Clinical trials: A Target Trial Emulation Study
Septic Shock, Multiorgan Failure
Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study
This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).
- Conditions
- Septic Shock, Multiorgan Failure, Sepsis
- Trial name
- NCT07539883
- Where
- South Korea
- Volunteers
- 360 people
- Sponsor
- Seoul National University Bundang Hospital
Hip Osteoarthritis
Effectiveness of Total Hip Arthroplasty for Patients With Osteoarthritis, a Target Trial Emulation Study
The aim of this study is to assess the effect of total hip arthroplasty on hip disability and pain compared to non-surgery in patients with hip osteoarthritis, using target trial emulation to emulate a randomized controlled trial.
- Trial name
- EAGLE (NCT06263569)
- Testing
- Total hip arthroplasty
- Where
- Netherlands
- Volunteers
- 156 people
- Sponsor
- JointResearch
Non Small Cell Lung Cancer, T790M
Real-World Study of Aumolertinib in Patients With Advanced EGFR T790M-Positive NSCLC
The single-arm phase II APOLLO study demonstrated favorable antitumor activity and an acceptable safety profile for aumolertinib in patients with EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer after…
- Conditions
- Non Small Cell Lung Cancer, T790M, EGFR Activating Mutation
- Trial name
- AUMO-RWE (NCT07838532)
- Testing
- Aumolertinib monotherapy （development code: HS-10296）
- Where
- China
- Volunteers
- 637 people
- Sponsor
- Xin Li
type1diabetes, Renal Failure
Kidney Alone Versus Islet-After-Kidney in Type 1 Diabetic Kidney Transplant Recipient.
Islet transplantation is associated with a benefit on glycaemic control compared to optimized insulin therapy in recent clinical trials.
- Conditions
- type1diabetes, Renal Failure, End Stage Renal Disease
- Trial name
- KA-IAK (NCT05662267)
- Testing
- Pancreatic islet transplantation after kidney transplantation
- Where
- France
- Volunteers
- 327 people
- Sponsor
- University Hospital, Lille
Total Hip Arthroplasty (THA), Antibiotic Prophylaxis
Infection-related Revision Rates After Single-dose Versus Multiple-dose Antibiotic Prophylaxis in Primary Hip and Knee Arthroplasty: a Comparative Implementation Study.
Prosthetic Joint Infection (PJI) is a significant issue in joint replacement surgeries, causing additional surgeries and substantial healthcare costs.
- Conditions
- Total Hip Arthroplasty (THA), Antibiotic Prophylaxis, Revision Arthroplasty, Total Knee Arthroplasty
- Trial name
- REVISE (NCT07053943)
- Where
- Netherlands
- Volunteers
- 70,000 people
- Sponsor
- JointResearch
NSCLC, Non Small Cell Lung Cancer
Impact of Concomitant Use of Steroids and Immune-Checkpoint Inhibitors on Survival Outcomes in NSCLC Patients
The goal of this observational study is to assess the effects of systemic corticosteroid use during immune checkpoint inhibitor (ICI) therapy in patients with non-small cell lung cancer (NSCLC).
- Trial name
- NCT06751108
- Testing
- Corticosteroids (CS), Immune Checkpoint Inhibitors
- Where
- South Korea
- Volunteers
- 2,000 people
- Sponsor
- Seoul National University
Left Ventricular (LV) Systolic Dysfunction
AI-Enabled Electrocardiogram-Guided Guideline-Directed Medical Therapy on Incident Left Ventricular Dysfunction: A Target Trial Emulation Study
This multicenter retrospective study evaluates whether artificial intelligence-enabled electrocardiography (AI-ECG) can identify individuals at high risk for left ventricular dysfunction and whether targeted guideline-directed…
- Trial name
- NCT07355023
- Testing
- Guideline-directed medical therapies
- Where
- Taiwan
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Tri-Service General Hospital (TSGH)
A Target Trial Emulation Study, Donor Age
Younger vs. Older Donors in Allo-HSCT: TTE
Hematopoietic stem cell transplantation is an important therapeutic approach for hematologic malignancies, and the impact of donor age on transplant outcomes remains an active area of investigation.
- Conditions
- A Target Trial Emulation Study, Donor Age, ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION
- Trial name
- NCT07666568
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Postoperative Delirium (POD)
The Impact of Methylprednisolone Sodium Succinate on Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgery: A Target Trial Emulation Study
Glucocorticoids can be used to inhibit postoperative systemic inflammatory response syndrome. They may reduce the risk of major complications and mortality.
- Trial name
- NCT07271394
- Testing
- Administration of methylprednisolone sodium succinate during general anesthesia induction, No administration of methylprednisolone sodium succinate during general anesthesia induction
- Where
- China
- Volunteers
- 25,800 people
- Sponsor
- Chinese PLA General Hospital
HCC - Hepatocellular Carcinoma, Hepatic Arterial Infusion Chemotherapy
HAIC in Combination With PD-1 Inhibitors and Lenvatinib for High Tumor Burden Advanced HCC (CHANCE2416)
The purpose of this study is to evaluate the safety and efficacy of hepatic arterial infusion chemotherapy (HAIC) in combination with PD-1 inhibitors and Lenvatinib in patients with high tumor burden advanced-stage hepatocellular…
- Conditions
- HCC - Hepatocellular Carcinoma, Hepatic Arterial Infusion Chemotherapy, BCLC Stage C Hepatocellular Carcinoma, Lenvatinib
- Trial name
- NCT06631326
- Testing
- hepatic artery infusion chemotherapy, Lenvatinib + PD-1 monoclonal antibody
- Where
- China
- Volunteers
- 244 people
- Sponsor
- First Hospital of China Medical University
Hemorrhage, Shock, Traumatic
The AT-REBOA Target Trial
Temporary aortic occlusion can limit haemorrhage, can help to maintain perfusion to the heart and brain, and may be associated with improved survival.
- Conditions
- Hemorrhage, Shock, Traumatic, Cardiac Arrest Due to Trauma, Polytrauma
- Trial name
- AT-REBOA (NCT06312436)
- Testing
- Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)
- Where
- 2 sites in Austria
- Volunteers
- 44 people
- Sponsor
- Medical University of Graz
Recurrent or Metastatic Cervical Cancer
TTE Study of QL1706 in Recurrent/Metastatic Cervical Cancer
The goal of this observational study is to evaluate the effectiveness and safety of Iparomlimab and Tuvonralimab (QL1706)-based therapy in patients with recurrent or metastatic cervical cancer who have experienced disease…
- Trial name
- NCT07652983
- Volunteers
- 280 people
- Sponsor
- Qilu Hospital of Shandong University
Bloodstream Infection, Pneumonia - Bacterial
Combination vs. Monotherapy for Stenotrophomonas Maltophilia Infections
The goal of this multicentre observational study is to analyse the treatment strategies and the outcomes for patients with S. maltophilia infections using target trial emulation methodology.
- Conditions
- Bloodstream Infection, Pneumonia - Bacterial, S Maltophilia Infections
- Trial name
- EMULATE-Sm (NCT07593547)
- Where
- Spain
- Volunteers
- 1,718 people
- Sponsor
- Instituto de Investigación Sanitaria Gregorio Marañón
Neuromyelitis Optica Spectrum Disorder (NMOSD)
Efficacy and Safety of Conventional Immunosuppressant Therapies in Elderly Patients With Neuromyelitis Optica Spectrum Disorder
Newly diagnosed NMOSD patients
- Trial name
- NCT07032337
- Volunteers
- 2,985 people
- Sponsor
- Samsung Medical Center
HER2-Positive Breast Cancer, Advanced Breast Cancer
First-Line Dual Versus Single HER2-Targeted Therapy With Docetaxel for Advanced HER2-Positive Breast Cancer
This retrospective observational cohort study emulates a target trial to compare the effectiveness and safety of two first-line treatment strategies for women with HER2-positive unresectable locally advanced, recurrent, or…
- Trial name
- NCT07829900
- Testing
- Pertuzumab, Trastuzumab, Docetaxel
- Where
- China
- Volunteers
- 2,250 people
- Sponsor
- Xin Li
Myocardial Infarction Type 2
Effect of Classic Secondary Prevention in Type 2 MI: A Target Trial Emulation Study
A classic heart attack is caused by a blockage to the coronary arteries that supplies the heart muscle with oxygenated blood. The medical term for this condition is type 1 myocardial infarction.
- Trial name
- NCT06736353
- Testing
- Beta Blocker Therapy or No Therapy (Control), RAAS blocker Therapy or No therapy (Control), Statin Therapy or No Therapy (Control)
- Where
- Sweden
- Volunteers
- 14,000 people
- Sponsor
- Uppsala University
Rectal Cancer
Robotic Versus Laparoscopic Surgery for Middle and Low Rectal Cancer: a Target Trial Emulation
This study aims to compare the effectiveness of robotic surgery versus laparoscopic surgery in treating low rectal cancer. While robotic surgery has gained popularity, there is limited long-term evidence regarding its outcomes.
- Trial name
- NCT06814093
- Testing
- Robotic surgery, Laparoscopic surgery
- Where
- China
- Volunteers
- 2,702 people
- Sponsor
- Xu jianmin
Rheumatic Diseases
Methotrexate Monitoring Target Trial Emulation
The goal of this retrospective, observational study is to learn more about the risks and benefits of methotrexate lab monitoring.
- Trial name
- NCT07512401
- Testing
- Standard methotrexate lab monitoring, Reduced methotrexate lab monitoring
- Volunteers
- 2,414 people
- Sponsor
- Mayo Clinic
Hematopoietic Malignancies, Haploidentical Hematopoietic Stem Cell Transplantation
Cousin vs. Sibling Donors in Haplo-HSCT
This observational study aims to emulate a hypothetical pragmatic, multicenter, non-blinded clinical trial enrolling adult patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) with grafts…
- Conditions
- Hematopoietic Malignancies, Haploidentical Hematopoietic Stem Cell Transplantation, Donor
- Trial name
- NCT07662382
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- The First Affiliated Hospital of Soochow University
Cirrhosis, Decompensated Cirrhosis of Liver
Effect of Non-Selective Beta-Blockers on Outcomes in Cirrhosis Patients After Hospitalization: A Retrospective Cohort Using Target Trial Design
The goal of this observational study is to learn if non-selective beta-blockers (NSBB) improve outcomes in patients with chronic hepatitis B or C who are discharged after hospitalization for acute decompensation of cirrhosis.
- Trial name
- NCT06977685
- Testing
- Non-selective beta-blockers
- Where
- South Korea
- Volunteers
- 7,725 people
- Sponsor
- Samsung Medical Center