Clinical trials: Suicide and Depression
Substance-related Disorders, Depression
Primary Care iSBIRT to Reduce Serious Teen Health Risks
The goal of the project is to develop and test an internet/intranet-based Screening, Brief Intervention, and Referral to Treatment (iSBIRT) system for adolescents that targets a broad range of serious health-risks and problem…
- Conditions
- Substance-related Disorders, Depression, High-risk Sex
- Trial name
- NCT00891631
- Testing
- iSBIRT, iSBIRT/TE
- Where
- United States
- Sponsor
- Boston Children's Hospital
Depression, Anxiety
Efficacy of a Brief Intervention to Improve Sexual and Gender Minorities' Mental Health: Randomized Controlled Trial.
Experiences of violence, from micro to physical aggressions, have a deleterious impact on mental health. According to the Minority Stress Theory, unfavorable social conditions (such as anticipated and experienced discrimination…
- Conditions
- Depression, Anxiety, Psychological Distress, Social Phobia
- Trial name
- ESCREVA-SE (NCT05349877)
- Testing
- Expressive writing, Self-affirmation
- Where
- Brazil
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidade Católica do Rio Grande do Sul
Community Adolescents at Risk for Depression and Suicide
Application and Evaluation of Group Cognitive Intervention for Depressed Adolescents
Cognitive behavioral therapy (CBT) is effective and CBT with parental involvement has potential in preventing and treating adolescent depression.
- Trial name
- NCT00946413
- Testing
- CBT plus parent education, CBT alone
- Where
- Taiwan
- Volunteers
- 31 people
- Sponsor
- Taipei Medical University Hospital
Suicide, Depressive Disorder, Major
Promote Access to Stop Suicide: Comparison of Follow up Services for Youth at Risk for Suicide
This research study is designed to answer specific questions about new ways to provide services for youth at-risk of suicide.
- Conditions
- Suicide, Depressive Disorder, Major, Anxiety Disorders, Suicidal Ideation
- Trial name
- PASS (NCT03016572)
- Testing
- Standard of Care, Crisis Intervention, Wraparound Services
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- The Cleveland Clinic
Depression, Post Traumatic Stress Disorder
The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Registry
While effective interventions for depression exist, their success rates are unsatisfactory and their provision is haphazard. The Canadian Depression Research and Intervention Network (CDRIN) Maritimes Depression Hub will improve…
- Conditions
- Depression, Post Traumatic Stress Disorder, Bipolar Disorder, Mood Disorder
- Trial name
- NCT02443636
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Non Suicidal Self Injury, Suicidal Ideation
aiTBS for NSSI and Suicide in Adolescent Depression
Repetitive transcranial magnetic stimulation (rTMS) has been successfully used to help patients with treatment resistant depression.
- Conditions
- Non Suicidal Self Injury, Suicidal Ideation, Suicide and Self-harm
- Trial name
- NCT06210100
- Testing
- Active iTBS
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Central South University
Bipolar Disorder, Depression
Brain Tissue Collection for Neuropathological Studies
The purpose of this study is to collect and study the brain tissue of deceased individuals to learn more about the nervous system and mental disorders.
- Conditions
- Bipolar Disorder, Depression, Anxiety Disorders, Schizophrenia
- Trial name
- NCT00001260
- Where
- 3 sites in United States
- Volunteers
- 2,161 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Depression, Anxiety, Post Traumatic Stress Disorder
Adaptation and Evaluation of the KEEP Model
This study capitalizes on an opportunity to formally evaluate local adaptations of "Keeping Foster and Kinship Parents Supported and Trained" (KEEP), an evidence-based foster parent intervention, to reduce mental health…
- Conditions
- Depression, Anxiety, Post Traumatic Stress Disorder, Suicide and Self-harm, Externalizing Behavior
- Trial name
- NCT05816421
- Testing
- KEEP, Non-Affinity KEEP
- Where
- United States
- Volunteers
- 283 people
- Sponsor
- Oregon Social Learning Center
Suicide Attempt, Depression
Effects of a Multifaceted School-Based Intervention to Protect Mental Health and Prevent Suicidal Behaviour in Adolescents in Spain
What is this study about? This study aims to find out if a school-based program can help improve mental health and prevent suicidal thoughts and behaviors in teenagers in Spain.
- Conditions
- Suicide Attempt, Depression, Adolescent Mental Health, Self-Harm
- Trial name
- NCT06996054
- Testing
- Multifaceted School-Based Mental Health and Suicide Prevention Program
- Volunteers
- 2,280 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
Depression and Suicide Ideation, Anxiety
Culturally Adapted Psychological Support for Conflict-Affected Afghans: Study Protocol on Mental Health & Violence
This pilot study examines the feasibility and acceptability of a culturally adapted psychological intervention-Problem Management Plus with Emotional Processing (PM+ EP)-for young Afghans aged 16-30 experiencing high…
- Conditions
- Depression and Suicide Ideation, Anxiety, PTSD
- Trial name
- NCT06980441
- Testing
- Problem Management Plus with Emotional Processing module
- Where
- Afghanistan
- Volunteers
- 60 people
- Sponsor
- Peace of Mind Association (PoMA)
Anxiety Disorders, Depression
Pharmacogenomics of Antidepressant Response in Children and Adolescents
This study will identify variations in genes that may be involved in the development of suicidal events or certain behaviors in youth who are exposed to antidepressant medications.
