Clinical trials: Achalasia Cardia
Achalasia
Post Operative Pain Control of POEM Procedure
Peroral endoscopic myotomy (POEM) is a minimally invasive treatment for esophageal achalasia with a natural orifice transluminal endoscopic procedure and far less invasive than the standard surgical or laparoscopic Heller myotomy…
- Trial name
- NCT04177342
- Testing
- Fentanyl, Oxycodone
- Volunteers
- 196 people
- Sponsor
- Chen Wannan
Esophageal Achalasia
Per Oral Endoscopic Myotomy (POEM) and Prolonged Dilatation (PRD) for Achalasia
Achalasia is an esophageal motility disorder, which leads to clinical symptoms such as dysphagia, regurgitation, chest pain and consecutive weight loss.
- Trial name
- POETA (NCT02518542)
- Testing
- Endoscopic intervention A, Endoscopic intervention B, Endoscopic intervention C
- Where
- Austria
- Volunteers
- 400 people
- Sponsor
- Medical University of Vienna
Achalasia
Pneumatic Dilatation or Surgical Myotomy for Achalasia
Patients with newly diagnosed achalasia have been submitted to either treatment with pneumatic dilatation or surgical myotomy. Minimal follow up five years.
- Trial name
- NCT02086669
- Testing
- Pneumatic dilatation, Laparoscopic myotomy
- Where
- Sweden
- Volunteers
- 56 people
- Sponsor
- Karolinska University Hospital
Achalasia Cardia
Serum Anti-enteric Neuronal Antibodies in Patients With Achalasia and Their Association With Clinical Profiles
Achalasia is a rare esophageal motility disorder characterized by impaired relaxation of the lower esophageal sphincter and progressive esophageal dilation.
- Trial name
- NCT07451301
- Testing
- peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 195 people
- Sponsor
- Peking Union Medical College Hospital
Esophageal Achalasia, Esophageal Motility Disorders
POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia
Achalasia is a disorder of the esophagus in which the muscular valve between the esophagus and the stomach fails to relax, and the body of the esophagus loses its normal coordinated squeezing movement.
- Conditions
- Esophageal Achalasia, Esophageal Motility Disorders, Gastroesophageal Reflux
- Trial name
- POEM-HD (NCT07814027)
- Testing
- Peroral endoscopic myotomy, Laparoscopic Heller myotomy with Dor fundoplication
- Where
- Egypt
- Volunteers
- 220 people
- Sponsor
- Minia University
Dysphagia, Achalasia, Esophageal
Evolution of the Chicago Classification: Bridging Physiology and Mechanics
Swallowing difficulties are extremely common and result in substantial morbidity, reduction in the quality of life, and mortality related to malnutrition and complications from regurgitation and aspiration.
- Conditions
- Dysphagia, Achalasia, Esophageal, Ineffective Esophageal Motility
- Trial name
- NCT06883175
- Testing
- FLIP, HRM, Prucalopride
- Where
- United States
- Volunteers
- 575 people
- Sponsor
- Northwestern University
Achalasia
Per-Oral Endoscopic Esophagomyotomy (POEM)
Achalasia is an esophageal motility disease that usually requires surgical intervention (esophagomyotomy). Laparoscopic techniques have reduced the morbidity associated with myotomy, but post-op GERD, wound infection, hernia and…
- Trial name
- POEM (NCT01635374)
- Testing
- Per-Oral Endoscopic Esophagomyotomy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Northwestern University
Achalasia
The Role That Peroral Endoscopic Myotomy (POEM) Could Play in the Treatment of Achalasia
Based on the work of the Doctors at the Mayo Clinic Rochester, a new technique for a less invasive treatment for Achalasia has been developed.
- Trial name
- POEM (NCT01584635)
- Testing
- Peroral Endoscopic Myotomy a less invasive treatment for Achalasia
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Esophageal Achalasia
POEM vs. Pneumatic Dilation for Esophageal Achalasia
The purpose of this study is to determine the efficacy and safety of peroral endoscopic myotomy (POEM) compared with pneumatic dilation in the treatment of esophageal achalasia.
- Trial name
- NCT01768091
- Testing
- POEM, Pneumatic dilation
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Esophageal Achalasia
Quality of Life After POEM for Achalasia
Achalasia is an esophageal motility disorder, characterized by insufficient lower esophageal sphincter relaxation and loss of esophageal peristalsis.
- Trial name
- NCT05010889
- Testing
- Peroral endoscopic myotomy (POEM)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Achalasia
Autonomic Dysfunction and Hemodynamic Instability During Per-oral Endoscopic Myotomy
This prospective observational study aims to investigate the association between the autonomic dysfunction and hemodynamic instability during per-oral endoscopic myotomy under general anesthesia in achalasia patients.
- Trial name
- NCT05772260
- Testing
- Per-oral endoscopic myotomy
- Where
- South Korea
- Volunteers
- 41 people
- Sponsor
- Gangnam Severance Hospital
Perforation Esophagus, Esophageal Cancer
Feasibility and Efficacy of a Combination of a SEMS and Vacuum Wound Treatment (VACStent)
Open, prospective, one-arm feasibility and efficacy study of a European conformity (CE) certified Combination product of two CE certified medical devices in the intended indication.
- Conditions
- Perforation Esophagus, Esophageal Cancer, Esophageal Achalasia, Esophageal Diseases
- Trial name
- VACStent (NCT03962179)
- Testing
- VACStent
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital of Cologne
Achalasia
POEM Anterior Versus Posterior Approach
Per-oral endoscopic myotomy (POEM) is an incisionless procedure used to treat esophageal achalasia, performed by GI endoscopist without cutting any surface of the human body.
- Trial name
- NCT02454335
- Testing
- Peroral Endoscopic Myotomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University
Comparison of Short- Term Success Rates of POEM With LHM, Comparison of Long-term Success Rates of POEM With LHM
Comparison of Peroral Endoscopic Myotomy (POEM) With Laparoscopic Heller Myotomy (LHM) for Treatment of Achalasia
For the treatment of Achalasia, LHM has been the only surgical therapy. Recently, an endoscopic approach for this therapy has been developed (peroral endoscopic Myotomy POEM).
- Trial name
- POEM3 (NCT02018705)
- Where
- 5 sites in Denmark, Germany and 2 more
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Esophageal Achalasia
A Randomized Comparison of Laparoscopic Myotomy and Pneumatic Dilatation for Achalasia
The purpose of this study is to compare pneumatic dilatation and laparoscopic Heller myotomy in patients with achalasia in order to learn which of these two treatments should be recommended to patients in the future.
- Trial name
- NCT00188344
- Testing
- pneumatic dilatation, laparoscopic myotomy with partial fundoplication
- Where
- 2 sites in Canada
- Volunteers
- 56 people
- Sponsor
- University Health Network, Toronto
Achalasia, Esophageal, Achalasia
The Use of Indocyanine Green Fluorescence (ICG) During Laparoscopic Heller- Dor
The aim this prospective observational study is to evaluate the role of Indocyanine Green Fluorescence (ICG) in patients with achalasia underwent to Heller-Dor laparoscopic.
- Conditions
- Achalasia, Esophageal, Achalasia, Indocyanine Green (ICG), Indocyanine Green
- Trial name
- NCT07181070
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Federico II University
Achalasia, Alacrima
Genetic Evaluation of AAAS Gene in Early-Onset Achalasia and Alacrima Patients
The AAAS gene has been known to cause achalasia, alacrima, adrenal abnormalities and a progressive neurological syndrome. A considerable proportion of achalasia patients have been known to show alacrima (decreased secretion of…
- Trial name
- AAAS (NCT00856921)
- Volunteers
- 19 people
- Sponsor
- Asan Medical Center
Esophageal Achalasia, Gastroparesis
Respiratory and Hemodynamic Implications of Endoscopic Myotomy of the Esophagus and Stomach
The goal of this observational study is to learn about hemodynamic and respiratory repercussions during general anesthesia in patients with achalasia or gastroparesis who underwent an endoscopic treatment such as a peroral…
- Trial name
- NCT05602272
- Testing
- General anesthesia for per-oral endoscopic myotomy
- Where
- Switzerland
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Esophageal Achalasia
Clinical Impact of Peroral Endoscopic Myotomy for Esophageal Achalasia
Achalasia is a rare esophageal motility disorder, which is characterized clinically by symptoms of dysphagia, regurgitation, weight loss and chest pain.
- Trial name
- NCT01649843
- Testing
- POEM
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Shanghai Zhongshan Hospital
Esophageal Motility Disorders, Achalasia
Clinical Outcomes, Safety, and Effectiveness of Speedboat UltraSlim™ in Per-Oral Endoscopic Myotomy (POEM)
This study is a prospective registry designed to evaluate the clinical outcomes, safety, and effectiveness of per-oral endoscopic myotomy (POEM) performed using the Speedboat UltraSlim™ device in patients with achalasia or other…
- Trial name
- SU-POEM (NCT07496840)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Baylor College of Medicine