Tobacco-Related CarcinomaNCT06249984
Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
A study testing Biospecimen Collection, Carbon Monoxide Measurement and Smokeless Tobacco Use in people with Tobacco-Related Carcinoma, run by Ohio State University Comprehensive Cancer Center at 2 sites in United States.
Trial summary
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long… Read more about this study
- Who is it for?
- Ages 21 years and olderHealthy volunteers can take part
- Conditions the study is for
- Tobacco-Related Carcinoma
- What is being tested?
- Biospecimen Collection, Carbon Monoxide Measurement and Smokeless Tobacco Use
- Type of treatment
- Surgery or procedure, Lifestyle or therapy programme
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 80 participants
- Where
- 2 sitesUnited States
- Study dates
- 20 Dec 2024to 31 Jan 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 21 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project
- Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week.
- Age 21 years or older
- Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification
- Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
- Willing to abstain from nicotine and tobacco products 12-hours before study visit
- Ability to read and speak English
Who cannot join
- Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit)
- Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
- History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months
- Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months
- Severe periodontal or oral lesions
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
United States2 sites, 2 recruiting
- Not yet recruiting
Ohio State University Comprehensive Cancer Center
Columbus, Ohio, 43210
Brittney L. Keller-Hamilton, Phd, MPH, 614-366-9652, keller-hamilton.1@osu.edu
Brittney L. Keller-Hamilton, Phd, MPH
- Recruiting
Center for Tobacco Research
Columbus, Ohio, 43214
Hayley Curran, MPH, 7402818555, curran.144@osu.edu
Brittney Keller-Hamilton, PhD, 7402818555, bkh-lab@osumc.edu
About this study
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.
Read the detailed description
PRIMARY OBJECTIVES:
- Estimate the association between style of moist snuff and SLT addiction among Ohio Appalachian adolescents and adults.
II. Characterize the carcinogen and free-base nicotine content of SLT products used by adolescents and adults with varying levels of SLT dependence in Ohio Appalachia.
III. Assess effects of moist snuff tobacco cut and FBN content on product use, effects, and appeal among Appalachian adults with high versus (vs.) low SLT dependence.
OUTLINE: Participants attend 5 study visits in a randomized order.
VISIT I: Participants use their usual brand of moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT II: Participants use low FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT III: Participants use low FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT IV: Participants use high FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT V: Participants use high FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
- Conditions
- Tobacco-Related Carcinoma
- Being tested
- Biospecimen Collection, Carbon Monoxide Measurement, Smokeless Tobacco Use, Survey Administration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Biospecimen CollectionProcedure or surgery
Also called Biological Sample Collection, Biospecimen Collected, Specimen Collection
Undergo blood sample collection
Carbon Monoxide MeasurementProcedure or surgery
Also called Carbon Monoxide, CMONOX
Undergo CO test
Smokeless Tobacco UseBehavioural
Also called Tobacco, Smokeless
Use moist snuff
Survey AdministrationOther
Ancillary studies
| Study group | Role | What they receive |
|---|---|---|
| Prevention (Smokeless tobacco use: Usual Brand) | Placebo comparator | Participants use their usual brand of moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. Receives: Procedure: Biospecimen Collection; Procedure: Carbon Monoxide Measurement; Behavioral: Smokeless Tobacco Use; Other: Survey Administration |
| Prevention (Smokeless tobacco use: Low FBN Long Cut) | Active comparator | Participants use low FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. Receives: Procedure: Biospecimen Collection; Procedure: Carbon Monoxide Measurement; Behavioral: Smokeless Tobacco Use; Other: Survey Administration |
| Prevention (Smokeless tobacco use: Low FBN Fine Cut) | Active comparator | Participants use low FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. Receives: Procedure: Biospecimen Collection; Procedure: Carbon Monoxide Measurement; Behavioral: Smokeless Tobacco Use; Other: Survey Administration |
| Prevention (Smokeless tobacco use: High FBN Long Cut) | Active comparator | Participants use high FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. Receives: Procedure: Biospecimen Collection; Procedure: Carbon Monoxide Measurement; Behavioral: Smokeless Tobacco Use; Other: Survey Administration |
| Prevention (Smokeless tobacco use: High FBN Fine Cut) | Active comparator | Participants use high FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. Receives: Procedure: Biospecimen Collection; Procedure: Carbon Monoxide Measurement; Behavioral: Smokeless Tobacco Use; Other: Survey Administration |
What is being measured
The primary outcome is the main question the study is designed to answer.
