebo-controlled Trial
In a randomized, placebo-controlled trial, 35 patients with HIBI were randomly designated to receive either MLC901 or placebo capsules over six months.
- Trial name
- NCT05621590
- Testing
- MLC 901
- Where
- Iran
- Volunteers
- 35 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Traumatic Brain Injury, Cerebral Edema
Safety and Efficacy of ABX-101 in Participants Aged 18 to 50 Years of Age With Moderate to Severe Traumatic Brain Injury
The purpose of this study is to investigate the clinical improvement measured by the Glasgow Outcome Scale Extended (GOS-E) with ABX-101 compared with Placebo intramuscular injection in participants with moderate to severe TBI.
- Trial name
- NCT06096415
- Testing
- ABX-101 1mg, ABX-101 2mg
- Volunteers
- 45 people
- Sponsor
- Abalonex, LLC
TBI (Traumatic Brain Injury)
Long Lasting Effect of Hyperbaric Oxygen Therapy on Cognitive Function in Traumatic Brain Injury Patients
To evaluate the cognitive functions of patients who suffered brain injury due to traumatic head injury and were previously treated in a hyperbaric chamber between one and four years after the end of treatment.
- Trial name
- NCT07430150
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Traumatic Brain Injury
Overground Virtual Reality (VR) Gait Rehabilitation for Traumatic Brain Injury (TBI)
The purpose of this study is to evaluate a new virtual reality (VR)-based rehabilitation program designed to help individuals with traumatic brain injury (TBI) improve their walking abilities in real-world settings.
- Trial name
- NCT07038889
- Testing
- C-Mill VR+ by Motek, Walk-over-Ground
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Indiana University
Traumatic Brain Injury
Intermittent Oro-esophageal Tube Feeding in Traumatic Brain Injury Patients
This was a multicenter randomized controlled study of 98 severe Traumatic Brain Injury patients with tracheostomy. Patients enrolled were divided randomly into the observation group with Intermittent Oro-esophageal Tube Feeding…
- Trial name
- NCT06328985
- Testing
- Rehabilitation therapy, Intermittent Oro-esophageal Tube Feeding, Nasogastric tube feeding
- Where
- 2 sites in China
- Volunteers
- 98 people
- Sponsor
- Zeng Xi
Brain Injuries, Traumatic, Cognitive Impairment
Combined Cognitive and Vocational Interventions After Mild-to-moderate TBI: a Randomized Controlled Trial
A considerable number of patients with mild and moderate traumatic brain injury (TBI) experience long-lasting somatic, cognitive, and emotional symptoms that may hamper their capacity to return to work (RTW).
- Trial name
- NCT03092713
- Testing
- Combined cognitive (Compensatory Cognitive Training - CCT) and vocational rehabilitation (Supported Employment), Control Group
- Where
- Norway
- Volunteers
- 121 people
- Sponsor
- Oslo University Hospital
Traumatic Brain Injury
Spectral Correlates of Impulsivity in Patients With Traumatic Brain Injury
Transcranial electrical stimulation (tES) is a non-invasive form of brain stimulation that has previously been to shown to have therapeutic potential in traumatic brain injury (TBI) patients.
- Trial name
- NCT04239274
- Testing
- transcranial direct current stimulation, transcranial pulsed current stimulation
- Sponsor
- Medical University of South Carolina
Fatigue Symptom, Fatigue Intensity
Monitoring Fatigue In Daily Life In Adults With Cerebral Palsy or Acquired Brain Injury
The goal of this observational study is to learn about levels and patterns of fatigue in adults with cerebral palsy (CP) and acquired brain injury (ABI) in daily life.
- Conditions
- Fatigue Symptom, Fatigue Intensity, Cerebral Palsy (CP), Acquired Brain Injury Including Stroke
- Trial name
- NCT07135791
- Testing
- Real-time monitoring
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
TBI (Traumatic Brain Injury)
Nanopulse Laser Therapy
The purpose of this study is to evaluate the safety and effectiveness of a novel noninvasive therapy, Nanopulse Laser Therapy (NPLT), to improve recovery following traumatic brain injury (TBI).
- Trial name
- NCT07520383
- Testing
- Nano-Pulsed Laser Therapy (NPLT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Head Injury, Minor, Concussion, Mild
Heading in Football: Impact on Neural Blood Biomarkers
The goal of this observational study is to evaluate the safety of heading in football. We will study the release of biomarkers in blood that reflect microscopic neural damage.
- Conditions
- Head Injury, Minor, Concussion, Mild, CTE - Chronic Traumatic Encephalopathy, Neurodegeneration
- Trial name
- HEADLINE (NCT06147596)
- Testing
- Head impact exposure
- Where
- Netherlands
- Volunteers
- 335 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Mild Traumatic Brain Injury
Home-Based, Online, Mindfulness and Cognitive Training for Soldiers and Veterans With TBI
This study is a parallel arm, double-blind, randomized, controlled clinical trial to assess the safety and efficacy of an experimental software program designed to improve cognitive functions versus a computer-based software…
- Trial name
- CogMind (NCT02922569)
- Testing
- Computerized Plasticity-Based Adaptive Cognitive Training, Commercially available computerized training, Mindfulness Training
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Posit Science Corporation
Brain Injury, Craniocerebral Trauma
PariS-TBI Study : Paris Severe Traumatic Brain Injury Study
The primary objective of the protocol is to study the long-term outcome of a large group of traumatic brain injury patients. This outcome is to be described in terms of activity, participation, quality of life, SOCIO-professional…
- Conditions
- Brain Injury, Craniocerebral Trauma, Trauma Nervous System
- Trial name
- PariS-TBI (NCT01437683)
- Where
- France
- Volunteers
- 252 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris