Clinical trials: ACL Injury, active
ACL Tears
BioBrace® Augmentation in Anterior Cruciate Ligament Reconstruction Procedures
This research study will evaluate mid-term clinical safety and performance outcomes of the BioBrace® Reinforced Implant when used to augment a tissue graft during anterior cruciate ligament (ACL) reconstruction.
- Trial name
- NCT06948591
- Testing
- Anterior cruciate ligament reconstruction with BioBrace® augmentation, Arthroscopic anterior cruciate ligament reconstruction
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- CONMED Corporation
Osteoarthritis, Knee, Post-traumatic Osteoarthritis
Preventing Injured Knees From osteoArthritis: Severity Outcomes
This study is being done to find out if metformin is effective at reducing pain by delaying the onset of post-traumatic osteoarthritis (PTOA) after anterior cruciate ligament (ACL) reconstruction.
- Conditions
- Osteoarthritis, Knee, Post-traumatic Osteoarthritis, ACL Tear
- Trial name
- PIKASO (NCT06096259)
- Testing
- Metformin
- Where
- 9 sites in United States
- Volunteers
- 512 people
- Sponsor
- Brigham and Women's Hospital
ACL Tear
Quadriceps Strengthening ACL Reconstruction
The purpose of this study is to characterize quadriceps function and squat biomechanics during the early strengthening phase in adolescent patients undergoing a standardized combined neuromuscular electrical stimulation (NMES)…
- Trial name
- ACL (NCT07015541)
- Testing
- NMES and BFR, Standard physical therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
ACL Injury, Meniscal Injuries
Intraoperative Energy Expenditure During ACL Reconstruction Surgery
This prospective observational study evaluates the intraoperative energy expenditure of the surgeon during anterior cruciate ligament reconstruction procedures.
- Trial name
- NCT07683247
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- ASL Lecce
ACL - Anterior Cruciate Ligament Rupture
Soft-tissue Quadriceps Autograft ACL-reconstruction in the Skeletally-immature vs. Hamstrings
To date, the use of the quadriceps tendon as an autograft option in primary paediatric Anterior Cruciate Ligament (ACL) reconstruction has not been well studied.
- Trial name
- SQuASH (NCT03896464)
- Testing
- Soft tissue hamstring autograft, Quadriceps tendon autograft
- Where
- 6 sites in Canada, Japan
- Volunteers
- 352 people
- Sponsor
- McMaster University
ACL - Anterior Cruciate Ligament Rupture
SharkScrew ACL RCT
This prospective, randomized controlled trial will compare three tibial interference screw types used for graft fixation during primary anterior cruciate ligament (ACL) reconstruction: a polyetheretherketone (PEEK) screw, a…
- Trial name
- NCT07830953
- Testing
- ACL Reconstruction with a Biocomposite Screw, ACL Reconstruction using a PEEK Screw, ACL Reconstruction using an Allograft Screw
- Where
- Austria
- Volunteers
- 33 people
- Sponsor
- Austrian Workers Compensation Board Styria
ACL Injury
Functional Movement Training Versus Functional Stability Training in Post-ACL Surgery
This randomized controlled trial study will include 32 athletes aged 18-35 who had ACL surgery. After surgery, participants will be selected and assigned randomly to the Functional Movement Training or Functional Stability…
- Trial name
- NCT07725016
- Testing
- Functional Movement training, Functional stability training
- Where
- Pakistan
- Volunteers
- 32 people
- Sponsor
- Riphah International University
Knee Osteoarthristis, ACL Injuries
Treatment of Post Traumatic Knee Osteoarthritis With Extracorporeal Shockwave Therapy
This study is recruiting current or former athletes who had ACL reconstruction surgery over a year ago and have been diagnosed with knee osteoarthritis (OA).
- Conditions
- Knee Osteoarthristis, ACL Injuries, Post-Traumatic
- Trial name
- PTOA Knee (NCT06686680)
- Testing
- extracorporeal shockwave therapy (ESWT)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Spaulding Rehabilitation Hospital
ACL Injury
Motor Imagery-Enhanced Rehabilitation Modulates Cortical Plasticity and Functional Recovery After ACL Reconstruction
Part 1: Neural Correlates of Motor Imagery in ACLR Patients This cross-sectional study aims to systematically compare differences in electroencephalographic (EEG) activity between patients who have returned to sport one year…
- Trial name
- NCT07833189
- Testing
- Motor Imagery Therapy (i.e., "mentally practicing movement"), conventional rehabilitation"
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
ACL, Anterior Cruciate Ligament
Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction
The goal of this study is to gather pilot data to help inform a future clinical trial. As such, the investigators will employ a randomized clinical trial design, but data will only be collected on 9 total subjects.