- Conditions
- Anxiety Disorders, Depression, Eating Disorders, Obsessive-Compulsive Disorder
- Trial name
- PARCA (NCT00516932)
- Where
- United States
- Volunteers
- 211 people
- Sponsor
- Duke University
Suicide, Suicide, Attempted
Suicide Prevention and Intervention in Spain: the SURVIVE Study
Suicide is one of the leading causes of avoidable death worldwide. Gathering population-representative data on the incidence of suicidal behavior, as well as developing effective secondary prevention strategies are imperative…
- Conditions
- Suicide, Suicide, Attempted, Depression
- Trial name
- SURVIVE (NCT04343703)
- Testing
- Telephone-based management, iFightDepression for Suicide, Treatment as Usual
- Where
- 8 sites in Spain
- Volunteers
- 1,742 people
- Sponsor
- Parc de Salut Mar
Suicide, Attempted
Bipolarity - Depression in Children and Adolescent Suicide Attempters: Better Diagnosis to Prevent Recurrence
The purpose of the study is to describe the number of diagnosis of bipolar depression and comorbid suicidal behavior according to the diagnostic criteria of the DSM-5.
- Trial name
- NCT03116503
- Testing
- diagnosis of bipolar disorder and comorbid depression
- Where
- France
- Volunteers
- 58 people
- Sponsor
- Fondation Lenval
Depression - Major Depressive Disorder, Irritability
Teen Vulnerability to Irritability: Brain and Estrogen Changes
Purpose: Risk of severe psychopathology increases dramatically during adolescence, especially for females. Changes in ovarian steroids across the menstrual cycle produce windows of vulnerability to mood disturbances, particularly…
- Trial name
- TeenVIBE (NCT07544966)
- Testing
- Kurvelo
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Post Traumatic Concerns, Post Traumatic Stress Disorder
A Comparative Effectiveness Trial of Optimal Patient-Centered Care
The nation's trauma care system, which includes trauma center hospitals \& emergency departments, is where over 30 million Americans receive care after traumatic injuries each year.
- Conditions
- Post Traumatic Concerns, Post Traumatic Stress Disorder, Depression and Suicide Ideation, Alcohol and Drug Use
- Trial name
- TSOS 5 (NCT02274688)
- Testing
- Stepped Care Management
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Washington
Suicidal Ideation, Suicidal and Self-injurious Behavior
Optimizing Suicide Prevention Strategies for Pediatric Primary Care
Increasing rates of suicidal thoughts and behaviors among adolescents must be addressed. The study will adapt and collect preliminary effectiveness data on a digital suicide prevention intervention that can be delivered in…
- Conditions
- Suicidal Ideation, Suicidal and Self-injurious Behavior, Depression
- Trial name
- NCT06194331
- Testing
- iCHART/cASAP, Treatment as usual
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Pittsburgh
Anhedonia, Depression and Suicide Ideation
Get ActivE Study for At-risk Youth
The study will adapt and deploy a digital Behavioral Activation app with mobile sensing, supported by health coaches, that encourages youth to engage in positive activities.
- Trial name
- GetActivE (NCT06829953)
- Testing
- GET ActivE, Treatment As Usual
- Where
- 2 sites in United States
- Volunteers
- 75 people
- Sponsor
- University of Pittsburgh
Self Harm, Depression
Computer Assisted Family Intervention to Treat Self-Harm Disparities in Latinas and Sexual/Gender Minority Youth
This study is designed to refine and test the efficacy of a computer assisted culturally informed and flexible/adaptive intervention for Latino adolescents for whom self-harm behaviors are a health disparity-specifically, Latinas…
- Conditions
- Self Harm, Depression, Emotion Dysregulation, Suicidal Ideation
- Trial name
- NCT03709472
- Testing
- Computer Assisted CIFFTA, Behavioral: Traditional face-to-face treatment-no technology
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of Miami
Depressive Disorder, Major, Bipolar Depression
Triple Chronotherapy in Adolescents
Study Purpose This study is a randomized controlled trial examining the effectiveness of TCT in the acute treatment of depression and suicidality in adolescents compared to usual treatment care, which includes individual and…
- Conditions
- Depressive Disorder, Major, Bipolar Depression, Suicidal Ideation
- Trial name
- TCT-RCT (NCT03679962)
- Testing
- Triple Chronotherapy, Treatment as Usual
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Billings Clinic
Depression, Suicidal Ideation
Screening Wizard- Phase 2
Screening Wizard (SW). Primary Care Providers (PCPs) are often uncertain about how to best refer adolescents who screen positive for depression or suicidality.
- Trial name
- NCT04646369
- Testing
- "screening as usual", Screening Wizard 2.0, Screening Wizard 2.0 + SOVA
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh