Clinical trials: AI
Preoperative Anxiety, Perceived Control
Structured Communication About Artificial Intelligence in Perioperative Care (AI-COM)
This study investigates whether structured communication about artificial intelligence (AI) in perioperative care can reduce preoperative anxiety and improve perceived control among adult patients undergoing elective surgery.
- Conditions
- Preoperative Anxiety, Perceived Control, AI-Related Uncertainty
- Trial name
- AI-COM (NCT07393945)
- Testing
- Structured Artificial Intelligence Communication, Attention-Control Supportive Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Agri Ibrahim Cecen University
Chronic Kidney Disease (Stages 3b-5)
Monitoring Hyperkalemia Using Point-of-care AI-enabled ECG Device Among Patients With Chronic Kidney Disease Stages 3b-5
The clinical trial will be conducted in a real-world outpatients setting with the goal of learning if monitoring serum potassium frequently among patients with moderate-to-advanced stages of chronic kidney disease leading to…
- Trial name
- POCKET (NCT06901960)
- Testing
- A mobile artificial intelligence-enhanced electrocardiogram device estimating plasma potassium categories (<5 mmol/L, 5 - <5.5 mmol/L, 5.5 - <6.0 mmol/L and ≥ 6.0 mmol/L)
- Where
- 3 sites in China
- Volunteers
- 1,066 people
- Sponsor
- Peking University First Hospital
Decision Support Systems, Clinical, Referral and Consultation
Testing an AI Tool to Help Primary Care Clinicians With Specialty Consultation Questions
The goal of this study is to test an artificial intelligence (AI) tool called SAGE. SAGE helps primary care doctors with questions that often need a specialist. Primary care doctors are the doctors people usually see first.
- Trial name
- SAGE (NCT07706920)
- Testing
- SAGE (AI clinical decision support), Standard eConsult
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stanford University
Acute Myocardial Infarction, Heart Failure
The Benefits of Wearable AI in Post-Discharge Management of AMI Patients
Myocardial infarction (MI) remains a major threat to human health. Although interventional treatment techniques have advanced rapidly, many patients still experience major adverse cardiovascular events (MACE) and require hospital…
- Trial name
- NCT07288229
- Testing
- Optimized Integrated Management Based on AI-Guided Wearable Data
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Cerebrovascular Diseases, Lung
Clinical Application of a Low-Dose CBCT AI Model
Cone Beam CT (CBCT) is an imaging modality used in interventional digital subtraction angiography (DSA). It produces three-dimensional images via cone-beam X-ray scanning and computer reconstruction.
- Conditions
- Cerebrovascular Diseases, Lung, Liver
- Trial name
- NCT07845929
- Testing
- DeepPriorCBCT-V2, Clinical standard protocol (Full-radiation-dose CBCT)
- Where
- 5 sites in China
- Volunteers
- 1,380 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Coronary Artery Disease, Hypercholesterolemia
A Trial Assessing the Effectiveness of Evolocumab in Reducing the Plaque Burden in Participants With Subclinical Atheroma
The main aim of this trial is to demonstrate that Evolocumab plus routine lipid management is superior to routine lipid management alone in modifying plaque (non-calcified) volume as measured by Artificial Intelligence-enabled…
- Conditions
- Coronary Artery Disease, Hypercholesterolemia, Atheroma, Atherosclerotic Plaque
- Trial name
- NCT07803679
- Testing
- Evolocumab, Routine Lipid Management, Autoinjector
- Volunteers
- 308 people
- Sponsor
- Amgen
Lung Cancer Screening
Clinical Evaluation of the Lung Cancer AI-based Decision Support Tool in Low-Dose Lung CT
The goal of this observational study is to clinically validate the accuracy of an AI-based decision support tool-the Lung Cancer Detection System (LCDS)-for detecting lung nodules in asymptomatic adults aged 50-79 with a history…
- Trial name
- GenMedAILCSD1 (NCT07052773)
- Testing
- Lung Cancer Detection System (LCDS)
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Genesis Medical AI
Symptomatic Irreversible Pulpitis
Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic
This study evaluates postoperative pain and treatment outcomes following vital pulp therapy and root canal treatment in patients with symptomatic teeth.
- Trial name
- NCT07549620
- Testing
- Vital Pulp Therapy, Root Canal Treatment
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Endoscopic Ultrasound
Effectiveness of an Ai-based Endoscopic Ultrasound Navigation System in the Training of Endoscopic Ultrasonics
In the early stage, the investigators successfully constructed an artificial intelligence model-based ultrasonic endoscopy-assisted film reading system and named the modified system biliopancreatic Master.
- Trial name
- NCT05421520
- Testing
- Artificial intelligence assisted system
- Where
- 2 sites in China
- Volunteers
- 12 people
- Sponsor
- Renmin Hospital of Wuhan University
Neoplasms (Cancer / Tumors), Colorectal Neoplasms
A Preregistered Multi-Cohort Evaluation of the FATHOM AI System for Molecular Testing Prioritization to Support Clinical Trial Enrollment
Many clinical trials evaluating cancer treatments require patients to undergo testing for specific molecular markers as part of eligibility screening, typically using immunohistochemistry or sequencing.
