Clinical trials: TKA
Osteoarthritis, Metal Ion Levels
Serum Metal Ion Concentration After Total Knee Arthroplasty (TKA)
All metal implants release metal ions because of corrosion. Total knee arthroplasty implants have large metal surface areas and therefore substantial potential for corrosion.
- Trial name
- NCT00862511
- Testing
- Coated Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Technische Universität Dresden
Knee Disease, Nerve Pain
Triple Injection Peri-sartorius (TIPS) Block
Comparison between the pain scores after total knee arthroplasty in patients receiving triple injection peri-sartorius (TIPS) block versus femoral nerve block (FNB)
- Trial name
- NCT05289427
- Testing
- ultrasound guided triple injection peri-sartorius block, Femoral Nerve Block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Alexandria University
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Pain, Analgesic Efficacy
Local Anesthetic in Total Knee Arthroplasty (TKA): Volume Versus Concentration
In a randomized, double-blind, cross-over trial, 48 patients scheduled for total knee arthroplasty with placement of an intracapsular catheter will be randomized to receive bolus injection of ropivacaine in high volume/low…
- Trial name
- NCT01012232
- Testing
- 20 mL ropivacaine 5 mg/mL, 10 mL ropivacaine 10 mg/mL
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Lundbeck Foundation
Knee Arthropathy, Anesthesia, Local
Modified TIPS Block for Total Knee Arthroplasty
The is carried out to compare triple injection peri-sartorial block to a modified block including an extra local anesthetic injection deep to the adductor longs muscle via a medial to lateral approach regarding the peri-operative…
- Trial name
- NCT06539910
- Testing
- General Anesthesia, TIPS block, Modified TIPS block
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Alexandria University
Postoperative Complication
Efficacy of Wound Care and Reduction of Wound Complications by Use of AQUACEL® Ag Surgical Dressing in MIS TKA
The investigators hypothesized that AQUACEL® Ag Surgical dressing would have a significant improvement in the efficacy of wound care and wound complications compared with traditional Sofra-Tulle® dressings after minimally…
- Trial name
- NCT02445300
- Testing
- AQUACEL® Ag Surgical dressing (study group), Sofra-Tulle® dressing (control group)
- Volunteers
- 285 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Knee Osteoarthritis
Custom Guides for Total Knee Arthroplasty (TKA)
The goal of the study is to know if the reconstruction of the lower limb mechanical axis and the patient knee function is improved after Total Knee Arthroplasty (TKA) using patient specific instruments.
- Trial name
- NCT01573208
- Testing
- Custom guides
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Lausanne Hospitals
Postoperative Pain Management
Pain Treatment After TKA With LIA and Intra-articular Continuous Infusion Pump
The purpose of this study is to evaluate the effect on postoperative pain and function by adding intraarticular continuous infusion pump with local anesthetic after total knee arthroplasty where local infiltration analgesia has…
- Trial name
- NCT01726686
- Testing
- Ropivacaine
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Knee Injuries and Disorders, Osteo Arthritis Knee
RELIABILITY AND VALIDITY OF THE DT BALANCE TEST IN PATIENTS WITH TKA
The ability to perform a cognitive task while walking simultaneously is essential in real daily life. However, the psychometric properties of dual-task walking tests have not been well established in patients undergoing total…
- Trial name
- DT TKA (NCT06108466)
- Where
- Turkey (Türkiye)
- Volunteers
- 31 people
- Sponsor
- Dokuz Eylul University
Degenerative Arthritis of Knee
Visionaire™ Versus Standard Instrumentation Safety and Efficacy in Total Knee Arthroplasty (TKA)
The objective of this study is to assess outcomes following TKA, utilizing two surgical techniques. Patients will be randomized to one of two arms: TKA with standard instrumentation and TKA with VISIONAIRE™ patient-matched…
- Trial name
- NCT01084772
- Testing
- VISIONAIRE Total Knee Arthroplasty, Standard Total Knee Arthroplasty
- Where
- 7 sites in United States, Australia
- Volunteers
- 134 people
- Sponsor
- Smith & Nephew, Inc.
