Clinical trials: ACE Inhibitor-Induced Angioedema
Angioedema
AMelioration of Angiotensin Converting Enzyme Inhibitor Induced Angioedema Study
This is a multicenter study recruiting patients with angioedema induced by ACEI. Open-label treatment with subcutaneous Icatibant compared to a historic group of 47 patients with ACE inhibitor induced angioedema which the…
- Trial name
- NCT01154361
- Testing
- Icatibant (subcutaneous) and plazebo (intravenous), Cortisone + Clemastin (intravenous) and plazebo (subcutaneous)
- Where
- Germany
- Sponsor
- Technical University of Munich
Angioedema, Angioedemas, Hereditary
Angioedema Biomarker Research Study
This clinical trial aims to evaluate and compare novel and commercially available diagnostic assays through blood tests for the differential diagnosis and comprehensive assessment of patients experiencing recurrent angioedema…
- Conditions
- Angioedema, Angioedemas, Hereditary, Urticaria, Mastocytosis
- Trial name
- NCT06210698
- Testing
- Venipuncture
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Foundation For Rare Disease Research
ACE Inhibitor Induced Angioedema
Evaluation of Ecallantide for Treatment of Angiotensin Converting Enzyme (ACE) Inhibitor Induced Angioedema
A double-blind, randomized, controlled trial comparing the safety and effectiveness of conventional therapy with ecallantide to conventional therapy with placebo.
- Trial name
- NCT01343823
- Testing
- ecallantide 60 mg, ecallantide 30 mg, ecallantide 10 mg
- Where
- 39 sites in United States
- Volunteers
- 79 people
- Sponsor
- Shire
Angiotensin Converting Enzyme Inhibitor Induced Angioedema
Blinded Safety & Efficacy Placebo Controlled Study of Icatibant for Angiotensin Converting Enzyme Inhibitor Induced Angioedema
This study is being conducted to compare the safety and efficacy of icatibant with placebo in the treatment for Angiotensin-Converting Enzyme Inhibitor (ACE-I)-Induced Angioedema in Adults.
- Trial name
- NCT01919801
- Testing
- Icatibant
- Where
- 55 sites in United States, Canada and 2 more
- Volunteers
- 118 people
- Sponsor
- Shire
Angioedema
Evaluation of Ecallantide for the Acute Treatment of Angiotensin Converting Enzyme Inhibitor Induced Angioedema
The investigators will conduct a double-blind, randomized controlled trial comparing the safety and effectiveness of ecallantide to conventional therapy.
- Trial name
- ACE (NCT01036659)
- Testing
- ecallantide - Kallikrein inhibitor that blocks the production of bradykinin
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Bernstein, Jonathan A., M.D.
ACE Inhibitor-Induced Angioedema
Safety and Efficacy of Conestat Alfa for ACE-Induced Angioedema
Angiotensin-converting enzyme inhibitors (ACE-Is), prescribed most often to treat hypertension, have been used extensively since the 1980s.
- Trial name
- NCT06679426
- Testing
- Conestat Alfa
- Volunteers
- 24 people
- Sponsor
- University of Cincinnati
Angioedema
Evaluation of Tranexamic Acid for Angiotensin-converting Enzyme Inhibitor-induced Angioedema in the Emergency Department
Angiotensin-converting enzyme inhibitor ACEi induced angioedema ACEi-AE is defined as physical swelling of the deep skin layers or mucous membranes due to increased vascular permeability and leakage of fluid into the interstitial…
- Trial name
- NCT06096077
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Methodist Health System
Angioedema Caused by Angiotensin-Converting-Enzyme Inhibitor
Treatment of Angiotensin Converting Enzyme Inhibitor-induced Angioedema
Angiotensin Converting Enzyme (ACE) inhibitors are among the most important and widely prescribed drugs. They reduce the morbidity and mortality associated with high blood pressure, heart disease, and kidney disease.
- Trial name
- NCT04679311
- Testing
- High ACE Activity Fresh Frozen Plasma, Normal Saline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine