Clinical trials: Abuse Liability
Opioid-use Disorder
Evaluation of Doxazosin to Alter the Abuse of Oxycodone
Healthy, adult men and women, aged 21 to 59 years, who abuse opioids and are physically dependent on them will be recruited to participate in a study to examine the ability of doxazosin, an epinephrine receptor blocker, to alter…
- Trial name
- NCT03415581
- Testing
- Intranasal Oxycodone, Cue Session
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- New York State Psychiatric Institute
Tobacco-Related Carcinoma
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]).
- Trial name
- NCT06249984
- Testing
- Biospecimen Collection, Carbon Monoxide Measurement, Smokeless Tobacco Use
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Smoking, Smoking Behaviors
Abuse Liability for Eight Electronic Nicotine Products
This will be a randomized, open-label, 8-way crossover, single-site study designed to evaluate elements of abuse liability (AL), including subjective effects and physiological measures (pharmacodynamics [PD]), and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07323511
- Testing
- Product A, Product B, Product C
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Abuse Potential
Study Evaluating the Abuse Potential of NEURONTIN® in Healthy Non-drug Dependent, Recreational Opioid Users
This will be a randomized, double-blind, double-dummy, placebo- and active-controlled, 6 treatment, 6-period crossover single-dose, Williams square design study in healthy male and/or female adult, non-drug-dependent recreational…
- Trial name
- NCT05319756
- Testing
- gabapentin 600 mg, gabapentin 1200 mg, gabapentin 600 mg and oxycodone HCl 20 mg
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Viatris Specialty LLC
ADHD, Narcolepsy
Pilot Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Abuse Liability of an Abuse-Deterrent Immediate-Release Formulation (ADAIR)
This is a pilot randomized, double-blind, active-controlled, 2-treatment, crossover study to evaluate the PK, user experience and abuse liability of manipulated ADAIR compared to a manipulated commercially-available d-amphetamine…
- Trial name
- NCT04232644
- Testing
- ADAIR 10mg IR capsules, Crushed d-amphetamine sulfate IR tablets
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Vallon Pharmaceuticals, Inc.
Smoking Behaviors
C-FLASH (Cigarillo Flavor and Abuse Liability, Attention, and Substitution in youtH)
The purpose of this research is to understand how flavor affects young adult's perceptions of little cigar or cigarillo use.
- Trial name
- NCT04358705
- Testing
- Aim 1: Online survey, Eye Tracking Activity, Eye tracking survey
- Where
- United States
- Volunteers
- 658 people
- Sponsor
- Case Comprehensive Cancer Center
Healthy Volunteer
A Study of the Abuse Liability Potential of Cenobamate in Recreational Drug Users
This randomized, single-dose, placebo- and active-controlled, crossover study will evaluate the abuse liability potential of cenobamate in recreational drug users with sedative drug use experience.
- Trial name
- NCT03509285
- Testing
- Alprazolam, Cenobamate
- Where
- 2 sites in United States, Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- SK Life Science, Inc.
Opioid Abuse
Study of the Abuse Liability of Oxycodone HCl/Niacin in Subjects With a History of Opioid Abuse
The purpose of this study is to assess the abuse liability of 4 times (8 tablets) the usual recommended dose of Acurox (oxycodone HCl 40 mg plus niacin 240 mg) versus oxycodone HCL 40 mg alone in subjects with a history of opioid…
- Trial name
- NCT00699010
- Testing
- Acurox 5/30mg taken first, Oxycodone 5mg taken first
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Acura Pharmaceuticals Inc.
Tobacco Use
Oral Nicotine Pouch Marketing Features Influence on Perceptions
This study tests the effects of three oral nicotine marketing features on product perceptions.