Moist snuff tobacco FBN content on product use
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Measured: Up to 2 years
Moist snuff tobacco cut on product effects
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of cut on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Measured: Up to 2 years
Moist snuff tobacco FBN content on product effects
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Measured: Up to 2 years
Moist snuff tobacco cut on product appeal
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use, nicotine delivery, and subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of cut on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Measured: Up to 2 years
Moist snuff tobacco FBN content on product appeal
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use, nicotine delivery, and subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Measured: Up to 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Feb 2024
- Study start20 Dec 2024
- Primary completion1 Mar 2027 (estimated)
- Study completion31 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Tobacco-Related CarcinomaStudies of the same condition, open and under way.
- More trials run by Ohio State University Comprehensive Cancer CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- Within-subjects factorial design
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Sponsor type
- University, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Responsible party
- Principal investigator, Brittney Keller-Hamilton, Ohio State University Comprehensive Cancer Center
- Investigators
- Brittney L Keller-Hamilton, PhD, MPH, Principal investigator, Ohio State University Comprehensive Cancer Center
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06249984
- Sponsor's protocol ID
- OSU-22228
- Other IDs
- NCI-2023-01289, K01DA055696
- Status last verified
- Aug 2026
- First submitted
- 22 Jan 2024
- Last updated
- 17 Aug 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 17 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Tobacco Cut and Nicotine Form on the Abuse Liability of Moist Snuff
- ClinicalTrials.gov ID
- NCT06249984
- Acronym / sponsor ID
- OSU-22228
- Conditions
- Tobacco-Related Carcinoma
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Ohio State University Comprehensive Cancer CenterUniversity, hospital or other
- Collaborators
- National Institute on Drug Abuse (NIDA)
- Study start
- 20 Dec 2024 (actual)
- Primary completion
- 1 Mar 2027 (estimated)
- Study completion
- 31 Jan 2028 (estimated)
- First posted
- 8 Feb 2024 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This clinical trial tests the effects of tobacco cut and nicotine form on the abuse liability in participants who use moist snuff (smokeless tobacco [SLT]). Two features of moist snuff that are key targets of manipulation from the tobacco industry and drivers of its addiction potential are length of tobacco cut (long versus fine) and nicotine form (low versus high levels of nicotine in the free-base form). Finer tobacco cuts and higher levels of free-base nicotine (FBN) result in faster, greater nicotine delivery. Researchers want to gain information on how certain characteristics of moist snuff affect how long people use it, how it delivers nicotine, or how much people like it. This clinical trial may provide justifications for local, state, or federal regulations aimed at reducing the appeal and addictiveness of moist snuff.
Detailed description
PRIMARY OBJECTIVES:
- Estimate the association between style of moist snuff and SLT addiction among Ohio Appalachian adolescents and adults.
II. Characterize the carcinogen and free-base nicotine content of SLT products used by adolescents and adults with varying levels of SLT dependence in Ohio Appalachia.
III. Assess effects of moist snuff tobacco cut and FBN content on product use, effects, and appeal among Appalachian adults with high versus (vs.) low SLT dependence.
OUTLINE: Participants attend 5 study visits in a randomized order.
VISIT I: Participants use their usual brand of moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT II: Participants use low FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT III: Participants use low FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT IV: Participants use high FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
VISIT V: Participants use high FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Single blind (participant)
- Number of arms
- 5
- Model description
- Within-subjects factorial design
| Arm | Type | Receives |
|---|---|---|
| Prevention (Smokeless tobacco use: Usual Brand) | Placebo comparator | Procedure: Biospecimen Collection, Procedure: Carbon Monoxide Measurement, Behavioral: Smokeless Tobacco Use, Other: Survey AdministrationParticipants use their usual brand of moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. |
| Prevention (Smokeless tobacco use: Low FBN Long Cut) | Active comparator | Procedure: Biospecimen Collection, Procedure: Carbon Monoxide Measurement, Behavioral: Smokeless Tobacco Use, Other: Survey AdministrationParticipants use low FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. |
| Prevention (Smokeless tobacco use: Low FBN Fine Cut) | Active comparator | Procedure: Biospecimen Collection, Procedure: Carbon Monoxide Measurement, Behavioral: Smokeless Tobacco Use, Other: Survey AdministrationParticipants use low FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. |
| Prevention (Smokeless tobacco use: High FBN Long Cut) | Active comparator | Procedure: Biospecimen Collection, Procedure: Carbon Monoxide Measurement, Behavioral: Smokeless Tobacco Use, Other: Survey AdministrationParticipants use high FBN long cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. |
| Prevention (Smokeless tobacco use: High FBN Fine Cut) | Active comparator | Procedure: Biospecimen Collection, Procedure: Carbon Monoxide Measurement, Behavioral: Smokeless Tobacco Use, Other: Survey AdministrationParticipants use high FBN fine cut moist snuff on study. Participants also undergo blood sample collection and carbon monoxide testing on study. |
Who may qualify
- Ages
- 21 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (7 listed)
- Adults aged 21 and older who reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification and use SLT daily for at least 3 months and using 1.5 cans/week will be considered for this project
- Established moist snuff user (has used moist snuff daily for at least the past 3 months, uses at least 1.5 cans/week.
- Age 21 years or older
- Reside in Appalachian counties and surrounding rural areas under the RUCA code 10 classification
- Willing to complete 5 study visits and provide informed consent study procedures, including abstaining from all tobacco, nicotine, and marijuana for 12 hours before clinic visits
Key exclusion criteria (5 listed)
- Pregnant, planning to become pregnant, or breastfeeding (will be verified with a urine pregnancy test at the first session visit)
- Unstable or significant psychiatric conditions (past and stable conditions will be allowed)
- History of cardiac event or distress, including but not limited to uncontrolled high blood pressure, chest pain, and shortness of breath, within the past 3 months
- Working with a cessation counselor, using cessation devices such as Chantix or Wellbutrin, or planning to quit within the next 3 months
- Severe periodontal or oral lesions
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Biospecimen CollectionAlso: Biological Sample Collection, Biospecimen Collected, Specimen CollectionUndergo blood sample collection | Procedure or surgery | Prevention (Smokeless tobacco use: High FBN Fine Cut), Prevention (Smokeless tobacco use: High FBN Long Cut), Prevention (Smokeless tobacco use: Low FBN Fine Cut), Prevention (Smokeless tobacco use: Low FBN Long Cut), Prevention (Smokeless tobacco use: Usual Brand) |
| Carbon Monoxide MeasurementAlso: Carbon Monoxide, CMONOXUndergo CO test | Procedure or surgery | Prevention (Smokeless tobacco use: High FBN Fine Cut), Prevention (Smokeless tobacco use: High FBN Long Cut), Prevention (Smokeless tobacco use: Low FBN Fine Cut), Prevention (Smokeless tobacco use: Low FBN Long Cut), Prevention (Smokeless tobacco use: Usual Brand) |
| Smokeless Tobacco UseAlso: Tobacco, SmokelessUse moist snuff | Behavioural | Prevention (Smokeless tobacco use: High FBN Fine Cut), Prevention (Smokeless tobacco use: High FBN Long Cut), Prevention (Smokeless tobacco use: Low FBN Fine Cut), Prevention (Smokeless tobacco use: Low FBN Long Cut), Prevention (Smokeless tobacco use: Usual Brand) |
| Survey AdministrationAncillary studies | Other | Prevention (Smokeless tobacco use: High FBN Fine Cut), Prevention (Smokeless tobacco use: High FBN Long Cut), Prevention (Smokeless tobacco use: Low FBN Fine Cut), Prevention (Smokeless tobacco use: Low FBN Long Cut), Prevention (Smokeless tobacco use: Usual Brand) |
Primary outcome
Moist snuff tobacco FBN content on product use
Time frame: Up to 2 years
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Moist snuff tobacco cut on product effects
Time frame: Up to 2 years
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of cut on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Moist snuff tobacco FBN content on product effects
Time frame: Up to 2 years
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Moist snuff tobacco cut on product appeal
Time frame: Up to 2 years
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use, nicotine delivery, and subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of cut on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Moist snuff tobacco FBN content on product appeal
Time frame: Up to 2 years
Will be assessed by a randomized 2x2 within-subjects design to test whether variations in cut and level of FBN are associated with product use, nicotine delivery, and subjective effects among Appalachian moist snuff users. Data will be summarized descriptively, overall and stratified by dependence. The investigators will use linear mixed effects models to assess the main effects of FBN content on moist snuff use duration and amount, self-reported measures, and plasma nicotine delivery (i.e., maximum absorption; total absorption; and speed of absorption). Product interaction terms will be used to evaluate whether effects of moist snuff style on outcome variables are modified by level of SLT dependence.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 17 Aug 2026.
- The JameslineLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Brittney L Keller-Hamilton, PhD, MPH principal investigator
Ohio State University Comprehensive Cancer Center
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Biospecimen Collection, Carbon Monoxide Measurement and Smokeless Tobacco Use in people with Tobacco-Related Carcinoma, run by Ohio State University Comprehensive Cancer Center at 2 sites in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 7 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 17 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact The Ohio State Comprehensive Cancer Center (800-293-5066, OSUCCCClinicaltrials@osumc.edu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Moist snuff tobacco FBN content on product use (time frame: Up to 2 years). The study lists 5 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Aug 2026.