Clinical trials: Randomised Controlled Trial
Bronchopulmonary Dysplasia
TINN2: Treat Infection in NeoNates 2
The aim of the TINN2 study is to evaluate the efficacy of azithromycin in prevention of bronchopulmonary dysplasia in preterm neonates.
- Trial name
- TINN2 (NCT02282176)
- Testing
- Azithromycin
- Where
- 16 sites in Belgium, France and 7 more
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Asthma
Anti-Inflammatory Reliever South Africa
This is a Phase 3 single-centre open label randomised controlled trial with two equal sized groups to assess the efficacy of budesonide/formoterol 80/4.5 (6-11 years) and 160/4.5 (12-18 years) compared to the standard of care in…
- Trial name
- AIRSA001 (NCT06429475)
- Testing
- Budesonide/formoterol, standard of care
- Where
- 2 sites in South Africa
- Volunteers
- 1,038 people
- Sponsor
- University of KwaZulu
Hyperthermic Intraperitoneal Chemotherapy, Neoadjuvant Chemotherapy
Efficacy of Neoadjuvant Hyperthermic Intraperitoneal Chemotherapy in Advanced High-grade Serous Ovarian Cancer (the NHIPEC Trial)
Background: Neoadjuvant chemotherapy (NACT) is an important treatment option for patients with ovarian cancer. Although intravenous NACT can improve optimal resection rates and decrease surgical morbidity and mortality, these…
- Trial name
- NHIPEC (NCT05246020)
- Testing
- HIPEC, intravenous chemotherapy
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Pediatric Cancer
Nurse-led Transitional Care to Improve Symptom Management in Childhood Cancer Survivors
This study aims to evaluate the feasibility and preliminary effectiveness of a nurse-facilitated interdisciplinary transitional care programme, based on the Omaha system, for Chinese childhood cancer survivors (CCSs) and their…
- Trial name
- NCT07273682
- Testing
- Counseling based on Omaha system, Usual Care
- Volunteers
- 68 people
- Sponsor
- The Hong Kong Polytechnic University
Cystic Fibrosis, Bronchiectasis
Prevention of Bronchiectasis in Infants With Cystic Fibrosis
The general aim of this project is to conduct a randomized, double-blind, placebo-controlled clinical trial of azithromycin to determine whether treatment from infancy is safe and will prevent the onset of bronchiectasis.
- Trial name
- COMBATCF (NCT01270074)
- Testing
- Azithromycin
- Where
- 10 sites in Australia, New Zealand
- Volunteers
- 130 people
- Sponsor
- The University of Queensland
Acute Respiratory Distress Syndrome
Open Lung Ventilation in ARDS: The PHARLAP Trial
Some people develop the condition called acute respiratory distress syndrome (ARDS). This is a condition where the lungs have become injured from one of a number of various causes, and do not work as they normally do to provide…
- Trial name
- PHARLAP (NCT01667146)
- Testing
- PHARLAP mechanical ventilation strategy, Control group mechanical ventilation strategy
- Where
- 27 sites in Australia, Ireland and 3 more
- Volunteers
- 115 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Maternal Mortality, Perinatal Mortality
Evaluation of a Smartphone Application to Reduce Adverse Pregnancy Outcomes in Ethiopia
The purpose of this trial is to determine if the safe delivery smartphone application distributed to health workers in Ethiopia will decrease perinatal mortality and the incidence of postpartum haemorrhage.
- Trial name
- NCT01945931
- Testing
- Safe Delivery Smartphone Application
- Where
- Denmark
- Volunteers
- 3,601 people
- Sponsor
- University of Copenhagen
Overweight and Obesity
mHealth for Prevention of Childhood Obesity in Mexico
Background: The sending of text messages (short messaging service, SMS) has been proven as an effective strategy in behavior change.
- Trial name
- mHealth (NCT04250896)
- Testing
- Control group, SMS´s sending by cell phone for behavior change
- Where
- Mexico
- Volunteers
- 1,000 people
- Sponsor
- Mexican National Institute of Public Health
Skin Hyperpigmentation, Dry Skin; Eczema
Efficacy and Safety Assessment of Niacinamide Cosmetic Preparation: a Randomized Controlled Trial
Niacinamide in lower concentrations has been recognized as a cosmetic ingredient with hydrating properties. Therefore, aim was to test the efficacy and safety of niacinamide cosmetic preparation in A Randomized, Controlled Trial.
- Trial name
- NCT06189105
- Testing
- miss alice face it you love me serum, No treatment (usual skincare rutine)
- Where
- Croatia
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Split, School of Medicine
Food Allergy, Food Allergy in Infants
The Clinical Impact of the Basophil Activation Test to Diagnose Food Allergy
The BAT Impact study is a prospective multicentre study in the UK using a biomarker-led study design to compare the incidence of adverse events (defined as allergic reactions during oral food challenges) in a…
- Conditions
- Food Allergy, Food Allergy in Infants, Food Allergy in Children, Food Allergen Sensitisation
- Trial name
- NCT05309772
- Testing
- Basophil activation test (BAT), Oral food challenge (OFC)
- Where
- 11 sites in United Kingdom
- Volunteers
- 398 people
- Sponsor
- King's College London
Female Breast Cancer
Acupuncture for Joint Symptoms in Patients With Breast Cancer
Joint symptoms including stiffness, local pain and aches are common adverse reactions among breast cancer (BC) patients undergoing hormone treatments, while effective interventions for managing such symptoms have not been well…
- Trial name
- NCT03836872
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 64 people
- Sponsor
- The Hong Kong Polytechnic University
Scoliosis Idiopathic
Effect of Scoliosis-Specific Exercise on Lower Limb Biomechanics
PURPOSE: To examine the effect of Physiotherapeutic Scoliosis-Specific Exercise on limb biomechanical parameters in adolescents with idiopathic scoliosis.
- Trial name
- NCT06266637
- Testing
- Conventional Physical Therapy Program, Physiotherapeutic Scoliosis-Specific Exercise (Schroth)
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Delta University for Science and Technology
Complications of Surgical and Medical Care: General Terms
Effective Feedback to Improve Primary Care Prescribing Safety
We hypothesise that feedback and feedback + psychology informed intervention delivered to primary care medical practices will reduce high-risk prescribing to patients compared to a simple educational intervention alone.
- Trial name
- EFIPPS (NCT01602705)
- Testing
- Usual care, Feedback of Performance, Feedback of Performance + Health Psychology Informed Intervention
- Where
- United Kingdom
- Volunteers
- 262 people
- Sponsor
- University of Dundee
Neonates and Preterm Infants, Infant Respiratory Distress Syndrome
Duration of Surfactant Administration and Impact on Stabilisation of Vital Parameters in Very Preterm Neonates: 1 Minutes Versus 5 Minutes
Respiratory distress syndrome (RDS) is common in very preterm infants due to surfactant deficiency. Surfactant replacement therapy is lifesaving, and current guidelines recommend the less invasive surfactant administration (LISA)…
- Conditions
- Neonates and Preterm Infants, Infant Respiratory Distress Syndrome, Surfactant Deficiency Syndrome Neonatal, Surfactant
- Trial name
- SurfStab I (NCT07261787)
- Testing
- Poractant alfa (Curosurf®) - 1-minute administration, Poractant alfa (Curosurf®) - 5-minute administration
- Where
- Austria
- Volunteers
- 76 people
- Sponsor
- Medical University of Graz
Scoliosis Idiopathic
Self Correction Exercises for Idiopathic Scoliosis Among Adolescents. A Randomised Controlled Trial
Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity with an unknown cause that affects adolescents aged 10 or older.
- Trial name
- NCT03779581
- Testing
- Self Correction exercises, orthotic devices
- Where
- Saudi Arabia
- Volunteers
- 108 people
- Sponsor
- Majmaah University
HPV Infection, HPV-Related Carcinoma
To Evaluate the Safety and Immunogenicity of 15-valent HPV Recombinant Vaccine in Chinese People Aged 9-45 Years
To evaluate the safety and Immunogenicity of 15-valent HPV vaccine in 9-45year-old participants.
- Conditions
- HPV Infection, HPV-Related Carcinoma, HPV-Related Intraepithelial Neoplasia, Genital Wart
- Trial name
- NCT06756269
- Testing
- Medium dose for 15-HPV vaccine, High dose for 15-HPV vaccine, 9-HPV vaccine
- Where
- China
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Shanghai Bovax Biotechnology Co., Ltd.
Food Allergy in Children, Food Allergy
Boiled Tree Nut for Oral Immunotherapy in Food-allergic Children
As the global prevalence of food allergy steadily increases, tree nut (TN) becomes one of the main triggers of food-allergic reactions and food anaphylaxis.
- Trial name
- NCT06467994
- Testing
- Cashew oral immunotherapy
- Where
- Hong Kong
- Volunteers
- 75 people
- Sponsor
- Chinese University of Hong Kong
Malaria, Mosquito-Borne Disease
Evaluation of the Protective Efficacy of a Spatial Repellent to Reduce Malaria Prevalence in Uganda
A cluster-randomized double-blinded control trial will be conducted in Uganda to demonstrate and quantify the protective efficacy (PE) of Mossie-GO, an active spatial repellent system disseminating transfluthrin, in reducing the…
- Trial name
- Mossie-GO (NCT06232954)
- Testing
- Mossie-Go containing treated transfluthrin disc, Mossie-Go containing untreated blank disc
- Where
- Uganda
- Volunteers
- 5,600 people, healthy volunteers welcome
- Sponsor
- Africa Power Limited
Bimaxillary Proclination
Anchorage Reinforcement in Bimaxillary Proclination Cases
Bimaxillary protrusion are common in Malaysia due to the prevalence in the two biggest races (Malay and Chinese). However, evidence for treatment methods and outcomes for bimaxillary protrusion patients are scarce.
- Trial name
- NCT04705545
- Testing
- transpalatal arch group, Nance button
- Where
- Malaysia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Respiratory Distress Syndrome in Premature Infant
The NONA-LISA Trial
The NONA-LISA trial will be an investigator-initiated, multicentre, pragmatic, parallel-group, blinded RCT conducted at four university hospitals across Denmark.
- Trial name
- NONA-LISA (NCT05609877)
- Testing
- Isotonic saline, Less Invasive Surfactant Administration (LISA), Fentanyl
- Where
- 4 sites in Denmark
- Volunteers
- 324 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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