Clinical trials: Symptom Management
Neonatal, Pain Management
The Effect of Scents Applied During Heel Blood Collection on Newborn Crying Duration, Pain, and Physiological Parameters
One of the most common and painful procedures in newborns is taking a capillary blood sample from the heel. This basic procedure, widely used in early health assessments, particularly in newborn screening tests, can cause mild to…
- Trial name
- Randomized (NCT07350980)
- Testing
- oil
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Hemopneumothorax, Pneumothorax
Role of Antibiotics to Reduce Infectious Complications in Tube Thoracotomy Management of Traumatic Hemopneumothorax
The purpose of this study is to examine the efficacy of prophylactic antibiotics in patients with chest tubes for management of thoracic injuries in the reduction of the incidence of empyema as compared to placebo.
- Trial name
- NCT01127880
- Testing
- Ancef or Clindamycin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Percutaneous Internal Ring Suturing, Pain Management
Comparison of the Postoperative Analgesic Effects of RSB and CEB in Pediatric Patients Scheduled for Percutaneous Internal Ring Suturing
Inguinal hernia is one of the most common surgical pathologies in children, and the minimally invasive percutaneous internal ring suturing (PIRS) technique is widely preferred.
- Trial name
- NCT07147062
- Testing
- Rectus Sheath Block, Caudal Epidural Block
- Where
- Turkey (Türkiye)
- Volunteers
- 65 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Appendectomy, Laparoscopic, Pediatric Anesthesia
Rectus Sheath Block and Local Wound Infiltration in Pediatric Laparoscopic Appendectomies
Laparoscopic appendectomy surgeries are among the most commonly performed procedures in childhood. However, they are associated with moderate to severe postoperative pain.
- Conditions
- Appendectomy, Laparoscopic, Pediatric Anesthesia, Nerve Block/Methods, Regional Anesthesia
- Trial name
- NCT06913205
- Where
- Turkey (Türkiye)
- Volunteers
- 145 people
- Sponsor
- Bursa City Hospital
Immune Thrombocytopenia
Eltrombopag vs Standard Front Line Management for Newly Diagnosed Immune Thrombocytopenia (ITP) in Children
This is an investigator initiated, multicenter, open label, randomized phase 3 study for subjects with newly diagnosed ITP from ages 1 to less than 18 years old.
- Trial name
- NCT03939637
- Testing
- Eltrombopag, Steroids, IVIG
- Where
- 27 sites in United States
- Volunteers
- 122 people
- Sponsor
- Baylor College of Medicine
Surgery--Complications
Cognitive Aids for the Management of Deteriorating Surgical Patients
Background and Goal of Study: Adherence to best practice management of emergencies improves through the use of cognitive aids. Aim of this study was to develop and validate cognitive aids for management of deteriorating surgical…
- Trial name
- CAMDS (NCT03812861)
- Testing
- CAMDS bundle
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Pediatric Obesity
Is it Helpful to Use Fitbits in a Family Based Weight Loss Program?
This study evaluates the role of personal activity trackers to help improve weight loss or weight maintenance for children and their parents enrolled in a comprehensive weight loss program.
- Trial name
- NCT03215641
- Testing
- Fitbit
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
Severe Spasticity
Safety Study of 3 mg/mL Baclofen Injection (Intrathecal) Using A Programmable Pump
Safety study to assess the 3 mg/mL baclofen injection (intrathecal) using a programmable pump
- Trial name
- NCT01520545
- Testing
- Gablofen® 3 mg/mL (baclofen injection), SynchroMed® II Programmable Pump
- Where
- 13 sites in United States
- Volunteers
- 153 people
- Sponsor
- Piramal Critical Care, Ltd.
HSP, Hereditary Spastic Paraplegia
Safety and Efficacy of AAV9/AP4B1 (BFB-101) For Patients With AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47)
Safety and Efficacy of AAV9/AP4B1 For Patients with AP4B1-related Hereditary Spastic Paraplegia Type 47 (SPG47): A Phase 1/2 Single-Center, Open-Label Study of Stereotactic Intra-cisterna Magna Administration.
