Clinical trials: Trauma Coagulopathy
Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia
Palliative Care Needs of Children With Rare Diseases and Their Families
The palliative care needs of family caregivers of children with rare diseases and their children are largely unmet, including the need for support to prepare for future medical decision making.
- Conditions
- Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia, Asparagine Synthetase Deficiency, CHARGE Syndrome
- Trial name
- FACE-Rare (NCT06938542)
- Testing
- Family Centered pediatric palliative care for family caregivers of children with rare diseases.
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Children's National Research Institute
Henoch-Schönlein Purpura, Gastrointestinal Injury
Mycophenolate Mofetil in Gastrointestinal Henoch-Schonlein Purpura
Henoch Schönlein purpura (HSP) is the most common type of vasculitis in children, with an incidence of ~10/100,000, whereas >90% of the patients develop symptoms at <10 years of age.
- Conditions
- Henoch-Schönlein Purpura, Gastrointestinal Injury, Mycophenolate Mofetil
- Trial name
- NCT05951517
- Testing
- MMF
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hemorrhage, Coagulopathy
Implementing Treatment Algorithms for the Correction of Trauma Induced Coagulopathy
This trial compares the haemostatic effect of viscoelastic haemostatic assay (VHA)-guided transfusion strategy versus non-VHA guided transfusion strategy in haemorrhaging trauma patients.
- Conditions
- Hemorrhage, Coagulopathy, Trauma
- Trial name
- iTACTIC (NCT02593877)
- Testing
- VHA algorithm
- Where
- 7 sites in Denmark, Germany and 3 more
- Volunteers
- 412 people
- Sponsor
- Queen Mary University of London
Traumatic Brain Injury, Coagulation Disorder
Evaluating the Use of Thromboelastography to Diagnose Coagulopathy After Traumatic Brain Injury
The investigators will obtain thromboelastography (TEG) on pediatric patients admitted to the Rady Children's Hospital ICU after traumatic brain injury on admission to our ICU and after 24 hours of care.
- Trial name
- NCT01589172
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Trauma
Rotational Thromboelastometry Activated Transfusion In Trauma Trial
This is a randomized controlled trial to compare viscoelastic (VE) guided resuscitation to fixed-ratio resuscitation in trauma patients with hemorrhagic shock on the utilization of blood products, effects on coagulation and…
- Trial name
- ROTATE-IT (NCT03765866)
- Testing
- Thromboelastometry guided transfusion
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Texas Southwestern Medical Center
Major Trauma, Traumatic Brain Injury
Severe Trauma Registry in Tarragona
Severe trauma is one of the leading causes of morbidity, mortality, and disability worldwide. Currently, it is the primary cause of death among individuals under 45 years of age.
- Trial name
- IcuTrauma (NCT06007807)
- Where
- Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospital Universitari Joan XXIII de Tarragona.
Severe Trauma
Utility of Point-of-care Device for Rapid Determination of Cogulopathy in Trauma Patients
Traumatic coagulopathy is frequent and is an independent risk factor of mortality. Its detection mainly relies upon classic biological test like the prothrombin time and the international normaliezd ratio (INR).
- Trial name
- Coaguchek (NCT02869737)
- Testing
- Coagucheck, Roche, France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Acquired Bleeding Disorder, Trauma
Efficacy and Safety of Activated Recombinant Human Factor VII in Severely Injured Trauma Patients
This trial is conducted in Africa, Asia, Europe, Oceania and North America. The aim of this trial is to evaluate the efficacy of activated recombinant human factor VII given in conjunction with standard therapy in the treatment…
- Trial name
- NCT01563523
- Testing
- activated recombinant human factor VII
- Where
- 9 sites in Australia, Austria and 7 more
- Volunteers
- 283 people
- Sponsor
- Novo Nordisk A/S
Trauma, Hemorrhage
Transfusion for Major Haemorrhage in Trauma - Characteristics and Outcomes
Background: Trauma is the leading cause of death in young adults worldwide and the most common causes of mortality are haemorrhage and brain injury.
- Conditions
- Trauma, Hemorrhage, Shock, Traumatic, Acute Coagulopathy
- Trial name
- NCT05573841
- Where
- Sweden
- Volunteers
- 161 people
- Sponsor
- Karolinska University Hospital
Wound; Rupture, Surgery, Cesarean Section, Postpartum Hemorrhage
HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency
The objective of the Expanded Access Program is to provide HEMOLEVEN, a replacement coagulation factor XI, to patients with severe inherited factor XI deficiency where, in the opinion of the treating physician, the benefits of…
- Conditions
- Wound; Rupture, Surgery, Cesarean Section, Postpartum Hemorrhage, Surgery
- Trial name
- EAP (NCT01701947)
- Testing
- Hemoleven
- Where
- United States
- Sponsor
- Laboratoire français de Fractionnement et de Biotechnologies
Snake Bites, Coagulopathy, Consumption
Hemostatic Variables In Snakebite Study
Background Novelty The global assays of coagulation, namely the viscoelastometric tests and clot waveform has never been studied in detail before in snakebite victims.
