Clinical trials: Ablation of Atrial Fibrillation
Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation
OPTION-EMEA Clinical Trial
The OPTION-EMEA post-market study is intended to gather real world clinical data for patients undergoing AF ablation with the FARAPULSE™ Pulsed Field Ablation (PFA) System and subsequent left atrial appendage closure (LAAC) with…
- Conditions
- Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation, Left Atrial Appendage Closure, Pulsed Field Ablation
- Trial name
- OPTION-EMEA (NCT07349121)
- Testing
- Concomitant pulsed field ablation (PFA) and left atrial appendage closure (LAAC) during one interventional case, Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure
- Where
- 11 sites in Belgium, Croatia and 3 more
- Volunteers
- 500 people
- Sponsor
- Boston Scientific Corporation
Atrial Fibrillation (AF), Ablation Treatment
Mazdutide for Reducing Atrial Fibrillation Recurrence After Catheter Ablation in Obese Patients
This is a multicenter, open-label, superiority randomized controlled trial enrolling adult patients aged 18 to 75 years. All participants have abdominal obesity (BMI ≥ 28 kg/m² with specific waist circumference standards) and…
- Conditions
- Atrial Fibrillation (AF), Ablation Treatment, Obesity & Overweight, Mazdutide
- Trial name
- MOTIVE-AF (NCT07897305)
- Testing
- Mazdutide, Conventional treatment
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation (AF), Cardiac Arrhythmia
Association Between Circulating BDNF Levels and Atrial Cardiomyopathy in Patients Undergoing Ablation for Persistent Atrial Fibrillation
trial fibrillation (AF) is the most common cardiac arrhythmia worldwide, and its prevalence continues to rise. AF is associated with serious complications, including embolic strokes, heart failure, and mortality.
- Conditions
- Atrial Fibrillation (AF), Cardiac Arrhythmia, Atrial Fibrillation Ablation, BDNF
- Trial name
- METAPROFIL 2 (NCT07648329)
- Testing
- blood draw, CT scan
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Atrial Fibrillation, Pulsed Field Ablation
A Registry on the FARAVIEW Technology of the OPAL HDx Mapping System When Used With the FARAWAVE NAV Ablation Catheter in the Treatment of Atrial Fibrillation
The study is designed to collect data on the acute and long-term (1 year) safety and effectiveness outcome when an ablation procedure is performed in a commercial and standard of care setting with the FARAPULSE™ Pulsed Field…
- Conditions
- Atrial Fibrillation, Pulsed Field Ablation, FARAPULSE
- Trial name
- OPALISE (NCT06808217)
- Testing
- FARAPULSE Pulsed Field Ablation System
- Where
- 22 sites in Austria, France and 8 more
- Volunteers
- 550 people
- Sponsor
- Boston Scientific Corporation
Paroxysmal Atrial Fibrillation, Pulsed Field Ablation
Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left Atrial Function Protection
This is a prospective clinical study aiming to evaluate the clinical efficacy and safety of a novel domestic pulsed field ablation (PFA) system in the treatment of paroxysmal atrial fibrillation (PAF), and to specifically assess…
- Conditions
- Paroxysmal Atrial Fibrillation, Pulsed Field Ablation, Catheter Ablation, Left Atrial Function
- Trial name
- NCT07865221
- Testing
- Novel Pulsed Field Ablation System, Radiofrequency Ablation Catheter
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University General Hospital
Persistent Atrial Fibrillation, Atrial Fibrillation (AF)
Atrial Remodeling After PFA Substrate Modification for Persistent AF (PeAF)
Atrial fibrillation (AF) is associated with both electrical and structural remodeling of the left atrium. While successful catheter ablation has been shown to reverse some aspects of atrial remodeling, the impact of pulsed-field…
- Conditions
- Persistent Atrial Fibrillation, Atrial Fibrillation (AF), Atrial Remodeling, Pulsed Field Ablation
- Trial name
- NCT07675395
- Testing
- Pulsed-Field Ablation with FARAWAVE Catheter System
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Atrial Fibrillation (AF), Atrial Fibrillation Ablation
Catheter Ablation vs Conservative Care in Elderly Patients With Atrial Fibrillation
ACE-AF is a multicenter randomized study in people aged 78 years and older with symptomatic atrial fibrillation (AF). AF is a common heart rhythm disorder in older adults and can cause reduced quality of life and lead to serious…
- Conditions
- Atrial Fibrillation (AF), Atrial Fibrillation Ablation, Elderly
- Trial name
- ACE-AF (NCT07424690)
- Testing
- Catheter Ablation for Atrial Fibrillation, Optimized Medical Therapy for Atrial Fibrillation, Implantable Loop Recorder (ILR)
- Where
- 2 sites in Sweden
- Volunteers
- 282 people
- Sponsor
