Clinical trials: Achalasia
Reflux, Gastroesophageal, Achalasia
The Effect of Physiotherapy on Post POEM Reflux
Per-oral endoscopic myotomy has been used as a treatment method of esophageal achalasia. Patients who undergo POEM as a treatment of achalasia are often presented with development of reflux as a side effect of the surgery.
- Conditions
- Reflux, Gastroesophageal, Achalasia, Esophagitis
- Trial name
- NCT05326113
- Testing
- Physiotherapy, Control group
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Esophagus Disorder, Esophageal Achalasia
Impact of Antibiotic Prophylaxis in Per-oral Endoscopic Myotomy for Esophageal Motor Disorders
No recommendation regarding antibiotic prophylaxis and preparation modalities are available for patients with esophageal motor disorders who benefit from Per-Oral Endoscopic Myotomy (POEM).
- Trial name
- NCT03944863
- Testing
- Antibiotics
- Volunteers
- 252 people
- Sponsor
- Société Française d'Endoscopie Digestive
Achalasia
Short Vs Standard Length Myotomy in Achalasia
The objective of this randomized controlled trial (non-inferiority study) is to evaluate the outcomes of 4 cm short myotomy compared to the 8 cm standard length myotomy in Per-Oral Endoscopic Myotomy (POEM) for patients with…
- Trial name
- NCT04798547
- Testing
- Short Myotomy, Standard Length Myotomy
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Anorectal Disorder, Fecal Incontinence
Normal Values in Ano-rectal 3D High Resolution Manometry
Ano-rectal manometry is indicative in patients with either fecal incontinence or constipation. Recently anorectal 3D- high resolution manometry has been developed.
- Conditions
- Anorectal Disorder, Fecal Incontinence, Constipation
- Trial name
- NOMAD (NCT01710579)
- Testing
- Anorectal 3D-high resolution manometry, Anorectal radial endosonography (rotative 360° probe), Dynamic anorectal endosonography (sagittal and radial)
- Where
- France
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Achalasia, Dysphagia
Efficacy & Safety of Submucosal Endoscopic Myotomy With Mucosal Flap (SEMF) in the Treatment of Patients With Achalasia
The purpose of this study is to learn about the safety and usefulness of a procedure called endoscopic submucosal myotomy, which is a new technique in the treatment of achalasia.
- Trial name
- NCT01438398
- Testing
- Submucosal endoscopic myotomy with mucosal flap technique, Submucosal Endoscopic Mucosal Flap (SEMF) technique
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Winthrop University Hospital
Esophageal Achalasia, Esophageal Motility Disorders
Different Surgical Procedures of Peroral Endoscopic Myotomy(POEM) for Esophageal Achalasia
This study compares the clinical efficacy of safety of circular myotomy and full-thickness myotomy guided by peroral endoscopic in treatment of incision length of ≤7cm and of ≥7cm in achalasia patients.
- Trial name
- NCT03012854
- Testing
- short-myotomy, long-myotomy, full-thickness myotomy
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Achalasia
POEM- Peroral Endoscopic Myotomy for Esophageal Motility Disorders
POEM has recently described as an alternative treatment for achalasia in humans. In this procedure the esophageal sphincter is incised through a submucosal tunnel in the esophagus.
- Trial name
- POEM (NCT01512719)
- Testing
- POEM
- Where
- 3 sites in Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Ineffective Motility, Diffuse Esophageal Spasms
Reversibility of Dysmotility After Gastric Banding
In the current study we plan to evaluate the effects of the conversion from gastric banding to gastric bypass on esophageal function using combined monitoring.
- Conditions
- Ineffective Motility, Diffuse Esophageal Spasms, Achalasia-Like Dysmotility
- Trial name
- NCT00680030
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
Achalasia
A Prospective Study Comparing Two Reconstructive Operation Techniques After Myotomy of Achalasia
Achalasia is a rare motor disorder of the gastroesophageal junction which is associated with an increased pressure of the esophageal sphincter. This leads to impairment to swallow and heartburn.
