Clinical trials: ART
Infertility, ART
Automation of the In Vitro Fertilization Laboratory
Enrolled patients will undergo an Assisted Reproductive technology (ART) treatment using intracytoplasmic sperm injection (ICSI, the direct injection of a single sperm cell into an oocyte) as the method of insemination.
- Trial name
- NCT06581068
- Testing
- AURA assisted ART treatment
- Where
- 2 sites in Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Covid19, Hiv
Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa
Background: Coronavirus disease 2019 (COVID-19) has affected almost every country in the world, especially in terms of health system capacity and economic burden.
- Conditions
- Covid19, Hiv, ART
- Trial name
- ENDOCOVID (NCT04709302)
- Testing
- COVID-19, HIV, ART
- Where
- 3 sites in Nigeria, South Africa
- Volunteers
- 342 people
- Sponsor
- Medical University of Graz
ICSI, IVF
Dual Trigger VS HCG Trigger for Final Oocyte Maturation in Normal Responders
To compare the embryological and reproductive outcomes of dual trigger versus conventional hCG trigger for final oocyte maturation in normal responder patients undergoing ICSI cycles.
- Conditions
- ICSI, IVF, Normal Responders, Infertility Assisted Reproductive Technology
- Trial name
- DT-HCG-IVF (NCT07861399)
- Testing
- Dual trigger (human chorionic gonadotropin plus GnRH-agonist), hCG trigger
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Al-Azhar University
HIV, Pregnancy
Cash Transfers to Pregnant Women With HIV
The goal of this study is to evaluate the effectiveness and implementation of an unconditional cash transfer intervention to improve mental bandwidth, ART adherence, and postpartum retention among pregnant women with HIV in…
- Conditions
- HIV, Pregnancy, HIV Antiretroviral Therapy (ART) Adherence, Post-partum
- Trial name
- NCT07226492
- Testing
- Unconditional Cash Transfer (UCT)
- Where
- 8 sites in Botswana
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
HIV, Stable ART
Proof of Principle Study of Pulse Dosing of IL-15 to Deplete the Reservoir in HIV Infected People
To assess the safety and tolerability of ALT-803, as well as, the potential efficacy of ALT-803 in HIV
- Trial name
- ALT-803 (NCT02191098)
- Testing
- ALT-803
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Minnesota
HIV, ART
The SMART ART Study
The investigators propose A Sequential Multiple Assignment Randomized Trial of scalable interventions for ART delivery in South Africa- the SMART ART study-a randomized study to test adaptive ART delivery for persons with…
- Trial name
- NCT05090150
- Testing
- Home delivery of ART, Smart Lockers (Pele boxes), Best clinic practices + conditional lottery incentives
- Where
- South Africa
- Volunteers
- 874 people
- Sponsor
- Massachusetts General Hospital
HIV Infections, PLWH
RV630 - Approach to Control HIV With Immune Enhancement and Vaccination (ACHIEV
This is a phase I, randomized, double-blind, placebo-controlled clinical trial to investigate the safety of VRC07-523LS and PGDM1400LS in combination with ChAdOx1.tHIVconsv1, ChAdOx1.HIVconsv62 prime, MVA.tHIVconsv4 and…
- Conditions
- HIV Infections, PLWH, ART, Acute HIV Infection
- Trial name
- ACHIEV (NCT06484335)
- Testing
- VRC07-523LS, PGDM1400LS, ChAdOx1.tHIVconsv1
- Where
- Thailand
- Volunteers
- 48 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
HIV, HIV Antiretroviral Therapy (ART) Adherence
Pilot Study to Evaluate the Decentralization of Patient Care Among People With HIV in Out-of-hospital Settings
The goal of this 24-week, open-label, randomized pilot study is to assess the feasibility and impact of decentralized HIV care in a community setting (BCN Checkpoint), focusing on patient satisfaction and experience and carbon…
- Conditions
- HIV, HIV Antiretroviral Therapy (ART) Adherence, Health Care Delivery
- Trial name
- OOH (NCT07792070)
- Testing
- Implemention of the decentralization of patient care into communitary facilities such as BCN Checkpoint/BCN Prep·Point.
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la Promoción de la Salud y la Ciencia
Infertility (IVF Patients), Infertility Assisted Reproductive Technology
Purpose to Evaluate the Effectiveness of the Superovulation Stimulation Protocol Using Human Chorionic Gonadotropin (hCG) by Demonstrating Its Equivalence to Standard Controlled Ovarian Stimulation Protocols in Terms of Oocytes Retrieved, Blastulation While Maintaining an Economic Advantage
This study evaluates a more affordable medication protocol for ovarian stimulation during in vitro fertilization (IVF). Standard IVF protocols use medications called gonadotropins to stimulate the ovaries to produce multiple…
- Conditions
- Infertility (IVF Patients), Infertility Assisted Reproductive Technology, Infertile Patients, Infertility Drugs
- Trial name
- NCT07771283
- Testing
- Human Chorionic Gonadotropin (hCG), GnRH antagonist, Dual trigger (human chorionic gonadotropin plus GnRH-agonist)
- Where
- 3 sites in Uganda, Ukraine
- Volunteers
- 360 people
- Sponsor
- LTD "EKODNIPRO", Medical centre Medical Plaza Dnipro
HIV Antiretroviral Therapy (ART) Adherence
Optimizing Care Delivery to Support Reengagement in PLWH Returning to HIV Care After Treatment Lapses in Zambia
1.0 Introduction The scale-up of human immunodeficiency virus (HIV) treatment services has expanded rapidly in Zambia, facilitated by evolution of the HIV response from centralized services to decentralized care and now towards…
- Trial name
- Reengagement (NCT06803316)
- Where
- Zambia
- Volunteers
- 658 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
HIV Infections, ART
Accelerated ART Initiation for PWHIV Who Are Out of Care
The main purpose of the study is to evaluate the effectiveness, of the ACCELERATE model of care to achieve HIV viral suppression at Week 24.
- Conditions
- HIV Infections, ART, Noncompliance, Patient
- Trial name
- ACCELERATE (NCT06374758)
- Testing
- The Accelerate model of care, bictegravir/emtricitabine/tenofovir alafenamide 50/200/25 mg
- Where
- 4 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Missouri-Columbia
ART Adherence
Randomized Trial to Optimize Virologic Suppression Rates Using a Point-of-Care Urine Monitoring Assay (ROVING PUMA)
Antiretroviral therapy (ART) has significantly decreased the morbidity and mortality of HIV infection. However, adherence challenges in taking daily oral ART persist.
- Trial name
- ROVING-PUMA (NCT06423612)
- Testing
- POC urine assay informed enhanced ART adherence counselling for viral suppression
- Where
- South Africa
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
HIV, Human Immunodeficiency Virus
Delivery Optimization for Pre-Exposure Prophylaxis (DO PrEP) Study
The overall goal is to determine whether an end-to-end decentralized delivery service for PrEP is more effective, safe, acceptable, and cost-effective than facility-based PrEP delivery.
- Conditions
- HIV, Human Immunodeficiency Virus, ART
- Trial name
- NCT06176859
- Testing
- HIV PrEP Delivery
- Where
- South Africa
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Abuse, Mindfulness
Mindfulness-Art Therapy Intervention in Abused Adolescents
Adolescence is an important stage of development when many mental health difficulties first appear. Young people who have experienced abuse are especially vulnerable, as abuse can lead to intense feelings of shame and negatively…
- Conditions
- Abuse, Mindfulness, Art Therapy
- Trial name
- NCT07674056
- Testing
- Mindfulness and Art Therapy Group Program
- Where
- Iran
- Volunteers
- 40 people
- Sponsor
- Ardakan University
HIV Antiretroviral Therapy (ART) Adherence, Alcohol Consumption
Pilot of an Intervention to Reduce Alcohol Use and Improve ART Adherence Among Men Living With HIV With Pregnant Partners in Uganda.
Hazardous alcohol use, which is common among men in Uganda, is a primary driver of both HIV risk and intimate partner violence (IPV) in this setting.
- Trial name
- Kisoboka Amaka (NCT06900634)
- Testing
- Kisoboka Amaka, Screening and Referral
- Where
- Uganda
- Volunteers
- 60 people
- Sponsor
- San Diego State University
HIV Care Loss to Followup, HIV Antiretroviral Therapy (ART) Adherence
Developing and Testing a Digital Health Tool for INterseCtional Stigma Assessment and Reduction at Multiple Levels and mUltiple DimEnsions (INCLUDE) to Improve HIV Care in ART Centers in Nepal
People living with HIV (PLWH) have poor clinical outcomes when they are excluded from care due to intersectional stigma related to HIV, mental health (MH), and other dimensions.
- Conditions
- HIV Care Loss to Followup, HIV Antiretroviral Therapy (ART) Adherence, HIV Stigma, Mental Health Conditions
- Trial name
- INCLUDE (NCT07370298)
- Testing
- INCLUDE
- Where
- Nepal
- Volunteers
- 88 people
- Sponsor
- Possible
HIV, Art Therapy
Comparative Trial Between Ainuovirine(ANV)/Lamivudine(3TC)/Tenofovir(TDF) and Efavirenz(EFV)/Lamivudine/Tenofovir Regimens
This is a prospective, multicenter, open-label, parallel-controlled study. The primary objective is to prospectively explore and compare the virological efficacy of Ainuovirine/Lamivudine/Tenofovir and…
- Conditions
- HIV, Art Therapy, TB - Tuberculosis
- Trial name
- ALT VS TLE (NCT07631897)
- Testing
- Ainuovirine, Lamivudine and Tenofovir Disoproxil Fumarate Tablets, Tenofovir, Lamivudine and Efavirenz Disoproxil Fumarate Tablets
- Volunteers
- 60 people
- Sponsor
- Shanghai Public Health Clinical Center
Sperm DNA Fragmentation, Sperm DNA Impact on ART Outcomes
Clinical Thresholds of Double-strand Breaks in Sperm's DNA in ART
The goal of this prospective observational study is to learn about the impact of double-strand sperm DNA fragmentation (dsSDF) on assisted reproductive technology (ART) outcomes and to derive clinically relevant threshold values…
- Trial name
- DSBs (NCT07621991)
- Testing
- LensHooke X12 Device
- Where
- 2 sites in India
- Volunteers
- 484 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
HIV - Human Immunodeficiency Virus, HIV Antiretroviral Therapy (ART) Adherence
Improving the HIV Care Continuum With mHealth Technology
Youth living with HIV (YLHIV) face barriers to engagement and retention in HIV care, show poor medication adherence, and often fail to achieve and maintain viral suppression.
- Conditions
- HIV - Human Immunodeficiency Virus, HIV Antiretroviral Therapy (ART) Adherence, mHealth Application, mHealth Intervention
- Trial name
- NCT07631104
- Testing
- MindBodyU Intervention
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of South Carolina
HIV Antiretroviral Therapy (ART) Adherence
Hybrid Type-1 Effectiveness-Implementation Trial of Motivation Matters!
The goal of this clinical trial is to learn if an interactive mHealth intervention will be effective in helping HIV-positive women in high-burden settings who are initiating antiretroviral therapy (ART) take their ART regularly…
- Trial name
- NCT06745050
- Testing
- Text message mHealth Evidence-based intervention
- Where
- Kenya
- Volunteers
- 350 people
- Sponsor
- University of Washington