- Trial name
- HISS (NCT04520282)
- Where
- India
- Volunteers
- 96 people
- Sponsor
- Jubilee Mission Medical College and Research Institute
Multiple Trauma, Massive Bleeding
Evaluation of the TICCS Capacity to Identify Trauma Patients With Acute Coagulopathy and Massive Bleeding
A prospective single-centre non-comparative non-interventional open study has been designed to validate, in a target number of 100 trauma patients, the correlation between TICCS evaluated on the site of injury and…
- Conditions
- Multiple Trauma, Massive Bleeding, Early Complication of Trauma
- Trial name
- NCT02132208
- Where
- Belgium
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Régional de la Citadelle
Trauma, Hemorrhage
Fibrinogen Early In Severe Trauma studY Junior
1. Haemorrhage in severe trauma is a significant cause of mortality and is potentially the most preventable cause of death in paediatric trauma patients 2.
- Conditions
- Trauma, Hemorrhage, Coagulopathy, Pediatrics
- Trial name
- FEISTY Jnr (NCT03508141)
- Testing
- Fibrinogen Concentrate, Cryoprecipitate
- Where
- 10 sites in Australia
- Volunteers
- 44 people
- Sponsor
- Gold Coast Hospital and Health Service
Abdominal Injuries, Wounds and Injuries
Predictors of In-Hospital Mortality in Severe Abdominal Trauma
Severe abdominal trauma is a leading cause of early death from bleeding and of later death from sepsis and organ failure. Clinicians use scoring systems to estimate the risk of dying, but most of these scores were developed and…
- Conditions
- Abdominal Injuries, Wounds and Injuries, Wounds, Nonpenetrating, Wounds, Penetrating
- Trial name
- NCT07843628
- Where
- Egypt
- Volunteers
- 430 people
- Sponsor
- Minia University
Trauma Induced Coagulopathy, Trauma Coagulopathy
Point of Care Fibrinogen Measurement in Trauma Patients in the Emergency Department
Background: Why This Study Matters When someone suffers a severe injury (like from a car crash), they can bleed heavily. One complication doctors often face is something called Trauma-Induced Coagulopathy (TIC).
- Conditions
- Trauma Induced Coagulopathy, Trauma Coagulopathy, Fibrinogen Deficiency, Fibrinogen; Deficiency, Acquired
- Trial name
- POCFIB (NCT07097337)
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Erasmus Medical Center
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Trauma, Hemorrhage
Transfusion Using Stored Whole Blood
Massive hemorrhage is a major cause of potentially preventable death following trauma. A common consequence of hemorrhagic shock is uncontrollable bleeding from coagulopathy, leading to death from exsanguination.
- Conditions
- Trauma, Hemorrhage, Coagulopathy
- Trial name
- NCT02926274
- Where
- United States
- Volunteers
- 330 people
- Sponsor
- University of California, Los Angeles
Bleeding, Cardiac Defect
ZEPLAST- PED: ZEro_PLASma Trial in Small Infants Undergoing Cardiac Surgery
In pediatric patients (newborns and infants weighing less than 10 kg) undergoing cardiac surgery with extracorporeal circulation postoperative bleeding represents a known complication with a significant impact on outcome.
- Conditions
- Bleeding, Cardiac Defect, Surgery--Complications, Fibrinogenopenia; Acquired
- Trial name
- ZEPLAST-PED (NCT04434001)
- Testing
- Fibrinogen Concentrate Human, Prothrombin Complex Concentrate, Fresh Frozen Plasma
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Policlinico S. Donato
Coagulation Defect, Snake Bites
Study Comparing Modified Lee White Clotting Time Against Twenty Minute Whole Blood Clotting Test in Snakebite Victims
20 minute Whole Blood Clotting Test(20'WBCT) recommended by World Health Organisation guidelines is probably the most routinely employed bed side screening tool in the country.
- Trial name
- LAT (NCT03890016)
- Testing
- 20'Whole Blood ClottingTest (WBCT), Modified Lee and White (MLW) Method Clotting Time
- Where
- India
- Volunteers
- 230 people
- Sponsor
- Appu Suseel
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International