- Trial name
- NCT01933373
- Testing
- Toupet, Dor
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Karolinska University Hospital
Achalasia
Comprehensive Esophageal Diagnostics Study
The prospective clinical trial will study muscle fibrosis in relation to lower esophageal sphincter (LES) measurements on Functional Lumen Imaging Probe (FLIP) Topography (the novel technology that utilizes impedance planimetry)…
- Trial name
- NCT04641702
- Testing
- Atropine challenge, Esophageal muscle biopsy
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Emory University
Achalasia
Per-Oral Endoscopic Myotomy
This is a prospective chart review/data collection study of the per oral endoscopic myotomy (POEM) procedure, that will include questionnaires administered throughout the study.
- Trial name
- POEM (NCT01402518)
- Testing
- Per-oral enodscopic myotomy
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, San Diego
Achalasia
VZV in the Enteric Nervous System: Pathogenesis and Consequences
Varicella zoster virus (VZV) is the cause of chickenpox and shingles, but it also infects, becomes latent, and reactivates in nerve cells of the bowel to cause a gastrointestinal disorder ("enteric shingles").
- Trial name
- NCT05550194
- Testing
- ValACYclovir 1000 MG, Shingrix
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Vanderbilt University Medical Center
Achalasia
Per-Oral Endoscopic Esophagomyotomy (POEM)
Achalasia is an esophageal motility disease that usually requires surgical intervention (esophagomyotomy). Laparoscopic techniques have reduced the morbidity associated with myotomy, but post-op GERD, wound infection, hernia and…
- Trial name
- POEM (NCT01635374)
- Testing
- Per-Oral Endoscopic Esophagomyotomy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Northwestern University
Esophageal Achalasia, Achalasia
Achalasia Patient Reported Outcomes
Patients that are either scheduled to undergo or have undergone an achalasia procedure at the Mayo Clinic Rochester are asked to participate.
- Conditions
- Esophageal Achalasia, Achalasia, Achalasia, Esophageal
- Trial name
- NCT02606578
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Mayo Clinic
Esophageal Achalasia
Comparison Study of Conventional POEM and Hybrid POEM for Esophageal Achalasia
Peroral endoscopic myotomy (POEM) has recently been introduced as promising alternative to laparoscopic Heller myotomy for patients with idiopathic achalasia.
- Trial name
- NCT01742494
- Testing
- Water-jet POEM, Conventional POEM
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai Zhongshan Hospital
Achalasia
POEM: Long vs Short Myotomy for Achalasia. RCT
Per-Oral Endoscopic Myotomy (POEM) is increasingly used for the treatment of achalasia. In published series, a 12cm-POEM is usually performed. Surgical myotomy is typically shorter (8cm).
- Trial name
- NCT03450928
- Testing
- Peroral Endoscopic Myotomy (POEM)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Catholic University of the Sacred Heart
Achalasia, Gastroesophageal Reflux
ARAT for Reflux Disease After Peroral Endoscopic Myotomy in Patients With Achalasia
The peroral endoscopic myotomy for the treatment of achalasia is associated with a higher incidence of gastroesophageal reflux disease compared with Heller's myotomy.
- Trial name
- ARAT (NCT04065516)
- Testing
- ARAT technique
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Achalasia Cardia, Tumor
Artificial Intelligence-Guided Detection of Blood Vessels to Enhance Safety in Third-Space Endoscopic Procedures
This prospective study aims to evaluate the performance of a novel Artificial Intelligence (AI) clinical decision support tool during third space endoscopic procedures, such as Endoscopic Submucosal Dissection (ESD) and Peroral…
- Trial name
- NCT07399652
- Testing
- AI generated segmentation mask for sub-mucosal blood vessels
- Where
- India
- Volunteers
- 40 people
- Sponsor
- Asian Institute of Gastroenterology, India
Achalasia
Efficacy of Dark Chocolate in Achalasia Patients
Flavanols, present in dark chocolate, were shown to induce Nitric Oxide synthesis. Since Nitric Oxide facilitates smooth muscle relaxation, it might ease the relaxation of the LES (lower esophageal sphincter)as well.
- Trial name
- NCT00790465
- Testing
- dark chocolate
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Achalasia Cardia
Randomised Trial Between LHM Alone Vs LHM With Anterior Fundoplication In Achalasia Cardia
Back ground: Achalasia Cardia (AC) manifests with major symptom dysphagia. Surgery as the treatment modality relieves dysphagia in most of the patients.
- Trial name
- NCT03438838
- Testing
- Laparoscopic Heller's myotomy, Anterior Fundoplication
- Where
- India
- Volunteers
- 20 people
- Sponsor
- Govind Ballabh Pant Hospital