- Conditions
- ACL, Anterior Cruciate Ligament, ACL Injury
- Trial name
- Mi-SPA (NCT06529692)
- Testing
- Split-Belt Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Michigan
ACL Injury, Hemodynamics
A Paradigm Shift in Musculoskeletal Rehabilitation Assessment After ACL Reconstruction Using Near-Infrared Spectroscopy
This study aims to establish and compare muscle haemodynamic response patterns in physically active subjects with anterior cruciate ligament (ACL) reconstruction, at different time points after surgery, against healthy controls…
- Conditions
- ACL Injury, Hemodynamics, Oxygen Consumption Based Assessment of Hemodynamics, Exercise
- Trial name
- HemoNIRS-LCA (NCT06621355)
- Testing
- Incremental Interval Test on a Cycle Ergometer
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Universitat de Lleida
Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear
Active Noise-Cancelling Headphones With Closed-Loop Communication During Arthroscopic ACL Reconstruction
Operating room noise may interfere with communication, concentration, and surgical workflow. Active noise-cancelling (ANC) headphones can reduce background auditory distractions; however, their potential benefit during surgery…
- Conditions
- Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Injury
- Trial name
- ANC-ACL-2026 (NCT07589582)
- Testing
- Active Noise-Cancelling Headphones With Closed-Loop Communication, Standard Operating Room Communication
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
ACL Injury, Anterior Cruciate Ligament Injuries
Comparing Perioperative Education Modalities for ACL Reconstruction on Patient Satisfaction, Self-Efficacy, and Surgical Outcomes
The purpose of this research is to find out whether the way information about surgery is presented to patients affects patient satisfaction, knowledge retention, and surgical outcomes such as anxiety
- Trial name
- NCT05273463
- Testing
- Video-Based Intervention, Classroom-Based Intervention
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Mayo Clinic
Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction
Clinical and Functional Outcomes After ACL Reconstruction Versus Primary Repair
The anterior cruciate ligament (ACL) is the primary structure responsible for controlling anterior-posterior translation and rotational stability of the knee joint.
- Conditions
- Anterior Cruciate Ligament (ACL) Tear, Anterior Cruciate Ligament Reconstruction, Isokinetic Test
- Trial name
- NCT07318272
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Gazi University
Anterior Cruciate Ligament (ACL) Rupture, Anterior Cruciate Ligament (ACL) Reconstruction
Comparison of Video Based Phone App vs. Supervised Preoperative Exercise for ACL Reconstruction
The goal of this clinical trial is to learn if using a phone app for exercises is as effective as working with a physical therapist before anterior cruciate ligament knee surgery.
- Conditions
- Anterior Cruciate Ligament (ACL) Rupture, Anterior Cruciate Ligament (ACL) Reconstruction, Anterior Cruciate Ligament (ACL) Injury
- Trial name
- ACL-PREHAB-APP (NCT07322497)
- Testing
- Mobile App Exercise Program, Supervised Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
ACL - Anterior Cruciate Ligament Rupture, ACL Injuries
Non-Narcotic Pain Control After ACL Reconstruction
This is a double-blind randomized controlled trial of standard of care therapy, either oral ketorolac (experimental group) or oral oxycodone (control group) to demonstrate efficacy in reducing the percentage of narcotic doses…
- Trial name
- NCT06973785
- Testing
- dispense of study drug, Ketorolac
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
ACL - Anterior Cruciate Ligament Rupture
Correlation Study Between the Classification of Arthrogenic Motor Inhibition (AMI) and Clinical Assessment After ACL Rupture
The goal of this interventional study is to measure medial vastus inhibition and associate it with AMI classification in patients with ACL rupture.
- Trial name
- AMIVAL (NCT06945133)
- Testing
- Clinical testing
- Where
- France
- Volunteers
- 90 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL - Anterior Cruciate Ligament Rupture
Microbiological Molecular Profile of the Knee Joint During Primary Reconstruction or Revision Surgery of the ACL
Anterior cruciate ligament (ACL) reconstructions are common surgical procedures, but a significant number fail for reasons that are not fully understood.
- Trial name
- INFECTIOGEN (NCT07009392)
- Testing
- NGS Analysis
- Where
- France
- Volunteers
- 100 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
ACL - Anterior Cruciate Ligament Rupture
Description of Return to Sport in Amateur Athletes Who Underwent Several Functional Tests (K-STARTS, Vertical Jumps and Soleus Muscle Strength) After Initial ACL Reconstruction
ACL injuries are incapacitating for both professional and amateur athletes, with long-term repercussions on performance and return to sport (RTS). Surgical reconstruction of the ACL is the main treatment option.
- Trial name
- K-STARTS + (NCT07249645)
- Testing
- Physical tests
- Volunteers
- 230 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Bone Graft; Complications, ACL Injuries
Radiographic Findings and Clinical Outcomes After Bone Grafting Patellar Defect in ACL Reconstruction
All patients will be randomly assigned using a computer randomization algorithm to one of two matched cohort groups. Patients will not be advised which group they belong to until after the completion of the study.
- Trial name
- BTB BackFill (NCT06975306)
- Testing
- autologous bone grafts, Demineralized bone matrix (DBM)
- Where
- 3 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Arizona