Clinical trials: A Randomized Controlled Trial
Myasthenia Gravis, Generalized
A Study to Assess the Effect of CellCept (Mycophenolate Mofetil) and Reduced Corticosteroids in Controlling Symptoms of Myasthenia Gravis
The efficacy and safety of CellCept (1g po, bid for 36 weeks) will be assessed in patients with myasthenia gravis receiving prednisone, or other corticosteroids.
- Trial name
- NCT00683969
- Testing
- mycophenolate mofetil (CellCept)
- Where
- 43 sites in United States, Canada and 12 more
- Volunteers
- 136 people
- Sponsor
- Hoffmann-La Roche
Wounds
Trial of Vacuum Assisted Closure® Therapy Versus Control Therapy in Angiogenesis
The purpose of this study is to determine: 1. If vacuum assisted closure (VAC®) therapy results in altered proteomic expression of angiogenic markers compared to moist wound therapy. 2.
- Trial name
- NCT00234559
- Testing
- VAC® Therapy System
- Sponsor
- KCI USA, Inc
Antibody-Mediated Rejection (AMR)
A Study of Mezagitamab in Adults With Late Antibody-Mediated Rejection (AMR) After a Kidney Transplant
Antibody-mediated rejection (AMR) is a major cause of worsening kidney function after a kidney transplant (kidney allograft dysfunction) and can lead to kidney failure.
- Trial name
- NCT07613359
- Testing
- Mezagitamab
- Where
- 35 sites in United States, China and 3 more
- Volunteers
- 36 people
- Sponsor
- Takeda
Traumatic Injury
Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( TAP Study )
This is a prospective, multicenter, randomized, double-blind, placebo-controlled, parallel-group, large simple trial to investigate the efficacy and safety of a single intravenous (IV) infusion of BE1116 in subjects who have…
- Trial name
- NCT05568888
- Testing
- BE1116
- Where
- 113 sites in United States, Australia and 1 more
- Volunteers
- 1,366 people
- Sponsor
- CSL Behring
Type 2 Diabetes Mellitus
To Compare the Efficacy and Safety of INS068 and Insulin Glargine in Subjects With Type 2 Diabetes Mellitus Treated With Basal Insulin.
The study aims to evaluate the efficacy and safety of INS068 once daily (QD) in subjects with type 2 diabetes not adequately controlled with basal insulin compared to insulin Glargine QD for 26weeks.
- Trial name
- NCT05702073
- Testing
- INS068 injection, Insulin Glargine
- Where
- China
- Volunteers
- 423 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Crohn's Disease
Effects of Adalimumab on Mucosal Healing in Subjects With Crohn's Disease Involving the Colon
The goal of this study was to test whether adalimumab can induce mucosal healing in subjects with moderate to severe ileocolonic Crohn's Disease.
- Trial name
- NCT00348283
- Testing
- adalimumab
- Where
- 21 sites in United States, Austria and 6 more
- Volunteers
- 135 people
- Sponsor
- Abbott
Schizophrenia
A Clinical Trial to Evaluate the Efficacy and Safety of SEP-363856 in Acutely Psychotic People With Schizophrenia, Followed by an Open-label Extension Phase
A clinical study to investigate the effect of 2 doses of an investigational drug in acutely psychotic adult patients with schizophrenia. The study will consist of a double-blind phase followed by an open-label extension phase.
- Trial name
- NCT04825860
- Testing
- SEP-363856 50 mg, SEP-363856 75 mg
- Where
- 54 sites in China, Japan and 2 more
- Volunteers
- 83 people
- Sponsor
- Sumitomo Pharma Co., Ltd.
Seasonal Allergic Rhinitis
A Study to Evaluate the Safety & Effectiveness of a Nasal Spray to Treat Seasonal Allergies
The Purpose of this study is to determine if one allergy medication (0.15% azelastine hydrochloride) is more effective than Placebo alone
- Trial name
- NCT00719862
- Testing
- 0.15% azelastine hydrochloride Nasal Spray
- Where
- 34 sites in United States
- Volunteers
- 481 people
- Sponsor
- Meda Pharmaceuticals
Osteoarthritis
Efficacy and Safety of Intraarticular Injections of Hyalgan in the Treatment of Osteoarthritis of the Knee
Evaluate the efficacy and safety of Hyalgan, at a dose of 20mg/2ml administered as 5 intraarticular injections at weekly intervals, for the sustained relief of pain and amelioration of joint dysfunction in patients of OA of the…
- Trial name
- NCT01319461
- Testing
- Hyalgan, sterile normal saline
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Med Pharma Co., Ltd.
Cystic Fibrosis, Bronchiectasis
A Study to Test How Well BI 1291583 is Tolerated by People With Cystic Fibrosis Bronchiectasis (Clairafly™)
This study is open to adults aged 18 years and older with cystic fibrosis bronchiectasis. The purpose of this study is to find out whether a medicine called BI 1291583 is tolerated by people with cystic fibrosis bronchiectasis.
- Trial name
- NCT05865886
- Testing
- BI 1291583
- Where
- 24 sites in United States, Belgium and 5 more
- Volunteers
- 22 people
- Sponsor
- Boehringer Ingelheim
Chronic Migraine
A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine
In this clinical trial, participants with chronic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck.
- Trial name
- MINT-C (NCT07018713)
- Testing
- Xeomin
- Where
- 111 sites in United States, Austria and 11 more
- Volunteers
- 808 people
- Sponsor
- Merz Therapeutics GmbH
Paroxysmal Nocturnal Hemoglobinuria
A Phase III Study of NTQ5082 Capsules in the Treatment of Paroxysmal Nocturnal Hemoglobinuria Patients
NTQ5082 capsules are a small molecule CFB inhibitor. This study is a multicenter, randomized, open-label, active-controlled Phase III clinical trial designed to evaluate the efficacy and safety of NTQ5082 capsules in the…
- Trial name
- NCT07177859
- Testing
- NTQ5082 capsules 200 mg, Eculizumab Injection
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Nanjing Chia-tai Tianqing Pharmaceutical
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Agili-C™ Implant Performance Evaluation
The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee.
- Trial name
- NCT03299959
- Testing
- Agili-C implant, SSOC
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 251 people
- Sponsor
- Smith & Nephew, Inc.
Vitiligo
A Trial of SHR0302Base in Patients With Vitiligo
The purpose of this study is to evaluate the efficacy and safety of SHR0302Base in participants with nonsegmental vitiligo.
- Trial name
- NCT06790862
- Testing
- SHR0302Base gel
- Where
- China
- Volunteers
- 155 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Type II Diabetes, Dyslipidemia
Metformin/Atorvastatin Combination Therapy in Subjects With Type II Diabetes and Dyslipidemia (Phase 3)
A Multi-center, Randomized, double-blind, active-controlled, phase 3 trial to evaluate the safety and efficacy of Metformin/Atorvastatin in subjects with Type II Diabetes and dyslipidemia.
- Trial name
- NCT02947620
- Testing
- Metformin/Atorvastatin 1500mg/40mg, QD, Metformin 1500mg, QD, Atorvastatin 40mg, QD
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Hypertension
Trial to Evaluate the Efficacy and Safety of a Combination Therapy of Candesartan and Amlodipine Versus Candesartan Monotherapy in Hypertensive Patients Inadequately Controlled by Candesartan Monotherapy
A Phase 3 Trial to Evaluate the Efficacy and Safety of a Combination Therapy of Candesartan and Amlodipine Versus Candesartan Monotherapy in Hypertensive Patients Inadequately Controlled by Candesartan Monotherapy
- Trial name
- NCT02651870
- Testing
- Candesartan 16mg, Amlodipine 5mg, Amlodipine 10mg
- Where
- South Korea
- Volunteers
- 135 people
- Sponsor
- Chong Kun Dang Pharmaceutical
Venous Leg Ulcer (VLU), Venous Leg Ulcers
Evaluating Intact Fish Skin Graft and Standard of Care Versus Standard of Care Alone in Nonhealing Venous Leg Ulcers
The purpose of this study is to determine the between-arm difference in the proportion of subjects achieving complete closure of hard-to-heal venous leg ulcers (VLU) between Intact Fish Skin Graft plus standard of care (IFSG/SOC)…
- Conditions
- Venous Leg Ulcer (VLU), Venous Leg Ulcers, Venous Leg, Nonhealing Venous Leg Ulcer
- Trial name
- THOR (NCT06693570)
- Testing
- Intact Fish Skin Graft (IFSG) + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Kerecis Ltd.
Schizophrenia
Efficacy and Safety of Asenapine With Placebo and Olanzapine (41022)(P05947)
Schizophrenia is a brain disease. The primary features of schizophrenia are characterized by Positive symptoms (symptoms that should not be there, inability to think clearly, to distinguish reality from fantasy i.e., hearing…
- Trial name
- NCT00151424
- Testing
- asenapine, Olanzapine
- Volunteers
- 277 people
- Sponsor
- Organon and Co
Osteoarthritis
An Efficacy, Safety and Effects on Quality of Life of Tramadol/Paracetamol as Add-on Therapy in Chronic Osteoarthritis
The purpose of this study is to evaluate the efficacy, safety and effects on Quality of Life (QOL) of tramadol/paracetamol (APAP) as an add-on therapy (medication taken in addition to another medication) in Filipino participants…
- Trial name
- NCT01728246
- Testing
- Tramadol/Paracetamol (APAP), Non-Tramadol/APAP
- Where
- Philippines
- Volunteers
- 473 people
- Sponsor
- Janssen Pharmaceutica
Diabetes Mellitus, Type 2
SAL067 Treatment in Patients With Type 2 Diabetes Who Are Not Controlled by Metformin
This is the phase 3 randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and long-term safety of SAL067 in T2DM patients uncontrolled by metformin, comprising 24 weeks of double-blind treatment…
- Trial name
- NCT05801627
- Testing
- SAL067
- Where
- China
- Volunteers
- 408 people
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.