Clinical trials: Nutritional Deficiency
Propionic/Methylmalonic Acidemias, Maple Syrup Urine Disease
Selective Screening of Children for Hereditary Metabolic Diseases by Tandem Mass Spectrometry in Kazakhstan
Inborn errors of metabolism (IEM) are not have specific clinical signs, they masquerade as other diseases, and are difficult to diagnose using only clinical manifestations or routine laboratory tests.
- Conditions
- Propionic/Methylmalonic Acidemias, Maple Syrup Urine Disease, Citrullinemia, Argininosuccinic Aciduria
- Trial name
- NCT05910151
- Testing
- Obtaining Dry Blood Spots From Healthy Newborns (Aged 1-7 Days), Obtaining Dry Blood Spots From Healthy Children Aged 8 Days - 7 Years, Obtaining Dry Blood Spots From Healthy Children Aged 8-18 Years
- Where
- Kazakhstan
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- West Kazakhstan Medical University
Severe Acute Malnutrition
Efficacy and Acceptability of RUTFs in Indonesia
Severe wasting or Severe Acute Malnutrition (SAM) continues to be a major public health problem in Indonesia, affecting more than 2 million children under 5 years old.
- Trial name
- NCT05614505
- Testing
- Ready to use therapeutic foods
- Where
- Indonesia
- Volunteers
- 300 people
- Sponsor
- Institut de Recherche pour le Developpement
Cytomegalovirus Infections, HIV Infections
A Randomized, Double-Blind Study of the Efficacy and Safety of Oral Ganciclovir for the Prevention of CMV Disease in People Infected With the Human Immunodeficiency Virus
To evaluate the efficacy of oral ganciclovir in preventing progression to cytomegalovirus (CMV) disease (e.g., CMV retinitis, gastrointestinal CMV disease) in CMV-infected people with HIV infection and CD4 lymphocyte counts <=…
- Trial name
- NCT00002095
- Testing
- Ganciclovir
- Where
- 19 sites in United States
- Volunteers
- 700 people
- Sponsor
- Hoffmann-La Roche
Acute Malnutrition With no Complications
Effectiveness of an Alternative Protocol in the Management of Acute Malnutrition
This experimental study aims to test an alternative protocol for managing acute malnutrition in children aged 6-59 months in Burkina Faso.
- Trial name
- Alternat-MAL (NCT06792370)
- Testing
- ready-to-use therapeutic food (for children with MAM), Ready-to-use supplementary food, Ready to Use Therapeutic Food - Reduced dose 1
- Where
- Burkina Faso
- Volunteers
- 3,521 people
- Sponsor
- Institut de Recherche en Sciences de la Sante, Burkina Faso
Iron Deficiency, Anaemia in Children Type1DM
Iron Deficincy Among Children With type1 DM in Assiut University Hospital
detect the prevelance of anemic and non anemic iron deficiency in children with type 1 diabetes.assess the impact of anemic and non anemic iron deficiency in children with type 1 diabetes on their general condition
- Trial name
- NCT06570837
- Testing
- Iron
- Volunteers
- 141 people
- Sponsor
- Assiut University
Obesity, Child
Thiamin Deficiency in Obese Thai Children
This study is aimed to assess the prevalence of thiamin deficiency in obese Thai children.
- Conditions
- Obesity, Child, Thiamine Deficiency
- Trial name
- NCT02464865
- Testing
- Thiamine 1, Non-thiamine, Thiamine 2
- Where
- Thailand
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Immunization Coverage, Vaccination
Increasing Measles Vaccination Coverage Through Supplementation With an SQ-LNS Incentive in Children Aged 6-23 Months
Provision of SQ-LNS also holds promise in incentivizing vaccination as well as other health services. The investigators will estimate 1) the effectiveness of a SQ-LNS mass supplementation program added to routine immunization…
- Conditions
- Immunization Coverage, Vaccination, Nutrition
- Trial name
- NCT06387511
- Testing
- Small-quantity lipid-based nutrition supplements (SQ-LNS) NutriVax, Sensitization on vaccination and on Infant and Young Child Feeding (IYCF) practices
- Where
- Nigeria
- Volunteers
- 3,814 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
Hurler Syndrome
Intrathecal Enzyme Replacement for Hurler Syndrome
This protocol will examine whether the enzyme alpha-L-iduronidase (Laronidase), delivered into the spinal fluid of patients with Hurler syndrome at intervals before and after bone marrow transplant, is a safe and effective…
- Trial name
- NCT00638547
- Testing
- IRT Laronidase
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Pregnancy Related, Pregnancy Loss
Microbiome and Malnutrition in Pregnancy
This study is being conducted to investigate how a mother's nutritional status and her gut microbiome during pregnancy contribute to the birth outcomes and health of her baby.
- Conditions
- Pregnancy Related, Pregnancy Loss, Pregnancy Complications, Pregnancy; Parasitic Disease
- Trial name
- MMIP (NCT04992104)
- Where
- 2 sites in Canada
- Volunteers
- 800 people
- Sponsor
- The Hospital for Sick Children
Iron Deficiency, Iron Deficiency Anemia
Effect of Iron Fortified Wheat Flour on Cognition and Iron Status in Indian School Children
This study is designed to evaluate the efficacy of NaFeEDTA-fortified whole wheat flour in improving cognition, hemoglobin, iron status and total body iron among school children in urban Bangalore.
