Clinical trials: Substance Use Disorders
Pain, Postoperative, Orthognathic Surgery
Personalization of Opioid Prescription Following Orthognathic Surgery
This study aims to investigate pain management and satisfaction following orthognathic surgery, which is a type of surgery that corrects jaw and facial bone issues.
- Conditions
- Pain, Postoperative, Orthognathic Surgery, Opioid Use, Patient Satisfaction
- Trial name
- NCT05708521
- Testing
- Personalization of dose and frequency and instituting a tapering protocol of hydromorphone post-orthognathic surgery, Standardized dose and frequency of hydromorphone with no tapering post-orthognathic surgery
- Where
- Canada
- Volunteers
- 201 people
- Sponsor
- Nova Scotia Health Authority
Substance-related Disorders, Alcohol-Related Disorders
LaunchPad: Supporting Healthy Decisions and Preventing Drug Use After High School
LaunchPad is an online substance use prevention program for high school seniors. The program is designed to help seniors develop skills and make informed decisions as they transition from high school to young adulthood.
- Conditions
- Substance-related Disorders, Alcohol-Related Disorders, Tobacco Use Disorder, Marijuana Use
- Trial name
- NCT07655609
- Testing
- Introduction, Norms re: Protective Behavior Strategies (PBS), Life Skills
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Prevention Strategies, LLC
Substance-Related Disorders, Alcohol-Related Disorders
Computer-delivered Psychosocial Intervention for Adolescent Substance Use Disorders
The purpose of this study is to develop and evaluate the acceptability and preliminary efficacy of a web-based, skills training program for adolescents with substance use disorders.
- Conditions
- Substance-Related Disorders, Alcohol-Related Disorders, Marijuana Abuse
- Trial name
- NCT00957775
- Testing
- Usual care, Computer-delivered ACRA
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- National Development and Research Institutes, Inc.
Tobacco Use Disorder, Smoking Cessation
Mobile Health (mHealth) Application for Smoking Cessation Among Adolescents in Indonesia
This mixed-methods study develops and evaluates a mobile health (mHealth) application for smoking cessation among Indonesian adolescents aged 13-15 years.
- Conditions
- Tobacco Use Disorder, Smoking Cessation, Adolescent Smoking
- Trial name
- NCT07198828
- Testing
- mHealth Smoking Cessation Application, Paper-based Control Materials
- Where
- Indonesia
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Adolescent Problem Behavior, Truancy; Unsocialized
Substance Use Interventions for Truant Adolescents
This study evaluates a brief motivation-building intervention for parents and teens to reduce truancy and substance use. It is hypothesized that the motivational intervention will result in better outcomes compared to an…
- Conditions
- Adolescent Problem Behavior, Truancy; Unsocialized, Marijuana Abuse, Truancy; Socialized
- Trial name
- GOALS (NCT03655574)
- Testing
- Motivational + Family Check-up (MET+FCU), Psychoeducation
- Where
- 2 sites in United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Brown University
Posttraumatic Stress Disorder, Substance Use Disorders
Treating Violence-related PTSD and Substance Risk in Low-income, Urban Adolescents
This project will provide initial feasibility and efficacy data for the implementation of Narrative Exposure Therapy (NET) to urban, at-risk youth.
- Trial name
- POWER-NET (NCT03737383)
- Testing
- Narrative Exposure Therapy
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Substance Abuse, Mindfulness
Master Mind Program Evaluation Study
The purpose of this study is to conduct a randomized controlled trial to evaluate the efficacy of the Master Mind program, a mindfulness education substance abuse prevention program.
- Trial name
- MasterMind (NCT03212066)
- Testing
- Master Mind
- Where
- United States
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Innovation Research & Training
PTSD - Post Traumatic Stress Disorder, Substance Use
CBITS-RTM Pilot Study
This pilot study, conducted in partnership with juvenile detention centers, evaluates an adapted CBITS-RTM intervention delivered in a detention school setting.
- Trial name
- NCT07682441
- Testing
- Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, San Francisco
Cannabis Use, Alcohol Use, Unspecified
CARS: Cannabis and Alcohol Reduction Study
The study will test a computerized treatment with subjects ages 13-17 years who are seeking treatment for alcohol and/or cannabis use. Follow-up assessments will be conducted at one- and three-months following treatment.
- Conditions
- Cannabis Use, Alcohol Use, Unspecified, Substance Use, Substance Use Disorders
- Trial name
- CARS (NCT05486234)
- Testing
- modified Approach-Avoidance Task (mAAT), which aims to modify automatic approach bias, modified Approach-Avoidance Task (mAAT) that does not aim to modify automatic approach bias.
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Medical University of South Carolina
Cannabis Use Disorder
N-Acetylcysteine for Youth Cannabis Use Disorder
This is a 12-week randomized, placebo-controlled trial of N-acetylcysteine for cannabis use disorder (CUD) in youth (N=192). Participants will be randomized to double-blind NAC or PBO, yielding two equally-allocated treatment…
- Trial name
- NCT03055377
- Testing
- N-acetyl cysteine
- Where
- United States
- Volunteers
- 192 people
- Sponsor
- Medical University of South Carolina
Tobacco Dependence
Provider and Peer Delivered Youth Smoking Intervention
The purpose of this study was to determine whether a pediatric practice-based smoking prevention and cessation intervention increases abstinence rates among adolescents.
- Trial name
- NCT00435344
- Testing
- Pediatric Practice-Based Smoking Intervention
- Where
- United States
- Volunteers
- 2,711 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2
Currently one in five high school students smoke. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158158
- Testing
- Usual Care, Smoking Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Psychosis, Alcohol Use Disorder
Effects of Action-Based Cognitive Remediation on Substance Misuse in Early Phase Psychosis
Psychotic disorders impact 4.6 people per 1000 globally, with approximately 1.5 million Canadians affected. The age of onset for psychotic disorders often begin during the critical years of youth and early adulthood, resulting in…
- Conditions
- Psychosis, Alcohol Use Disorder, Cannabis Use Disorder
- Trial name
- NCT07056894
- Testing
- Action-Based Cognitive Remediation
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Nova Scotia Health Authority
Vaping, Vaping Cessation
Social Media Support Groups for Adolescent Vaping Cessation
The purpose of this study is to pilot test feasibility and acceptability of the Quit the Hit Toolkit, a social media-based nicotine vaping cessation program for adolescents and young adults, adapted for use in community settings.
- Conditions
- Vaping, Vaping Cessation, Nicotine Dependence
- Trial name
- NCT07540780
- Testing
- Social Media Intervention
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Substance Use
'Keepin' It REAL in Mexico: An Adaptation and Multisite RCT Implementation of a Substance Abuse Prevention Curriculum for Adolescents in Three Mexico Cities.
Sharp increases in substance use rates among youth in Mexico are a major concern, both in Mexico and the US. Although the Mexican government has elevated substance abuse prevention as a national priority, there are few…
- Trial name
- NCT03233386
- Testing
- Mantente REAL
- Where
- United States
- Volunteers
- 5,524 people
- Sponsor
- Arizona State University
Substance Use
Health and Resilience Projects: Foundations
The Health and Resilience Project (HARP): Foundations is investigating the efficacy of the Strong African American Families (SAAF) intervention in promoting the health and well being of African American adolescents.
- Trial name
- HARP-F (NCT05253235)
- Testing
- SAAF, Receipt of parenting book
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Drug Use, Drug Abuse
Acute Intervention to Reduce Distress Following Sexual Assault
The purpose of this study was to evaluate whether a brief intervention in video format delivered in the post assault medical exam setting and including education about assault reactions and instruction in and modeling of…
- Conditions
- Drug Use, Drug Abuse, Posttraumatic Stress Disorder
- Trial name
- NCT01622855
- Testing
- PPRS
- Where
- United States
- Volunteers
- 442 people
- Sponsor
- Medical University of South Carolina
Opioid Withdrawal (Disorder), Opioid Use Disorder
A Pharmacokinetic, Safety, and Tolerability Study of LUCEMYRA in the Treatment of Opioid Withdrawal Management in Adolescent Subjects
The goal of this clinical study is to evaluate the pharmacokinetic (PK), safety, and tolerability of LUCEMYRA in adolescents age ≥12 to <18 years old abruptly discontinuing opioid use.
- Trial name
- NCT06711640
- Testing
- LUCEMYRA (lofexidine) tablets
- Where
- United States
- Sponsor
- USWM, LLC (dba US WorldMeds)
PTSD, Alcohol Use Disorders
Integrative Risk Reduction and Treatment for Teen Substance Use Problems and PTSD
Adolescents receiving RRFT and their caregivers will report significantly fewer substance use problems (quantity of use, frequency of use, and abuse symptoms) during treatment and follow-up than control adolescents who receive…
- Conditions
- PTSD, Alcohol Use Disorders, Substance Use Disorders
- Trial name
- RRFT (NCT01751035)
- Testing
- Risk Reduction through Family Therapy, Treatment as Usual
- Where
- United States
- Volunteers
- 135 people
- Sponsor
- Medical University of South Carolina