Knee Osteoarthritis
A Prospective, Randomized Study Comparing Cemented and Cementless Total Knee Replacement
The purpose of this study is to compare the the Nexgen knee replacement system using cementless fixation with the same system using cemented fixation.
- Trial name
- NCT01194817
- Testing
- High-Flexion Knee Replacement System using Cemented Fixation, High-Flexion Knee Replacement System using Cementless Fixation
- Volunteers
- 100 people
- Sponsor
- Anderson Orthopaedic Research Institute
Knee Osteoarthritis
Validity and Reliability of 30SFPW Test Patients With TKA
Walking speed after total knee arthroplasty (TKA) can be used as a simple tool to monitor postoperative recovery. There are different protocols for gait assessment in patients with TKA.
- Trial name
- NCT06202170
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Dokuz Eylul University
Osteoarthritis, Depression
Psychological, Sexually and Social Consequences of Osteoarthritis Treatment With THA or TKA and Joint Preserving Surgery
The project runs as a Ph.d. project at the Faculty of Health Sciences- University of Copenhagen. In Denmark the investigators operate around 16.000 artificial hips and knees yearly, mainly due to osteoarthritis.
- Conditions
- Osteoarthritis, Depression, Hip Dysplasia
- Trial name
- NCT01305759
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- Hvidovre University Hospital
Osteoarthritis, Rheumatoid Arthritis
Minimally Invasive Versus Conventional Approaches in Navigated Total Knee Arthroplasty (TKA)
50 patients are randomized to two groups who receive a navigated knee prosthesis. Aim of the study is a comparison between a minimally invasive and a conventional approach.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis
- Trial name
- NCT00839020
- Testing
- Navigated TKA with a minimally invasive approach, Navigated TKA with a conventional approach
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- Aesculap AG
Knee Osteoarthristis
Robotic Medial Congruent Vs. Conventional Medial Pivot TKA
This multicenter, prospective cohort study will evaluate whether Robotic-Assisted total knee arthroplasty (RATKA) with a Medial Congruent implant is a successful method to improve implant alignment, insert thickness accuracy, and…
- Trial name
- NCT06858358
- Testing
- Robotic assisted total knee arthroplasty, Conventional total knee arthroplasty (cTKA)
- Where
- 2 sites in Romania
- Volunteers
- 300 people
- Sponsor
- George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures
Arthroplasty, Replacement, Knee
Long-term Study of the DePuy Low Contact Stress (LCS) Complete Total Knee System
The main objective of this study is to evaluate how the LCS Complete mobile-bearing total knee system and surgical instrumentation performs.
- Trial name
- NCT00733915
- Testing
- L.C.S. Complete Knee (DePuy Low Contact Stress Complete Knee System)
- Where
- Ireland
- Volunteers
- 241 people
- Sponsor
- DePuy International
Bilateral Total Knee Chronic Pain Following Arthroplasty
Risk of Chronic Post-surgical Pain After TKA
Chronic post-surgical pain (CPSP) is a common surgical complication. The role of timing in the development of CPSP after bilateral total knee arthroplasty (BTKA) is not well studied.
- Trial name
- NCT06079749
- Testing
- Simultaneous BTKA, Staged BTKA
- Volunteers
- 403 people
- Sponsor
- Gangnam Severance Hospital
Osteoarthritis, Rheumatoid Arthritis
PS150 Total Knee Arthroplasty Outcomes Registry
This registry is intended to evaluate the clinical outcomes of the DePuy P.F.C. Sigma PS150 RP Total Knee System. 200 participants will be enrolled prospectively or retrospectively and the follow up period will be 5 years.
- Trial name
- NCT02319291
- Testing
- P.F.C. Sigma PS150 RP Total Knee System
- Where
- 4 sites in Australia, South Korea
- Volunteers
- 175 people
- Sponsor
- DePuy Orthopaedics
Revision Total Knee Arthroplasty, Osteoarthritis, Knee
Gut Microbiome in Orthopaedics: Revision Total Knee Arthroplasty
Many patients who receive knee replacement surgery must return for a revision (or repeat) surgery due to ongoing pain, stiffness, infection, or implant loosening.
- Trial name
- GUMBO (NCT06951477)
- Testing
- Revision Total Knee Arthroplasty
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's