- Trial name
- NCT06605924
- Testing
- Tobacco-free, Discrete, Convenient
- Where
- United States
- Volunteers
- 5,133 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Smoking, Smoking Behaviors
Abuse Liability of Two Modern Oral Nicotine Pouched Products
This is a single-site, open-label, randomized, 4-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine…
- Conditions
- Smoking, Smoking Behaviors, Tobacco Use, Tobacco Smoking
- Trial name
- NCT07595055
- Testing
- Usual Brand (UB) filtered, menthol or non-menthol combustible cigarette, Modern Oral Pouch Wintergreen-A 9 mg Nicotine, Modern Oral Pouch Wintergreen-B 9 mg Nicotine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Opioid Use Disorder
NT-814: Evaluation of Its Ability to Alter the Abuse Liability of Oxycodone in an Exploratory Clinical Study
Healthy adult men who abuse opioids and are physically dependent on them will be invited to participate in a study to examine the ability of NT-814, a neurokinin (NK) antagonist at the 1 and 3 receptor subtypes, to alter the…
- Trial name
- NT-814 (NCT02692157)
- Testing
- NT-814 50 mg, NT-814 100 mg, NT-814 200 mg
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Smoking
Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Electronic Cigarettes vs Combustible Cigarettes and Nicotine Gum
The purpose of this study is to measure plasma nicotine uptake parameters, physiological measures, and subjective effect measures in smokers during and following a single ad libitum use of three electronic cigarettes versus…
- Trial name
- NCT02269514
- Testing
- Own Brand Cigarette, Electronic Cigarette #1, Electronic Cigarette #2
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Vapor Company
Tobacco Use
Baby Albert: Electronic Cigarette Pharmacokinetics (PK) and Abuse Liability
The overall aim of the current research is to understand purchasing and product choice behaviors of tobacco/nicotine users if banning the sale of fully nicotinized cigarettes were to go into effect.
- Trial name
- NCT03637452
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Opioid-related Disorders
Abuse Liability of Suboxone Versus Subutex
The study is designed to compare the abuse liabilities of intravenous buprenorphine and buprenorphine/naloxone in individuals who are physically dependent on sublingual buprenorphine.
- Trial name
- NCT00710385
- Testing
- Heroin, Naloxone, Low Bup Dose
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Opioid Abuse, Unspecified, Opioid Dependence
Reducing the Abuse of Opioids in Drug Users
The consequences of prescription opioid abuse are serious and the number of deaths from unintended overdose have quadrupled over the last 15+ years.
- Trial name
- NCT03837860
- Testing
- Oxycodone/Risperidone, Oxycodone/Ziprasidone
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Abuse Liability of Staccato Alprazolam
Staccato Alprazolam Abuse Liability
Compare the abuse liabilities of Staccato Alprazolam, oral immediate-release alprazolam, and Staccato Placebo.
- Trial name
- NCT00603980
- Testing
- Inhaled alprazolam 0.5 mg, Inhaled alprazolam 1 mg, Inhaled alprazolam 2 mg
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Nova Pneuma Inc.
Smoking, Tobacco Use
CSD201301: Study to Assess Elements of Abuse Liability for Four P13 Nicotine Pouches
This is a two-site, open-label, randomized, 6-way cross-over study designed to evaluate elements of abuse liability (AL) including subjective effects and physiological measures (pharmacodynamics [PD]) and plasma nicotine uptake…
- Conditions
- Smoking, Tobacco Use, Tobacco Smoking
- Trial name
- NCT05294497
- Testing
- Product A, Product B, Product C
- Where
- 2 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Primary Insomnia
Safety and Efficacy of Chronic Hypnotic Use
The purpose of the study is to determine how safe and effective it is for people with insomnia to use zolpidem on a nightly basis for one year.
- Trial name
- NCT01006525
- Testing
- zolpidem
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Drug Abuse, Healthy
Study in Healthy Recreational Polydrug Users to Measure the Abuse Potential of TC-5214
This is a single dose, crossover study to assess the abuse potential of TC-5214 compared to placebo, ketamine, and phentermine in healthy recreational polydrug users.
- Trial name
- TC-5214 (NCT01500018)
- Testing
- TC-5214, Ketamine, Phentermine
- Volunteers
- healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
A Study to Characterize the Abuse Liability of ALO-02 in Healthy, Non-Dependent, Recreational Opioid Users When ALO-02 Capsules Are Crushed and Snorted
The main purpose of this study is to determine if oxycodone and naltrexone combination capsules (ALO-02) have the potential to be abused when they are crushed and snorted.
- Trial name
- NCT01775189
- Testing
- crushed ALO-02 30 mg/3.6 mg, crushed oxycodone IR 30 mg
- Where
- Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pfizer