- Conditions
- HSP, Hereditary Spastic Paraplegia, Hereditary Spastic Paraparesis, Hereditary Spastic Paraplegia Type 50
- Trial name
- NCT06948019
- Testing
- BFB-101 (AAV9-CBh-AP4B1)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- BlackfinBio Ltd
Early Onset Neonatal Sepsis
Management of Early Onset Neonatal Septicaemia: Selection of Optimal Antibacterial Regimen for Empiric Treatment
A prospective two-center antibiotic regimen switch study will be conducted to compare the clinical efficacy of two antibiotic regimens - penicillin/gentamicin versus ampicillin/gentamicin - in the empirical treatment of early…
- Trial name
- NCT00487019
- Where
- 2 sites in Estonia
- Volunteers
- 281 people
- Sponsor
- University of Tartu
Bile Duct Neoplasms
Covered or Uncovered Bile Duct Stents
The study is investigator initiated. Tumors that gives the narrowing of the bile ducts prevents bile from flowing from the liver to the intestine resulting in jaundice and the risk of bacterial growth in bile with severe…
- Trial name
- NCT01232101
- Testing
- covered or uncovered stents
- Where
- Sweden
- Volunteers
- 71 people
- Sponsor
- Göteborg University
Anaplastic Lymphoma Kinase (ALK)- Positive Tumors, Non-small Cell Lung Cancer (NSCLC)
Managed Access Programs for LDK378, Ceritinib
The purpose of this registration is to list Managed Access Programs (MAPs) related to LDK378, Ceritinib.
- Trial name
- NCT05100134
- Testing
- ceritinib
- Sponsor
- Novartis Pharmaceuticals
Amblyopia, Strabismus
The Use of Interactive Binocular Treatment (I-BiT) for the Management of Anisometropic, Strabismic and Mixed Amblyopia in Children Aged 3.5 - 12 Years
Around one child in fifty has a lazy eye (termed amblyopia) where the eye is structurally normal but the vision fails to develop correctly.
- Trial name
- I-BiT Plus (NCT02810847)
- Testing
- I-Bit plus
- Volunteers
- 182 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Hematopoietic and Lymphoid Cell Neoplasm, Malignant Solid Neoplasm
Palliative, Rehabilitation, and Integrated Medicine Handbook for Self Care at Work
This study investigates the usefulness of the Self Care at Work Handbook in order to generate an improved version. Information from this study may help researchers identify potential factors associated with perception and…
- Trial name
- NCT05038384
- Testing
- Survey Administration
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Immune Thrombocytopenia, Treatment
Daratumumab Versus Rituximab in the Management of Pediatric Primary Immune Thrombocytopenia (ITP)
This randomized, open-label study aim to compare the efficacy and safety of Daratumumab (anti-CD38 monoclonal antibody) with Rituximab in pediatric ITP patients.This study will be conducted in pediatric ITP patients who had not…
- Trial name
- NCT07362238
- Testing
- Rituximab, Daratumumab
- Where
- China
- Volunteers
- 122 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Endoscopic Surgical Procedure
Percutaneous Sigmoid Fixation For Management Of Recurrent Sigmoid Volvulus
The investigators included all patients who were presented to emergency department with recurrent sigmoid volvulus at Zagazig University hospital between (August 2024 to August 2025).
- Trial name
- NCT07155304
- Testing
- percutaneous sigmoid colon fixation
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Pain, Sickle Cell Disease
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
The study, known as the Peer suppoRt for adolescents and Emerging adults with Sickle cell pain: promoting ENgagement in Cognitive behavioral thErapy (PRESENCE), aims to determine the effectiveness of digital CBT in reducing pain…
- Trial name
- PRESENCE (NCT06374238)
- Testing
- CBT+ Health coach, CBT w/o Health Coach ( self-guided), Usual Care
- Where
- 14 sites in United States
- Volunteers
- 390 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease (COPD)
Management of Patients With Respiratory Symptoms in Sweden
This is a web-based randomized survey to evaluate management of respiratory symptoms among physicians in Sweden. The aim of this study is to determine if there is a gender bias in the diagnosis of COPD and how often physicians…
- Trial name
- NCT02728674
- Testing
- Person in the case is a male., Person in the case is a female., Symptom in the case is breathlessness.
- Where
- Sweden
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Obesity
Impact of Fitbit Plus Weight Management Program on Physical Activity and Metabolic Disease in Obese Adolescents
This study is evaluating the feasibility and efficacy of using Fitbit Charge HR devices to remotely track the physical activity of obese pediatric patients who are concurrently enrolled in a comprehensive weight loss intervention…
- Trial name
- NCT02507791
- Testing
- Fitbit Charge HR plus weekly phone calls to review physical activity data
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University Hospitals Cleveland Medical Center
Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis
Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen Peroxide
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years.
- Conditions
- Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis, Tonsillectomy
- Trial name
- NCT07675278
- Testing
- Adrenaline, Hydrogen Peroxide
- Where
- Pakistan
- Volunteers
- 64 people
- Sponsor
- Rawalpindi Medical College