- Conditions
- Iron Deficiency, Iron Deficiency Anemia, Cognition
- Trial name
- NCT00741143
- Testing
- Fortification of wheat flour with NaFeEdta
- Where
- India
- Volunteers
- 194 people, healthy volunteers welcome
- Sponsor
- St. John's Research Institute
Neonatal Hyperbilirubinemia
Efficacy of Yinzhihuang Oral Liquid on Indirect Bilirubin of Neonates With Glucose-6-phosphate Dehydrogenase Deficiency
Neonatal Glucose-6-phosphate Dehydrogenase(G6PD) Deficiency is one of the significant reason for neonatal hyperbilirubinemia and even irreversible bilirubin encephalopathy.The neonates may be attacked due to acute infection…
- Trial name
- NCT02594904
- Testing
- Yinzhihuang Oral Liquid
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Southern Medical University, China
Malnutrition
Different Strategies for Preventing Severe Acute Malnutrition in Niger
Options for large-scale preventive distributions include fortified blended flours, ready-to-use foods and direct cash transfer either alone or in combination with family protective rations.
- Trial name
- NCT01828814
- Where
- Niger
- Volunteers
- 7,836 people, healthy volunteers welcome
- Sponsor
- Epicentre
PCOS Disease
Studying the Starvation Effect on Androgen Metabolism in 20 Healthy Young Women and Comparison to Women With PCOS.
In this study, the investigators wanted to investigate the energy homeostasis and the steroid metabolism of 20 healthy, young and normal weight women aged between 16-35 years before and after a 48 hours fasting period.
- Trial name
- SEA (NCT03573063)
- Testing
- Androgen metabolism after starvation
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Anemia, Iron-Deficiency
Epidemiological Study of Iron Deficiency and Iron Deficiency Anemia in Chinese Pregnant Women
The purpose of this study is to know the prevalence of iron deficiency (ID) and iron deficiency anemia (IDA) among pregnant women in Chinese urban district at present, and to analyze the epidemiological characteristics of ID/IDA…
- Trial name
- EIDACPW (NCT02887963)
- Where
- China
- Volunteers
- 12,000 people
- Sponsor
- West China Hospital
Severe Combined Immunodeficiency, Neonatal Screening
Neonatal Screening of Severe Combined Immunodeficiencies
The goal of the proposed research is to observe the prevalence and establish the validity of a newborn screening method for severe combined immunodeficiency (SCID).
- Trial name
- NCT02590328
- Where
- China
- Volunteers
- 180,000 people
- Sponsor
- Children's Hospital of Fudan University
Study Focus on the Effect of Malnutrition and Dental Problem
Effect of Malnutrition on Primary and Permanent Dentation
The caries index delayed eruption and enamel malformation will recorded for a 2 group of participants
- Trial name
- NCT04747028
- Testing
- Dmf score
- Volunteers
- 200 people
- Sponsor
- Cairo University
Fanconi Anemia
Long-Term Follow-up: Phase I/II Clinical Study to Evaluate the Safety and Efficacy of the Infusion of RP-L102
Long-Term Follow-up: Phase I/II clinical study to evaluate the safety and efficacy of the infusion of RP-L102
- Trial name
- NCT07527975
- Testing
- RP-L102
- Where
- 3 sites in United States, Spain and 1 more
- Volunteers
- 14 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Kwashiorkor
The Role of Sulfur Amino Acids in Risk of Kwashiorkor
This observational cross-sectional study is investigating if young children in populations with higher prevalence of kwashiorkor malnutrition have lower dietary sulfur amino acid intake than populations with lower prevalence of…
- Trial name
- NCT03520621
- Testing
- No intervention
- Where
- Democratic Republic of the Congo
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Tufts University
Acute Malnutrition, Severe, Malnutrition, Child
Increasing the Coverage of Severe Acute Malnutrition (SAM) Treatment in Ethiopia
The R-SWITCH intervention aims to address the low coverage of treatment for severe wasting (SAM) by leveraging existing community groups to deliver an integrated package focused on prevention, screening, referral, and treatment…
- Conditions
- Acute Malnutrition, Severe, Malnutrition, Child, Wasting
- Trial name
- R-SWITCH (NCT06380504)
- Testing
- R-SWITCH integrated intervention package
- Where
- Ethiopia
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- International Food Policy Research Institute
Hematologic Malignancies
A Single-arm Safety Study of Transplantation Using Umbilical Cord Blood and Human Placental-derived Stem Cells From Partially Matched Related Donors in Persons With Certain Malignant Blood Diseases and Non-malignant Disorders
To investigate the safety of partially matched related human placental-derived stem cells (HPDSC) administered in conjunction with umbilical cord blood (UCB) stem cells from the same donor in subjects with various malignant or…
- Trial name
- HPDSC (NCT00596999)
- Testing
- UCB and HPDSC
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Celgene Corporation
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