Clinical trials: Pre-Diabetes
Metabolic Cardiovascular Syndrome
Health Improvement After Pregnancy (HIP) Program Randomized Control Trial
Recent Canadian studies, public opinion polls and the Canadian Heart Health Strategy and Action Plan state that women's heart health is a key national priority; it should be addressed through improving heart health awareness and…
- Trial name
- HIP (NCT02077179)
- Testing
- HIP Program
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Queen's University
Pre Diabetic
Effects of Intermittent Fasting Variations on Metabolic, Inflammatory, and Nutrigenomic Profiles in Prediabetes: A Randomized Controlled Trial
Prediabetes is a metabolic condition associated with increased risk of type 2 diabetes and cardiovascular disease. Intermittent fasting (IF) has emerged as a potential dietary intervention to improve metabolic health, yet…
- Trial name
- NCT07408791
- Testing
- Diet
- Where
- Indonesia
- Volunteers
- 120 people
- Sponsor
- DINA KEUMALA SARI
Respiratory Disorder, Cardiovascular Diseases
Study of RE.DOCTOR Vitals® Software Accuracy
The purpose of this observational trial is to advance digital health monitoring through the analysis of Photoplethysmography (PPG) waveforms collected via RE.DOCTOR Vitals software.
- Conditions
- Respiratory Disorder, Cardiovascular Diseases, Diabetes, Pre-Diabetes
- Trial name
- RE-VITAL (NCT06237322)
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- RE.DOCTOR LLC
Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators
This Study Will Evaluate Cardiorespiratory and Muscular Fitness to Examine Associations With Anthropometric Characteristics and Other Indicators of Cardiometabolic Risk Among Patients With or Without Autism Spectrum Disorder
The goal of this observational study is to evaluate cardiorespiratory and muscular fitness in children with obesity, with and without autism spectrum disorder (ASD), and examine how fitness relates to body measurements, body…
- Conditions
- Autism Spectrum Disorder (ASD), Cardiometabolic Health Indicators, Cardiometabolic Risk Factors, Metabolic Syndrome
- Trial name
- ROACH (NCT07804680)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Virginia
Obesity, Prediabetic State
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.
The study aims to investigate the effects of oral inositols on insulin-resistance and metabolic variables (triglycerides, total cholesterol, HDL cholesterol) in children aged 8-12 years with obesity and insulin-resistance.
- Conditions
- Obesity, Prediabetic State, Dyslipidemias, Insulin Resistance
- Trial name
- ONIRICO (NCT05701813)
- Testing
- INOSITOLS, CELLULOSE
- Volunteers
- 56 people
- Sponsor
- Azienda Ospedaliera Universitaria Integrata Verona
Diabetes Mellitus, Chronic Disease
Meta-analyses of Liquid Versus Solid Calories and Body Weight
Consumption of sugar-sweetened beverages (SSBs) has been linked to rising rates of overweight and obesity. The most prominent mechanism to explain the link between SSBs and obesity is that liquid calories are not perceived by the…
- Conditions
- Diabetes Mellitus, Chronic Disease, Cardiovascular Diseases, Prediabetic State
- Trial name
- NCT02702440
- Testing
- Liquid calories from sugars
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Obesity, PreDiabetes
Mechanisms of Inflammation, Immunity, Islet Cell and Intestinal Hormone Changes in Youth at Risk for Diabetes
This study intends to assess the role of inflammation in insulin resistant conditions (i.e., obesity and pre-diabetes) and the subsequent development of disease, such as type 2 diabetes (T2D) and cardiovascular disease (CVD), in…
- Conditions
- Obesity, PreDiabetes, Adolescent Obesity, Inflammation
- Trial name
- MI4D (NCT04031222)
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
Type 2 Diabetes, Chronic Disease
PRE-STARt Intervention - Trial of an Interactive Family Based Lifestyle Programme
To investigate whether the interactive family based lifestyle programme leads to behaviour change at 6 months with the primary outcome being increased levels of moderate to vigorous physical activity (MVPA).
- Conditions
- Type 2 Diabetes, Chronic Disease, Obesity
- Trial name
- NCT02845791
- Testing
- Interactive Lifestyle programme workshop
- Where
- United Kingdom
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Type 1 Diabetes
Primary Intervention With Mucosal Insulin
A dose with proven drug bioavailability to the immune system for use in a phase II/III primary T1DM (type 1 diabetes) vaccination trial (POINT study) in genetically at risk subjects.
- Trial name
- Pre-POINT (NCT02620553)
- Testing
- Human Insulin
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Prediabetic State
Finding the Patient's Voice Diabetes Prevention Programs
This study uses patient engagement to develop a diabetes prevention program focused on adolescents and families.
- Trial name
- NCT02700503
- Testing
- Encourage 2.0
- Where
- 3 sites in United States
- Volunteers
- 146 people
- Sponsor
- Indiana University
Cystic Fibrosis
The Impact of Insulin Therapy on Protein Turnover in Pre-Diabetic Cystic Fibrosis Patients
Insulin replacement therapy may be effective in breaking the cycle of protein catabolism, undernutrition and overall clinical deterioration in pre-diabetic, insulin insufficient CF youth because of its potent anabolic effect.
- Trial name
- NCT02496780
- Testing
- novolog insulin, levemir insulin
- Where
- 2 sites in United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Type 1 Diabetes Mellitus
Diabetes Autoimmunity Study in the Young
Type 1 diabetes (T1D) affects 1.4 million people in the U.S. and its incidence has doubled over the past 20 years. The Diabetes Autoimmunity in the Young Study (DAISY) will estimate overall burden of T1D and other autoimmune…
- Trial name
- DAISY (NCT03205865)
- Volunteers
- 2,700 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2, Schizophrenia
Metformin in Co-morbid Diabetes or Prediabetes and Serious Mental Illness
Schizophrenia is associated with a lifespan shortened by 20 years, due to cardiovascular disease (CVD), with antipsychotic (AP) medications understood to contribute to this risk through associated metabolic side-effects.
- Trial name
- NCT02167620
- Testing
- Metformin
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Centre for Addiction and Mental Health
Prediabetes, Type 1 Diabetes
TEFA Family Prevention: Glutenfree Diet to Preserve Beta-cell Function
To evaluate the effect of Gluten Free Diet (GFD) on beta-cell function and glucose metabolism in subjects with one or several islet autoantibodies without and with dysglycemia at baseline.
- Trial name
- TEFA (NCT02605148)
- Testing
- Gluten free diet, Omega 3 fatty acid, Vitamin D
- Where
- Sweden
- Volunteers
- 60 people
- Sponsor
- Lund University
Type1diabetes, Childhood ALL
Hb A1C Pre and Post Confinement in Latin American Children With Type 1 Diabetes: Dulce Study Group
A multicenter retrospective observational study among children with type 1 diabetes will be performed. The Objective of this study will be to determine a) the association between the increase in Hba1c in children with type 1…
- Trial name
- NCT04640064
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Hospital General Puyo
Overweight, Glucose Intolerance
Diabetes Prevention In Estrie
This study compared the efficacy at one year of an interdisciplinary approach including individual counseling and group seminars versus group seminars alone to induce weight loss in subjects at high risk of developing type 2…
- Trial name
- NCT00991549
- Testing
- interdisciplinary intervention or meeting-seminars
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- Université de Sherbrooke
Pre Diabetes
Diabetes Prevention Program in Youth
The purpose of this study is to test the effectiveness of an out-of-school diabetes prevention program for youth (ages 7-15) with a family history of pre-diabetes or type 2 diabetes.
- Trial name
- NCT03042936
- Testing
- Insulin Superheroes Club Curriculum
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Type 1 Diabetes (T1D), Registry
UK Islet Autoantibody Registry
Type 1 diabetes (T1D) is a life-long condition where the immune system destroys part of the body (the pancreas) which makes the chemical, insulin. Insulin is needed to control blood sugar levels.
- Conditions
- Type 1 Diabetes (T1D), Registry, Pre-diabetes, Screening
- Trial name
- UKIAb Registry (NCT07125365)
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Oxford
Cystic Fibrosis Related Diabetes, Pancreatic Insufficiency
Pilot and Feasibility Study for the Treatment of Pre-diabetes in Patients With Cystic Fibrosis
The purpose of this study is to provide the necessary data and experience to design a larger, full scale clinical trial to determine if a certain medicine (repaglinide), which increases the amount of insulin secreted by the…
- Trial name
- NCT00763412
- Testing
- repaglinide
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Arbelaez, Ana Maria