- Karolinska University Hospital
Persistent Atrial Fibrillation, Cardiac Arrhythmia
Investigation of Cardioversion Versus Therapeutic Ablation for Persistent AF (ORBICA-AF)
The main aim of the research is to investigate whether patients undergoing pulmonary vein isolation with catheter ablation for persistent atrial fibrillation (AF) will have lower rates of AF recurrence than those treated by DC…
- Conditions
- Persistent Atrial Fibrillation, Cardiac Arrhythmia, Catheter Ablation
- Trial name
- ORBICA-AF (NCT06096246)
- Testing
- Pulmonary vein isolation, DC Cardioversion, Implantable loop recorder
- Where
- United Kingdom
- Volunteers
- 208 people
- Sponsor
- Barts & The London NHS Trust
Combined Pulsed-field Ablation (PFA)
Combined Pulsed-field Ablation (PFA) and Left Atrial Appendage Occlusion Using Watchman Flx or Amulet
AF ablation is an established treatment option for non-valvular atrial fibrillation (NVAF). While AF ablation helps to maintain cardiac rhythm in sinus, the stroke risk associated with AF persists after ablation.
- Trial name
- COMPAWA (NCT05560204)
- Testing
- Combined Pulsed-field Ablation (PFA) + Left Atrial Appendage Occlusion (LAAO)
- Where
- Hong Kong
- Volunteers
- 200 people
- Sponsor
- Prince of Wales Hospital, Shatin, Hong Kong
Atrial Fibrillation, Maze Procedure
CellFX® Nanosecond Pulsed Field Ablation (nsPFA)™ Cardiac Surgery Clamp System to Treat Atrial Fibrillation
The primary objective of this Pivotal study is to demonstrate the safety and effectiveness of the Pulse Biosciences nsPFA™ Cardiac Surgery System in treating atrial fibrillation during concomitant cardiac surgical procedures.
- Conditions
- Atrial Fibrillation, Maze Procedure, AF, Ablation
- Trial name
- NANOCLAMP-AF (NCT06959121)
- Testing
- CellFX® nsPFA™ Cardiac Surgery System
- Where
- 3 sites in United States
- Volunteers
- 135 people
- Sponsor
- Pulse Biosciences, Inc.
Atrial Fibrillation (AF), Pulsed Field Ablation
Evaluation of the Factors Associated With BRADYcardia Following Pulmonary Vein Isolation Using Pulsed Field Ablation
The study aims to identify factors associated with bradycardia during the hospital stay after ablation of atrial fibrillation performed with pulsed field technology.
- Conditions
- Atrial Fibrillation (AF), Pulsed Field Ablation, Bradycardia
- Trial name
- BRADY-PFA (NCT07809347)
- Testing
- Pulmonary vein isolation
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Wroclaw Medical University
Atrial Fibrillation, Catheter Ablation
Randomized Controlled Trial- Ablation Strategy for Paroxysmal Atrial Fibrillation - Trigger and Substrate Guided Wide Area Radiofrequency Ablation Compared to Pulsed Field Ablation Pulmonary Vein Isolation
Atrial fibrillation (AF) is a common heart rhythm disorder affecting over a million people in North America and is associated with serious complications including stroke, heart failure, reduced quality of life, and premature…
- Conditions
- Atrial Fibrillation, Catheter Ablation, Radiofrequency Catheter Ablation
- Trial name
- AWARE-2 (NCT04823299)
- Testing
- PVI-ONLY, CONTROL ARM, PVI-PLUS ARM, INTERVENTIONAL ARM
- Where
- 2 sites in Canada
- Volunteers
- 556 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Atrial Fibrillation, Thoracoscopic Ablation
Thoracoscopic Versus Catheter Ablation in Persistent Atrial Fibrillation With Enlarged Left Atrium
This is a prospective, single-center, open-label, randomized controlled trial comparing thoracoscopic surgical ablation with percutaneous endocardial catheter ablation as the first rhythm-control procedure in patients with…
- Conditions
- Atrial Fibrillation, Thoracoscopic Ablation, Endocardial Ablation
- Trial name
- NCT07783984
- Testing
- Thoracoscopic ablation, Percutaneous catheter ablation
- Where
- South Korea
- Volunteers
- 194 people
- Sponsor
- Samsung Medical Center
Atrial Fibrillation, Post-Catheter Ablation Atrial Arrhythmia Recurrence
Ezetimibe for Arrhythmia Recurrence After AF Ablation
This single-center, prospective, single-blind randomized controlled pilot trial aims to explore whether oral ezetimibe can reduce the 6-month recurrence rate of atrial tachyarrhythmia after catheter ablation in patients with…
- Trial name
- EAFA (NCT07752758)
- Testing
- Ezetimibe, Standardized post-ablation clinical management
- Volunteers
- 120 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Atrial Fibrillation (AF), Pulsed-field Ablation
Durability of Pulmonary Vein Isolation With Farapulse System Using Minimal Fluoroscopy
Objective: To evaluate the feasibility, acute, and three-month efficacy and safety of near-zero fluoroscopy PVI performed with the Farapulse system (Faravawe catheter, Faradrive sheath, Faraview module).
