Clinical trials: A Randomized Controlled Trial
Intrabony Periodontal Defect
Clinical Evaluation of Injectable Alb-PRF in the Management of Intrabony Defect in Stage-III Periodontitis Patients
Clinical Evaluation of Injectable Albumin Platelet Rich Fibrin Versus Platelet Rich Fibrin in the Management of Intra-bony Defect in Stage-III Periodontitis Patients.
- Trial name
- NCT06297577
- Testing
- Albumin Platelet Rich Fibrin (Alb-PRF) combined with minimally invasive surgical technique (MIST), Minimally invasive surgical technique (MIST)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Odontologic Disorders
Patient Reported Experience Measures Following a First Remote Orthodontic Consultation : a Randomized Controlled Trial
The objective of this present randomized controlled trial was to investigate patient's and practitioner's Reported Outcomes Measures (PROMs) following a first standard face-to-face consultation versus a first orthodontic…
- Trial name
- NCT05646277
- Testing
- e-Consultation, Consultation
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nice
Chronic Rhinosinusitis (Diagnosis)
Silver Nanoparticle Investigation for Treating Chronic Sinusitis
Chronic rhinosinusitis is a highly prevalent disease resulting in high economic burden. Effective therapeutic options are needed. Rhinosinusitis-related biofilms are a likely contributor to recalcitrant disease.
- Trial name
- SNITCH (NCT03243201)
- Testing
- Colloidal silver nanoparticles, Purified Water
- Volunteers
- healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Chronic Low Back Pain (CLBP)
Impairment Based Treatment Versus Modified Functional Restoration Program in Chronic Low Back Pain Patients
The aim of this feasibility study is to evaluate the practicality of conducting a future randomized controlled trial comparing two rehabilitation approaches for older adults with degenerative chronic low back pain…
- Trial name
- FIRM-CLBP (NCT07699419)
- Testing
- Impairment-based trearment, Modified Functional restoration program
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Respiratory Syncytial Virus Infections
RSV-MVA-BN Vaccine Phase I Trial, Intranasal Application in Adults.
A total of 96 subjects will be recruited into 5 groups. Each subject will receive either two vaccinations with MVA-BN-RSV vaccine or placebo.
- Trial name
- NCT02864628
- Testing
- MVA-BN-RSV
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bavarian Nordic
Oral Ulcer, Oral Mucositis
A Study of Phenytoin Mucoadhesive Film for Oral Ulcers in Healthy Volunteers
The goal of this clinical trial is to learn if a new 1% Phenytoin mucoadhesive film is safe and works to treat oral ulcers in healthy adult volunteers and patients with oral ulcers.
- Conditions
- Oral Ulcer, Oral Mucositis, Aphthous Stomatitis
- Trial name
- PHENO-FILM (NCT07890428)
- Testing
- 1% Phenytoin Mucoadhesive Film, Blank Mucoadhesive Film
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Infertility, IVF
Addition of Dydrogesterone to the Luteal Phase Support After Fresh Embryo Transfer
Randomized controlled study, open label to compare effectiveness of addition of dydrogesterone 20mg to the standard luteal phase support treatment after fresh embryos transfer.
- Trial name
- NCT04408144
- Testing
- Dydrogesterone 10mg Oral Tablet
- Where
- Israel
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Laniado Hospital
Red Blood Cell Health, Biological Aging
Effect of Pentadecanoic Acid Supplementation on Red Blood Cell Health and Biological Aging in Healthy Older Adults
This Phase II randomized, double-blind, placebo-controlled, parallel-group study will evaluate the effects of pentadecanoic acid (C15:0) supplementation on red blood cell (RBC) health and predicted biological age in healthy…
- Conditions
- Red Blood Cell Health, Biological Aging, Healthy Aging
- Trial name
- NCT07812792
- Testing
- Pentadecanoic Acid
- Where
- Canada
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- ReCellience15, Inc
Ankylosing Spondylitis, Work Productivity
Work Productivity and Social Activities In Patients With Ankylosing Spondylitis
The aim of this study is to evaluate the relationship between decrease in work productivity and social activities in patients with Ankylosing Spondylitis (AS) with disease activity, depression and quality of life together with…
- Trial name
- NCT04749537
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Hyaluronic Acid (HA)
A Comparative Clinical Assessment of Adjunctive Hyaluronic Acid With 3D Printed Versus Milled CAD CAM Provisional Dental Restorations on Active Periodontal Status and Surface Roughness and Biocompatibility
A Comparative Clinical Assessment of Adjunctive Hyaluronic Acid with 3D Printed Versus Milled CAD CAM Provisional Dental Restorations on active Periodontal status and Surface Roughness and biocompatibility (A Randomized…
- Trial name
- NCT07625839
- Testing
- commonly used hyaluronic Acid with both procedures 3D Printed Versus Milled CAD CAM Provisional Dental Restorations
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Gingivitis
Antimicrobial Efficacy of Biogenic Gold Nano Particle From Pelargonium Graveolens Leaves Extract Mouthwash for Children
The study is randomized controlled trial ... The null hypothesis of the present study is that there is no antibacterial efficacy of gold nanoparticles of pelargonium graveolens mouthwash against Streptococcus mutans and Candida…
- Conditions
- Dental Caries, Gingivitis, Periodontitis
- Trial name
- GNPG (NCT05816512)
- Testing
- Gold Nano particle from Pelargonium Graveolens Mouthwash, Chlorhexidine gluconate mouthwash .
