Clinical trials: Ventilator-Associated Pneumonia (VAP)
Ventilator Associated Pneumonia ( VAP)
Pre-clinical Diagnosis Using Integrated Microbial and Host Response Signatures to Improve Outcomes From Ventilator-associated Pneumonia in Critically Ill Children
Ventilator-associated pneumonia (VAP), defined as pneumonia occurring 48 hours after initiation of invasive mechanical ventilation, is insidious in onset and severe in consequence.
- Trial name
- VAP-Dx (NCT07026656)
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Cambridge
Ventilator Associated Pneumonia
Study of Knowledge Translation of Clinical Practice Guidelines for Ventilator Associated Pneumonia
The purpose of this prospective, multicentre, time-series study is to develop, implement, refine, and evaluate a sustainable behaviour change strategy in the intensive care unit (ICU).
- Trial name
- ABATEVAP (NCT00434460)
- Testing
- Education
- Where
- 11 sites in United States, Canada
- Volunteers
- 1,320 people
- Sponsor
- Canadian Critical Care Trials Group
Ventilator Associated Pneumonia
Oral Care as a Preventive Measure of VAP; Miswak Versus Chlorhexidine and Toothbrush.
Dental plaque score calculation and swabs of Oropharynx and teeth were collected on admission. For group I, Miswak stick was used 4 hourly for oral care. For group II, 0.12% Chlorhexidine/ toothbrush were used 4 hourly
- Trial name
- NCT02288390
- Testing
- Oral care in mechanically ventilated patients
- Volunteers
- 40 people
- Sponsor
- University of Alexandria
Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection
Impact of Nurses' Behavior Change and Evidence-Based Practice Implementation on Quality Indicators in Intensive Care Units in Low- and Middle-Income Countries
Study title: Impact of nurses' behavior change and implementing evidence-based practice to improve quality indicators in intensive care units in low-and middle-income countries Background and Rationale: Quality care is crucial…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Central Line-Associated Bloodstream Infection, Pressure Ulcers (Hospital-acquired Pressure Injuries), Prolonged Intensive Care Unit Length of Stay
- Trial name
- NCT07397364
- Testing
- Evidence based practices bundles of care
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Ventilator Associated Pneumonia ( VAP)
Impact of Oral Care on Ventilator Associated Pneumonia
The goal of this clinical trial was to find out whether cleaning the mouths of children in the Pediatric Intensive Care Unit (PICU) with toothbrushing and chlorhexidine lowers the chance of getting lung infections in patients on…
- Trial name
- OH-VAP (NCT07287566)
- Testing
- Toothbrushing + Chlorhexidine, Routine oral care + Chlorohexidine
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Ain Shams University
Ventilator Associated Pneumonia (VAP)
Pulmonary Infections and Barotrauma Associated With MV IN PICU
This study aims to determine the incidence, risk factors and outcome of ventilation associated common complication in the PICUs at Assiut University Children Hospital in Egypt.
- Trial name
- NCT05792501
- Testing
- Mechanical ventilation
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Pneumonia, Ventilator-Associated, Colistin Adverse Reaction
Aerosolized Plus Intravenous vs. Intravenous Colistin for VAP Due to Pandrugs-resistant A. Baumannii in Neonates
This study is planned to compare the clinical efficacy and safety of aerosolized plus intravenous colistin vs. intravenous colistin as adjunctive therapy for the treatment of ventilator-associated pneumonia (VAP) due to…
- Conditions
- Pneumonia, Ventilator-Associated, Colistin Adverse Reaction, Infection Due to Multidrug Resistant Acinetobacter, Infection Resistant to Multiple Drugs
- Trial name
- NCT02806141
- Testing
- Aerosolized plus intravenous colistin, Intravenous colistin
- Where
- Thailand
- Volunteers
- 204 people
- Sponsor
- Hat Yai Medical Education Center
Ventilator Associated Pneumonia
Reducing the Incidence of VAP in Critically Ill Children and Assessment of Oral Care With CHX
This was a single-centered, randomized, placebo-controlled double-blind clinical trial conducted in the pediatric intensive care unit (PICU), in patients who were aged 1 month to 18 years, needing MV for at least 48 hours, to…
- Trial name
- NCT04527276
- Testing
- Oral care with 0,12% Chlorhexidine
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Medeniyet University
Ventilator-Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) in Intensive Care Unit (ICU)
Ventilator-associated pneumonia (VAP) is very common in the intensive care unit (ICU), affecting 9 to 40% of ICU patients and mortality rates range from 20 to 50% and may reach more than 70% when the infection is caused by…
- Trial name
- NCT00935285
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- University of Thessaly
Ventilator Associated Pneumonia
GRam Stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) Trial
Background: Optimising the use of antibiotic agents is a pressing challenge to overcoming the rapid emergence and spread of multidrug-resistant pathogens in intensive care units (ICUs).
- Trial name
- NCT03506113
- Testing
- Gram stain-guided antibiotic choice, Guidelines-based antibiotics choice
- Where
- 12 sites in Japan
- Volunteers
- 206 people
- Sponsor
- Osaka General Medical Center
Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD)
National Surveillance and Prevention of Neonatal VAP
The goal of this observational study is to improve how hospital-acquired lung infections (called ventilator-associated pneumonia, or VAP) are diagnosed, treated and prevented in very low birth weight (VLBW) infants, babies born…
- Conditions
- Ventilator-Associated Pneumonia (VAP), Neonatal, Bronchopulmonary Dysplasia (BPD), Antibiotic-Resistant Organisms (AROs), Health-Care Associated Infection (HAI)
- Trial name
- NCT07109791
- Where
- Canada
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Ventilator Associated Pneumonia
Effectiveness of a VAP Prevention Bundle in the PICU
This observational monocentric prospective study aims to evaluate the efficacy of new measures for ventilator associated pneumonia (VAP) management in the pediatric population in the pediatric intensive care unit (PICU) of…
- Trial name
- NCT03763695
- Testing
- Measures for the VAP prevention in the PICU, Evaluation of VAP incidence before the protocol introduction
- Where
- Italy
- Volunteers
- 242 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ventilator-associated Pneumonia
Methods of Chlorhexidine Cleansing to Prevent Ventilator-Associated Pneumonia (VAP)
Ventilator-associated pneumonia (VAP) is common in patients receiving mechanical ventilation, and is associated with longer hospital stay, increased treatment costs, and higher rates of morbidity and mortality .
- Trial name
- VAP (NCT02077920)
- Testing
- Chlorhexidine, 0.9% sodium chloride injection, Endotracheal tube
- Where
- China
- Volunteers
- 192 people
- Sponsor
- General Hospital of Shenyang Military Region
VAP - Ventilator Associated Pneumonia
Ventilator-associated Pneumonia (VAP) Diagnostic Stewardship Trial
This is a prospective pilot/feasibility trial of a bundled diagnostic stewardship intervention at the level of the microbiologic testing pathway in ventilator-associated pneumonia (VAP).
- Trial name
- NCT05176353
- Testing
- VAP diagnostic stewardship bundle
- Where
- United States
- Volunteers
- 4,892 people
- Sponsor
- University of Michigan
Ventilator Associated Pneumonia
Role of Lactoferrin in Prevention of Ventilator Associated Pneumonia in Neonates.
The aim of the study is to 1. Evaluate the preventive value of Lactoferrin on VAP among ventilated neonates. 2. Evaluate the Primary outcome of Lactoferrin on: Sepsis, Feeding intolerance, Vomiting, Constipation or diarrhea 3.
- Trial name
- NCT07255742
- Testing
- Lactoferrin in prevention of VAP, Control
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Dalia Mohamed Salah
Ventilator-Associated Pneumonia Prevention and Intensive Care Nursing Care
Theory-Based Educational Program for VAP Prevention and Nursing Care in Intensive Care Units
Ventilator-associated pneumonia (VAP) is an important challenge in intensive care and requires nurses to apply evidence-based preventive practices consistently in mechanically ventilated patients.
- Trial name
- TSEP-VAP-2026 (NCT07820826)
- Testing
- Theory-Based Structured Educational Program, Usual Care
- Where
- Jordan
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- JAWAD AHMAD ABU-SHENNAR
Ventilator-associated Pneumonia
Study of Biotene OralBalance Gel for Oral Care in Critically-Ill Mechanically Ventilated Neonates
The goal of this pilot study is to test the hypothesis that mechanically ventilated infants receiving Biotene OralBalance® gel for oral care would have a reduced intubation time compared to infants receiving oral care placebo.
- Trial name
- NCT01314742
- Testing
- Biotene OralBalance® gel, Sterile Water moisten cotton tipped applicator
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Wake Forest University Health Sciences
Traumatic Brain Injury, Ventilator Associated Pneumonia
Effect of E-BAL on Severity of VAP Assessed Through CPIS on the Patients of Traumatic Brain Injury in Neurocritical Care, Also Effect on Days of Ventilation and ICU Stay.
Severe traumatic brain injury (STBI) is a leading cause of disability, mortality, and economic burden worldwide. The impact of severe traumatic brain injury (STBI) on the economy of developing countries like Pakistan is…
- Trial name
- NCT04977843
- Testing
- EARLY BRONCHOALVEOLAR LAVAGE
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Jinnah Hospital
VAP - Ventilator Associated Pneumonia
Performance Study of Targeted Sequencing Technology for VAP
Main purpose: To evaluate the feasibility of tNGS for pathogen detection and drug resistance analysis in VAP patients. Research site and research population: This study is planned to be conducted in hospitals, targeting VAP…
- Trial name
- NCT06035796
- Testing
- tNGS
- Volunteers
- 150 people
- Sponsor
- The First Hospital of Jilin University
Ventilator Acquired Pneumonia
Assessment of the Role of Probiotics in Prevention of Ventilator-Associated Pneumonia in Neonates
Evaluate the preventive value of probiotics on VAP among ventilated neonates.
- Trial name
- NCT07001163
- Testing
- Probiotic
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Lamiaa Khaled Zidan