- Trial name
- Faraview Remap (NCT07752771)
- Testing
- catheter ablation
- Where
- Hungary
- Volunteers
- 20 people
- Sponsor
- Semmelweis University
Atrial Fibrillation (AF), Atrial Fibrillation Catheter Ablation
The COMBINE-AF Trial
The goal of this clinical trial is to test if a more complete ablation procedure works better than the standard procedure for people with long-lasting persistent atrial fibrillation (AF).
- Trial name
- COMBINE-AF (NCT07633509)
- Testing
- Linear ablation of mitral isthmus and tricuspid isthmus, Ethanol, Radiofrequency Ablation Catheter
- Where
- 3 sites in China
- Volunteers
- 430 people
- Sponsor
- Yunlong Wang
Atrial Fibrillation, Obesity & Overweight
Effect of Tirzepatide on Recurrence of Atrial Fibrillation After Catheter Ablation in Obese Patients
Obese patients with atrial fibrillation (AF) have a high recurrence rate after catheter ablation, even at experienced centers. Weight reduction improves post-ablation outcomes, but lifestyle measures alone are difficult to…
- Conditions
- Atrial Fibrillation, Obesity & Overweight, Catheter Ablation
- Trial name
- TEAR-AF (NCT07715929)
- Testing
- Tirzepatide, Structured Lifestyle Intervention
- Volunteers
- 710 people
- Sponsor
- Yunlong Wang
Atrial Fibrillation, Atrial Tachycardia
Empiric Pulsed Field Pulmonary Vein Isolation During Atrial Tachycardia Ablation in Adults With Congenital Heart Disease
This is a prospective, single-arm intervention trial whereby we will test the safety and efficacy of performing pulmonary vein isolation (PVI) using pulsed field ablation (PFA) in adult patients with congenital heart disease…
- Conditions
- Atrial Fibrillation, Atrial Tachycardia, Atrial Flutter, Congenital Heart Disease
- Trial name
- NCT06969378
- Testing
- Pulsed field ablation using a pentaspline ablation catheter
- Sponsor
- Boston Children's Hospital
ATRIAL APPENDAGE CLOSURE for ATRIAL FIBRILLATION, PFA Ablation and LAAC Procedures
Left Atrial Appendage Closure With Versus Without Pulsed Field Ablation in Atrial Fibrillation Patients With Mild Symptoms and High Stroke Risk
This study is a prospective, multicenter, single-blinded, randomized controlled trial to investigate whether concomitant left atrial appendage closure (LAAC) and pulsed field ablation (PFA) is more effective than LAAC alone in…
- Trial name
- REVERSE-OPTION (NCT07453940)
- Testing
- LAAC plus PFA for persistent AF with high risk of stroke, LAAC for persistent AF with high risk of stroke
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Sir Run Run Shaw Hospital
Atrial Fibrillation Ablation, Persistent Atrial Fibrillation
Tirzepatide to Reduce rEcurrence And Burden After Ablation of Atrial Fibrillation
The goal of this clinical trial is to determine whether tirzepatide can reduce atrial fibrillation (AF) burden after catheter ablation in overweight or obese patients with persistent AF.
- Conditions
- Atrial Fibrillation Ablation, Persistent Atrial Fibrillation, Obesity & Overweight
- Trial name
- TREAT-AF (NCT07382024)
- Testing
- Tirzepatide, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital