Clinical trials: Abdominal Discomfort
Functional Dyspepsia, Small Intestinal Bacterial Overgrowth
Does Small Intestinal Bacterial Overgrowth Contribute to Functional Dyspepsia
The prevalence of functional dyspepsia (FD) is estimated to be 15% of the adult population. FD is commonly described as a condition of chronic abdominal discomfort localized to the upper abdomen.
- Conditions
- Functional Dyspepsia, Small Intestinal Bacterial Overgrowth, Chronic Abdominal Discomfort
- Trial name
- NCT00956397
- Testing
- Rifaximin, Lactulose Breath Test
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Henry C. Lin, MD
Colic
Study to Evaluate Efficacy and Safety of Oral Doses of Hyoscine Butylbromide for the Treatment of Occasional Abdominal Pain, Cramping, and Discomfort
Study to determine whether hyoscine butylbromide can provide adequate symptomatic relief of a single episode - defined as lasting not longer than 1 day - and multiple episodes of abdominal pain or discomfort associated with…
- Trial name
- NCT02242292
- Testing
- Hyoscine butylbromide
- Volunteers
- 527 people
- Sponsor
- Boehringer Ingelheim
Abdominal Discomfort
Benefit and Tolerability of a Probiotic Product in Infants With Abdominal Discomfort
To demonstrate benefit and tolerability of a probiotic product in infants with abdominal discomfort.
- Trial name
- NCT01893814
- Testing
- Probiotics, Control
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- Probi AB
Hunger, Depression
Carbohydrate Rich Drink Reduces Pre-endoscopic Discomfort for Patients Going for Elective Endoscopic Procedures
The study is a randomised controlled trial that aims to evaluate whether carbohydrate loading pre-endoscopy can improve patients' overall satisfaction and is not associated with negative impact on endoscopic quality or increased…
- Conditions
- Hunger, Depression, Anxiety, Vomiting
- Trial name
- NCT05342116
- Testing
- Nestle Preload, Water
- Where
- Singapore
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tan Tock Seng Hospital
Irritable Bowel Syndrome
Saccharomyces Cerevisiae for Irritable Bowel Syndrome
This study is designed to see the response of saccharomyces cerevisiae for symptomatic improvement of patients with IBS
- Trial name
- IBS (NCT05149599)
- Testing
- Saccharomyces cerevisiae
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Ziauddin University
Intestinal Discomfort, Abdominal Pain/ Discomfort
Evaluation of the Synergistic Effect of Combining a Prebiotic and a Postbiotic on Intestinal Discomfort
This study aims to investigate the beneficial effects of the daily consumption of a synbiotic formulation-combining a prebiotic (Berberine, BBR) and a postbiotic (inactivated Bifidobacterium Longum, B.longum)-in adults…
- Trial name
- Synfood (NCT07420231)
- Testing
- Berberine, Bifidobacterium longum, Bifidobacterium longum and Berberine
- Where
- Belgium
- Volunteers
- 140 people
- Sponsor
- Université Catholique de Louvain
Abdominal Pain
Study to Evaluate the Efficacy and Safety of Hyoscine Butylbromide Tablets for the Treatment of Occasional or Recurrent Episodes of Gastric or Intestinal Spasm-like Pain or Discomfort
In contrast with Hyoscine Butylbromide Capsule 10mg, Study is to evaluate the efficacy and safety of Hyoscine Butylbromide tablets 10 mg (20mg, 3 times daily, orally) over a period of 3 days for the treatment of occasional or…
- Trial name
- NCT02242305
- Testing
- Hyoscine Butylbromide - Tablet, Hyoscine Butylbromide - Capsule
- Volunteers
- 302 people
- Sponsor
- Boehringer Ingelheim
Chronic Pain, Ventral Hernia
Chronic Complaints After Small Umbilical Hernia Repair
There are only little data on the risk of chronic complaints (pain and discomfort) following open non-mesh sutured repairs of small umbilical or epigastric hernias.
- Trial name
- NCT01741740
- Volunteers
- 295 people
- Sponsor
- Hvidovre University Hospital
Constipation, Abdominal Pain
Effects of a Prebiotic-Probiotic Combination on Constipation Symptoms and Quality of Life
This study aims to evaluate whether a combination of a prebiotic (1-kestose) and a probiotic (Lacticaseibacillus rhamnosus BBH112) improves gastrointestinal symptoms and quality of life in adults with constipation-related…
- Conditions
- Constipation, Abdominal Pain, Abdominal Bloating, Abdominal Discomfort
- Trial name
- NCT07923279
- Testing
- Lacticaseibacillus rhamnosus BBH112, 1-Kestose (GF2)
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Seoul National University Hospital
Abdominal Discomfort, Bloating
Study to Evaluate a Probiotic in Healthy Subjects With a History of Abdominal Discomfort and Bloating
This is a multicenter, double-blind, randomized, placebo-controlled, 6-week study of a probiotic for abdominal discomfort and bloating in healthy subjects.
- Trial name
- NCT01099696
- Testing
- B. infantis 35624
- Where
- 10 sites in United States
- Volunteers
- 302 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Irritable Bowel Syndrome
A Six-month Study to Compare Outcome Differences and Visceral Response ... Irritable Bowel Syndrome
The purpose of this study is to assess the effect of participation in one of the following interventions: (1) IBS Stress Management; (2) IBS Symptom Management; or (3) IBS Educational Training on improving IBS associated…
- Trial name
- NCT00368771
- Testing
- IBS Stress Management, IBS Symptom Management, IBS Educational Training
- Volunteers
- 163 people
- Sponsor
- University of California, Los Angeles
Catheter Related Complication
Intrathecal Morphine for Radical Robot Assisted Prostatectomy (TORNADO)
investigators aim to compare the efficacy of intrathecal morphine, intravenous tramadol and transversus abdominis plane block in the treatment of catheter related bladder discomfort syndrome in patients scheduled for robotic…
- Trial name
- TORNADO (NCT04814745)
- Testing
- intrathecal infusion, Intravenous Infusion, Ropivacaine injection
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Breast Cancer, Chemotherapy-induced Diarrhea
Probiotics for Abemaciclib-Induced Abdominal Discomfort.
This study aims to evaluate whether the addition of probiotics can help reduce abdominal discomfort (such as diarrhea) in breast cancer patients receiving Abemaciclib treatment.
- Trial name
- NCT07605728
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Leeuwenhoek Laboratories Co. Ltd.
Gastritis, Peptic Ulcer Disease
Frequent Ketamine Use and Gastrointestinal, Liver and Biliary Sequelae
30% of ketamine users complain of abdominal discomfort. Long-term ketamine use is associated with hepatotoxicity and pathologic changes to the biliary tract.
- Conditions
- Gastritis, Peptic Ulcer Disease, Cholangiopathy, Liver Fibrosis
- Trial name
- NCT02165488
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Gut Health, Microbiome
A Clinical Trial to Evaluate the Effects of a Fibre Supplement on Microbiome and Gut Health
This study will evaluate the effects of the Artah Essential Fibre+ supplement on the microbiome and gut health over an 8-week period.
- Conditions
- Gut Health, Microbiome, Bloating, Indigestion
- Trial name
- NCT07781488
- Testing
- Essential Fibre+
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Artah Nutrition Limited
Gastroenteritis Acute, Gastrointestinal Symptoms
Diagnostic PCR Panel in Children With Acute Gastrointestinal Symptoms
This investigator-initiated randomized controlled trial compares the clinical impact of real time PCR of fecal samples in children with acute gastrointestinal symptoms at a pediatric emergency room.
- Conditions
- Gastroenteritis Acute, Gastrointestinal Symptoms, Abdominal Pain/ Discomfort, Vomiting in Infants and/or Children
- Trial name
- RealCAGI RCT (NCT07280624)
- Testing
- Multiplex PCR gastrointestinal panel
- Volunteers
- 526 people
- Sponsor
- University of Oulu
Gut Health
A Study to Evaluate the Effects of a Butyrate-Polyphenol Formulation on Gut Health and Associated Symptoms
The purpose of the study is to evaluate the efficacy of a butyrate/polyphenol formulation on modulation of the gut microbiome and gastrointestinal symptoms using questionnaires in individuals with self-reported gastrointestinal…
- Trial name
- NCT07371975
- Testing
- Butyrate + Polyphenol Formulation
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Supplement Formulators, Inc.
Chronic Pain
Lichtenstein Patch or Prolene Hernia System (PHS) for Inguinal Hernia Repair
This randomised prospective study was designed to compare the convalescence and the long-term sequelae in inguinal hernia repair with either a bilayer mesh as devised by Gilbert (Prolene Hernia System®) or an onlay mesh applied…
- Trial name
- NCT01070693
- Testing
- Open mesh inguinal hernia repair, Prolene Hernia System, Lichtenstein technique
- Where
- Finland
- Volunteers
- 300 people
- Sponsor
- Helsinki University Central Hospital
Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS)
Feasibility Study of a Guided Imagery Therapy Mobile Application for Functional Abdominal Pain Disorders in Children
Chronic abdominal pain is common among children, and the majority of cases are attributed to functional abdominal pain disorders. One approach to treating these disorders is by using psychological therapies.
- Conditions
- Functional Abdominal Pain Disorders, Irritable Bowel Syndrome (IBS), Functional Gastrointestinal Disorders (FGIDs), Gastrointestinal and Digestive Disorder
- Trial name
- NCT07222943
- Testing
- Guided Imagery Therapy
- Where
- 2 sites in United States
- Volunteers
- 63 people
- Sponsor
- Baylor College of Medicine
Postoperative Thirst, Comfort
Effect of Postoperative Oral Rinsing on Dehydration-Related Discomfort, Comfort, and Bowel Sounds
The aim of this study is to evaluate the effects of oral rinsing with water in the postoperative period on thirst, comfort level, and bowel motility in patients undergoing abdominal surgery under general anesthesia.
- Conditions
- Postoperative Thirst, Comfort, Bowel Movements, Abdominal Surgeries
- Trial name
- NCT07236749
- Testing
- oral rinsing, rutine service operation
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Cumhuriyet University