- Conditions
- Neoplasms (Cancer / Tumors), Colorectal Neoplasms, Lung Neoplasms, Endometrial Neoplasms
- Trial name
- FATHOM (NCT07814872)
- Where
- United States
- Volunteers
- 30,000 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Flat Colorectal Lesion
Comparison of Flat Colorectal Lesion Detection by Artificial Intelligence-assisted Colonoscopy Versus Endoscopists
The development of artificial intelligence (AI) systems in the field of colorectal endoscopy is currently booming, colorectal cancer being, by its frequency and severity, a real public health problem.
- Trial name
- AIChallengeMed (NCT05942677)
- Testing
- proportion of colorectal lesions
- Where
- France
- Volunteers
- 160 people
- Sponsor
- Hospices Civils de Lyon
Stress Reduction
AI-Guided Stress Management Breathing Practices Via a Wearable Device
This study explores the effectiveness of AI-guided breathing practices for stress management in adults. In this randomized controlled trial, 120 participants will be recruited and assigned to an intervention group (n=90) or a…
- Trial name
- NCT06881875
- Testing
- AI-guided breathing practices, Progressive muscle relaxation
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Peking University
Early Pregnancy
Conversational AI Platform for Early Pregnancy Care City-wide Recruitment: A Feasibility Study
This study seeks to determine pregnant patients in the Philadelphia area can be recruited to a conversational AI texting platform.
- Trial name
- CIRCA (NCT07197892)
- Testing
- CIRCA Texting Platform
- Where
- United States
- Volunteers
- 2,637 people
- Sponsor
- University of Pennsylvania
COVID-19
Crowdsourcing an Open COVID-19 Imaging Repository for AI Research
The objectives of this project are to (1) assemble a crowdsourced, de-identified radiographic repository; and (2) train and validate existing COVID-NET deep learning diagnostic models.
- Trial name
- NCT05384912
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Central Florida
Gaucher Disease Type 1
A Second-generation AI Based Therapeutic Regimen in Patients With Gaucher Disease Treated With Enzyme Replacement Therapy.
An open-labeled, prospective, single-center proof-of-concept study. Patients with Gaucher Disease aged 18-75 who received intravenous Enzyme Replacement Therapy once every two weeks were enrolled.
- Trial name
- NCT06050967
- Testing
- Enzyme replacement therapy for Gaucher disease in combination with altus care application
- Where
- Israel
- Volunteers
- 5 people
- Sponsor
- Hadassah Medical Organization
Colon Polyps, Colonoscopy
Impact of Artificial Intelligence on Trainee Polyp Miss Rates
Based on prior studies, trainee and practicing gastroenterologists miss pre-cancerous polyps (adenomas and serrated polyps) during colonoscopy.
- Conditions
- Colon Polyps, Colonoscopy, Artificial Intelligence (AI)
- Trial name
- NCT06676930
- Testing
- Colonoscopy With Computer-Aided Detection, Colonoscopy without Computer-Aided Detection
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Northwestern University
Atrial Fibrillation
Use of Volta Medical AI-software During Atrial Fibrillation Ablation to Identify Patients Who May Need More Than Pulmonary Vein Isolation.
DISPLAY-AF is a prospective, multicenter, single-arm post-market clinical follow-up investigation designed to evaluate whether spatiotemporal dispersion areas identified by the Volta AF-Xplorer II artificial intelligence (AI)…
- Trial name
- DISPLAY-AF (NCT07807423)
- Testing
- Complete biatrial mapping
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Volta Medical
Serious Illness, Existential Distress
AI Assisted Personalized Legacy Program (Reflections: My Story) for Patients With Serious Illness
The purpose of this study is to determine if it is feasible and acceptable to recruit for and deliver the AI Assisted Personalized Legacy Program intervention to patients with serious illness.
- Trial name
- NCT07009210
- Testing
- AI Assisted Personalized Legacy Program
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Emergency Medicine, Artificial Intelligence (AI)
Diagnostic Accuracy of GPT-4o and Claude for HEART Score Calculation in Chest Pain
This prospective observational diagnostic accuracy study evaluates whether large language models (LLMs) - GPT-4o (OpenAI, gpt-4o-2024-11-20) and Claude (Anthropic, claude-sonnet-4-6) - can accurately calculate HEART scores from…
- Conditions
- Emergency Medicine, Artificial Intelligence (AI), Artificial Intelligence (AI) in Diagnosis, Chest Pain Rule Out Myocardial Infarction
- Trial name
- LLM-HEART (NCT07626060)
- Testing
- GPT-4o HEART Score Calculator, Claude HEART Score Calculator, Three-Expert Consensus HEART Score
- Where
- Turkey (Türkiye)
- Volunteers
- 690 people
- Sponsor
- Marmara University Pendik Training and Research Hospital
Cancer
Glasgow Low-dose CT and AI-based Diagnostics to Case Find Lung Cancer and Other Cardio-respiratory Long-term Conditions - Feasibility Study
Lung cancer is one of the most common and serious cancers in Scotland and is often diagnosed at a late stage. Early detection is crucial to improving survival rates.
- Trial name
- GALACTIC-1 (NCT07372508)
- Testing
- Low dose Chest CT
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- NHS Greater Glasgow and Clyde