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ahmed Yousif Mahdi
COVID-19 Pandemic, Simulation of Physical Illness
COVID-19 Simulation Education on Nursing Students
This study aims to determine the effect of simulation education as an approach to patients with COVID-19 on nursing students' perception and fear of the COVID-19 disease.
- Trial name
- NCT05576636
- Testing
- Simulation training, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Mehmet Akif Ersoy University
HIV Infections
A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of rgp120/HIV-1MN (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults.
PRIMARY: To examine the safety and potential improvement in immune responses elicited by combining rsgp120/HIV-1MN with the adjuvant QS-21.
- Trial name
- NCT00001044
- Testing
- Aluminum hydroxide, QS-21, rgp120/HIV-1MN
- Where
- 4 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Nurse, Attention
Effects of Aerobic Exercise Training on Nurses' Sleep Quality, Fatigue, Attention and Cortisol Profile
Shift work in nursing has been found to result in sleep disruption and sleep deprivation, and in sleepiness or fatigue at work. Slow reaction, insufficient attention and poor judgement often come with increased fatigue, which…
- Conditions
- Nurse, Attention, Aerobic Exercise, Sleep Quality
- Trial name
- NCT03759509
- Testing
- aerobic exercise
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
COVID-19
Clinical Trial to Evaluate the Safety and Immunogenicity of the COVID-19 Vaccine
This is a randomized, placebo-controlled, two center, Phase I trial in healthy adult volunteer participants consisting of two phases, an unblinded dose escalation and a double blind treatment phase to investigate the safety…
- Trial name
- COVID-19-101 (NCT04497298)
- Testing
- Two COVID-19 vaccine candidate (TMV-083/V-591) administrations - Low dose, Two COVID-19 vaccine candidate (TMV-083/V-591) administrations - High dose, One COVID-19 vaccine candidate (TMV-083/V-591) administration - High dose
- Where
- 2 sites in Belgium, France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Retrograde Bladder Fill
A Randomized Controlled Trial on the Effect of Retrograde Partial Bladder Fill on Time to Discharge and Overall Medical Staff Satisfaction
This study is a randomized controlled trial on the effect of retrograde partial bladder fill on time to discharge in patients who have had urological surgery for BPH, and whether it affects overall medical staff satisfaction.
- Trial name
- NCT04309032
- Testing
- retrograde bladder filling with 0.9% normal saline 250cc prior to removal of foley catheter
- Where
- South Korea
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healing Wound
Wound Healing with Hyaluronic Acid After Alveolar Ridge Preservation
After tooth extraction, shrinkage of the bone is expected after 6 months. These changes may hamper dental implant placement and compromise soft tissue aesthetics.
- Trial name
- NCT04467736
- Testing
- Gengigel Forte©
- Where
- Belgium
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Influenza, H7N9 Influenza
Safety and Immunogencity of H7N9 Influenza Antigen With 2 Adjuvant Formulations in Healthy Adults in Brazil
The overall aim of this study is to evaluate the safety, immunogenicity and dose sparing effects of H7N9 influenza antigen formulated with 2 different adjuvants .
- Trial name
- NCT03330899
- Testing
- H7N9 antigen + adjuvant IB160, H7N9 antigen + adjuvant SE, H7N9 antigen without adjuvant
- Where
- 3 sites in Brazil
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- Butantan Institute
HIV Infections
A Phase I, Multicenter, Randomized, Double-Blind, Placebo-Controlled HIV-1 Vaccine Trial to Evaluate the Safety and Immunogenicity of MN Recombinant Soluble gp120/HIV-1 (rsgp120/HIV-1) (Genentech) in Combination With QS21 Adjuvant and/or Alum in Healthy Adults
To extend the evaluation of safety and immunogenicity of MN recombinant soluble gp120/HIV-1 (MN rsgp120/HIV-1) in combination with QS21 with or without alum and on two different vaccination schedules.
- Trial name
- NCT00001052
- Testing
- Aluminum hydroxide, QS-21, rgp120/HIV-1MN
- Where
- 5 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Inflammatory Bowel Diseases
Preoperative Oral ImmunoNuTrition to Improve Surgical Outcomes for IBD Patients (PINT)
The central focus of this trial is to understand the effectiveness of Preoperative Immunonutrition (PINT) in improving surgical outcomes for patients with inflammatory bowel disease (IBD).
- Trial name
- PINT (NCT03333148)
- Testing
- Nestle IMPACT Immunonutrition, Arm B- Standard of Care
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
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